The importance of leukotrienes in airway inflammation in a mouse model of asthma

Journal of Experimental Medicine

Volumn 184, Issue 4, 1996, Pages 1483-1494

  Henderson Jr , William R ^a   Lewis, David B ^b   Albert, Richard K ^a   Zhang, Yu ^b   Lamm, Wayne J E ^a   Chiang, Gertrude K S ^a   Jones, Falaah ^a   Eriksen, Pia ^a,c   Tien, Ying Tzang ^a   Jonas, Mechthild ^a   Chi, Emil Y ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; LEUKOTRIENE; LEUKOTRIENE B4; LEUKOTRIENE C4; LIPOXYGENASE INHIBITOR; METHACHOLINE; OVALBUMIN; ZILEUTON;

ALLERGIC ASTHMA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; BRONCHUS MUCUS; CELL INFILTRATION; CONTROLLED STUDY; EOSINOPHILIA; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ALLERGENS; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; ASTHMA; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTOR AGENTS; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOGLOBULIN E; INFLAMMATION; LEUKOTRIENE B4; LEUKOTRIENE C4; LIPOXYGENASE INHIBITORS; MEMBRANE PROTEINS; METHACHOLINE CHLORIDE; MICE; MICE, INBRED BALB C; MUCUS; OVALBUMIN; PULMONARY EOSINOPHILIA; RESPIRATORY FUNCTION TESTS; RESPIRATORY SYSTEM;

EID: 10244267521     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.4.1483     Document Type: Article

References (55)

1. Samuelsson, B., S.-E. Dahlén, J.Å. Lindgren, C.A. Rouzer, and C.N. Serhan. 1987. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science (Wash. DC). 237:1171-1176.
2. Henderson, W.R., Jr. 1994. The role of leukotrienes in inflammation. Ann. Intern. Med. 121:684-697.
3. 4 in inflammation. Crit. Rev. Immunol. 10:1-12.
4. Drazen, J.M., K.F. Austen, R.A. Lewis, D.A. Clark, G. Goto, A. Marfat, and E.J. Corey. 1980. Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. Proc. Natl. Acad. Sci. USA. 77:4354-4358.
5. 4. Proc. Natl. Acad. Sci. USA 80:1712-1716.
6. 4 and granulocytic infiltration into asthmatic airways. Lancet. 341:989-990.
7. 4 effects on human eosinophil and neutrophil motility in vitro. J. Leukoc. Biol. 55:183-191.
8. 4 do not increase the pulmonary vascular filtration coefficient of excised guinea pig lungs. J. Appl. Physiol. 62:1-9.
9. 4 on segmental pulmonary vascular pressures. J. Appl. Physiol. 66:458-464.
10. Casale, T.B., D. Wood, H.B. Richerson, S. Trapp, W.J. Metzger, D. Zavala, and G.W. Hunninghake. 1987. Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with methacholine bronchial hyperresponsiveness. J. Clin. Invest. 79:1197-1203.
11. 4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge. Am. Rev. Respir. Dis. 142: 112-119.
12. Wenzel, S.E., J.Y. Westcott, and G.L. Larsen. 1991. Bronchoalveolar lavage fluid mediator levels 5 minutes after allergen challenge in atopic subjects with asthma: relationship to the development of late asthmatic responses. J. Allergy Clin. Immunol. 87:540-548.
13. Bousquet, J., P. Chanez, J.Y. Lacoste, G. Barnéon, N. Ghavanian, I. Enander, P. Venge, S. Ahlstedt, J. Simony-Lafontaine, P. Godard, and F.-B. Michel. 1990. Eosinophilic inflammation in asthma. N. Engl. J. Med. 323:1033-1039.
14. Beasley, R., W.R. Roche, J.A. Roberts, and S.T. Holgate. 1989. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am. Rev. Respir. Dis. 139:806-817.
15. + T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am. Rev. Respir. Dis. 146:374-377.
16. Renz, H., H.R. Smith, J.E. Henson, B.S. Ray, C.G. Irvin, and E.W. Gelfand. 1992. Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse. J. Allergy Clin. Immunol. 89:1127-1138.
17. Gavett, S.H., D.J. O'Hearn, X. Li, S.-K. Huang, F.D. Finkelman, and M. Wills-Karp. 1995. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J. Exp. Med. 182: 1527-1536.
18. Carter, G.W., P.R. Young, D.H. Albert, J. Bouska, R. Dyer, R.L. Bell, J.B. Summers, and D.W. Brooks. 1991. 5-Lipoxygenase inhibitory activity of zileuton. J. Pharmacol. Exp. Ther. 256:929-937.
19. Dixon, R.A.F., R.E. Diehl, E. Opas, E. Rands, P.J. Vickers, J.F. Evans, J.W. Gillard, and D.K. Miller. 1990. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature (Lond.). 343:282-284.
20. Gillard, J., A.W. Ford-Hutchinson, C. Chan, S. Charleson, D. Denis, A. Foster, R. Fortin, S. Leger, C. S. McFarlane, H. Morton et al. 1989. L-663,536 (MK-886)(3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2- dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can. J. Physiol. Pharmacol. 67:456-464.
21. Amdur, M.O., and J. Mead. 1958. Mechanics of respiration in unanesthetized guinea pigs. Am. J. Physiol. 192:364-368.
22. Martin, T.R., N.P. Gerard, S.J. Galli, and J.M. Drazen. 1988. Pulmonary responses to bronchoconstrictor agonists in the mouse. J. Appl. Physiol. 64:2318-2323.
23. Levitt, R.C., and W. Mitzner. 1988. Expression of airway hyperreactivity to acetylcholine as a simple autosomal recessive trait in mice. FASEB J. 2:2605-2608.
24. Basten, A., M.H. Boyer, and P.B. Beeson. 1970. Mechanism of eosinophilia. I. Factors affecting the eosinophil response of rats to Trichinella spiralis. J. Exp. Med. 131:1271-1287.
25. Henderson, W.R., Jr., and E.Y. Chi. 1992. Degranulation of cystic fibrosis nasal polyp mast cells. J. Pathol. 166:395-404.
26. Su, M., E.Y. Chi, M.J. Bishop, and W.R. Henderson, Jr. 1993. Lung mast cells increase in number and degranulate during pulmonary artery occlusion/reperfusion injury in dogs. Am. Rev. Respir. Dis. 147:448-456.
27. Troyer, H. 1980. Carbohydrates. In Principles and Techniques of Histochemistry. Little, Brown, and Company, Boston, MA. 89-121.
28. Sheehan, D.C., and B.B. Hrapchak. 1980. Carbohydrates. In Theory and Practice of Histotechnology. Battelle Press, Columbus, OH. 159-179.
29. Thornton, D.J., D.F. Holmes, J.K. Sheehan, and I. Carlstedt. 1989. Quantitation of mucus glycoproteins blotted onto nitrocellulose membranes. Anal. Biochem. 182:160-164.
30. Fung, D.C.K., M. Somerville, P.S. Richardson, and J.K. Sheehan. 1995. Mucus glycoconjugate complexes released from feline trachea by a bacterial toxin. Am. J. Respir. Cell Mol. Biol. 12:296-306.
31. Logun, C., J. Mullol, D. Rieves, A. Hoffman, C. Johnson, R. Miller, J. Goff, M. Kaliner, and J.H. Shelhamer. 1991. Use of a monoclonal antibody enzyme-linked immunosorbent assay to measure human respiratory glycoprotein production in vitro. Am. J. Respir. Cell Mol. Biol. 5:71-79.
32. Mancino, D., and Z. Ovary. 1980. Adjuvant effects of amorphous silica and of aluminum hydroxide on IgE and IgG1 antibody production in different inbred mouse strains. Int. Arch. Allergy Appl. Immunol. 61:253-258.
33. Yong, E.C., E.Y. Chi, and W.R. Henderson, Jr. 1994. Toxoplasma gondii alters eicosanoid release by human mononuclear phagocytes: role of leukotrienes in interferon γ-induced antitoxoplasma activity. J. Exp. Med. 180:1637-1648.
34. Rokach, J., E.C. Hayes, Y. Girard, D.L. Lombardo, A.L. Maycock, A.S. Rosenthal, R.N. Young, R.F. Zawboni, and H.J. Zweerink. 1984. The development of sensitive and specific radioimmunoassays for leukotrienes. Prostaglandins Leukot. Med. 13:21-25.
35. Wenzel, S.E., J.B. Trudeau, D.A. Kaminsky, J. Cohn, R.J. Martin, and J.Y. Westcott. 1995. Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma. Am. J. Respir. Crit. Care Med. 152:897-905.
36. 4 in humans. Effect of indomethacin. Am. Rev. Respir. Dis. 141: 1441-1445.
37. Larivée, P., S.J. Levine, R.D. Rieves, and J.H. Shelhamer. 1994. Airway inflammation and mucous hypersecretion. In Airway Secretion. Physiological Bases for the Control of Mucous Hypersecretion. T. Takishima and S. Shimura, editors. Marcel Dekker, Inc., New York, NY. 469-511.
38. 4 on mucin release into the cat trachea in vivo and in vitro. Br. J. Pharmacol. 77:391-393.
39. 4: comparison of potency in canine trachea in vivo. Prostaglandins. 25:237-243.
40. 4) induces mucus secretion from goblet cells in the guinea pig respiratory epithelium. Exp. Lung Res. 16:711-725.
41. 4, increase the release of mucus from human airways in vitro. Am. Rev. Respir. Dis. 126:449-451.
42. 4 on glycoproteins and lysosyme secretion by human bronchial mucosa. Prostaglandins. 25:155-170.
43. Shelhamer, J.H., Z. Marom, and M. Kaliner. 1980. Immunologic and neuropharmacologic stimulation of mucus glycoproteins from human airways. J. Clin. Invest. 66:1400-1408.
44. Lundgren, J.M., and J.H. Shelhamer. 1990. Pathogenesis of airway mucus hypersecretion. J. Allergy Clin. Immunol. 85: 399-419.
45. 4, zymosan activated serum, histamine, tabanid extract and N-formyl-methionyl-leucyl-phenylalanine on the in vitro migration of equine eosinophils. Can. J. Vet. Res. 54:400-404.
46. Sun, F.F., N.J. Crittenden, C.I. Czuk, B.M. Taylor, B.K. Stout, and H.G. Johnson. 1991. Biochemical and functional differences between eosinophils from animal species and man. J. Leukoc. Biol. 50:140-150.
47. 4 and its 2-ω-oxidation products in vitro. Prostaglandins. 31: 851-858.
48. Morita, E., J.-M. Schröder, and E. Christophers. 1989. Differential sensitivities of purified human eosinophils and neutrophils to defined chemotaxins. Scand. J. Immunol. 29:709-716.
49. 4-receptor antagonist. Eur. J. Pharmacol. 191:273-280.
50. Watanabe, A., P. Rossi, P.M. Renzi, L.-J. Xu, R.D. Guttmann, and J.G. Martin. 1995. Adoptive transfer of allergic airway responses with sensitized lymphocytes in BN rats. Am. J. Respir. Crit. Care Med. 152:64-70.
51. Corry, D.B., H.G. Folkesson, M.L. Warnock, D.J. Erle, M.A. Matthay, J.P. Wiener-Kronish, and R.M. Locksley. 1996. Interleukin 4, but not interlenkin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183:109-117.
52. Foster, P.S., S.P. Hogan, A.J. Ramsay, K.I. Matthaei, and I.G. Young. 1996. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity and lung damage in a mouse asthma model. J. Exp. Med. 183:195-201.
53. Skloot, G., S. Permutt, and A. Togias. 1995. Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration. J. Clin. Invest. 96:2393-2403.
54. Ingram, R.H., Jr. 1991. Asthma and airway hyperresponsiveness. Annu. Rev. Med. 42:139-150.
55. Chapman, I.D., A. Foster, and J. Morley. 1993. The relationship between inflammation and hyperreactivity of the airways in asthma. Clin. Exp. Allergy. 23:168-171.