Evidence for a two membrane-spanning autonomous mitochondrial DNA replisome

Journal of Cell Biology

Volumn 163, Issue 3, 2003, Pages 503-510

  Meeusen, Shelly ^a   Nunnari, Jodi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Membrane spanning; Mitochondria; mtDNA; Nucleoid; Replisome

Indexed keywords

BROXURIDINE; DNA POLYMERASE; MACROPHAGE INFLAMMATORY PROTEIN 1; MITOCHONDRIAL DNA; NUCLEOPROTEIN;

ARTICLE; DNA REPAIR; DNA REPLICATION; INHERITANCE; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SACCHAROMYCES CEREVISIAE;

CELLS, CULTURED; DNA POLYMERASE I; DNA REPLICATION; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; GREEN FLUORESCENT PROTEINS; INDOLES; INTRACELLULAR MEMBRANES; LUMINESCENT PROTEINS; MITOCHONDRIA; NUCLEAR PROTEINS; NUCLEOPROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0242593934     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200304040     Document Type: Article

References (33)

1. Azpiroz, R., and R.A. Butow. 1993. Patterns of mitochondrial sorting in yeast zygotes. Mol. Biol. Cell. 4:21-36.
2. Bahler, J., J.Q. Wu, M.S. Longtine, N.G. Shah, A. McKenzie, III, A.B. Steever, A. Wach, P. Philippsen, and J.R. Pringle. 1998. Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast. 14:943-951.
3. Bevis, B.J., and B.S. Glick. 2002. Rapidly maturing variants of the Discosoma red fluorescent protein (DsRed). Nat. Biotechnol. 20:83-87. (published erratum appears in Nat. Biotechnol. 2002. 20:1159)
4. Bevis, B.J., and B.S. Glick. 2002. Rapidly maturing variants of the Discosoma red fluorescent protein (DsRed). Nat. Biotechnol. 20:83-87. (published erratum appears in Nat. Biotechnol. 2002. 20:1159)
5. Birky, C.W., Jr. 1978. Transmission genetics of mitochondria and choroplasts. Annu. Rev. Genet. 12:471-512.
6. Boldogh, I., N. Vojtov, S. Karmon, and L.A. Pon. 1998. Interaction between mitochondria and the actin cytoskeleton in budding yeast requires two integral mitochondrial outer membrane proteins, Mmm1p and Mdm10p. J. Cell Biol. 141:1371-1381.
7. Burgess, S.M., M. Delannoy, and R.E. Jensen. 1994. MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria. J. Cell Bio. 126:1375-1391.
8. Chen, X.J., M.X. Guan, and G.D. Clark-Walker. 1993. MGM101, a nuclear gene involved in maintenance of the mitochondrial genome in Saccharomyces cerevisiae. Nucleic Acids Res. 21:3473-3477.
9. Coen, D., J. Deutsch, P. Netter, E. Petrochilo, and P. Slonimski. 1970. Mitochondrial genetics. I. Methodology and phenomenology. Symp. Soc. Exp. Biol. 24:449-496.
10. Diffley, J.F., and B. Stillman. 1991. A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria. Proc. Natl. Acad. Sci. USA. 88:7864-7868.
11. Diffley, J.F., and B. Stillman. 1992. DNA binding properties of an HMG1-related protein from yeast mitochondtia. J. Biol. Chem. 267:3368-3374.
12. Foury, F. 1989. Cloning and sequencing of the nuclear gene MIP1 encoding the catalytic subunit of the yeast mitochondrial DNA polymetase. J. Biol. Chem. 264:20552-20560.
13. Garrido, N., L. Griparic, E. Jokitalo, J. Wartiovaara, A.M. van der Bliek, and J.N. Spelbrink. 2003. Composition and dynamics of human mitochondrial nucleoids. Mol. Biol. Cell. 14:1583-1596.
14. Gietz, R.D., and R.H. Schiestl. 1991. Transforming yeast with DNA. Methods Mol. Cell. Biol. 5:255-269.
15. Guthrie, C., and G. Fink. 1991. Guide to Yeast Genetics and Molecular Biology. Academic Press Inc., San Diego. 933 pp.
16. Hobbs, A.E., M. Srinivasan, J.M. McCaffery, and R.E. Jensen. 2001. Mmm1p, a mitochondrial outer membrane protein, is connected to mitochondrial DNA (mtDNA) nucleoids and required for mtDNA stability. J. Cell. Biol. 152:401-410.
17. Hoffmann, H.P., and C.J. Avers. 1973. Mitochondrion of yeast: ultrastructural evidence for one giant, branched organelle per cell. Science. 181:749-751.
18. Jones, B.A., and W.L. Fangman. 1992. Mitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynamin. Genes Dev. 6:380-389.
19. Kaufman, B.A., S.M. Newman, R.L. Hallberg, C.A. Slaughter, P.S. Perlman, and R.A. Butow. 2000. In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins. Proc. Natl. Acad. Sci. USA. 97:7772-7777.
20. Lemon, K.P., and A.D. Grossman. 1998. Localization of bacterial DNA polymerase: evidence for a factory model of replication. Science. 282:1516-1519.
21. Lemon, K.P., and A.D. Grossman. 2000. Movement of replicating DNA through a stationary replisome. Mol. Cell. 6:1321-1330.
22. Meeusen, S., Q. Tieu, E. Wong, E. Weiss, D. Schieltz, J.R. Yates, and J. Nunnari. 1999. Mgm101p is a novel component of the mitochondrial nucleoid that binds DNA and is required for the repair of oxidatively damaged mitochondrial DNA. J. Cell Biol. 145:291-304.
23. Miyakawa, I., H. Aoi, N. Sando, and T. Kuroiwa. 1984. Fluorescence microscopic studies of mitochondrial nucleoids during meiosis and sporulation in the yeast, Saccharomyces cerevisiae. J. Cell Sci. 66:21-38.
24. Nunnari, J., W.F. Marshall, A. Straight, A. Murray, J.W. Sedat, and P. Walter. 1997. Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA. Mol. Biol. Cell. 8:1233-1242.
25. Ogbadoyi, E.O., D.R. Robinson, and K. Gull. 2003. A high-order trans-membrane structural linkage is responsible for mitochondrial genome positioning and segregation by flagellar basal bodies in trypanosomes. Mol. Biol. Cell. 14: 1769-1779.
26. Okamoto, K., P.S. Perlman, and R.A. Butow. 1998. The sorting of mitochondrial DNA and mitochondrial protein in zygotes: preferential transmission of mitochondrial DNA to the medial bud. J. Cell Biol. 142:613-623.
27. Robinson, D.R., and K. Gull. 1991. Basal body movements as a mechanism for mitochondrial genome segregation in the trypanosome cell cycle. Nature. 352:731-733.
28. Spelbrink, J.N., F.Y. Li, V. Tiranti, K. Nikali, Q.P. Yuan, M. Tariq, S. Wanrooij, N. Garrido, G. Comi, L. Morandi, et al. 2001. Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria. Nat. Genet. 28:223-231.
29. Strausberg, R.L., and P.S. Perlman. 1978. The effect of zygotic bud position on the transmission of mitochondrial genes in Saccharomyces cerevisiae. Mol. Gen. Genet. 163:131-144.
30. Williamson, D.H., and D.J. Fennell. 1979. Visualization of yeast mitochondrial DNA with the fluorescent stain "DAPI." Methods Enzymol. 56:728-733.
31. Wong, E.D., J.A. Wagner, S.W. Gorsich, J.M. McCaffery, J.M. Shaw, and J. Nunnari. 2000. The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J. Cell Biol. 151:341-352.
32. Wong, E.D., J.A. Wagner, S.V. Scott, V. Okreglak, T.J. Holewinske, A. Cassidy-Stone, and J. Nunnari. 2003. The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion. J. Cell Biol. 160:303-311.
33. Zinn, A.R., J.K. Pohlman, P.S. Perlman, and R.A. Butow. 1987. Kinetic and segregational analysis of mirochondrial DNA recombination in yeast. Plasmid. 17:248-256.