No sex please, we're mitochondria: A hypothesis on the somatic unit of inheritance of mammalian mtDNA

BioEssays

Volumn 22, Issue 6, 2000, Pages 564-572

  Jacobs, Howard T ^a   Lehtinen, Sanna K ^a   Spelbrink, Johannes N ^a  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ANIMAL; BIOLOGICAL MODEL; EVOLUTION; GENETICS; MAMMAL; REVIEW;

ANIMALS; DNA, MITOCHONDRIAL; EVOLUTION; MAMMALS; MODELS, GENETIC;

ANIMALIA; MAMMALIA;

EID: 0034121640     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-1878(200006)22:6<564::AID-BIES9>3.0.CO;2-4     Document Type: Review

References (53)

1. Nunnari J, Marshall WF, Straight A, Murray A, Sedat JW, Walter P. Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondnal fusion and fission and the intramitochondrial segregation of mitochondrial DNA. Mol Biol Cell 1997;8: 1233-1242.
2. 2+ responses. Science 1998;280:1763-1766.
3. Smirnova E, Shurland DL, Ryazantsev SN, van der Bliek AM. A human dynamin-related protein controls of the mitochondria. J Cell Biol 1998;43: 351-358.
4. Preiss T, Lowerson SA, Weber K, Lightowlers RN. Human mitochondria - distinct organelles or dynamic network. Trends Genet 1995;11: 211-212.
5. Yoneda M, Miyatake T, Attardi G. Complementation of mutant and wild-type human mitochondrial DNAs coexisting since the mutation event and lack of complementation of DNAs introduced separately into a cell within distinct organelles. Mol Cell Biol 1994;14:2699-2712.
6. Linnane AW, Znang CF, Baumer A, Nagley P. Mitochondrial DNA mutation and the aging process - bioenergy and pharmacological intervention. Mutation Res 1992;275:195-208.
7. Miquel J. An integrated theory of aging as the result of mitochondrial DNA mutation in differentiated cells. Arch Gerontol Geriatr 1991;12: 99-117.
8. Chomyn A, Attardi G. Mitochondrial gene products. Curr Topics in Bioenerget 1987;15:295-329.
9. Lightowlers RN, Chinnery PF, Turnbull DM, Howell N. Mammalian mitochondrial genetics: heredity, heteroplasmy and disease. Trends in Genet 1997;13:450-455.
10. Marchington DR, Hartshorne GM, Barlow D, Poulton J. Homopolymeric tract heteroplasmy in mtDNA from tissues and single oocytes: Support for a genetic bottleneck. Am J Hum Genet 1997;60:408-416.
11. Piko L, Taylor KD. Amounts of mitochondrial DNA and abundance of some mitochondrial gene transcripts in early mouse embryos. Dev Biol 1987;123:364-374.
12. Jenuth JP, Peterson AC, Fu K, Shoubridge EA. Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondral DNA. Nat Genet 1996;14:146-151.
13. Matthews PM, Brown RM, Morten K, Marchington D, Poulton J, Brown G. Intracellular heteroplasmy for disease-associated point mutations in mtDNA - implications for disease expression and evidence for mitotic segregation of heteroplasmic units of mtDNA. Hum Genet 1995;96: 261-268.
14. Shoubridge EA. Segregation of mitochondrial DNAs carrying a pathogenic point mutatior (tRNA (leu3243)) in cybrid cells. Biochem Biophys Res Commun 1995;213:189-195.
15. Lehtinen SK, Hance N, El Meziane A, Juhola MK, Juhola KMI, Karhu R, Spelbrink JN, Holt IJ, Jacobs HT. Genotypic stability, segregation and selection in heteroplasmic human cell-lines containing np 3243 mutant mtDNA. Genetics 2000;154:363-380.
16. Enriquez JA, Cabezas-Herrera J, Bayona-Bafaluy, MP, Attardi G. Very rare complementation between mitochondria carrying different mtDNA mutation points to intrinsic genetic autonomy of the organelles in cultured human cells. J Biol Chem 2000;in press.
17. Takai D, Isobe K, Hayashi JI. Transcomplementation between different types of respiration-deficient mitochondria with different pathogenic mutant mitochondrial DNAs. J Biol Chem 1999;274:11199-11202.
18. Takai D, Inoue K, Goto Y, Nonaka I, Hayashi JI. The interorganellar interaction between distinct human mitochondria with deletion mutant mtDNA from a patient with mitochondrial disease and with HeLa mtDNA. J Biol Chem 1997;272:6028-6033.
19. Walker UA, Miranda AF, Schon EA, Davidson MM. Genetic complementation of pathogenic mitochondrial DNA point mutations in postmitotic muscle cultures. Neurology 1997;48:51002.
20. Sobreira C, King MP, Davidson M, Schon EA, Miranda AF. In vitro restoration of respiratory chain function by genetic complementation of two nonoverlapping mitochondrial DNA deletions in postmitotic muscle. Neurology 1996;46:60003.
21. Hayashi JI, Takemitsu M, Goto Y, Nonaka I. Human mitochondria and mitochondrial genome function as a single dynamic cellular unit. J Cell Biol 1994;125:43-50.
22. Robin ED, Wong R. Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells. J Cell Physiol 1988;136: 507-513.
23. Veltri KL, Espiritu M, Singh G. Distinct genomic copy number in mitochondria of different mammalian organs. J Cell Physiol 1990;143: 160-164.
24. Van den Bogert C, De Vries H, Holtrop M, Muus P, Dekker HL, Van Galen MJ, Bolhuis PA, Taanman JW. Regulation of the expression of mitochondrial proteins: relationship between mtDNA copy number and cytochrome-c oxidase activity in human cells and tissues. Biochim Biophys Acta 1993;1144:177-183.
25. Jenuth JP, Petersor AC, Shoubridge EA. Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice. Nat Genet 1997;16: 93-95.
26. Matthews PM, Hopkin J, Brown RM, Stephenson JBP, Hilton-Jones D, Brown GK. Comparison of the relative levels of the 3243 (A->G) mtDNA mutation in heteroplasmic adult and fetal tissues. J Med Genet 1994; 31:41-44.
27. Attardi G, Yoneda M, Chomyn A. Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems. Biochim Biophys Acta 1995; 1271:241-248.
28. Dunbar DR, Moonie PA, Zeviani M, Holt IJ. Complex I deficiency is associated with 3243G:C mitochondrial DNA in osteosarcoma cell cyorids. Hum Mol Genet 1996;5:123-129.
29. Moslemi AR, Tulinius M, Holme E, Oldfors A. Threshold expression of the tRNA(Lys) A8344G mutation in single muscle fibres. Neuromusc Dis 1998;8:345-349.
30. Bogenhagen D, Clayton DA. Mouse cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle. Cell 1977; 11:719-727.
31. Flory PJ, Vinograd J, 5-bromodeoxyuridine labeling of monomeric and catenated circular mitochondrial DNA in HeLa cells. J Mol Biol 1973; 74:81-94.
32. Brasseur G, Tron G, Dujardin G, Slonimski PP, Brivet-Chevillotte P. The nuclear ABC1 gene is essential for the correct conformation and functioning of the cytochrome bc1 complex and the neighbouring complexes II and IV in the mitochondria! respiratory chain. Eur J Biochem 1997;246:103-111.
33. James AM, Sheard PW, Wei YH, Murphy MP. Decreased ATP synthesis is phenotypically expressed during increased energy demand in fibroblasts containing mitochondrial tRNA mutations - Implications for neurodegenerative and mitochondrial DNA diseases. Eur J Biochem 1999;259:462-469.
34. Clayton DA. Replication of animal mitochondrial DNA Cell 1982;28: 693-705.
35. Albring M, Griffith J, Attardi G. Association of a protein structure of probable membrane derivation with HeLa cell mitochondrial DNA near its origin of replication. Proc Natl Acad Sci USA 1977;74:1348-1352.
36. Barat M, Rickwood D, Dufresne C, Mounolou JC. Characterization of DNA-protein complexes from the mitochondria of Xenopus laevis oocytes. Exp Cell Res 1985;157:207-217.
37. Kuroiwa T, Ohta T, Kuroiwa H, Shigeyuki K. Molecular and cellular mechanisms of mitochondrial nuclear division and mitochondriokinesis Microscopy Res Technique 1994;27:220-232.
38. Kuroiwa T, Kuroiwa H, Sakai A, Takahashi H, Toda K, Itoh R. The division apparatus of plastids and mitochondria. Int Rev Cytol 1998;181:1-41.
39. Oldenburg DJ, Bendich AJ. Fluorescence microscopy of DNA-protein structures from osmotically lysed mitochondria of yeast and tobacco Protoplasma 1998;201:53-63.
40. Sasaki N, Sakai A, Kawano S, Kuroiwa H, Kuroiwa T. DNA synthesis in isolated mitochondrial nucleoids from plasmodia of Physarum polycephalum. Protoplasma 1998;203:221-231.
41. Newman, SM, Zelenaya-Troitskaya O, Perlman PS, Butow RA. Analysis of mitochondrial DNA nucleoids in wild-type and a mutant strain of Saccharomyces cerevisiae that lacks tne mitochondrial HMG box protein Abf2p. Nucl Acids Res 1996;24:386-393.
42. Maleszka R, Skelly PJ, Clark-Walker GD. Rolling circle replication of DNA in yeast mitochondria. EMBO J 1991;10:3923-3929.
43. Baxevanis AD, Landsman D. The HMG-1 box protein family: classification and functional relationships. Nucleic Acids Res 1995;23:1604-1613.
44. Zelenaya-Troitskaya O, Newman SM, Okamoto K, Perlman PS, Butow RA. Functions of the high mobility group protein, Abf2p, in mitochondrial DNA segregation, recombination and copy number in Saccharomyces cerevisiae. Genetics 1998;148:1763-1776.
45. Larsson NG, Wang J, Wilhelmsson H, Oldfors A, Rustin P, Lewandoski M, Barsh GS, Clayton DA. Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet 1998; 18:231-236.
46. Miyakawa I, Fumoto S, Kuroiwa T, Sando N. Characterization of DNA-binding proteins involved in the assembly of mitochondrial nucleoids in the yeast Saccharomyces cerevisiae. Plant Cell Physol 1995;36: 1179-1188.
47. Meeusen S, Tieu QT, Wong E, Weiss E, Schieltz D, Yates JR, Nunnari J. Mgm101p is a novel component of the mitochondrial nucleoid that binds DNA and is required for the repair of oxidatively damaged mitochondrial DNA. J Cell Biol 1999;145:291-304.
48. Hermann GJ, Shaw JM. Mitochondrial dynamics in yeast. Ann Rev Cell Dev Biol 1998;14:265-303.
49. Nijtmans LGJ, Taanman JW, Muijsers AO, Speijer D, Van den Bogert C. Assembly of cytochrome c cxidase in cultured human cells. Eur J Biochem 1998;254:389-394.
50. Arlt H, Tauer R, Feldmann H, Neupert W, Langer T. The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondria. Cell 1996;85:875-885.
51. Shepard KA, Yaffe MP. The yeast dynamin-like protein, Mgm1p functions on the mitochondrial outer membrane to mediate mitochondrial inheritance. J Cell Biol 1999;144 711-720.
52. Satoh M, Kuroiwa T. Organization of multiple nucleoids and DNA molecules in mitochondria of a human cell. Exp Cell Res 1991;196: 137-140.
53. Laderman KA, Penny JR, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G. Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells. J Biol Chem 1996;271:15891-15897.