메뉴 건너뛰기




Volumn 1658, Issue 1-2, 2004, Pages 122-132

Understanding aging: Revealing order out of chaos

Author keywords

Aging; DNA damage; Life span; Mitochondria; Mitochondrial respiratory chain; Oxidative stress

Indexed keywords

ANTIOXIDANT; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; OXIDIZING AGENT; REACTIVE OXYGEN METABOLITE;

EID: 3543028676     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbabio.2004.04.020     Document Type: Review
Times cited : (88)

References (201)
  • 3
    • 0025117953 scopus 로고
    • An attempt at a rational classification of theories of ageing
    • Medvedev Z.A. An attempt at a rational classification of theories of ageing. Biol. Rev. Camb. Philos. Soc. 65(3):1990;375-398
    • (1990) Biol. Rev. Camb. Philos. Soc. , vol.65 , Issue.3 , pp. 375-398
    • Medvedev, Z.A.1
  • 4
    • 0004326472 scopus 로고
    • Understanding aging
    • P.W. et al. Barlow. Cambridge: Cambridge Univ. Press
    • Holliday R. Understanding aging. Barlow P.W., et al. Developmental and Cell Biology Series. 1985;Cambridge Univ. Press, Cambridge
    • (1985) Developmental and Cell Biology Series
    • Holliday, R.1
  • 5
    • 0003293418 scopus 로고
    • On the nature of the function expressive of the law of human mortality and on a new mode of determining the value of life contingencies
    • Gompertz B. On the nature of the function expressive of the law of human mortality and on a new mode of determining the value of life contingencies. Philos. Trans. R. Soc. Lond. 115:1825;513-585
    • (1825) Philos. Trans. R. Soc. Lond. , vol.115 , pp. 513-585
    • Gompertz, B.1
  • 7
    • 0003460359 scopus 로고
    • The Genetical Theory of Natural Selection
    • New York: Dover Publications
    • Fisher R.A. The Genetical Theory of Natural Selection. 2nd revisited ed.:1958;Dover Publications, New York
    • (1958) 2nd Revisited Ed.
    • Fisher, R.A.1
  • 12
    • 0002134284 scopus 로고
    • Old age and natural death
    • Medawar P.B. Old age and natural death. Mod. Q. 1:1946;30-56
    • (1946) Mod. Q. , vol.1 , pp. 30-56
    • Medawar, P.B.1
  • 13
    • 0000055057 scopus 로고
    • Pleiotropy, natural selection, and the evolution of senescence
    • Williams G.C. Pleiotropy, natural selection, and the evolution of senescence. Evolution. 11:1957;398-411
    • (1957) Evolution , vol.11 , pp. 398-411
    • Williams, G.C.1
  • 14
    • 0019346543 scopus 로고
    • Genetics of life history in Drosophila melanogaster: I. Sib analysis of adult females
    • Rose M.R., Charlesworth B. Genetics of life history in Drosophila melanogaster: I. Sib analysis of adult females. Genetics. 97(1):1981;173-186
    • (1981) Genetics , vol.97 , Issue.1 , pp. 173-186
    • Rose, M.R.1    Charlesworth, B.2
  • 15
    • 0019347750 scopus 로고
    • Genetics of life history in Drosophila melanogaster: II. Exploratory selection experiments
    • Rose M.R., Charlesworth B. Genetics of life history in Drosophila melanogaster: II. Exploratory selection experiments. Genetics. 97(1):1981;187-196
    • (1981) Genetics , vol.97 , Issue.1 , pp. 187-196
    • Rose, M.R.1    Charlesworth, B.2
  • 16
    • 84966184704 scopus 로고
    • The genetic variation and covariation among fitness components in Drosophila melanogaster females and males
    • Tucic N., Cvetkovic D., Milanovic D. The genetic variation and covariation among fitness components in Drosophila melanogaster females and males. Heredity. 60(Pt 1):1988;55-60
    • (1988) Heredity , vol.60 , Issue.1 PART , pp. 55-60
    • Tucic, N.1    Cvetkovic, D.2    Milanovic, D.3
  • 17
    • 0025860961 scopus 로고
    • Quantitative genetics of postponed aging in Drosophila melanogaster. II. Analysis of selected lines
    • Hutchinson E.W., Shaw A.J., Rose M.R. Quantitative genetics of postponed aging in Drosophila melanogaster. II. Analysis of selected lines. Genetics. 127(4):1991;729-737
    • (1991) Genetics , vol.127 , Issue.4 , pp. 729-737
    • Hutchinson, E.W.1    Shaw, A.J.2    Rose, M.R.3
  • 18
    • 0025799566 scopus 로고
    • Quantitative genetics of postponed aging in Drosophila melanogaster. I. Analysis of outbred populations
    • Hutchinson E.W., Rose M.R. Quantitative genetics of postponed aging in Drosophila melanogaster. I. Analysis of outbred populations. Genetics. 127(4):1991;719-727
    • (1991) Genetics , vol.127 , Issue.4 , pp. 719-727
    • Hutchinson, E.W.1    Rose, M.R.2
  • 19
    • 0033979887 scopus 로고    scopus 로고
    • Genotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster
    • Vieira C., et al. Genotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster. Genetics. 154(1):2000;213-227
    • (2000) Genetics , vol.154 , Issue.1 , pp. 213-227
    • Vieira, C.1
  • 20
    • 0017782437 scopus 로고
    • Evolution of ageing
    • Kirkwood T.B. Evolution of ageing. Nature. 270(5635):1977;301-304
    • (1977) Nature , vol.270 , Issue.5635 , pp. 301-304
    • Kirkwood, T.B.1
  • 22
    • 0002141947 scopus 로고
    • Comparative and evolutionary aspects of longevity
    • C.E. Finch, & E.L. Schneider. New York: Van Norstrand Reinhold
    • Kirkwood T.B. Comparative and evolutionary aspects of longevity. Finch C.E., Schneider E.L. Handbook of the Biology of Aging. 1985;27-44 Van Norstrand Reinhold, New York
    • (1985) Handbook of the Biology of Aging , pp. 27-44
    • Kirkwood, T.B.1
  • 23
    • 0034614433 scopus 로고    scopus 로고
    • Longevity and the costs of reproduction in a historical human population
    • Lycett J.E., Dunbar R.I., Voland E. Longevity and the costs of reproduction in a historical human population. Proc. R. Soc. Lond., B Biol. Sci. 267(1438):2000;31-35
    • (2000) Proc. R. Soc. Lond., B Biol. Sci. , vol.267 , Issue.1438 , pp. 31-35
    • Lycett, J.E.1    Dunbar, R.I.2    Voland, E.3
  • 24
    • 0032585574 scopus 로고    scopus 로고
    • Human longevity at the cost of reproductive success
    • Westendorp R.G., Kirkwood T.B. Human longevity at the cost of reproductive success. Nature. 396(6713):1998;743-746
    • (1998) Nature , vol.396 , Issue.6713 , pp. 743-746
    • Westendorp, R.G.1    Kirkwood, T.B.2
  • 25
    • 0033601345 scopus 로고    scopus 로고
    • A delayed wave of death from reproduction in Drosophila
    • Sgro C.M., Partridge L. A delayed wave of death from reproduction in Drosophila. Science. 286(5449):1999;2521-2524
    • (1999) Science , vol.286 , Issue.5449 , pp. 2521-2524
    • Sgro, C.M.1    Partridge, L.2
  • 26
    • 0018609310 scopus 로고
    • DNA repair in a short- and a long-lived rodent species
    • Hart R.W., Sacher G.A., Hoskins T.L. DNA repair in a short- and a long-lived rodent species. J. Gerontol. 34(6):1979;808-817
    • (1979) J. Gerontol. , vol.34 , Issue.6 , pp. 808-817
    • Hart, R.W.1    Sacher, G.A.2    Hoskins, T.L.3
  • 27
    • 0011555560 scopus 로고
    • Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species
    • Hart R.W., Setlow R.B. Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species. Proc. Natl. Acad. Sci. U. S. A. 71(6):1974;2169-2173
    • (1974) Proc. Natl. Acad. Sci. U. S. A. , vol.71 , Issue.6 , pp. 2169-2173
    • Hart, R.W.1    Setlow, R.B.2
  • 28
    • 0021321375 scopus 로고
    • Correlation between ultraviolet-induced DNA repair in primate lymphocytes and fibroblasts and species maximum achievable life span
    • Hall K.Y., et al. Correlation between ultraviolet-induced DNA repair in primate lymphocytes and fibroblasts and species maximum achievable life span. Mech. Ageing Dev. 24(2):1984;163-173
    • (1984) Mech. Ageing Dev. , vol.24 , Issue.2 , pp. 163-173
    • Hall, K.Y.1
  • 29
    • 0020057719 scopus 로고
    • Correlation between DNA excision repair and mammalian lifespan in lens epithelial cells
    • Treton J.A., Courtois Y. Correlation between DNA excision repair and mammalian lifespan in lens epithelial cells. Cell Biol. Int. Rep. 6(3):1982;253-260
    • (1982) Cell Biol. Int. Rep. , vol.6 , Issue.3 , pp. 253-260
    • Treton, J.A.1    Courtois, Y.2
  • 30
    • 0029872174 scopus 로고    scopus 로고
    • Telomerase activity in human germline and embryonic tissues and cells
    • Wright W.E., et al. Telomerase activity in human germline and embryonic tissues and cells. Dev. Genet. 18(2):1996;173-179
    • (1996) Dev. Genet. , vol.18 , Issue.2 , pp. 173-179
    • Wright, W.E.1
  • 31
    • 0019165633 scopus 로고
    • Life-span and senescence in Podospora anserina: Effect of mitochondrial genes and functions
    • Belcour L., Begel O. Life-span and senescence in Podospora anserina: effect of mitochondrial genes and functions. J. Gen. Microbiol. 119:1980;505-515
    • (1980) J. Gen. Microbiol. , vol.119 , pp. 505-515
    • Belcour, L.1    Begel, O.2
  • 32
    • 0034736514 scopus 로고    scopus 로고
    • Evolution of the mitochondrial genetic system: An overview
    • Saccone C., et al. Evolution of the mitochondrial genetic system: an overview. Gene. 261(1):2000;153-159
    • (2000) Gene , vol.261 , Issue.1 , pp. 153-159
    • Saccone, C.1
  • 35
    • 0003693103 scopus 로고
    • London: Univeristy of London Press
    • Pearl R. The Rate of Living. 1928;Univeristy of London Press, London
    • (1928) The Rate of Living
    • Pearl, R.1
  • 36
    • 3543032552 scopus 로고
    • Species probes, longevity and aging
    • W. Regelson, & F.M. Sinex. New York: A.R. Liss
    • Cutler R.G. Species probes, longevity and aging. Regelson W., Sinex F.M. Aging Process. 1983;69-144 A.R. Liss, New York
    • (1983) Aging Process , pp. 69-144
    • Cutler, R.G.1
  • 37
    • 0029162729 scopus 로고
    • Birds as animal models for the comparative biology of aging: A prospectus
    • Holmes D.J., Austad S.N. Birds as animal models for the comparative biology of aging: a prospectus. J. Gerontol., Ser. A Biol. Sci. Med. Sci. 50(2):1995;B59-B66
    • (1995) J. Gerontol., Ser. a Biol. Sci. Med. Sci. , vol.50 , Issue.2 , pp. 59-B66
    • Holmes, D.J.1    Austad, S.N.2
  • 38
    • 0023922840 scopus 로고
    • Metabolic rates in genetically based long lived strains of Drosophila
    • Arking R., et al. Metabolic rates in genetically based long lived strains of Drosophila. Exp. Gerontol. 23(1):1988;59-76
    • (1988) Exp. Gerontol. , vol.23 , Issue.1 , pp. 59-76
    • Arking, R.1
  • 39
    • 0020066839 scopus 로고
    • Is cell aging caused by respiration-dependent injury to the mitochondrial genome?
    • Fleming J.E., et al. Is cell aging caused by respiration-dependent injury to the mitochondrial genome? Gerontology. 28(1):1982;44-53
    • (1982) Gerontology , vol.28 , Issue.1 , pp. 44-53
    • Fleming, J.E.1
  • 41
    • 0029439509 scopus 로고
    • Oxidative stress: The paradox of aerobic life
    • Davies K.J. Oxidative stress: the paradox of aerobic life. Biochem. Soc. Symp. 61:1995;1-31
    • (1995) Biochem. Soc. Symp. , vol.61 , pp. 1-31
    • Davies, K.J.1
  • 42
    • 0017253735 scopus 로고
    • Ageing of Neurospora crassa: I. Evidence for the free radical theory of ageing from studies of a natural-death mutant
    • Munkres K.D., Minssen M. Ageing of Neurospora crassa: I. Evidence for the free radical theory of ageing from studies of a natural-death mutant. Mech. Ageing Dev. 5:1976;79-98
    • (1976) Mech. Ageing Dev. , vol.5 , pp. 79-98
    • Munkres, K.D.1    Minssen, M.2
  • 43
    • 0027016046 scopus 로고
    • Lipofuscinogenesis in a model system of cultured cardiac myocytes
    • Marzabadi M.R., Yin D., Brunk U.T. Lipofuscinogenesis in a model system of cultured cardiac myocytes. EXS. 62:1992;78-88
    • (1992) EXS , vol.62 , pp. 78-88
    • Marzabadi, M.R.1    Yin, D.2    Brunk, U.T.3
  • 44
    • 0024998688 scopus 로고
    • Lipofuscin as an indicator of oxidative stress and aging
    • (discussion 27-29)
    • Sohal R.S., Brunk U.T. Lipofuscin as an indicator of oxidative stress and aging. Adv. Exp. Med. Biol. 266:1989;17-26. (discussion 27-29)
    • (1989) Adv. Exp. Med. Biol. , vol.266 , pp. 17-26
    • Sohal, R.S.1    Brunk, U.T.2
  • 45
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • Ames B.N., Shigenaga M.K., Hagen T.M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. U. S. A. 90(17):1993;7915-7922
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , Issue.17 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 46
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal R.S., Weindruch R. Oxidative stress, caloric restriction, and aging. Science. 273:1996;59-63
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 47
    • 0026795635 scopus 로고
    • Protein oxidation and aging
    • Stadtman E.R. Protein oxidation and aging. Science. 257(5074):1992;1220- 1224
    • (1992) Science , vol.257 , Issue.5074 , pp. 1220-1224
    • Stadtman, E.R.1
  • 48
    • 0032030309 scopus 로고    scopus 로고
    • Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing
    • Liu V.W., Zhang C., Nagley P. Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing. Nucleic Acids Res. 26(5):1998;1268-1275
    • (1998) Nucleic Acids Res. , vol.26 , Issue.5 , pp. 1268-1275
    • Liu, V.W.1    Zhang, C.2    Nagley, P.3
  • 49
    • 0027365312 scopus 로고
    • Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species
    • Ku H.H., Brunk U.T., Sohal R.S. Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species. Free Radic. Biol. Med. 15(6):1993;621-627
    • (1993) Free Radic. Biol. Med. , vol.15 , Issue.6 , pp. 621-627
    • Ku, H.H.1    Brunk, U.T.2    Sohal, R.S.3
  • 50
    • 0022457620 scopus 로고
    • Relationship between life expectancy, endogenous antioxidants and products of oxygen free radical reactions in the housefly, Musca domestica
    • Sohal R.S., Toy P.L., Allen R.G. Relationship between life expectancy, endogenous antioxidants and products of oxygen free radical reactions in the housefly, Musca domestica. Mech. Ageing Dev. 36(1):1986;71-77
    • (1986) Mech. Ageing Dev. , vol.36 , Issue.1 , pp. 71-77
    • Sohal, R.S.1    Toy, P.L.2    Allen, R.G.3
  • 51
    • 0023627355 scopus 로고
    • Successful selection for increased longevity in Drosophila: Analysis of the survival data and presentation of a hypothesis on the genetic regulation of longevity
    • Arking R. Successful selection for increased longevity in Drosophila: analysis of the survival data and presentation of a hypothesis on the genetic regulation of longevity. Exp. Gerontol. 22(3):1987;199-220
    • (1987) Exp. Gerontol. , vol.22 , Issue.3 , pp. 199-220
    • Arking, R.1
  • 52
    • 84966175214 scopus 로고
    • Selection for life span in Drosophila melanogaster
    • Luckinbill L.S., Clare M.J. Selection for life span in Drosophila melanogaster. Heredity. 55(Pt 1):1985;9-18
    • (1985) Heredity , vol.55 , Issue.1 PART , pp. 9-18
    • Luckinbill, L.S.1    Clare, M.J.2
  • 53
    • 0026058667 scopus 로고
    • Elevated paraquat resistance can be used as a bioassay for longevity in a genetically based long-lived strain of Drosophila
    • Arking R., et al. Elevated paraquat resistance can be used as a bioassay for longevity in a genetically based long-lived strain of Drosophila. Dev. Genet. 12(5):1991;362-370
    • (1991) Dev. Genet. , vol.12 , Issue.5 , pp. 362-370
    • Arking, R.1
  • 54
    • 0029610090 scopus 로고
    • Comparative biochemical and stress analysis of genetically selected Drosophila strains with different longevities
    • Force A.G., et al. Comparative biochemical and stress analysis of genetically selected Drosophila strains with different longevities. Dev. Genet. 17(4):1995;340-351
    • (1995) Dev. Genet. , vol.17 , Issue.4 , pp. 340-351
    • Force, A.G.1
  • 55
    • 0031968477 scopus 로고    scopus 로고
    • Immunological confirmation of elevated levels of CuZn superoxide dismutase protein in an artificially selected long-lived strain of Drosophila melanogaster
    • Hari R., Burde V., Arking R. Immunological confirmation of elevated levels of CuZn superoxide dismutase protein in an artificially selected long-lived strain of Drosophila melanogaster. Exp. Gerontol. 33(3):1998;227-237
    • (1998) Exp. Gerontol. , vol.33 , Issue.3 , pp. 227-237
    • Hari, R.1    Burde, V.2    Arking, R.3
  • 56
    • 0034032863 scopus 로고    scopus 로고
    • Forward and reverse selection for longevity in Drosophila is characterized by alteration of antioxidant gene expression and oxidative damage patterns*
    • [In Process Citation]
    • Arking R., et al. Forward and reverse selection for longevity in Drosophila is characterized by alteration of antioxidant gene expression and oxidative damage patterns*. [In Process Citation] Exp. Gerontol. 35(2):2000;167-185
    • (2000) Exp. Gerontol. , vol.35 , Issue.2 , pp. 167-185
    • Arking, R.1
  • 57
    • 0029087068 scopus 로고
    • A coordinate upregulation of antioxidant gene activities is associated with the delayed onset of senescence in a long-lived strain of Drosophila
    • Dudas S.P., Arking R. A coordinate upregulation of antioxidant gene activities is associated with the delayed onset of senescence in a long-lived strain of Drosophila. J. Gerontol., Ser. A Biol. Sci. Med. Sci. 50(3):1995;B117-B127
    • (1995) J. Gerontol., Ser. a Biol. Sci. Med. Sci. , vol.50 , Issue.3 , pp. 117-B127
    • Dudas, S.P.1    Arking, R.2
  • 58
    • 0027767242 scopus 로고
    • The effect of superoxide dismutase alleles on aging in Drosophila
    • Tyler R.H., et al. The effect of superoxide dismutase alleles on aging in Drosophila. Genetica. 91(1-3):1993;143-149
    • (1993) Genetica , vol.91 , Issue.13 , pp. 143-149
    • Tyler, R.H.1
  • 59
    • 0036237273 scopus 로고    scopus 로고
    • Metabolic alterations and shifts in energy allocations are corequisites for the expression of extended longevity genes in Drosophila
    • (discussion 463-465)
    • Arking R., et al. Metabolic alterations and shifts in energy allocations are corequisites for the expression of extended longevity genes in Drosophila. Ann. N. Y. Acad. Sci. 959:2002;251-262. (discussion 463-465)
    • (2002) Ann. N. Y. Acad. Sci. , vol.959 , pp. 251-262
    • Arking, R.1
  • 60
    • 0006580238 scopus 로고
    • Testing the free radical theory of aging
    • R.C. Adelman, & G.S. Roth. Boca Raton, FL: CRC Press
    • Balin A.K. Testing the free radical theory of aging. Adelman R.C., Roth G.S. Testing the Theories of Aging. 1983;137-182 CRC Press, Boca Raton, FL
    • (1983) Testing the Theories of Aging , pp. 137-182
    • Balin, A.K.1
  • 61
    • 0024273208 scopus 로고
    • Vitamin e supplementation and intense selection increase clonal life span in Paramecium tetraurelia
    • Thomas J., Nyberg D. Vitamin E supplementation and intense selection increase clonal life span in Paramecium tetraurelia. Exp. Gerontol. 23(6):1988;501-512
    • (1988) Exp. Gerontol. , vol.23 , Issue.6 , pp. 501-512
    • Thomas, J.1    Nyberg, D.2
  • 62
    • 0029857278 scopus 로고    scopus 로고
    • Effect of vitamin e on life span, malondialdehyde content and antioxidant enzymes in aging Zaprionus paravittiger
    • Kakkar R., Bains J.S., Sharma S.P. Effect of vitamin E on life span, malondialdehyde content and antioxidant enzymes in aging Zaprionus paravittiger. Gerontology. 42(6):1996;312-321
    • (1996) Gerontology , vol.42 , Issue.6 , pp. 312-321
    • Kakkar, R.1    Bains, J.S.2    Sharma, S.P.3
  • 63
    • 1042302134 scopus 로고    scopus 로고
    • Cyclic oxidation and reduction of methionine residues of proteins in antioxidant defense and cellular regulation
    • Stadtman E.R. Cyclic oxidation and reduction of methionine residues of proteins in antioxidant defense and cellular regulation. Arch. Biochem. Biophys. 423(1):2004;2-5
    • (2004) Arch. Biochem. Biophys. , vol.423 , Issue.1 , pp. 2-5
    • Stadtman, E.R.1
  • 64
    • 0028921517 scopus 로고
    • Methionine-induced alterations in the life span, antioxidant enzymes, and peroxide levels in aging Zaprionus paravittiger (Diptera)
    • Sharma S.P., Sharma M., Kakkar R. Methionine-induced alterations in the life span, antioxidant enzymes, and peroxide levels in aging Zaprionus paravittiger (Diptera). Gerontology. 41(2):1995;86-93
    • (1995) Gerontology , vol.41 , Issue.2 , pp. 86-93
    • Sharma, S.P.1    Sharma, M.2    Kakkar, R.3
  • 65
    • 0028853850 scopus 로고
    • Nematode development is inhibited by methyl viologen and high oxygen concentrations at a rate inversely proportional to life span
    • Hartman P., Childress E., Beyer T. Nematode development is inhibited by methyl viologen and high oxygen concentrations at a rate inversely proportional to life span. J. Gerontol., Ser. A Biol. Sci. Med. Sci. 50(6):1995;B322-B326
    • (1995) J. Gerontol., Ser. a Biol. Sci. Med. Sci. , vol.50 , Issue.6 , pp. 322-B326
    • Hartman, P.1    Childress, E.2    Beyer, T.3
  • 66
    • 0017864132 scopus 로고
    • Antioxidants prolong life span and inhibit the senescence-dependant accumulation of fluorescent pigment (lipofuscin) in clones of Podospora anserina
    • Munkres K.D., Rana R.S. Antioxidants prolong life span and inhibit the senescence-dependant accumulation of fluorescent pigment (lipofuscin) in clones of Podospora anserina. Mech. Ageing Dev. 7:1978;407-415
    • (1978) Mech. Ageing Dev. , vol.7 , pp. 407-415
    • Munkres, K.D.1    Rana, R.S.2
  • 67
    • 0032527920 scopus 로고    scopus 로고
    • Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice
    • Lipman R.D., et al. Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice. Mech. Ageing Dev. 103(3):1998;269-284
    • (1998) Mech. Ageing Dev. , vol.103 , Issue.3 , pp. 269-284
    • Lipman, R.D.1
  • 68
    • 0345019850 scopus 로고    scopus 로고
    • The effects of lifelong ubiquinone Q10 supplementation on the Q9 and Q10 tissue concentrations and life span of male rats and mice
    • Lonnrot K., et al. The effects of lifelong ubiquinone Q10 supplementation on the Q9 and Q10 tissue concentrations and life span of male rats and mice. Biochem. Mol. Biol. Int. 44(4):1998;727-737
    • (1998) Biochem. Mol. Biol. Int. , vol.44 , Issue.4 , pp. 727-737
    • Lonnrot, K.1
  • 69
    • 0034893757 scopus 로고    scopus 로고
    • Lack of an effect of vitamin e on lifespan of mice
    • Morley A.A., Trainor K.J. Lack of an effect of vitamin E on lifespan of mice. Biogerontology. 2(2):2001;109-112
    • (2001) Biogerontology , vol.2 , Issue.2 , pp. 109-112
    • Morley, A.A.1    Trainor, K.J.2
  • 70
    • 0004207663 scopus 로고    scopus 로고
    • Selective targeting of an antioxidant to mitochondria
    • Smith R.A., et al. Selective targeting of an antioxidant to mitochondria. Eur. J. Biochem. 263(3):1999;709-716
    • (1999) Eur. J. Biochem. , vol.263 , Issue.3 , pp. 709-716
    • Smith, R.A.1
  • 71
    • 0036237241 scopus 로고    scopus 로고
    • Prevention of mitochondrial oxidative damage using targeted antioxidants
    • Kelso G.F., et al. Prevention of mitochondrial oxidative damage using targeted antioxidants. Ann. N. Y. Acad. Sci. 959:2002;263-274
    • (2002) Ann. N. Y. Acad. Sci. , vol.959 , pp. 263-274
    • Kelso, G.F.1
  • 72
    • 0034656840 scopus 로고    scopus 로고
    • Mitochondrially targeted antioxidants and thiol reagents
    • Coulter C.V., et al. Mitochondrially targeted antioxidants and thiol reagents. Free Radic. Biol. Med. 28(10):2000;1547-1554
    • (2000) Free Radic. Biol. Med. , vol.28 , Issue.10 , pp. 1547-1554
    • Coulter, C.V.1
  • 73
    • 0348136710 scopus 로고    scopus 로고
    • Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants
    • Jauslin M.L., et al. Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J. 17(13):2003;1972-1974
    • (2003) FASEB J. , vol.17 , Issue.13 , pp. 1972-1974
    • Jauslin, M.L.1
  • 74
    • 0024392669 scopus 로고
    • The genetics of catalase in Drosophila melanogaster: Isolation and characterization of acatalasemic mutants
    • Mackay W.J., Bewley G.C. The genetics of catalase in Drosophila melanogaster: isolation and characterization of acatalasemic mutants. Genetics. 122(3):1989;643-652
    • (1989) Genetics , vol.122 , Issue.3 , pp. 643-652
    • MacKay, W.J.1    Bewley, G.C.2
  • 75
    • 0024547664 scopus 로고
    • Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity
    • Phillips J.P., et al. Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity. Proc. Natl. Acad. Sci. U. S. A. 86(8):1989;2761-2765
    • (1989) Proc. Natl. Acad. Sci. U. S. A. , vol.86 , Issue.8 , pp. 2761-2765
    • Phillips, J.P.1
  • 76
    • 0033571777 scopus 로고    scopus 로고
    • Overexpression of Mn-containing superoxide dismutase in transgenic Drosophila melanogaster
    • Mockett R.J., et al. Overexpression of Mn-containing superoxide dismutase in transgenic Drosophila melanogaster. Arch. Biochem. Biophys. 371(2):1999;260-269
    • (1999) Arch. Biochem. Biophys. , vol.371 , Issue.2 , pp. 260-269
    • Mockett, R.J.1
  • 77
    • 0026783733 scopus 로고
    • The effects of catalase gene overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster
    • Orr W.C., Sohal R.S. The effects of catalase gene overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster. Arch. Biochem. Biophys. 297(1):1992;35-41
    • (1992) Arch. Biochem. Biophys. , vol.297 , Issue.1 , pp. 35-41
    • Orr, W.C.1    Sohal, R.S.2
  • 78
    • 0025977719 scopus 로고
    • Expression of bovine superoxide dismutase in Drosophila melanogaster augments resistance of oxidative stress
    • Reveillaud I., et al. Expression of bovine superoxide dismutase in Drosophila melanogaster augments resistance of oxidative stress. Mol. Cell. Biol. 11(2):1991;632-640
    • (1991) Mol. Cell. Biol. , vol.11 , Issue.2 , pp. 632-640
    • Reveillaud, I.1
  • 79
    • 0032908347 scopus 로고    scopus 로고
    • FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies
    • Sun J., Tower J. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol. Cell. Biol. 19(1):1999;216-228
    • (1999) Mol. Cell. Biol. , vol.19 , Issue.1 , pp. 216-228
    • Sun, J.1    Tower, J.2
  • 80
    • 0028220114 scopus 로고
    • Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
    • Orr W.C., Sohal R.S. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science. 263(5150):1994;1128-1130
    • (1994) Science , vol.263 , Issue.5150 , pp. 1128-1130
    • Orr, W.C.1    Sohal, R.S.2
  • 81
    • 0031864164 scopus 로고    scopus 로고
    • Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
    • Parkes T.L., et al. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat. Genet. 19(2):1998;171-174
    • (1998) Nat. Genet. , vol.19 , Issue.2 , pp. 171-174
    • Parkes, T.L.1
  • 82
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Droge W. Free radicals in the physiological control of cell function. Physiol. Rev. 82(1):2002;47-95
    • (2002) Physiol. Rev. , vol.82 , Issue.1 , pp. 47-95
    • Droge, W.1
  • 83
    • 0842270038 scopus 로고    scopus 로고
    • Oxidative stress and aging
    • Droge W. Oxidative stress and aging. Adv. Exp. Med. Biol. 543:2003;191-200
    • (2003) Adv. Exp. Med. Biol. , vol.543 , pp. 191-200
    • Droge, W.1
  • 84
    • 0023809302 scopus 로고
    • Down's syndrome: Abnormal neuromuscular junction in tongue of transgenic mice with elevated levels of human Cu/Zn-superoxide dismutase
    • Avraham K.B., et al. Down's syndrome: abnormal neuromuscular junction in tongue of transgenic mice with elevated levels of human Cu/Zn-superoxide dismutase. Cell. 54(6):1988;823-829
    • (1988) Cell , vol.54 , Issue.6 , pp. 823-829
    • Avraham, K.B.1
  • 85
    • 0029757963 scopus 로고    scopus 로고
    • Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons
    • Bar-Peled O., et al. Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons. Proc. Natl. Acad. Sci. U. S. A. 93(16):1996;8530-8535
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , Issue.16 , pp. 8530-8535
    • Bar-Peled, O.1
  • 86
    • 0031940986 scopus 로고    scopus 로고
    • A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase
    • [see comment]
    • Melov S., et al. A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. [see comment] Nat. Genet. 18(2):1998;159-163
    • (1998) Nat. Genet. , vol.18 , Issue.2 , pp. 159-163
    • Melov, S.1
  • 87
    • 13044285432 scopus 로고    scopus 로고
    • Mitochondrial disease in superoxide dismutase 2 mutant mice
    • Melov S., et al. Mitochondrial disease in superoxide dismutase 2 mutant mice. Proc. Natl. Acad. Sci. U. S. A. 96(3):1999;846-851
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , Issue.3 , pp. 846-851
    • Melov, S.1
  • 88
    • 0023354422 scopus 로고
    • Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans
    • Johnson T.E. Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 84(11):1987;3777-3781
    • (1987) Proc. Natl. Acad. Sci. U. S. A. , vol.84 , Issue.11 , pp. 3777-3781
    • Johnson, T.E.1
  • 89
    • 0030657540 scopus 로고    scopus 로고
    • Daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
    • [see comments]
    • Lin K., et al. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. [see comments] Science. 278(5341):1997;1319-1322
    • (1997) Science , vol.278 , Issue.5341 , pp. 1319-1322
    • Lin, K.1
  • 90
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • Kenyon C., et al. A C. elegans mutant that lives twice as long as wild type. Nature. 366(6454):1993;461-464
    • (1993) Nature , vol.366 , Issue.6454 , pp. 461-464
    • Kenyon, C.1
  • 91
    • 0028930267 scopus 로고
    • Genes that regulate both development and longevity in Caenorhabditis elegans
    • Larsen P.L., Albert P.S., Riddle D.L. Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics. 139(4):1995;1567-1583
    • (1995) Genetics , vol.139 , Issue.4 , pp. 1567-1583
    • Larsen, P.L.1    Albert, P.S.2    Riddle, D.L.3
  • 92
    • 0030813398 scopus 로고    scopus 로고
    • Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • Kimura K.D., et al. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 277(5328):1997;942- 946
    • (1997) Science , vol.277 , Issue.5328 , pp. 942-946
    • Kimura, K.D.1
  • 93
    • 0029768753 scopus 로고    scopus 로고
    • A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
    • Morris J.Z., Tissenbaum H.A., Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 382(6591):1996;536-539
    • (1996) Nature , vol.382 , Issue.6591 , pp. 536-539
    • Morris, J.Z.1    Tissenbaum, H.A.2    Ruvkun, G.3
  • 94
    • 0032782364 scopus 로고    scopus 로고
    • The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
    • Honda Y., Honda S. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J. 13(11):1999;1385-1393
    • (1999) FASEB J. , vol.13 , Issue.11 , pp. 1385-1393
    • Honda, Y.1    Honda, S.2
  • 95
    • 0033551325 scopus 로고    scopus 로고
    • A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants
    • Taub J., et al. A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. Nature. 399(6732):1999;162-166
    • (1999) Nature , vol.399 , Issue.6732 , pp. 162-166
    • Taub, J.1
  • 96
    • 0027515616 scopus 로고
    • Aging and resistance to oxidative damage in Caenorhabditis elegans
    • Larsen P.L. Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 90(19):1993;8905-8909
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , Issue.19 , pp. 8905-8909
    • Larsen, P.L.1
  • 97
    • 0030014296 scopus 로고    scopus 로고
    • A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans
    • Murakami S., Johnson T.E. A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics. 143(3):1996;1207-1218
    • (1996) Genetics , vol.143 , Issue.3 , pp. 1207-1218
    • Murakami, S.1    Johnson, T.E.2
  • 98
    • 0027197284 scopus 로고
    • Oxidative stress and ageing in Caenorhabditis elegans
    • Vanfleteren J.R. Oxidative stress and ageing in Caenorhabditis elegans. Biochem. J. 292(Pt 2):1993;605-608
    • (1993) Biochem. J. , vol.292 , Issue.2 PART , pp. 605-608
    • Vanfleteren, J.R.1
  • 99
    • 0033613204 scopus 로고    scopus 로고
    • Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate
    • Van Voorhies W.A., Ward S. Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate. Proc. Natl. Acad. Sci. U. S. A. 96(20):1999;11399-11403
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , Issue.20 , pp. 11399-11403
    • Van Voorhies, W.A.1    Ward, S.2
  • 100
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • [see comment]
    • Murphy C.T., et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. [see comment] Nature. 424(6946):2003;277-283
    • (2003) Nature , vol.424 , Issue.6946 , pp. 277-283
    • Murphy, C.T.1
  • 101
    • 0042631524 scopus 로고    scopus 로고
    • Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16
    • McElwee J., Bubb K., Thomas J.H. Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell. 2(2):2003;111-121
    • (2003) Aging Cell , vol.2 , Issue.2 , pp. 111-121
    • McElwee, J.1    Bubb, K.2    Thomas, J.H.3
  • 102
    • 0037466652 scopus 로고    scopus 로고
    • DAF-16 target genes that control C. elegans life-span and metabolism
    • Lee S.S., et al. DAF-16 target genes that control C. elegans life-span and metabolism. Science. 300(5619):2003;644-647
    • (2003) Science , vol.300 , Issue.5619 , pp. 644-647
    • Lee, S.S.1
  • 103
    • 0033118981 scopus 로고    scopus 로고
    • CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans
    • Felkai S., et al. CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. EMBO J. 18(7):1999;1783-1792
    • (1999) EMBO J. , vol.18 , Issue.7 , pp. 1783-1792
    • Felkai, S.1
  • 104
    • 0031030678 scopus 로고    scopus 로고
    • Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1
    • [see comments]
    • Ewbank J.J., et al. Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. [see comments] Science. 275(5302):1997;980-983
    • (1997) Science , vol.275 , Issue.5302 , pp. 980-983
    • Ewbank, J.J.1
  • 105
    • 0029610003 scopus 로고
    • CAT5, a new gene necessary for derepression of gluconeogenic enzymes in Saccharomyces cerevisiae
    • Proft M., et al. CAT5, a new gene necessary for derepression of gluconeogenic enzymes in Saccharomyces cerevisiae. EMBO J. 14(24):1995;6116-6126
    • (1995) EMBO J. , vol.14 , Issue.24 , pp. 6116-6126
    • Proft, M.1
  • 106
    • 0029776793 scopus 로고    scopus 로고
    • Determination of life-span in Caenorhabditis elegans by four clock genes
    • Lakowski B., Hekimi S. Determination of life-span in Caenorhabditis elegans by four clock genes. Science. 272(5264):1996;1010-1013
    • (1996) Science , vol.272 , Issue.5264 , pp. 1010-1013
    • Lakowski, B.1    Hekimi, S.2
  • 107
    • 0036245337 scopus 로고    scopus 로고
    • Mechanisms of ageing: Public or private?
    • Partridge L., Gems D. Mechanisms of ageing: public or private? Nat. Rev. Genet. 3(3):2002;165-175
    • (2002) Nat. Rev. Genet. , vol.3 , Issue.3 , pp. 165-175
    • Partridge, L.1    Gems, D.2
  • 108
    • 0029952098 scopus 로고    scopus 로고
    • Dwarf mice and the ageing process
    • Brown-Borg H.M., et al. Dwarf mice and the ageing process. Nature. 384(6604):1996;33
    • (1996) Nature , vol.384 , Issue.6604 , pp. 33
    • Brown-Borg, H.M.1
  • 109
    • 0032447232 scopus 로고    scopus 로고
    • Does growth hormone prevent or accelerate aging?
    • Bartke A., et al. Does growth hormone prevent or accelerate aging? Exp. Gerontol. 33(7-8):1998;675-687
    • (1998) Exp. Gerontol. , vol.33 , Issue.78 , pp. 675-687
    • Bartke, A.1
  • 110
    • 0042203536 scopus 로고    scopus 로고
    • Multiplex stress resistance in cells from long-lived dwarf mice
    • Murakami S., Salmon A., Miller R.A. Multiplex stress resistance in cells from long-lived dwarf mice. FASEB J. 17(11):2003;1565-1566
    • (2003) FASEB J. , vol.17 , Issue.11 , pp. 1565-1566
    • Murakami, S.1    Salmon, A.2    Miller, R.A.3
  • 111
    • 0035067195 scopus 로고    scopus 로고
    • Free radical defenses in the liver and kidney of human growth hormone transgenic mice: Possible mechanisms of early mortality
    • Hauck S.J., Bartke A. Free radical defenses in the liver and kidney of human growth hormone transgenic mice: possible mechanisms of early mortality. J. Gerontol., Ser. A Biol. Sci. Med. Sci. 56(4):2001;B153-B162
    • (2001) J. Gerontol., Ser. a Biol. Sci. Med. Sci. , vol.56 , Issue.4 , pp. 153-B162
    • Hauck, S.J.1    Bartke, A.2
  • 112
    • 0027265595 scopus 로고
    • GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function
    • Godfrey P., et al. GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nat. Genet. 4(3):1993;227-232
    • (1993) Nat. Genet. , vol.4 , Issue.3 , pp. 227-232
    • Godfrey, P.1
  • 113
    • 12644257576 scopus 로고    scopus 로고
    • A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)
    • Zhou Y., et al. A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc. Natl. Acad. Sci. U. S. A. 94(24):1997;13215-13220
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , Issue.24 , pp. 13215-13220
    • Zhou, Y.1
  • 114
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
    • Liu J.P., et al. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell. 75(1):1993;59-72
    • (1993) Cell , vol.75 , Issue.1 , pp. 59-72
    • Liu, J.P.1
  • 115
    • 0035811073 scopus 로고    scopus 로고
    • Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
    • Flurkey K., et al. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl. Acad. Sci. U. S. A. 98(12):2001;6736-6741
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , Issue.12 , pp. 6736-6741
    • Flurkey, K.1
  • 116
    • 0034455827 scopus 로고    scopus 로고
    • Assessment of growth parameters and life span of GHR/BP gene-disrupted mice
    • Coschigano K.T., et al. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology. 141(7):2000;2608-2613
    • (2000) Endocrinology , vol.141 , Issue.7 , pp. 2608-2613
    • Coschigano, K.T.1
  • 117
    • 0347664057 scopus 로고    scopus 로고
    • IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    • [see comment]
    • Holzenberger M., et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. [see comment] Nature. 421(6919):2003;182-187
    • (2003) Nature , vol.421 , Issue.6919 , pp. 182-187
    • Holzenberger, M.1
  • 118
    • 0033198845 scopus 로고    scopus 로고
    • Different import pathways through the mitochondrial intermembrane space for inner membrane proteins
    • Leuenberger D., et al. Different import pathways through the mitochondrial intermembrane space for inner membrane proteins. EMBO J. 18(17):1999;4816-4822
    • (1999) EMBO J. , vol.18 , Issue.17 , pp. 4816-4822
    • Leuenberger, D.1
  • 119
    • 0033581704 scopus 로고    scopus 로고
    • The p66shc adaptor protein controls oxidative stress response and life span in mammals
    • Migliaccio E., et al. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature. 402(6759):1999;309-313
    • (1999) Nature , vol.402 , Issue.6759 , pp. 309-313
    • Migliaccio, E.1
  • 120
    • 85047695800 scopus 로고    scopus 로고
    • A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis
    • Trinei M., et al. A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene. 21(24):2002;3872-3878
    • (2002) Oncogene , vol.21 , Issue.24 , pp. 3872-3878
    • Trinei, M.1
  • 121
    • 0037452461 scopus 로고    scopus 로고
    • Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet
    • Napoli C., et al. Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet. Proc. Natl. Acad. Sci. U. S. A. 100(4):2003;2112-2116
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , Issue.4 , pp. 2112-2116
    • Napoli, C.1
  • 122
    • 0027933135 scopus 로고
    • Marked changes in mitochondrial DNA deletion levels in Alzheimer brains
    • Corraldebrinski M., et al. Marked changes in mitochondrial DNA deletion levels in Alzheimer brains. Genomics. 23(2):1994;471-476
    • (1994) Genomics , vol.23 , Issue.2 , pp. 471-476
    • Corraldebrinski, M.1
  • 123
    • 0026732706 scopus 로고
    • A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues
    • Cortopassi G.A., et al. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc. Natl. Acad. Sci. U. S. A. 89:1992;7370-7374
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 7370-7374
    • Cortopassi, G.A.1
  • 124
    • 0025674177 scopus 로고
    • Detection of a specific mitochondrial DNA deletion in tissues of older humans
    • Cortopassi G.A., Arnheim N. Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res. 23:1990;6927-6933
    • (1990) Nucleic Acids Res. , vol.23 , pp. 6927-6933
    • Cortopassi, G.A.1    Arnheim, N.2
  • 125
    • 0027366179 scopus 로고
    • Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys
    • Lee C.M., et al. Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys. J. Gerontol. 48(6):1993;B201-B205
    • (1993) J. Gerontol. , vol.48 , Issue.6 , pp. 201-B205
    • Lee, C.M.1
  • 126
    • 0028879644 scopus 로고
    • Multiple deletions are detectable in mitochondrial DNA of aging mice
    • Tanhauser S.M., Laipis P.J. Multiple deletions are detectable in mitochondrial DNA of aging mice. J. Biol. Chem. 270(42):1995;24769-24775
    • (1995) J. Biol. Chem. , vol.270 , Issue.42 , pp. 24769-24775
    • Tanhauser, S.M.1    Laipis, P.J.2
  • 127
    • 0027971105 scopus 로고
    • Detection and quantitation by competitive PCR of an age-associated increase in a 4.8-kb deletion in rat mitochondrial DNA
    • Edris W., et al. Detection and quantitation by competitive PCR of an age-associated increase in a 4.8-kb deletion in rat mitochondrial DNA. Mutat. Res. 316(2):1994;69-78
    • (1994) Mutat. Res. , vol.316 , Issue.2 , pp. 69-78
    • Edris, W.1
  • 128
    • 0029019546 scopus 로고
    • Increased frequency of deletions in the mitochondrial genome with age of Caenorhabditis elegans
    • Melov S., et al. Increased frequency of deletions in the mitochondrial genome with age of Caenorhabditis elegans. Nucleic Acids Res. 23(8):1995;1419-1425
    • (1995) Nucleic Acids Res. , vol.23 , Issue.8 , pp. 1419-1425
    • Melov, S.1
  • 129
    • 0002435738 scopus 로고
    • Mitochondrial DNA instabilities and rearrangements in yeasts and fungi
    • D.E. Berg, & M.M. Howe. Washington, DC: American Society for Microbiology
    • Dujon B., Belcour L. Mitochondrial DNA instabilities and rearrangements in yeasts and fungi. Berg D.E., Howe M.M. Mobile DNA. 1989;861-878 American Society for Microbiology, Washington, DC
    • (1989) Mobile DNA , pp. 861-878
    • Dujon, B.1    Belcour, L.2
  • 130
    • 0025836655 scopus 로고
    • Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction
    • Hayashi J., et al. Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction. Proc. Natl. Acad. Sci. U. S. A. 88(23):1991;10614-10618
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , Issue.23 , pp. 10614-10618
    • Hayashi, J.1
  • 132
    • 0026471872 scopus 로고
    • Accumulation of deletions in human mitochondrial DNA during normal aging: Analysis by quantitative PCR
    • Simonetti S., et al. Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR. Biochim. Biophys. Acta. 1180(2):1992;113-122
    • (1992) Biochim. Biophys. Acta , vol.1180 , Issue.2 , pp. 113-122
    • Simonetti, S.1
  • 133
    • 0026529192 scopus 로고
    • Significant existence of deleted mitochondrial DNA in cirrhotic liver surrounding hepatic tumor
    • Yamamoto H., et al. Significant existence of deleted mitochondrial DNA in cirrhotic liver surrounding hepatic tumor. Biochem. Biophys. Res. Commun. 182(2):1992;913-920
    • (1992) Biochem. Biophys. Res. Commun. , vol.182 , Issue.2 , pp. 913-920
    • Yamamoto, H.1
  • 134
    • 0032973569 scopus 로고    scopus 로고
    • Mitochondrial Group II Introns, cytochrome c oxidase, and senescence in Podospora anserina
    • Begel O., et al. Mitochondrial Group II Introns, cytochrome c oxidase, and senescence in Podospora anserina. Mol. Cell. Biol. 19(6):1999;4093-4100
    • (1999) Mol. Cell. Biol. , vol.19 , Issue.6 , pp. 4093-4100
    • Begel, O.1
  • 135
    • 0030582373 scopus 로고    scopus 로고
    • Age-related extensive fragmentation of mitochondrial DNA into minicircles
    • Hayakawa M., et al. Age-related extensive fragmentation of mitochondrial DNA into minicircles. Biochem. Biophys. Res. Commun. 226(2):1996;369-377
    • (1996) Biochem. Biophys. Res. Commun. , vol.226 , Issue.2 , pp. 369-377
    • Hayakawa, M.1
  • 136
    • 0031978512 scopus 로고    scopus 로고
    • Differential occurrence of mutations in mitochondrial DNA of human skeletal muscle during aging
    • Zhang C., et al. Differential occurrence of mutations in mitochondrial DNA of human skeletal muscle during aging. Hum. Mutat. 11(5):1998;360-371
    • (1998) Hum. Mutat. , vol.11 , Issue.5 , pp. 360-371
    • Zhang, C.1
  • 137
    • 0037081814 scopus 로고    scopus 로고
    • High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
    • Lin M.T., et al. High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Hum. Mol. Genet. 11(2):2002;133-145
    • (2002) Hum. Mol. Genet. , vol.11 , Issue.2 , pp. 133-145
    • Lin, M.T.1
  • 138
    • 0347600946 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in human colonic crypt stem cells
    • [see comment]
    • Taylor R.W., et al. Mitochondrial DNA mutations in human colonic crypt stem cells. [see comment] J. Clin. Invest. 112(9):2003;1351-1360
    • (2003) J. Clin. Invest. , vol.112 , Issue.9 , pp. 1351-1360
    • Taylor, R.W.1
  • 139
    • 0141954395 scopus 로고    scopus 로고
    • High mutational burden in the mtDNA control region from aged muscles: A single-fiber study
    • Del Bo R., et al. High mutational burden in the mtDNA control region from aged muscles: a single-fiber study. Neurobiol. Aging. 24(6):2003;829-838
    • (2003) Neurobiol. Aging , vol.24 , Issue.6 , pp. 829-838
    • Del Bo, R.1
  • 141
    • 0033595684 scopus 로고    scopus 로고
    • Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
    • Michikawa Y., et al. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science. 286(5440):1999;774-779
    • (1999) Science , vol.286 , Issue.5440 , pp. 774-779
    • Michikawa, Y.1
  • 142
    • 0035957323 scopus 로고    scopus 로고
    • Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication
    • Wang Y., et al. Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc. Natl. Acad. Sci. U. S. A. 98(7):2001;4022-4027
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , Issue.7 , pp. 4022-4027
    • Wang, Y.1
  • 143
    • 0029864498 scopus 로고    scopus 로고
    • Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA
    • Jazin E.E., et al. Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA. Proc. Natl. Acad. Sci. U. S. A. 93(22):1996;12382-12387
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , Issue.22 , pp. 12382-12387
    • Jazin, E.E.1
  • 144
    • 0036648997 scopus 로고    scopus 로고
    • Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA
    • [see comment]
    • Falkenberg M., et al. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. [see comment] Nat. Genet. 31(3):2002;289-294
    • (2002) Nat. Genet. , vol.31 , Issue.3 , pp. 289-294
    • Falkenberg, M.1
  • 145
    • 0036848145 scopus 로고    scopus 로고
    • Human mitochondrial DNA with large deletions repopulates organelles faster than full-length genomes under relaxed copy number control
    • Diaz F., et al. Human mitochondrial DNA with large deletions repopulates organelles faster than full-length genomes under relaxed copy number control. Nucleic Acids Res. 30(21):2002;4626-4633
    • (2002) Nucleic Acids Res. , vol.30 , Issue.21 , pp. 4626-4633
    • Diaz, F.1
  • 146
    • 0035794640 scopus 로고    scopus 로고
    • Replication and preferential inheritance of hypersuppressive petite mitochondrial DNA
    • MacAlpine D.M., et al. Replication and preferential inheritance of hypersuppressive petite mitochondrial DNA. EMBO J. 20(7):2001;1807-1817
    • (2001) EMBO J. , vol.20 , Issue.7 , pp. 1807-1817
    • MacAlpine, D.M.1
  • 147
    • 0018400885 scopus 로고
    • Visualization of yeast mitochondrial DNA with the fluorescent stain "dAPI"
    • Williamson D.H., Fennell D.J. Visualization of yeast mitochondrial DNA with the fluorescent stain "DAPI" Methods Enzymol. 56:1979;728-733
    • (1979) Methods Enzymol. , vol.56 , pp. 728-733
    • Williamson, D.H.1    Fennell, D.J.2
  • 148
    • 0023442326 scopus 로고
    • Isolation of morphologically intact mitochondrial nucleoids from the yeast, Saccharomyces cerevisiae
    • Miyakawa I., et al. Isolation of morphologically intact mitochondrial nucleoids from the yeast, Saccharomyces cerevisiae. J. Cell Sci. 88(Pt 4):1987;431-439
    • (1987) J. Cell Sci. , vol.88 , Issue.4 PART , pp. 431-439
    • Miyakawa, I.1
  • 149
    • 0038709292 scopus 로고    scopus 로고
    • Composition and dynamics of human mitochondrial nucleoids
    • Garrido N., et al. Composition and dynamics of human mitochondrial nucleoids. Mol. Biol. Cell. 14(4):2003;1583-1596
    • (2003) Mol. Biol. Cell , vol.14 , Issue.4 , pp. 1583-1596
    • Garrido, N.1
  • 150
    • 2442558106 scopus 로고    scopus 로고
    • Protein components of mitochondrial DNA nucleoids in higher eucaryotes
    • Bogenhagen D.F., et al. Protein components of mitochondrial DNA nucleoids in higher eucaryotes. Mol. Cell. Proteomics. 2(11):2003;1205-1216
    • (2003) Mol. Cell. Proteomics , vol.2 , Issue.11 , pp. 1205-1216
    • Bogenhagen, D.F.1
  • 151
    • 0034608792 scopus 로고    scopus 로고
    • In organello formaldehyde crosslinking of proteins to mtDNA: Identification of bifunctional proteins
    • Kaufman B.A., et al. In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins. Proc. Natl. Acad. Sci. U. S. A. 97(14):2000;7772-7777
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , Issue.14 , pp. 7772-7777
    • Kaufman, B.A.1
  • 152
    • 1542375269 scopus 로고    scopus 로고
    • Mechanism of DNA compaction by yeast mitochondrial protein Abf2p
    • Friddle R.W., et al. Mechanism of DNA compaction by yeast mitochondrial protein Abf2p. Biophys. J. 86:2004;1632-1639
    • (2004) Biophys. J. , vol.86 , pp. 1632-1639
    • Friddle, R.W.1
  • 153
    • 0031943922 scopus 로고    scopus 로고
    • Functions of the high mobility group protein, Abf2p, in mitochondrial DNA segregation, recombination and copy number in Saccharomyces cerevisiae
    • Zelenaya-Troitskaya O., et al. Functions of the high mobility group protein, Abf2p, in mitochondrial DNA segregation, recombination and copy number in Saccharomyces cerevisiae. Genetics. 148(4):1998;1763-1776
    • (1998) Genetics , vol.148 , Issue.4 , pp. 1763-1776
    • Zelenaya-Troitskaya, O.1
  • 154
    • 0031930319 scopus 로고    scopus 로고
    • Mitochondrial transcription factor a is necessary for mtDNA maintenance and embryogenesis in mice
    • [see comment]
    • Larsson N.G., et al. Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. [see comment] Nat. Genet. 18(3):1998;231-236
    • (1998) Nat. Genet. , vol.18 , Issue.3 , pp. 231-236
    • Larsson, N.G.1
  • 155
    • 2442431673 scopus 로고    scopus 로고
    • Mitochondrial transcription factor a regulates mtDNA copy number in mammals
    • Ekstrand M.I., et al. Mitochondrial transcription factor A regulates mtDNA copy number in mammals. Hum. Mol. Genet. 13(9):2004;935-944
    • (2004) Hum. Mol. Genet. , vol.13 , Issue.9 , pp. 935-944
    • Ekstrand, M.I.1
  • 156
    • 0025912955 scopus 로고
    • A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria
    • Diffley J.F., Stillman B. A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria. Proc. Natl. Acad. Sci. U. S. A. 88(17):1991;7864-7868
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , Issue.17 , pp. 7864-7868
    • Diffley, J.F.1    Stillman, B.2
  • 157
    • 0001392615 scopus 로고
    • Mitochondrial genetics and functions
    • J.N. Strathern, E.W. Jones, & J.R. Broach. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
    • Dujon B. Mitochondrial genetics and functions. Strathern J.N., Jones E.W., Broach J.R. The Molecular Biology of Yeast Saccharomyces. 1981;505-635 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • (1981) The Molecular Biology of Yeast Saccharomyces , pp. 505-635
    • Dujon, B.1
  • 158
    • 0242593934 scopus 로고    scopus 로고
    • Evidence of a two membrane-spanning autonomous mitochondrial DNA replisome
    • Meeusen S., Nunnari J. Evidence of a two membrane-spanning autonomous mitochondrial DNA replisome. J. Cell Biol. 163(3):2004;503-510
    • (2004) J. Cell Biol. , vol.163 , Issue.3 , pp. 503-510
    • Meeusen, S.1    Nunnari, J.2
  • 159
    • 0344392841 scopus 로고    scopus 로고
    • A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytosqueleton-based segregation machinery
    • Boldogh I.R., et al. A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytosqueleton-based segregation machinery. Mol. Biol. Cell. 14:2003;4618-4627
    • (2003) Mol. Biol. Cell , vol.14 , pp. 4618-4627
    • Boldogh, I.R.1
  • 160
    • 1442309968 scopus 로고    scopus 로고
    • Mmm2p, a mitochondrial outer membrane protein required for yeast mitochondrial shape and maintenance of mtDNA nucleoids
    • Youngman M.J., et al. Mmm2p, a mitochondrial outer membrane protein required for yeast mitochondrial shape and maintenance of mtDNA nucleoids. J. Cell Biol. 164(5):2004;677-688
    • (2004) J. Cell Biol. , vol.164 , Issue.5 , pp. 677-688
    • Youngman, M.J.1
  • 161
    • 0036239112 scopus 로고    scopus 로고
    • The mitochondrial nucleoid protein Mgm101p, of Saccharomyces cerevisiae is involved in the maintemance of rho(+) and ori/rep devoid petite genomes but is not required for hypersuppressive rho(-) mtDNA
    • Zuo X.M., Clarck-Walker G.D., Chen X.J. The mitochondrial nucleoid protein Mgm101p, of Saccharomyces cerevisiae is involved in the maintemance of rho(+) and ori/rep devoid petite genomes but is not required for hypersuppressive rho(-) mtDNA. Genetics. 160(4):2002;1389-1400
    • (2002) Genetics , vol.160 , Issue.4 , pp. 1389-1400
    • Zuo, X.M.1    Clarck-Walker, G.D.2    Chen, X.J.3
  • 162
    • 0034121640 scopus 로고    scopus 로고
    • No sex please, we're mitochondria: A hypothesis on the somatic unit of inheritance of mammalian mtDNA
    • Jacobs H.T., Lehtinen S.K., Spelbrink J.N. No sex please, we're mitochondria: a hypothesis on the somatic unit of inheritance of mammalian mtDNA. BioEssays. 22(6):2000;564-572
    • (2000) BioEssays , vol.22 , Issue.6 , pp. 564-572
    • Jacobs, H.T.1    Lehtinen, S.K.2    Spelbrink, J.N.3
  • 163
    • 0031736203 scopus 로고    scopus 로고
    • Somatic mutations of the mitochondrial genome in human colorectal tumours
    • Polyak K., et al. Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat. Genet. 20(3):1998;291-293
    • (1998) Nat. Genet. , vol.20 , Issue.3 , pp. 291-293
    • Polyak, K.1
  • 164
    • 0242677753 scopus 로고    scopus 로고
    • A function for the mitochondrial chaperonin Hsp60 in the structure and transmission of mitochondrial DNA nucleoids in Saccharomyces cerevisiae
    • Kaufman A.B., et al. A function for the mitochondrial chaperonin Hsp60 in the structure and transmission of mitochondrial DNA nucleoids in Saccharomyces cerevisiae. J. Cell Biol. 163(3):2004;457-461
    • (2004) J. Cell Biol. , vol.163 , Issue.3 , pp. 457-461
    • Kaufman, A.B.1
  • 165
    • 0033521622 scopus 로고    scopus 로고
    • Epistatic interactions of deletion mutants in the genes encoding the F1-ATPase in yeast Saccharomyces cerevisiae
    • Lai-Zhang J., Xiao Y., Mueller D.M. Epistatic interactions of deletion mutants in the genes encoding the F1-ATPase in yeast Saccharomyces cerevisiae. EMBO J. 18(1):1999;58-64
    • (1999) EMBO J. , vol.18 , Issue.1 , pp. 58-64
    • Lai-Zhang, J.1    Xiao, Y.2    Mueller, D.M.3
  • 166
    • 0031081410 scopus 로고    scopus 로고
    • A proposed refinement of the mitochondrial free radical theory of aging
    • de Grey A.D. A proposed refinement of the mitochondrial free radical theory of aging. BioEssays. 19(2):1997;161-166
    • (1997) BioEssays , vol.19 , Issue.2 , pp. 161-166
    • De Grey, A.D.1
  • 167
    • 0036935437 scopus 로고    scopus 로고
    • Maintenance of mitochondrial DNA integrity: Repair and degradation
    • Kang D., Hamasaki N. Maintenance of mitochondrial DNA integrity: repair and degradation. Curr. Genet. 41(5):2002;311-322
    • (2002) Curr. Genet. , vol.41 , Issue.5 , pp. 311-322
    • Kang, D.1    Hamasaki, N.2
  • 168
    • 0035170217 scopus 로고    scopus 로고
    • Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes
    • Jaiswal M., et al. Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes. Gastroenterology. 120(1):2001;190-199
    • (2001) Gastroenterology , vol.120 , Issue.1 , pp. 190-199
    • Jaiswal, M.1
  • 169
    • 0034979216 scopus 로고    scopus 로고
    • Oxidative cellular damage and the reduction of APE/Ref-1 expression after experimental traumatic brain injury
    • Lewen A., et al. Oxidative cellular damage and the reduction of APE/Ref-1 expression after experimental traumatic brain injury. Neurobiol. Dis. 8(3):2001;380-390
    • (2001) Neurobiol. Dis. , vol.8 , Issue.3 , pp. 380-390
    • Lewen, A.1
  • 170
    • 0036946576 scopus 로고    scopus 로고
    • Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis
    • Kikuchi H., et al. Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis. Acta Neuropathol. 103(4):2002;408-414
    • (2002) Acta Neuropathol. , vol.103 , Issue.4 , pp. 408-414
    • Kikuchi, H.1
  • 171
    • 0036639779 scopus 로고    scopus 로고
    • The mitochondrial DNA polymerase as a target of oxidative damage
    • Graziewicz M.A., Day B.J., Copeland W.C. The mitochondrial DNA polymerase as a target of oxidative damage. Nucleic Acids Res. 30(13):2002;2817-2824
    • (2002) Nucleic Acids Res. , vol.30 , Issue.13 , pp. 2817-2824
    • Graziewicz, M.A.1    Day, B.J.2    Copeland, W.C.3
  • 172
    • 2642580016 scopus 로고    scopus 로고
    • Premature ageing in mice expressing defective mitochondrial DNA polymerase
    • Trifunovic A., et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. 429(6990):2004;417-423
    • (2004) Nature , vol.429 , Issue.6990 , pp. 417-423
    • Trifunovic, A.1
  • 173
    • 0016731523 scopus 로고
    • On the formation of hydrogen peroxide and oxygen radicals in heart mitochondria
    • Loschen G., Azzi A. On the formation of hydrogen peroxide and oxygen radicals in heart mitochondria. Recent Adv. Stud. Cardiac Struct. Metab. 7:1975;3-12
    • (1975) Recent Adv. Stud. Cardiac Struct. Metab. , vol.7 , pp. 3-12
    • Loschen, G.1    Azzi, A.2
  • 174
    • 0142150051 scopus 로고    scopus 로고
    • Mitochondrial formation of reactive oxygen species
    • Turrens J.F. Mitochondrial formation of reactive oxygen species. J. Physiol. 552(2):2003;335-344
    • (2003) J. Physiol. , vol.552 , Issue.2 , pp. 335-344
    • Turrens, J.F.1
  • 175
    • 0036319021 scopus 로고    scopus 로고
    • Generation of reactive oxygen species by the mitochondrial electron transport chain
    • Liu Y., Fiskum G., Schubert D. Generation of reactive oxygen species by the mitochondrial electron transport chain. J. Neurochem. 80(5):2002;780-787
    • (2002) J. Neurochem. , vol.80 , Issue.5 , pp. 780-787
    • Liu, Y.1    Fiskum, G.2    Schubert, D.3
  • 176
    • 0037160091 scopus 로고    scopus 로고
    • Topology of superoxide production from different sites in the mitochondrial electron transport chain
    • St-Pierre J., et al. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J. Biol. Chem. 277(47):2002;44784-44790
    • (2002) J. Biol. Chem. , vol.277 , Issue.47 , pp. 44784-44790
    • St-Pierre, J.1
  • 177
    • 0036903625 scopus 로고    scopus 로고
    • Complex I-mediated reactive oxygen species generation: Modulation by cytochrome c and NAD(P)+ oxidation-reduction state
    • Kushnareva Y., Murphy A.N., Andreyev A. Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state. Biochem. J. 368(Pt 2):2002;545-553
    • (2002) Biochem. J. , vol.368 , Issue.2 PART , pp. 545-553
    • Kushnareva, Y.1    Murphy, A.N.2    Andreyev, A.3
  • 178
    • 0033858360 scopus 로고    scopus 로고
    • The contribution of mitochondrial respiratory complexes to the production of reactive oxygen species
    • McLennan H.R., Degli Esposti M. The contribution of mitochondrial respiratory complexes to the production of reactive oxygen species. J. Bioenerg. Biomembranes. 32(2):2000;153-162
    • (2000) J. Bioenerg. Biomembranes , vol.32 , Issue.2 , pp. 153-162
    • McLennan, H.R.1    Degli Esposti, M.2
  • 179
    • 0025800120 scopus 로고
    • Oxidative energy failure in post-mitotic cells: A major factor in senescence
    • Byrne E., Dennett X., Trounce I. Oxidative energy failure in post-mitotic cells: a major factor in senescence. Rev. Neurol. (Paris). 147(6-7):1991;532- 535
    • (1991) Rev. Neurol. (Paris) , vol.147 , Issue.67 , pp. 532-535
    • Byrne, E.1    Dennett, X.2    Trounce, I.3
  • 180
    • 0024394721 scopus 로고
    • Decline in skeletal muscle mitochondrial respiration chain function with ageing
    • [letter; comment]
    • Cardellach F., et al. Decline in skeletal muscle mitochondrial respiration chain function with ageing. [letter; comment] Lancet. 2(8653):1989;44-45
    • (1989) Lancet , vol.2 , Issue.8653 , pp. 44-45
    • Cardellach, F.1
  • 181
    • 0032055865 scopus 로고    scopus 로고
    • Analysis of oxygen consumption and mitochondrial permeability with age in mice
    • Goodell S., Cortopassi G. Analysis of oxygen consumption and mitochondrial permeability with age in mice. Mech. Ageing Dev. 101(3):1998;245-256
    • (1998) Mech. Ageing Dev. , vol.101 , Issue.3 , pp. 245-256
    • Goodell, S.1    Cortopassi, G.2
  • 182
    • 0027096139 scopus 로고
    • Age-related changes of mitochondrial F0F1 ATP synthase
    • Guerrieri F., et al. Age-related changes of mitochondrial F0F1 ATP synthase. Ann. N. Y. Acad. Sci. 671:1992;395-402
    • (1992) Ann. N. Y. Acad. Sci. , vol.671 , pp. 395-402
    • Guerrieri, F.1
  • 183
    • 0030582656 scopus 로고    scopus 로고
    • Absence of relationship between the level of electron transport chain activities and aging in human skeletal muscle
    • Barrientos A., et al. Absence of relationship between the level of electron transport chain activities and aging in human skeletal muscle. Biochem. Biophys. Res. Commun. 229(2):1996;536-539
    • (1996) Biochem. Biophys. Res. Commun. , vol.229 , Issue.2 , pp. 536-539
    • Barrientos, A.1
  • 184
    • 9844235346 scopus 로고    scopus 로고
    • Mitochondrial involvement in the ageing process. Facts and controversies
    • Brierley E.J., et al. Mitochondrial involvement in the ageing process. Facts and controversies. Mol. Cell. Biochem. 174(1-2):1997;325-328
    • (1997) Mol. Cell. Biochem. , vol.174 , Issue.12 , pp. 325-328
    • Brierley, E.J.1
  • 185
    • 0032518849 scopus 로고    scopus 로고
    • Biochemical parameters for the diagnosis of mitochondrial respiratory chain deficiency in humans, and their lack of age-related changes
    • Chretien D., et al. Biochemical parameters for the diagnosis of mitochondrial respiratory chain deficiency in humans, and their lack of age-related changes. Biochem. J. 329(Pt 2):1998;249-254
    • (1998) Biochem. J. , vol.329 , Issue.2 PART , pp. 249-254
    • Chretien, D.1
  • 186
    • 0032511842 scopus 로고    scopus 로고
    • An age-associated correlation between cellular bioenergy decline and mtDNA rearrangements in human skeletal muscle
    • Kopsidas G., et al. An age-associated correlation between cellular bioenergy decline and mtDNA rearrangements in human skeletal muscle. Mut. Res. 421(1):1998;27-36
    • (1998) Mut. Res. , vol.421 , Issue.1 , pp. 27-36
    • Kopsidas, G.1
  • 187
    • 0037016442 scopus 로고    scopus 로고
    • Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q
    • [see comment]
    • Larsen P.L., Clarke C.F. Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q. [see comment] Science. 295(5552):2002;120-123
    • (2002) Science , vol.295 , Issue.5552 , pp. 120-123
    • Larsen, P.L.1    Clarke, C.F.2
  • 188
    • 0038380464 scopus 로고    scopus 로고
    • Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans
    • Asencio C., et al. Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans. FASEB J. 17(9):2003;1135-1137
    • (2003) FASEB J. , vol.17 , Issue.9 , pp. 1135-1137
    • Asencio, C.1
  • 189
    • 0035515923 scopus 로고    scopus 로고
    • Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
    • Feng J., Bussiere F., Hekimi S. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev. Cell. 1(5):2001;633-644
    • (2001) Dev. Cell , vol.1 , Issue.5 , pp. 633-644
    • Feng, J.1    Bussiere, F.2    Hekimi, S.3
  • 190
    • 0035723838 scopus 로고    scopus 로고
    • Overexpression of the alternative oxidase restores senescence and fertility in a long-lived respiration-deficient mutant of Podospora anserina
    • Lorin S., et al. Overexpression of the alternative oxidase restores senescence and fertility in a long-lived respiration-deficient mutant of Podospora anserina. Mol. Microbiol. 42(5):2001;1259-1267
    • (2001) Mol. Microbiol. , vol.42 , Issue.5 , pp. 1259-1267
    • Lorin, S.1
  • 191
    • 0034636154 scopus 로고    scopus 로고
    • A causal link between respiration and senescence in Podospora anserina
    • Dufour E., et al. A causal link between respiration and senescence in Podospora anserina. Proc. Natl. Acad. Sci. U. S. A. 97(8):2000;4138-4143
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , Issue.8 , pp. 4138-4143
    • Dufour, E.1
  • 192
    • 0037228016 scopus 로고    scopus 로고
    • A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
    • Lee S.S., et al. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat. Genet. 33(1):2003;40-48
    • (2003) Nat. Genet. , vol.33 , Issue.1 , pp. 40-48
    • Lee, S.S.1
  • 193
    • 0037147103 scopus 로고    scopus 로고
    • Rates of behavior and aging specified by mitochondrial function during development
    • Dillin A., et al. Rates of behavior and aging specified by mitochondrial function during development. Science. 298(5602):2002;2398-2401
    • (2002) Science , vol.298 , Issue.5602 , pp. 2398-2401
    • Dillin, A.1
  • 194
    • 0344393021 scopus 로고    scopus 로고
    • Quality control and protein folding in the secretory pathway
    • Trombetta E.S., Parodi A.J. Quality control and protein folding in the secretory pathway. Annu. Rev. Cell Dev. Biol. 19:2003;649-676
    • (2003) Annu. Rev. Cell Dev. Biol. , vol.19 , pp. 649-676
    • Trombetta, E.S.1    Parodi, A.J.2
  • 196
    • 0035910525 scopus 로고    scopus 로고
    • Heat shock and oxidative stress-induced exposure of hydrophobic protein domains as common signal in the induction of hsp68
    • Gosslau A., et al. Heat shock and oxidative stress-induced exposure of hydrophobic protein domains as common signal in the induction of hsp68. J. Biol. Chem. 276(3):2001;1814-1821
    • (2001) J. Biol. Chem. , vol.276 , Issue.3 , pp. 1814-1821
    • Gosslau, A.1
  • 197
    • 0001700405 scopus 로고
    • The development of 'Senescence' in Podospora anserina
    • Smith J.R., Rubenstein I. The development of 'Senescence' in Podospora anserina. J. Gen. Microbiol. 76:1973;283-296
    • (1973) J. Gen. Microbiol. , vol.76 , pp. 283-296
    • Smith, J.R.1    Rubenstein, I.2
  • 198
    • 0033968516 scopus 로고    scopus 로고
    • The reductive hotspot hypothesis: An update
    • de Grey A.D. The reductive hotspot hypothesis: an update. Arch. Biochem. Biophys. 373(1):2000;295-301
    • (2000) Arch. Biochem. Biophys. , vol.373 , Issue.1 , pp. 295-301
    • De Grey, A.D.1
  • 199
    • 0034841703 scopus 로고    scopus 로고
    • Effects of mild heat shocks at young age on aging and longevity in Drosophila melanogaster
    • LeBourg E., et al. Effects of mild heat shocks at young age on aging and longevity in Drosophila melanogaster. Biogerontology. 2(3):2001;155-164
    • (2001) Biogerontology , vol.2 , Issue.3 , pp. 155-164
    • Lebourg, E.1
  • 200
    • 0038826959 scopus 로고    scopus 로고
    • Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress
    • Hercus M.J., Loeschcke V., Rattan S.I. Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress. Biogerontology. 4(3):2003;149-156
    • (2003) Biogerontology , vol.4 , Issue.3 , pp. 149-156
    • Hercus, M.J.1    Loeschcke, V.2    Rattan, S.I.3
  • 201
    • 0034902485 scopus 로고    scopus 로고
    • Hormesis, aging and longevity determination
    • [comment]. (discussion 319-320)
    • Hayflick L. Hormesis, aging and longevity determination. [comment] Hum. Exp. Toxicol. 20(6):2001;289-291. (discussion 319-320)
    • (2001) Hum. Exp. Toxicol. , vol.20 , Issue.6 , pp. 289-291
    • Hayflick, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.