The allergic cascade: Review of the most important molecules in the asthmatic lung

Immunology Letters

Volumn 113, Issue 1, 2007, Pages 6-18

  Bloemen, Karolien ^a   Verstraelen, Sandra ^a   Van Den Heuvel, Rosette ^a   Witters, Hilda ^a   Nelissen, Inge ^a   Schoeters, Greet ^a  

^a FLEMISH INSTITUTE FOR TECHNOLOGICAL RESEARCH VITO   (Belgium)

Author keywords

Airway hyperresponsiveness; Airway remodeling; Allergic cascade; Inflammation; Mediators

Indexed keywords

8 ISOPROSTANE; ADAM PROTEIN; CHEMOKINE; CYTOKINE; ENDOTHELIN 1; INTERLEUKIN 3; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; LEUKOTRIENE; LEUKOTRIENE B4; MATRIX METALLOPROTEINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROSTAGLANDIN D2; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ALLERGIC ASTHMA; BASOPHIL; CELL TYPE; CYTOKINE RELEASE; DENDRITIC CELL; DISEASE COURSE; ENDOTHELIUM CELL; EOSINOPHIL; EPITHELIUM CELL; HUMAN; INFLAMMATION; MACROPHAGE; MAST CELL; MEDIATOR RELEASE; NEUTROPHIL; PRIORITY JOURNAL; REVIEW; SMOOTH MUSCLE FIBER; T LYMPHOCYTE;

ALLERGENS; ANIMALS; ASTHMA; HUMANS; IMMUNITY, CELLULAR; INFLAMMATION MEDIATORS; LUNG;

EID: 34648820354     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2007.07.010     Document Type: Review

References (193)

1. Ronchetti R., Villa M.P., Barreto M., Rota R., Pagani J., Martella S., et al. Is the increase in childhood asthma coming to an end? Findings from three surveys of schoolchildren in Rome, Italy. Eur Respir J 17 5 (2001) 881-886
2. Bharadwaj A., and Agrawal D.K. Immunomodulation in asthma: a distant dream or a close reality?. Int Immunopharmacol 4 4 (2004) 495-511
3. Holt P.G. Antigen presentation in the lung. Am J Respir Crit Care Med 162 4 Pt 2 (2000) S151-S156
4. Corry D.B., and Kheradmand F. Induction and regulation of the IgE response. Nature 402 6760 Suppl (1999) B18-B23
5. Turner H., and Kinet J.P. Signalling through the high-affinity IgE receptor Fc epsilonRI. Nature 402 6760 Suppl (1999) B24-B30
6. Bradding P., and Holgate S.T. Immunopathology and human mast cell cytokines. Crit Rev Oncol Hematol 31 2 (1999) 119-133
7. Baraniuk J.N. Pathogenesis of allergic rhinitis. J Allergy Clin Immunol 99 2 (1997) S763-S772
8. Elias J.A. Airway remodeling in asthma. Unanswered questions. Am J Respir Crit Care Med 161 3 Pt 2 (2000) S168-S171
9. Elias J.A., Zhu Z., Chupp G., and Homer R.J. Airway remodeling in asthma. J Clin Invest 104 8 (1999.) 1001-1006
10. Bochner B.S., and Busse W.W. Advances in mechanisms of allergy. J Allergy Clin Immunol 113 5 (2004) 868
11. Kay A.B. Immunomodulation in asthma: mechanisms and possible pitfalls. Curr Opin Pharmacol 3 3 (2003) 220
12. Shahid S.K., Kharitonov S.A., Wilson N.M., Bush A., and Barnes P.J. Increased interleukin-4 and decreased interferon-gamma in exhaled breath condensate of children with asthma. Am J Respir Crit Care Med 165 9 (2002) 1290-1293
13. Leung T.-F., Wong G.W.K., Ko F.W.S., Li C.-Y., Yung E., Lam C.W.K., et al. Analysis of growth factors and inflammatory cytokines in exhaled breath condensate from asthmatic children. Int Arch Allergy Immunol 137 1 (2005) 66
14. Matsunaga K., Yanagisawa S., Ichikawa T., Ueshima K., Akamatsu K., Hirano T., et al. Airway cytokine expression measured by means of protein array in exhaled breath condensate: correlation with physiologic properties in asthmatic patients. J Allergy Clin Immunol 118 1 (2006) 84
15. Quaedvlieg V., Henket M., Sele J., and Louis R. Cytokine production from sputum cells in eosinophilic versus non-eosinophilic asthmatics. Clin Exp Immunol 143 1 (2006) 161-166
16. Kim C.K., Kim S.W., Park C.S., Kim B.I., Kang H., and Koh Y.Y. Bronchoalveolar lavage cytokine profiles in acute asthma and acute bronchiolitis. J Allergy Clin Immunol 112 1 (2003) 64
17. Shimbara A., Christodoulopoulos P., Soussi-Gounni A., Olivenstein R., Nakamura Y., Levitt R.C., et al. IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma. J Allergy Clin Immunol 105 1 Part 1 (2000) 108
18. Venkatesha R.T., Berla Thangam E., Zaidi A.K., and Ali H. Distinct regulation of C3a-induced MCP-1/CCL2 and RANTES/CCL5 production in human mast cells by extracellular signal regulated kinase and PI3 kinase. Mol Immunol 42 5 (2005) 581-587
19. Hart P.H. Regulation of the inflammatory response in asthma by mast cell products. Immunol Cell Biol 79 2 (2001) 149-153
20. Holsapple M.P., Jones D., Kawabata T.T., Kimber I., Sarlo K., Selgrade M.K., et al. Assessing the potential to induce respiratory hypersensitivity. Toxicol Sci 91 1 (2006) 4-13
21. Galli S.J., Metcalfe D.D., and Dvorak A.M. Basophils and mast cells and their disorders. In: Beutler E., Lichtman M.A., Coller B.S., Kipps T.J., and Seligssohn U. (Eds). Williams Haematology vol. 15 (2001), McGraw-Hill, New York 801-815
22. Johnson S.R., and Knox A.J. Synthetic functions of airway smooth muscle in asthma. Trends Pharmacol Sci 18 8 (1997) 288-292
23. Barnes P.J. The role of inflammation and anti-inflammatory medication in asthma. Respir Med 96 Suppl A (2002) S9-S15
24. Bousquet J., Jeffery P.K., Busse W.W., Johnson M., and Vignola A.M. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 161 5 (2000) 1720-1745
25. Pearlman D.S. Pathophysiology of the inflammatory response. J Allergy Clin Immunol 104 4 Pt 1 (1999) S132-S137
26. Nakae S., Ho L.H., Yu M., Monteforte R., Iikura M., Suto H., et al. Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and T(H)2 cytokine production in an asthma model in mice. J Allergy Clin Immunol 120 1 (2007) 48-55
27. Bradding P., Walls A.F., and Holgate S.T. The role of the mast cell in the pathophysiology of asthma. J Allergy Clin Immunol 117 6 (2006) 1277
28. Prussin C., and Metcalfe D.D. 5. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol 117 2 Suppl Mini-Primer (2006) S450-S456
29. Teran L.M. CCL chemokines and asthma. Immunol Today 21 5 (2000) 235-242
30. Holgate S.T., Bodey K.S., Janezic A., Frew A.J., Kaplan A.P., and Teran L.M. Release of RANTES, MIP-1alpha, and MCP-1 into asthmatic airways following endobronchial allergen challenge. Am J Respir Crit Care Med 156 5 (1997) 1377-1383
31. Cruikshank W.W., Long A., Tarpy R.E., Kornfeld H., Carroll M.P., Teran L., et al. Early identification of interleukin-16 (lymphocyte chemoattractant factor) and macrophage inflammatory protein 1 alpha (MIP1 alpha) in bronchoalveolar lavage fluid of antigen-challenged asthmatics. Am J Respir Cell Mol Biol 13 6 (1995) 738-747
32. Alam R. Chemokines in allergic inflammation. J Allergy Clin Immunol 99 3 (1997) 273-277
33. Forssmann U., Uguccioni M., Loetscher P., Dahinden C.A., Langen H., Thelen M., et al. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. J Exp Med 185 12 (1997) 2171-2176
34. Dahinden C.A., Kurimoto Y., De Weck A.L., Lindley I., Dewald B., and Baggiolini M. The neutrophil-activating peptide NAF/NAP-1 induces histamine and leukotriene release by interleukin 3-primed basophils. J Exp Med 170 5 (1989) 1787-1792
35. Barnes P.J., Chung K.F., and Page C.P. Inflammatory mediators of asthma: an update. Pharmacol Rev 50 4 (1998) 515-596
36. Bischoff S.C., Baggiolini M., de Weck A.L., and Dahinden C.A. Interleukin 8-inhibitor and inducer of histamine and leukotriene release in human basophils. Biochem Biophys Res Commun 179 1 (1991) 628
37. Schroeder J.T., MacGlashan Jr. D.W., and Lichtenstein L.M. Human basophils: mediator release and cytokine production. Adv Immunol 77 (2001) 93-122
38. Marone G., Triggiani M., and de Paulis A. Mast cells and basophils: friends as well as foes in bronchial asthma?. Trends Immunol 26 1 (2005) 25-31
39. Devouassoux G., Foster B., Scott L.M., Metcalfe D.D., and Prussin C. Frequency and characterization of antigen-specific IL-4- and IL-13-producing basophils and T cells in peripheral blood of healthy and asthmatic subjects. J Allergy Clin Immunol 104 4 Pt 1 (1999) 811-819
40. Bochner B.S., and Schleimer R.P. Mast cells, basophils, and eosinophils: distinct but overlapping pathways for recruitment. Immunol Rev 179 (2001) 5-15
41. Nickel R., Beck L.A., Stellato C., and Schleimer R.P. Chemokines and allergic disease. J Allergy Clin Immunol 104 4 Pt 1 (1999) 723-742
42. Zimmermann N., Hershey G.K., Foster P.S., and Rothenberg M.E. Chemokines in asthma: cooperative interaction between chemokines and IL-13. J Allergy Clin Immunol 111 2 (2003) 227
43. Lukacs N.W. Role of chemokines in the pathogenesis of asthma. Nat Rev Immunol 1 2 (2001) 108-116
44. Humbert M., Ying S., Corrigan C., Menz G., Barkans J., Pfister R., et al. Bronchial mucosal expression of the genes encoding chemokines RANTES and MCP-3 in symptomatic atopic and nonatopic asthmatics: relationship to the eosinophil-active cytokines interleukin (IL)-5, granulocyte macrophage-colony-stimulating factor, and IL-3. Am J Respir Cell Mol Biol 16 1 (1997) 1-8
45. Kay A.B., and Klion A.D. Anti-interleukin-5 therapy for asthma and hypereosinophilic syndrome. Immunol Allergy Clin North Am 24 4 (2004) 645-666 vii
46. Zimmerman B., Silverman F.S., Tarlo S.M., Chapman K.R., Kubay J.M., and Urch B. Induced sputum: comparison of postinfectious cough with allergic asthma in children. J Allergy Clin Immunol 105 3 (2000) 495
47. Koh G.C.H., Shek L.P.C., Goh D.Y.T., Van Bever H., and Koh D.S.Q. Eosinophil cationic protein: is it useful in asthma? A systematic review. Respir Med 101 4 (2007) 696-705
48. Hamid Q.A., and Minshall E.M. Molecular pathology of allergic disease I: lower airway disease. J Allergy Clin Immunol 105 1 Part 1 (2000) 20
49. Lee J.J., Dimina D., Macias M.P., Ochkur S.I., McGarry M.P., O'Neill K.R., et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science 305 5691 (2004) 1773-1776
50. Humbles A.A., Lloyd C.M., McMillan S.J., Friend D.S., Xanthou G., McKenna E.E., et al. A critical role for eosinophils in allergic airways remodeling. Science 305 5691 (2004) 1776-1779
51. Maddox L., and Schwartz D.A. The pathophysiology of asthma. Annu Rev Med 53 (2002) 477-498
52. Woodruff P.G., Khashayar R., Lazarus S.C., Janson S., Avila P., Boushey H.A., et al. Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. J Allergy Clin Immunol 108 5 (2001) 753-758
53. Gibson P.G., Simpson J.L., and Saltos N. Heterogeneity of airway inflammation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8. Chest 119 5 (2001) 1329-1336
54. Sampson A.P. The role of eosinophils and neutrophils in inflammation. Clin Exp Allergy 30 Suppl 1 (2000) 22-27
55. Shute J.K., Vrugt B., Lindley I.J., Holgate S.T., Bron A., Aalbers R., et al. Free and complexed interleukin-8 in blood and bronchial mucosa in asthma. Am J Respir Crit Care Med 155 6 (1997) 1877-1883
56. Smit J.J., and lukacs N.W. A closer look at chemokines and their role in asthmatic responses. Eur J Pharmacol 533 (2006) 277-288
57. Luster A.D. The role of chemokines in linking innate and adaptive immunity. Curr Opin Immunol 14 1 (2002) 129
58. Rot A., and von Andrian U.H. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 22 (2004) 891-928
59. Kroczek R., and Hamelmann E. T-cell costimulatory molecules: optimal targets for the treatment of allergic airway disease with monoclonal antibodies. J Allergy Clin Immunol 116 4 (2005) 906-909
60. Robinson D.S., Larche M., and Durham S.R. Tregs and allergic disease. J Clin Invest 114 10 (2004) 1389-1397
61. Chanez P., Bousquet J., Couret I., Cornillac L., Barneon G., Vic P., et al. Increased numbers of hypodense alveolar macrophages in patients with bronchial asthma. Am Rev Respir Dis 144 4 (1991) 923-930
62. Rosenwasser L.J. New immunopharmacologic approaches to asthma: role of cytokine antagonism. J Allergy Clin Immunol 105 2 Pt 2 (2000) S586-S592
63. Gosset P., Tillie-Leblond I., Oudin S., Parmentier O., Wallaert B., Joseph M., et al. Production of chemokines and proinflammatory and antiinflammatory cytokines by human alveolar macrophages activated by IgE receptors. J Allergy Clin Immunol 103 2 Pt 1 (1999) 289-297
64. Vissers J.L.M., van Esch B.C.A.M., Hofman G.A., and van Oosterhout A.J.M. Macrophages induce an allergen-specific and long-term suppression in a mouse asthma model. Eur Respir J 26 6 (2005) 1040-1046
65. Diehl S., and Rincon M. The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol 39 9 (2002) 531
66. Thepen T., Van Rooijen N., and Kraal G. Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice. J Exp Med 170 2 (1989) 499-509
67. Lipscomb M.F., and Masten B.J.P.R. Dendritic cells: immune regulators in health and disease. J Physiol Rev 82 1 (2002) 97-130
68. Penna G., Vulcano M., Sozzani S., and Adorini L. Differential migration behavior and chemokine production by myeloid and plasmacytoid dendritic cells. Hum Immunol 63 12 (2002) 1164-1171
69. Hammad H., Smits H.H., Ratajczak C., Nithiananthan A., Wierenga E.A., Stewart G.A., et al. Monocyte-derived dendritic cells exposed to Der p 1 allergen enhance the recruitment of Th2 cells: major involvement of the chemokines TARC/CCL17 and MDC/CCL22. Eur Cytokine Netw 14 4 (2003) 219-228
70. Tunon-De-Lara J.M., Redington A.E., Bradding P., Church M.K., Hartley J.A., Semper A.E., et al. Dendritic cells in normal and asthmatic airways: expression of the alpha subunit of the high affinity immunoglobulin E receptor (Fc epsilon RI-alpha). Clin Exp Allergy 26 6 (1996) 648-655
71. Pober J.S., Lapierre L.A., Stolpen A.H., Brock T.A., Springer T.A., Fiers W., et al. Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species. J Immunol 138 10 (1987) 3319-3324
72. Godding V., Stark J.M., Sedgwick J.B., and Busse W.W. Adhesion of activated eosinophils to respiratory epithelial cells is enhanced by tumor necrosis factor-alpha and interleukin-1 beta. Am J Respir Cell Mol Biol 13 5 (1995) 555-562
73. Pober J.S., Gimbrone Jr. M.A., Lapierre L.A., Mendrick D.L., Fiers W., Rothlein R., et al. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J Immunol 137 6 (1986.) 1893-1896
74. Moser R., Fehr J., and Bruijnzeel P.L. IL-4 controls the selective endothelium-driven transmigration of eosinophils from allergic individuals. J Immunol 149 4 (1992) 1432-1438
75. Bochner B.S., Klunk D.A., Sterbinsky S.A., Coffman R.L., and Schleimer R.P. IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells. J Immunol 154 2 (1995) 799-803
76. Manolitsas N.D., Trigg C.J., McAulay A.E., Wang J.H., Jordan S.E., D'Ardenne A.J., et al. The expression of intercellular adhesion molecule-1 and the beta 1-integrins in asthma. Eur Respir J 7 8 (1994) 1439-1444
77. Lee B.J., Naclerio R.M., Bochner B.S., Taylor R.M., Lim M.C., and Baroody F.M. Nasal challenge with allergen upregulates the local expression of vascular endothelial adhesion molecules. J Allergy Clin Immunol 94 6 Pt 1 (1994) 1006-1016
78. Montefort S., Feather I.H., Wilson S.J., Haskard D.O., Lee T.H., Holgate S.T., et al. The expression of leukocyte-endothelial adhesion molecules is increased in perennial allergic rhinitis. Am J Respir Cell Mol Biol 7 4 (1992) 393-398
79. Ghaffar O., Hamid Q., Renzi P.M., Allakhverdi Z., Molet S., Hogg J.C., et al. Constitutive and cytokine-stimulated expression of eotaxin by human airway smooth muscle cells. Am J Respir Crit Care Med 159 6 (1999) 1933-1942
80. Chung K.F., Patel H.J., Fadlon E.J., Rousell J., Haddad E.B., Jose P.J., et al. Induction of eotaxin expression and release from human airway smooth muscle cells by IL-1beta and TNFalpha: effects of IL-10 and corticosteroids. Br J Pharmacol 127 5 (1999) 1145-1150
81. Zuyderduyn S., Hiemstra P.S., and Rabe K.F. TGF-beta differentially regulates TH2 cytokine-induced eotaxin and eotaxin-3 release by human airway smooth muscle cells. J Allergy Clin Immunol 114 4 (2004) 791-798
82. Moore P.E., Church T.L., Chism D.D., Panettieri Jr. R.A., and Shore S.A. IL-13 and IL-4 cause eotaxin release in human airway smooth muscle cells: a role for ERK. Am J Physiol Lung Cell Mol Physiol 282 4 (2002) L847-L853
83. Pang L., and Knox A.J. Regulation of TNF-alpha-induced eotaxin release from cultured human airway smooth muscle cells by beta2-agonists and corticosteroids. FASEB J 15 1 (2001) 261-269
84. Lazzeri N., Belvisi M.G., Patel H.J., Chung K.F., Yacoub M.H., and Mitchell J.A. RANTES release by human airway smooth muscle: effects of prostaglandin E(2) and fenoterol. Eur J Pharmacol 433 2/3 (2001) 231-235
85. Watson M.L., Grix S.P., Jordan N.J., Place G.A., Dodd S., Leithead J., et al. Interleukin 8 and monocyte chemoattractant protein 1 production by cultured human airway smooth muscle cells. Cytokine 10 5 (1998) 346-352
86. John M., Au B.T., Jose P.J., Lim S., Saunders M., Barnes P.J., et al. Expression and release of interleukin-8 by human airway smooth muscle cells: inhibition by Th-2 cytokines and corticosteroids. Am J Respir Cell Mol Biol 18 1 (1998) 84-90
87. Ammit A.J., Hoffman R.K., Amrani Y., Lazaar A.L., Hay D.W., Torphy T.J., et al. Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth-muscle cells. Modulation by cyclic adenosine monophosphate. Am J Respir Cell Mol Biol 23 6 (2000) 794-802
88. Oltmanns U., Issa R., Sukkar M.B., John M., and Chung K.F. Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells. Br J Pharmacol 139 6 (2003) 1228-1234
89. Maruoka S., Hashimoto S., Gon Y., Takeshita I., and Horie T. PAF-induced RANTES production by human airway smooth muscle cells requires both p38 MAP kinase and Erk. Am J Respir Crit Care Med 161 3 Pt 1 (2000) 922-929
90. Black J.L., and Johnson P.R. Factors controlling smooth muscle proliferation and airway remodelling. Curr Opin Allergy Clin Immunol 2 1 (2002) 47-51
91. Saunders M.A., Mitchell J.A., Seldon P.M., Yacoub M.H., Barnes P.J., Giembycz M.A., et al. Release of granulocyte-macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone. Br J Pharmacol 120 4 (1997) 545-546
92. Song R., Ning W., Liu F., Ameredes B.T., Calhoun W.J., Otterbein L.E., et al. Regulation of IL-1beta-induced GM-CSF production in human airway smooth muscle cells by carbon monoxide. Am J Physiol Lung Cell Mol Physiol 284 1 (2003) L50-L56
93. Pang L., and Knox A.J. Bradykinin stimulates IL-8 production in cultured human airway smooth muscle cells: role of cyclooxygenase products. J Immunol 161 5 (1998) 2509-2515
94. Huang C.D., Tliba O., Panettieri Jr. R.A., and Amrani Y. Bradykinin induces interleukin-6 production in human airway smooth muscle cells: modulation by Th2 cytokines and dexamethasone. Am J Respir Cell Mol Biol 28 3 (2003) 330-338
95. Elias J.A., Wu Y., Zheng T., and Panettieri R. Cytokine- and virus-stimulated airway smooth muscle cells produce IL-11 and other IL-6-type cytokines. Am J Physiol 273 3 Pt 1 (1997) L648-L655
96. Ammit A.J., Lazaar A.L., Irani C., O'Neill G.M., Gordon N.D., Amrani Y., et al. Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists. Am J Respir Cell Mol Biol 26 4 (2002) 465-474
97. Amrani Y., Ammit A.J., and Panettieri Jr. R.A. Tumor necrosis factor receptor (TNFR)1, but not TNFR2, mediates tumor necrosis factor-alpha-induced interleukin-6 and RANTES in human airway smooth muscle cells: role of p38 and p42/44 mitogen-activated protein kinases. Mol Pharmacol 60 4 (2001) 646-655
98. McKay S., Bromhaar M.M., de Jongste J.C., Hoogsteden H.C., Saxena P.R., and Sharma H.S. Pro-inflammatory cytokines induce c-fos expression followed by IL-6 release in human airway smooth muscle cells. Mediators Inflamm 10 3 (2001) 135-142
99. Johnson C., and Galis Z.S. Matrix metalloproteinase-2 and -9 differentially regulate smooth muscle cell migration and cell-mediated collagen organization. Arterioscler Thromb Vasc Biol 24 1 (2004) 54-60
100. Hawker K.M., Johnson P.R.A., Hughes J.M., and Black J.L. Interleukin-4 inhibits mitogen-induced proliferation of human airway smooth muscle cells in culture. Am J Physiol Lung Cell Mol Physiol 275 3 (1998) L469-L477
101. Wills-Karp M. IL-12/IL-13 axis in allergic asthma. J Allergy Clin Immunol 107 1 (2001) 9-18
102. Grunstein M.M., Hakonarson H., Leiter J., Chen M., Whelan R., Grunstein J.S., et al. IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 282 3 (2002) L520-L528
103. Tliba O., Deshpande D., Chen H., Van Besien C., Kannan M., Panettieri Jr. R.A., et al. IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle. Br J Pharmacol 140 7 (2003) 1159-1162
104. Howarth P.H., Knox A.J., Amrani Y., Tliba O., Panettieri Jr. R.A., and Johnson M. Synthetic responses in airway smooth muscle. J Allergy Clin Immunol 114 2 Suppl (2004) S32-S50
105. Panina-Bordignon P., Papi A., Mariani M., Di Lucia P., Casoni G., Bellettato C., et al. The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest 107 11 (2001) 1357-1364
106. Sekiya T., Miyamasu M., Imanishi M., Yamada H., Nakajima T., Yamaguchi M., et al. Inducible expression of a Th2-type CC chemokine thymus- and activation-regulated chemokine by human bronchial epithelial cells. J Immunol 165 4 (2000) 2205-2213
107. Ying S., Robinson D.S., Meng Q., Rottman J., Kennedy R., Ringler D.J., et al. Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Eur J Immunol 27 12 (1997) 3507-3516
108. Marini M., Vittori E., Hollemborg J., and Mattoli S. Expression of the potent inflammatory cytokines, granulocyte-macrophage-colony-stimulating factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma. J Allergy Clin Immunol 89 5 (1992) 1001-1009
109. Prause O., Laan M., Lotvall J., and Linden A. Pharmacological modulation of interleukin-17-induced GCP-2-, GRO-alpha- and interleukin-8 release in human bronchial epithelial cells. Eur J Pharmacol 462 1-3 (2003) 193-198
110. Jenkins H.A., Cool C., Szefler S.J., Covar R., Brugman S., Gelfand E.W., et al. Histopathology of severe childhood asthma: a case series. Chest 124 1 (2003) 32-41
111. Bergeron C., and Boulet L.P. Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation. Chest 129 4 (2006) 1068-1087
112. Nagase H., and Woessner Jr. J.F. Matrix metalloproteinases. J Biol Chem 274 31 (1999) 21491-21494
113. Vignola A.M., Riccobono L., Mirabella A., Profita M., Chanez P., Bellia V., et al. Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am J Respir Crit Care Med 158 6 (1998) 1945-1950
114. Lemjabbar H., Gosset P., Lamblin C., Tillie I., Hartmann D., Wallaert B., et al. Contribution of 92 kDa gelatinase/type IV collagenase in bronchial inflammation during status asthmaticus. Am J Respir Crit Care Med 159 4 Pt 1 (1999) 1298-1307
115. Prikk K., Maisi P., Pirila E., Reintam M.A., Salo T., Sorsa T., et al. Airway obstruction correlates with collagenase-2 (MMP-8) expression and activation in bronchial asthma. Lab Invest 82 11 (2002) 1535-1545
116. Wenzel S.E., Balzar S., Cundall M., and Chu H.W. Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair. J Allergy Clin Immunol 111 6 (2003) 1345-1352
117. Johnson S., and Knox A. Autocrine production of matrix metalloproteinase-2 is required for human airway smooth muscle proliferation. Am J Physiol 277 6 Pt 1 (1999) L1109-L1117
118. Tanaka H., Miyazaki N., Oashi K., Tanaka S., Ohmichi M., and Abe S. Sputum matrix metalloproteinase-9: tissue inhibitor of metalloproteinase-1 ratio in acute asthma. J Allergy Clin Immunol 105 5 (2000) 900-905
119. Kelly E.A., Busse W.W., and Jarjour N.N. Increased matrix metalloproteinase-9 in the airway after allergen challenge. Am J Respir Crit Care Med 162 3 Pt 1 (2000) 1157-1161
120. Lee Y.C., Lee H.B., Rhee Y.K., and Song C.H. The involvement of matrix metalloproteinase-9 in airway inflammation of patients with acute asthma. Clin Exp Allergy 31 10 (2001) 1623-1630
121. Cataldo D.D., Bettiol J., Noel A., Bartsch P., Foidart J.M., and Louis R. Matrix metalloproteinase-9, but not tissue inhibitor of matrix metalloproteinase-1, increases in the sputum from allergic asthmatic patients after allergen challenge. Chest 122 5 (2002) 1553-1559
122. Bergeron C., Page N., Joubert P., Barbeau B., Hamid Q., and Chakir J. Regulation of procollagen I (alpha1) by interleukin-4 in human bronchial fibroblasts: a possible role in airway remodelling in asthma. Clin Exp Allergy 33 10 (2003) 1389-1397
123. Mautino G., Henriquet C., Jaffuel D., Bousquet J., and Capony F. Tissue inhibitor of metalloproteinase-1 levels in bronchoalveolar lavage fluid from asthmatic subjects. Am J Respir Crit Care Med 160 1 (1999) 324-330
124. Lacraz S., Nicod L.P., Chicheportiche R., Welgus H.G., and Dayer J.M. IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes. J Clin Invest 96 5 (1995) 2304-2310
125. Stearns M.E., Rhim J., and Wang M. Interleukin 10 (IL-10) inhibition of primary human prostate cell-induced angiogenesis: IL-10 stimulation of tissue inhibitor of metalloproteinase-1 and inhibition of matrix metalloproteinase (MMP)-2/MMP-9 secretion. Clin Cancer Res 5 1 (1999) 189-196
126. Djukanovic R. Asthma: a disease of inflammation and repair. J Allergy Clin Immunol 105 2 Pt 2 (2000) S522-S526
127. Ignotz R.A., and Massague J. Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem 261 9 (1986) 4337-4345
128. Fine A., and Goldstein R.H. The effect of transforming growth factor-beta on cell proliferation and collagen formation by lung fibroblasts. J Biol Chem 262 8 (1987) 3897-3902
129. Vignola A.M., Chanez P., Chiappara G., Merendino A., Pace E., Rizzo A., et al. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 156 2 Pt 1 (1997) 591-599
130. Panettieri R.A., Tan E.M., Ciocca V., Luttmann M.A., Leonard T.B., and Hay D.W. Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction in vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists. Am J Respir Cell Mol Biol 19 3 (1998) 453-461
131. Minshall E.M., Leung D.Y., Martin R.J., Song Y.L., Cameron L., Ernst P., et al. Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 17 3 (1997) 326-333
132. Doucet C., Brouty-Boye D., Pottin-Clemenceau C., Canonica G.W., Jasmin C., and Azzarone B. Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma. J Clin Invest 101 10 (1998) 2129-2139
133. Doucet C., Brouty-Boye D., Pottin-Clemenceau C., Jasmin C., Canonica G.W., and Azzarone B. IL-4, IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts. Int Immunol 10 10 (1998) 1421-1433
134. Wen F.Q., Kohyama T., Liu X., Zhu Y.K., Wang H., Kim H.J., et al. Interleukin-4- and interleukin-13-enhanced transforming growth factor-beta2 production in cultured human bronchial epithelial cells is attenuated by interferon-gamma. Am J Respir Cell Mol Biol 26 4 (2002) 484-490
135. Espinosa K., Bosse Y., Stankova J., and Rola-Pleszczynski M. CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. J Allergy Clin Immunol 111 5 (2003) 1032-1040
136. Fahy J.V. Remodeling of the airway epithelium in asthma. Am J Respir Crit Care Med 164 10 Pt 2 (2001) S46-S51
137. Longphre M., Li D., Gallup M., Drori E., Ordonez C.L., Redman T., et al. Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells. J Clin Invest 104 10 (1999) 1375-1382
138. Minshall E., Chakir J., Laviolette M., Molet S., Zhu Z., Olivenstein R., et al. IL-11 expression is increased in severe asthma: association with epithelial cells and eosinophils. J Allergy Clin Immunol 105 2 Pt 1 (2000) 232-238
139. Molet S., Hamid Q., Davoine F., Nutku E., Taha R., Page N., et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol 108 3 (2001) 430
140. Hurst S.D., Muchamuel T., Gorman D.M., Gilbert J.M., Clifford T., Kwan S., et al. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J Immunol 169 1 (2002) 443-453
141. Kazi A.S., Lotfi S., Goncharova E.A., Tliba O., Amrani Y., Krymskaya V.P., et al. Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent. Am J Physiol Lung Cell Mol Physiol 286 3 (2004) L539-L545
142. Keane M.P. Chemokine profiling in pulmonary fibrosis: ready for prime time?. Am J Respir Crit Care Med 170 5 (2004) 475-476
143. Puxeddu I., Bader R., Piliponsky A.M., Reich R., Levi-Schaffer F., and Berkman N. The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts. J Allergy Clin Immunol 117 1 (2006) 103-110
144. Rozyk K.J., Plusa T., Kuna P., and Pirozynska E. Monocyte chemotactic and activating factor/monocyte chemoattractant protein in bronchoalveolar lavage fluid from patients with atopic asthma and chronic bronchitis. Relationship to lung function tests, bronchial hyper-responsiveness and cytology of bronchoalveolar lavage fluid. Immunol Lett 58 1 (1997) 47-52
145. Gharaee-Kermani M., Denholm E.M., and Phan S.H. Costimulation of fibroblast collagen and transforming growth factor beta1 gene expression by monocyte chemoattractant protein-1 via specific receptors. J Biol Chem 271 30 (1996) 17779-17784
146. Yamamoto T., Eckes B., Mauch C., Hartmann K., and Krieg T. Monocyte chemoattractant protein-1 enhances gene expression and synthesis of matrix metalloproteinase-1 in human fibroblasts by an autocrine IL-1 alpha loop. J Immunol 164 12 (2000) 6174-6179
147. Carr M.W., Roth S.J., Luther E., Rose S.S., and Springer T.A. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci USA 91 9 (1994) 3652-3656
148. Choi E.S., Jakubzick C., Carpenter K.J., Kunkel S.L., Evanoff H., Martinez F.J., et al. Enhanced monocyte chemoattractant protein-3/CC chemokine ligand-7 in usual interstitial pneumonia. Am J Respir Crit Care Med 170 5 (2004) 508-515
149. Belperio J.A., Dy M., Murray L., Burdick M.D., Xue Y.Y., Strieter R.M., et al. The role of the Th2 CC chemokine ligand CCL17 in pulmonary fibrosis. J Immunol 173 7 (2004) 4692-4698
150. Glassberg M.K., Ergul A., Wanner A., and Puett D. Endothelin-1 promotes mitogenesis in airway smooth muscle cells. Am J Respir Cell Mol Biol 10 3 (1994) 316-321
151. Takuwa N., Takuwa Y., Yanagisawa M., Yamashita K., and Masaki T. A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts. J Biol Chem 264 14 (1989) 7856-7861
152. Springall D.R., Howarth P.H., Counihan H., Djukanovic R., Holgate S.T., and Polak J.M. Endothelin immunoreactivity of airway epithelium in asthmatic patients. Lancet 337 8743 (1991) 697-701
153. Yancopoulos G.D., Davis S., Gale N.W., Rudge J.S., Wiegand S.J., and Holash J. Vascular-specific growth factors and blood vessel formation. Nature 407 6801 (2000) 242-248
154. Hoshino M., Takahashi M., and Aoike N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol 107 2 (2001) 295-301
155. Li X., and Wilson J.W. Increased vascularity of the bronchial mucosa in mild asthma. Am J Respir Crit Care Med 156 1 (1997) 229-233
156. Tanaka H., Yamada G., Saikai T., Hashimoto M., Tanaka S., Suzuki K., et al. Increased airway vascularity in newly diagnosed asthma using a high-magnification bronchovideoscope. Am J Respir Crit Care Med 168 12 (2003) 1495-1499
157. Chetta A., Zanini A., Foresi A., D'Ippolito R., Tipa A., Castagnaro A., et al. Vascular endothelial growth factor up-regulation and bronchial wall remodelling in asthma. Clin Exp Allergy 35 11 (2005) 1437-1442
158. Kostenis E., and Ulven T. Emerging roles of DP and CRTH2 in allergic inflammation. Trends Mol Med 12 4 (2006) 148-158
159. Fujitani Y., Kanaoka Y., Aritake K., Uodome N., Okazaki-Hatake K., and Urade Y. Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice. J Immunol 168 1 (2002) 443-449
160. Honda K., Arima M., Cheng G., Taki S., Hirata H., Eda F., et al. Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine. J Exp Med 198 4 (2003) 533-543
161. Monneret G., Gravel S., Diamond M., Rokach J., and Powell W.S. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood 98 6 (2001) 1942-1948
162. Hirai H., Tanaka K., Yoshie O., Ogawa K., Kenmotsu K., Takamori Y., et al. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med 193 2 (2001) 255-261
163. Shiraishi Y., Asano K., Nakajima T., Oguma T., Suzuki Y., Shiomi T., et al. Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor. J Pharmacol Exp Ther 312 3 (2005) 954-960
164. Almishri W., Cossette C., Rokach J., Martin J.G., Hamid Q., and Powell W.S. Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats. J Pharmacol Exp Ther 313 1 (2005) 64-69
165. Yoshimura-Uchiyama C., Iikura M., Yamaguchi M., Nagase H., Ishii A., Matsushima K., et al. Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells/DP2. Clin Exp Allergy 34 8 (2004) 1283-1290
166. Mesquita-Santos F.P., Vieira-de-Abreu A., Calheiros A.S., Figueiredo I.H., Castro-Faria-Neto H.C., Weller P.F., et al. Cutting edge: prostaglandin D2 enhances leukotriene C4 synthesis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin. J Immunol 176 3 (2006) 1326-1330
167. Ying S., O'Connor B.J., Meng Q., Woodman N., Greenaway S., Wong H., et al. Expression of prostaglandin E(2) receptor subtypes on cells in sputum from patients with asthma and controls: effect of allergen inhalational challenge. J Allergy Clin Immunol 114 6 (2004) 1309-1316
168. Walters E.H., and Davies B.H. Dual effect of prostaglandin E2 on normal airways smooth muscle in vivo. Thorax 37 12 (1982) 918-922
169. Pavord I.D., and Tattersfield A.E. Bronchoprotective role for endogenous prostaglandin E2. Lancet 345 8947 (1995) 436-438
170. Tilley S.L., Hartney J.M., Erikson C.J., Jania C., Nguyen M., Stock J., et al. Receptors and pathways mediating the effects of prostaglandin E2 on airway tone. Am J Physiol Lung Cell Mol Physiol 284 4 (2003) L599-L606
171. Meja K.K., Barnes P.J., and Giembycz M.A. Characterization of the prostanoid receptor(s) on human blood monocytes at which prostaglandin E2 inhibits lipopolysaccharide-induced tumour necrosis factor-alpha generation. Br J Pharmacol 122 1 (1997) 149-157
172. Barnes P.J. The mode of action of corticosteroids in asthma. Res Immunol 149 3 (1998) 225
173. Montuschi P., and Barnes P.J. Exhaled leukotrienes and prostaglandins in asthma. J Allergy Clin Immunol 109 4 (2002) 615-620
174. Antczak A., Montuschi P., Kharitonov S., Gorski P., and Barnes P.J. Increased exhaled cysteinyl-leukotrienes and 8-isoprostane in aspirin-induced asthma. Am J Respir Crit Care Med 166 3 (2002) 301-306
175. Montuschi P., Corradi M., Ciabattoni G., Nightingale J., Kharitonov S.A., and Barnes P.J. Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients. Am J Respir Crit Care Med 160 1 (1999) 216-220
176. Zanconato S., Carraro S., Corradi M., Alinovi R., Pasquale M.F., Piacentini G., et al. Leukotrienes and 8-isoprostane in exhaled breath condensate of children with stable and unstable asthma. J Allergy Clin Immunol 113 2 (2004) 257
177. Bel E.H., van der Veen H., Kramps J.A., Dijkman J.H., and Sterk P.J. Maximal airway narrowing to inhaled leukotriene D4 in normal subjects. Comparison and interaction with methacholine. Am Rev Respir Dis 136 4 (1987) 979-984
178. Arm J.P., Spur B.W., and Lee T.H. The effects of inhaled leukotriene E4 on the airway responsiveness to histamine in subjects with asthma and normal subjects. J Allergy Clin Immunol 82 4 (1988) 654-660
179. O'Hickey S.P., Hawksworth R.J., Fong C.Y., Arm J.P., Spur B.W., and Lee T.H. Leukotrienes C4, D4, and E4 enhance histamine responsiveness in asthmatic airways. Am Rev Respir Dis 144 5 (1991) 1053-1057
180. Henderson Jr. W.R., Lewis D.B., Albert R.K., Zhang Y., Lamm W.J., Chiang G.K., et al. The importance of leukotrienes in airway inflammation in a mouse model of asthma. J Exp Med 184 4 (1996) 1483-1494
181. Cap P., Chladek J., Pehal F., Maly M., Petru V., Barnes P.J., et al. Gas chromatography/mass spectrometry analysis of exhaled leukotrienes in asthmatic patients. Thorax 59 6 (2004) 465-470
182. Busse W.W. Inflammation in asthma: the cornerstone of the disease and target of therapy. J Allergy Clin Immunol 102 4 Suppl 1 (1998) S17
183. Black P.N., Fuller R.W., Taylor G.W., Barnes P.J., and Dollery C.T. Effect of inhaled leukotriene B4 alone and in combination with prostaglandin D2 on bronchial responsiveness to histamine in normal subjects. Thorax 44 6 (1989) 491-495
184. Carpagnano G.E., Barnes P.J., Francis J., Wilson N., Bush A., and Kharitonov S.A. Breath condensate pH in children with cystic fibrosis and asthma: a new noninvasive marker of airway inflammation?. Chest 125 6 (2004) 2005-2010
185. Tufvesson E., and Bjermer L. Methodological improvements for measuring eicosanoids and cytokines in exhaled breath condensate. Respir Med 100 1 (2006) 34-38
186. Beghe B., Barton S., Rorke S., Peng Q., Sayers I., Gaunt T., et al. Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population. Clin Exp Allergy 33 8 (2003) 1111-1117
187. Laprise C., Sladek R., Ponton A., Bernier M.C., Hudson T.J., and Laviolette M. Functional classes of bronchial mucosa genes that are differentially expressed in asthma. BMC Genomics 5 1 (2004) 21
188. Van Eerdewegh P., Little R.D., Dupuis J., Del Mastro R.G., Falls K., Simon J., et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 418 6896 (2002) 426-430
189. Holgate S.T., Davies D.E., Powell R.M., and Holloway J.W. ADAM33: a newly identified protease involved in airway remodelling. Pulm Pharmacol Ther 19 1 (2006) 3
190. Profita M., La Grutta S., Carpagnano E., Riccobono L., Di Giorgi R., Bonanno A., et al. Noninvasive methods for the detection of upper and lower airway inflammation in atopic children. J Allergy Clin Immunol 118 (2006) 1068-1074
191. Leung T.F., Wong G.W., Ko F.W., Lam C.W., and Fok T.F. Increased macrophage-derived chemokine in exhaled breath condensate and plasma from children with asthma. Clin Exp Allergy 34 5 (2004) 786-791
192. Ko F.W.S., Lau C.Y.K., Leung T.F., Wong G.W.K., Lam C.W.K., Lai C.K.W., et al. Exhaled breath condensate levels of eotaxin and macrophage-derived chemokine in stable adult asthma patients. Clin Exp Allergy 36 1 (2006) 44-51
193. Baraldi E., Ghiro L., Piovan V., Carraro S., Ciabattoni G., Barnes P.J., et al. Increased exhaled 8-isoprostane in childhood asthma. Chest 124 1 (2003) 25-31