The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord

Genes and Development

Volumn 19, Issue 6, 2005, Pages 733-743

  Müller, Thomas ^a   Anlag, Katrin ^a   Wildner, Hendrik ^a   Britsch, Stefan ^a   Treier, Mathias ^b   Birchmeier, Carmen ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

bHLH; Pattern formation; Spinal cord

Indexed keywords

HELIX LOOP HELIX PROTEIN; HELIX LOOP HELIX PROTEIN OLIG3; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL TYPE; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; MOUSE; MOUSE MUTANT; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPINAL CORD NERVE CELL;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOTTING, SOUTHERN; BROMODEOXYURIDINE; CELL DIFFERENTIATION; CHICK EMBRYO; ELECTROPORATION; FLUORESCENT ANTIBODY TECHNIQUE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; IN SITU HYBRIDIZATION; MICE; MUTATION; POSTERIOR HORN CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD; STEM CELLS; TRANSCRIPTION FACTORS;

EID: 15444365575     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.326105     Document Type: Article

References (47)

1. Bermingham, N.A., Hassan, B.A., Wang, V.Y., Fernandez, M., Banfi, S., Bellen, H.J., Fritzsch, B., and Zoghbi, H.Y. 2001. Proprioceptor pathway development is dependent on Math1. Neuron 30: 411-422.
2. Briscoe, J. and Ericson, J. 1999. The specification of neuronal identity by graded Sonic Hedgehog signalling. Semin. Cell. Dev. Biol. 10: 353-362.
3. _. 2001. Specification of neuronal fates in the ventral neural tube. Curr. Opin. Neurobiol. 11: 43-49.
4. Briscoe, J., Sussel, L., Serup, P., Hartigan-O'Connor, D., Jessell, T.M., Rubenstein, J.L., and Ericson, J. 1999. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature 398: 622-627.
5. Briscoe, J., Pierani, A., Jessell, T.M., and Ericson, J. 2000. A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube. Cell 101: 435-445.
6. Brohmann, H., Jagla, K., and Birchmeier, C. 2000. The role of Lbx1 in migration of muscle precursor cells. Development 127: 437-445.
7. Brown, A.G. 1982. The dorsal horn of the spinal cord. Q. J. Exp. Physiol. 67: 193-212.
8. Caspary, T. and Anderson, K.V. 2003. Patterning cell types in the dorsal spinal cord: What the mouse mutants say. Nat. Rev. Neurosci. 4: 289-297.
9. Chen, Z.F., Rebelo, S., White, F., Malmberg, A.B., Baba, H., Lima, D., Woolf, C.J., Basbaum, A.I., and Anderson, D.J. 2001. The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron 31: 59-73.
10. Cheng, L., Arata, A., Mizuguchi, R., Qian, Y., Karunaratne, A., Gray, P.A., Arata, S., Shirasawa, S., Bouchard, M., Luo, P., et al. 2004. Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates. Nat. Neurosci. 7: 510-517.
11. Ding, Y.Q., Yin, J., Kania, A., Zhao, Z.Q., Johnson, R.L., and Chen, Z.F. 2004. Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord. Development 131: 3693-3703.
12. Gillespie, P.G. and Walker, R.G. 2001. Molecular basis of mechanosensory transduction. Nature 413: 194-202.
13. Goulding, M., Lanuza, G., Sapir, T., and Narayan, S. 2002. The formation of sensorimotor circuits. Curr. Opin. Neurobiol. 12: 508-515.
14. Gowan, K., Helms, A.W., Hunsaker, T.L., Collisson, T., Ebert, P.J., Odom, R., and Johnson, J.E. 2001. Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons. Neuron 31: 219-232.
15. Gross, M.K., Dottori, M., and Goulding, M. 2002. Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord. Neuron 34: 535-549.
16. Helms, A.W. and Johnson, J.E. 1998. Progenitors of dorsal commissural interneurons are defined by MATH1 expression. Development 125: 919-928.
17. _. 2003. Specification of dorsal spinal cord interneurons. Curr. Opin. Neurobiol. 13: 42-49.
18. Jessell, T.M. 2000. Neuronal specification in the spinal cord: Inductive signals and transcriptional codes. Nat. Rev. Genet. 1: 20-29.
19. Julius, D. and Basbaum, A.I. 2001. Molecular mechanisms of nociception. Nature 413: 203-210.
20. Lee, K.J., Mendelsohn, M., and Jessell, T.M. 1998. Neuronal patterning by BMPs: A requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord. Genes & Dev. 12: 3394-3407.
21. Lee, K.J., Dietrich, P., and Jessell, T.M. 2000. Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification. Nature 403: 734-740.
22. Liem Jr., K.F., Tremml, G., and Jessell, T.M. 1997. A role for the roof plate and its resident TGFβ-related proteins in neuronal patterning in the dorsal spinal cord. Cell 91: 127-138.
23. Lo, L.C., Johnson, J.E., Wuenschell, C.W., Saito, T., and Anderson, D.J. 1991. Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells. Genes & Dev. 5: 1524-1537.
24. Lu, Q.R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C.D., and Rowitch, D.H. 2002. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 109: 75-86.
25. Millonig, J.H., Millen, K.J., and Hatten, M.E. 2000. The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS. Nature 403: 764-769.
26. Mizuguchi, R., Sugimori, M., Takebayashi, H., Kosako, H., Nagao, M., Yoshida, S., Nabeshima, Y., Shimamura, K., and Nakafuku, M. 2001. Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons. Neuron 31: 757-771.
27. Moran-Rivard, L., Kagawa, T., Saueressig, H., Gross, M.K., Burrill, J., and Goulding, M. 2001. Evx1 is a postmitotic determinant of v0 interneuron identity in the spinal cord. Neuron 29: 385-399.
28. Muller, T., Brohmann, H., Pierani, A., Heppenstall, P.A., Lewin, G.R., Jessell, T.M., and Birchmeier, C. 2002. The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord. Neuron 34: 551-562.
29. Muroyama, Y., Fujihara, M., Ikeya, M., Kondoh, H., and Takada, S. 2002. Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes & Dev. 16: 548-553.
30. Nakada, Y., Hunsaker, T.L., Henke, R.M., and Johnson, J.E. 2004. Distinct domains within Mash1 and Math1 are required for function in neuronal differentiation versus neuronal cell-type specification. Development 131: 1319-1330.
31. Novitch, B.G., Chen, A.I., and Jessell, T.M. 2001. Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron 31: 773-789.
32. Pierani, A., Moran-Rivard, L., Sunshine, M.J., Littman, D.R., Goulding, M., and Jessell, T.M. 2001. Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. Neuron 29: 367-384.
33. Qi, Y., Cai, J., Wu, Y., Wu, R., Lee, J., Fu, H., Rao, M., Sussel, L., Rubenstein, J., and Qiu, M. 2001. Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor. Development 128: 2723-2733.
34. Qian, Y., Shirasawa, S., Chen, C.L., Cheng, L., and Ma, Q. 2002. Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1. Genes & Dev. 16: 1220-1233.
35. Rexed, B. 1952. The cytoarchitectonic organization of the spinal cord in the rat. J. Comp. Neurol. 96: 415-466.
36. Rowitch, D.H., Lu, Q.R., Kessaris, N., and Richardson, W.D. 2002. An 'oligarchy' rules neural development. Trends Neuzosci. 25: 417-422.
37. Sander, M., Paydar, S., Ericson, J., Briscoe, J., Berber, E., German, M., Jessell, T.M., and Rubenstein, J.L. 2000. Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates. Genes & Dev. 14: 2134-2139.
38. Schmidt, D., Ovitt, C.E., Anlag, K., Fehsenfeld, S., Gredsted, L., Treier, A.C., and Treier, M. 2004. The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development 131: 933-942.
39. Shirasaki, R. and Pfaff, S.L. 2002. Transcriptional codes and the control of neuronal identity. Annu. Rev. Neurosci. 25: 251-281.
40. Smith, S.T. and Jaynes, J.B. 1996. A conserved region of engrailed, shared among all en-, gsc-, Nk1-, Nk2- and rush-class homeoproteins, mediates active transcriptional repression in vivo. Development 122: 3141-3150.
41. Takebayashi, H., Nabeshima, Y., Yoshida, S., Chisaka, O., and Ikenaka, K. 2002a. The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages. Curr. Biol. 12: 1157-1163.
42. Takebayashi, H., Ohtsuki, T., Uchida, T., Kawamoto, S., Okubo, K., Ikenaka, K., Takeichi, M., Chisaka, O., and Nabeshima, Y. 2002b. Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube. Mech. Dev. 113: 169-174.
43. Triezenberg, S.J., Kingsbury, R.C., and McKnight, S.L. 1988. Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression. Genes & Dev. 2: 718-729.
44. Vallstedt, A., Muhr, J., Pattyn, A., Pierani, A., Mendelsohn, M., Sander, M., Jessell, T.M., and Ericson, J. 2001. Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification. Neuron 31: 743-755.
45. Zhou, Q. and Anderson, D.J. 2002. The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 109: 61-73.
46. Zhou, Q., Wang, S., and Anderson, D.J. 2000. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron 25: 331-343.
47. Zhou, Q., Choi, G., and Anderson, D.J. 2001. The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2. Neuron 31: 791-807.