Mitochondrial DNA - All things bad?

Trends in Genetics

Volumn 15, Issue 3, 1999, Pages 91-93

  Lightowlers, Robert N ^a   Jacobs, Howard T ^b,c   Kajander, Olli A ^c  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

AGING; BIOENERGY; CELL LEVEL; CELL VIABILITY; DELETION MUTANT; GENE DELETION; GENETIC MODEL; GERONTOLOGICAL RESEARCH; HUMAN; HYPOTHESIS; MITOCHONDRIAL RESPIRATION; MUTAGENESIS; MUTATION; POINT MUTATION; PRIORITY JOURNAL; RESPIRATORY CHAIN; REVIEW; SENESCENCE;

EID: 0033060033     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(98)01684-9     Document Type: Short Survey

References (27)

1. Nagley, P. and Wei, Y.H. (1998) Ageing and mitochondrial genetics. Trends Genet. 14, 1-5
2. Swerdlow, R.H. et al. (1997) Cybrids in Alzheimer's disease: a cellular model of the disease. Neurology 49, 918-925
3. Davis, R.E. et al. (1997) Mutations in cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proc. Natl. Acad. Sci. U. S. A. 94, 4526-4531
4. Gu, M. et al. (1998) Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease. Ann. Neurol. 44, 177-186
5. Hirano, M. et al. (1997) Apparent mtDNA heteroplasmy in Alzheimer's disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes. Proc. Natl. Acad. Sci. U.S.A. 94, 14894-14899
6. Schon, E.A. et al. (1998) Cybrids in Alzheimer's disease: a cellular model of the disease? Neurology 51, 326-327
7. Harman, D. (1981) The aging process. Proc. Natl. Acad. Sci. U. S. A. 78, 7124-7128
8. Fleming, J.E. et al. (1982) Is cell aging caused by respiration-dependent injury to mitochondrial genome? Gerontology 28, 44-53
9. Cortopassi, G.A. et al. (1992) A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc. Natl. Acad. Sci. U. S. A. 89, 7370-7374
10. Corral-Debrinski, M. et al. (1992) Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat. Genet. 2, 324-329
11. Liu, V.W.S. et al. (1998) Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing. Nucleic Acids Res. 26, 1268-1275
12. Liu, V.W.S. et at. (1998) Independent occurrence of somatic mutations in mitochondrial DNA of human skin from subjects of various ages. Hum. Mutat. 11, 191-196
13. 't Hart, L.M. et al. (1996) Heteroplasmy levels of a mitochondrial gene mutation associated with diabetes mellitus decrease in leucoyte DNA upon aging. Hum. Mutat. 7, 193-197
14. Zhang, C.F. et al. (1998) Differential occurrence of mutations in mitochondrial DNA of human skeletal muscle during aging. Hum. Mutat. 11, 360-371
15. Schon, E.A. et al. (1997) Mitochondrial DNA mutations and pathogenesis. J. Bioenerg. Biomembr. 29, 131-149
16. Hayashi, J-I. et al. (1991) Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction. Proc. Natl. Acad. Sci. U. S. A. 88, 10614-10618
17. Melov, S. et al. (1995) Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle. Nucleic Acids Res. 23, 4122-4126
18. Jazin, E.E. et al. (1996) Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA. Proc. Natl. Acad. Sci. U. S. A. 93, 12382-12387
19. Laderman, K.A. et al. (1996) Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells. J. Biol. Chem. 271, 15891-15897
20. Isobe, K. et al. (1996) Nuclear-recessive mutations of factors involved in mitochondrial translation are responsible for age-related respiration deficiency of human skin fibroblasts. J. Biol. Chem. 273, 4601-4606
21. Muller-Hocker, J. et at. (1993) Different in situ hybridisation patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly. Virchows Arch. A 422, 7-15
22. Brierley, E.J. et al. (1998) Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle. Ann. Neurol. 43, 217-223
23. Shigenaga, M.K. et al. (1994) Oxidative damage and mitochondrial decay in ageing. Proc. Natl. Acad. Sci. U. S. A. 91, 10771-10778
24. Chretien, D. et al. (1998) Biochemical parameters for the diagnosis of mitochondrial respiratory chain deficiency in humans and their lack of age-related changes. Biochem. J. 329, 249-254
25. Barrientos, A. et al. (1996) Absence of relationship between the level of electron transport chain activities and aging in human skeletal muscle. Biochem. Biophys. Res. Commun. 229, 536-539
26. Petruzzella, V. et al. (1992) In vivo effect of acetyl-L-carnitine on succinate oxidation, adenine-nucleotide pool and lipid composition of synaptic and nonsynaptic mitochondria from cerebral hemispheres of senescent rats. Arch. Gerontol. Geriatr. 14, 131-144
27. de Grey, A.D.N.J. (1998) A mechanism proposed to explain the rise in oxidative stress during aging. J. Anti-aging Med. 1, 53-65