Bronchial Mucosal Expression of the Genes Encoding Chemokines RANTES and MCP-3 in Symptomatic Atopic and Nonatopic Asthmatics: Relationship to the Eosinophil-active Cytokines Interleukin (IL)-5, Granulocyte Macrophage-Colony-Stimulating Factor, and IL-3

American Journal of Respiratory Cell and Molecular Biology

Volumn 16, Issue 1, 1997, Pages 1-8

  Humbert, Marc ^b   Ying, Sun ^c   Corrigan, Christopher ^c   Menz, Günter ^c   Barkans, Julia ^c   Pfister, Rudi ^c   Meng, Qiu ^c   Van Damme, Jo ^c   Opdenakker, Ghislain ^c   Durham, Stephen R ^c   Kay, A Barry ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b HÔPITAL ANTOINE BÉCLÈRE   (France)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHUS;

CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; INTERLEUKIN 5; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 3; RANTES;

ARTICLE; ASTHMA; BRONCHUS; COMPARATIVE STUDY; EOSINOPHIL; GENE EXPRESSION; GENETICS; HUMAN; IMMEDIATE TYPE HYPERSENSITIVITY; IN SITU HYBRIDIZATION; METABOLISM; MUCOSA;

ASTHMA; BRONCHI; CYTOKINES; EOSINOPHILS; GENE EXPRESSION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IN SITU HYBRIDIZATION; INTERLEUKIN-3; INTERLEUKIN-5; MONOCYTE CHEMOATTRACTANT PROTEINS; MUCOUS MEMBRANE; RANTES; RNA, MESSENGER;

EID: 0030638533     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.16.1.8998072     Document Type: Article

References (61)

1. Rackeman, F. M. 1947. A working classification of asthma. Am. J. Med. 3:601-606.
2. Walker, C., E. Bode, L. Boer, T. T. Hansel, K. Blaser, and J.-C. Virchow, Jr. 1992. Allergic and non-allergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am. Rev. Respir. Dis. 146:109-115.
3. Bentley, A. M., G. Menz, C. Storz, D. S. Robinson, B. L. Bradley, P. K. Jeffery, S. R. Durham, and A. B. Kay. 1992. Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa of intrinsic asthma: relationship to symptoms and bronchial responsiveness. Am. Rev. Respir. Dis. 146:500-506.
4. Humbert, M., J. A. Grant, L. Taborda-Barata, S. R. Durham, R. Pfister, G. Menz, J. Barkans, S. Ying, and A. B. Kay. 1996. High affinity IgE receptor (FcεRI)-bearing cells in bronchial biopsies from atopic and non-atopic asthma. Am. J. Respir. Crit. Care Med. 153:1931-1937.
5. Humbert, M., S. R. Durham, S. Ying, P. Kimmitt, J. Barkans, B. Assoufi, R. Pfister, G. Menz, D. S. Robinson, A. B. Kay, and C. J. Corrigan. 1996. IL-4 and IL-5 mRNA and protein in bronchial biopsies from atopic and non atopic asthma: evidence against "intrinsic" asthma being a distinct immunopathological disease. Am. J. Respir. Crit. Care Med. 154:1497-1504.
6. Bousquet, J., P. Chanez, J.-Y. Lacoste, G. Barnéon, N. Ghanavian, I. Enander, P. Venge, S. Ahlstedt, J. Simony-Lafontaine, P. Godard, and F.-B. Michel. 1990. Eosinophilic inflammation in asthma. N. Engl. J. Med. 323:1033-1039.
7. 2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med 326:298-304.
8. Corrigan, C. J., and A. B. Kay. 1992. T cells and eosinophils in the pathogenesis of asthma. Immunol. Today 13:501-507.
9. Hamid, Q., M. Azzawi, S. Ying, R. Moqbel, A. J. Wardlaw, C. J. Corrigan, B. Bradley, S. R. Durham, J. V. Collins, P. K. Jeffery, D. J. Quint, and A B. Kay. 1991 Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J. Clin. Invest. 87:1541-1546.
10. Lopez, A. F., C. J. Sanderson, J. R. Gamble, H. D. Campbell, I. G. Young, and M. A. Vadas. 1988. Recombinant human interleukin 5 is a selective activator of human eosinophil function. J. Exp. Med. 167:219-224.
11. Walsh, G. M., A. Hartnell, A. J. Wardlaw, K. Kurihara, C. J. Sanderson, and A. B. Kay 1990. IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner. Immunology 71:258-265.
12. Warringa, R. A. J., L. Koenderman, P. T. M. Kok, J. Krekniet, and P. L. B. Bruijnzeel. 1991. Modulation and induction of eosinophil chemotaxis by granulocyte-monocyte colony stimulating factor and interleukin 3. Blood 77: 2694-2700.
13. Wardlaw, A. J., R. Moqbel, and A. B. Kay. 1995. Eosinophils: biology and role in disease. Adv. Immunol. 60:151-266.
14. Humbert, M. 1996. Proeosinophilic cytokines in asthma. Clin. Exp. Allergy 26:123-127.
15. Baggiolini, M., and C. A. Dahinden. 1994. CC chemokines in allergic inflammation. Immunol. Today 15:127-133.
16. Baggiolini, M., B. Dewald, and B. Moser. 1994. Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv. Immunol. 55: 97-179.
17. Opdenakker, G., G. Froyen, P. Fiten, P. Proost, and J. Van Damme 1993. Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. Biochem. Biophys. Res. Commun. 191:535-542.
18. Opdenakker, G., P. Fiten, G. Nys, G. Froyen, N. Van Roy, F. Speleman, G. Laureys, and J. Van Damme. 1994. The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12. Genomics 21:403-408.
19. Prieschl, E. E., P. A. Kulmburg, and T. Baumruker. 1995. The nomenclature of chemokines. Int. Arch. Allergy Immunol. 107:475-483.
20. Butcher, E. C. 1991. Leukocyte-endothelial cell recognition: three (or more) steps to specificity or diversity. Cell 67:1033-1036.
21. Springer, T. A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301-314.
22. Schall, T. J., and K. B. Bacon. 1994. Chemokines, leukocyte trafficking, and inflammation. Curr. Opin. Immunol. 6: 865-873.
23. Rot, A., M. Krieger, T. Bruner, S. C. Bischoff, T. J. Schall, and C. A. Dahinden. 1992. RANTES and macrophage inflammatory protein 1α induce the migration and activation of normal human eosinophil granulocytes. J. Exp. Med. 176:1489-1495.
24. Kameyoshi, Y., A. Dorscher, A. I. Mallet, E. Christophers, and J. M. Schroder. 1992. Cytokine release by thrombin-stimulated platelets is a potent attractant for human eosinophils. J. Exp. Med. 176:587-592.
25. Meurer, R., G. Van Riper, W. Feeney, P. Cunningham, D. Hora, Jr., M. S. Springer, D. E. MacIntyre, and H. Rosen. 1993. Formation of eosinophilic and monocytic interdermal inflammatory sites in the dog by injection of human RANTES but not human monocyte chemoattractant protein 1, human macrophage inflammatory protein 1α, or human interleukin 8. J. Exp. Med. 178:1913-1921.
26. Alam, R., S. Stafford, P. Forsythe, R. Harrison, D. Faubion, M. A. LettBrown, and J. A. Grant. 1993. RANTES is a chemotactic and activating factor for human eosinophils. J. Immunol. 150:3442-3447.
27. Ebisawa, M., T. Yamada, C. Bickel, D. Klunk, and R. P. Schleimer. 1994. Eosinophilic transendothelial migration induced by cytokines: effect of the chemokine RANTES. J. Immunol. 153:2153-2160.
28. Dahinden, C. A., T. Geiser, T. Brunner, V. Von Tscharner, D. Caput, P. Ferrara, A. Minty, and M. Baggiolini. 1994. Monocyte chemotactic protein 3 is a most effective basophil- and eosinophil-activating cytokine. J. Exp. Med. 179:751-756.
29. Noso, N., P. Proost, J. Van Damme, and J.-M. Schroder. 1994. Human monocyte chemotactic proteins -2 and 3 (MCP-2 and MCP-3) attract human eosinophils and desensitize the chemotactic responses towards RANTES. Biochem. Biophys. Res. Commum. 200:1470-1476.
30. Ying, S., L. Taborda-Barata, Q. Meng, M. Humbert, and A. B. Kay. 1995. The kinetics of allergen-induced transcription of messenger RNA for monocyte chemotactic protein-3 and RANTES in the skin of human atopic subjects: relationship to eosinophil, T-cell, and macrophage recruitment. J. Exp. Med. 181:2153-2159.
31. Alam, R., P. Forsythe, S. Stafford, J. Heinrich, R. Bravo, P. Proost, and J. Van Damme. 1994. Monocyte chemotactic protein-2, monocyte chemotactic protein-3, and fibroblast-induced cytokine: three new chemokines induce chemotaxis and activation of basophils. J. Immunol. 153:3155-3159.
32. Kuna, P., S. R. Reddigari, T. J. Schall, D. Rucinski, M. Y. Viksman, and A. P. Kaplan. 1992. RANTES, a monocyte and T lymphocyte chemotactic cytokine releases histamine from human basophils. J. Immunol. 149:636-642.
33. Kuna, P., S. R. Reddigari, D. Rucinski, J. J. Oppenheim, and A. P. Kaplan. 1992. Monocyte chemotactic and activating factor is a potent histaminereleasing factor for human basophils. J. Exp. Med. 175:489-493.
34. Hargreave, F. E., G. Ryan, N. C. Thompson, P. M. O'Byrne, K. Latimer, E. F. Juniper, and J. Dolovich. 1981. Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance. J. Allergy Clin. Immunol. 68:347-355.
35. Aas, K. 1981. Heterogeneity of bronchial asthma: subpopulations or different stages of the disease. Allergy 36:3-14.
36. Humbert, M., D. S. Robinson, B. Assoufi, A. B. Kay, and S. R. Durham. 1996. Safety of fibreoptic bronchoscopy in asthmatic and control subjects and effect on asthma control over two weeks. Thorax 51:664-669.
37. Marfaing-Koka, A., O. Devergne, G. Gorgone, A. Portier, T. J. Schall, P. Galanaud, and D. Emilie. 1995. Regulation of the production of the RANTES chemokine by endothelial cells: synergistic induction by IFN-γ plus TNF-α and inhibition by IL-4 and IL-13. J. Immunol. 154:1870-1878.
38. Stellato, C., L. A. Beck, G. A. Gorgone, D. Proud, T. J. Schall, S. J. Ono, L. M. Lichtenstein, and R. P. Schleimer. 1995. Expression of the chemokine RANTES by a human bronchial epithelial cell line: modulation by cytokines and glucocorticoids. J. Immunol. 155:410-418.
39. Schall, T. J., J. Jongstra, B. J. Dyer, J. Jorgensen, C. Clayberger, M. M. Davis, and A. M. Krensky. 1988. A human T cell-specific molecule is a member of a new gene family. J. Immunol. 141:1018-1025.
40. Devergne, O., A. Marfaing-Koka, T. J. Schall, M-B. Léger-Ravet, M. Sedick, M. Peuchmaur, M.-C. Crevon, T. Kim, P. Galanaud, and D. Emilie. 1994. Production of the RANTES chemokine in delayed-type hypersensitivity reactions: involvement of macrophages and endothelial cells. J. Exp. Med. 179:1689-1694.
41. Jung Kwon, O., P. J. Jose, R. A. Robbins, T. J. Schall, T. J. Williams, and P. J. Barnes. 1995. Glucocorticoid inhibition of RANTES expression in human lung epithelial cells. Am. J. Respir. Cell Mol. Biol. 12:488-496.
42. Wang, J. H., J. L. Devalia, C. Xia, R. J. Sapsford, and R. J. Davies. 1996. Expression of RANTES by human bronchial epithelial cells m vitro and in vivo and the effects of corticosteroids. Am. J. Respir. Cell Mol. Biol. 14:27-35.
43. Ying, S., Q. Meng, L. Taborda-Barata, C. J. Corrigan, R. Moqbel, and A. B. Kay. 1996. Human eosinophils express mRNA encoding RANTES and store and release biologically active RANTES protein. Eur. J. Immunol. 26:70-76.
44. Corrigan, C. J., Q. Hamid, J. North, J. Barkans, R. Moqbel, S. R. Durham, and A. B. Kay. 1995. Peripheral blood CD4, but not CD8 T lymphocytes in patients with exacerbation of asthma transcribe and translate messenger RNA encoding cytokines which prolong eosinophil survival in the context of a Th2-type pattern: effect of glucocorticoid therapy. Am. J. Respir. Cell Mol. Biol. 12:567-578.
45. Till, S., B. Li, S. R. Durham, M. Humbert, B. Assoufi, D. Huston, R. Dickason, P. Jeannin, A. B. Kay, and C. Corrigan. 1995. Secretion of the eosinophil-active cytokines (IL-5, GM-CSF and IL-3) by bronchoalveolar lavage CD4+ and CD8+ T cell lines in atopic asthmatics and atopic and non-atopic controls. Eur. J. Immunol. 25:2727-2731.
46. Rajakulasingam, K., Q. Hamid, F. O'Brien, E. Schotman, P. J. Jose, T. J. Williams, M. Jacobson, J. Barkans, and S. R. Durham. 1996. Increases in RANTES mRNA and protein in the nasal mucosa and nasal secretions in hay fever patients after allergen challenge. J. Allergy Clin. Immunol. 97:193. (Abstr. 43)
47. American Thoracic Society. 1987. Standard for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am. Rev. Respir. Dis. 136:225-244.
48. Bischoff, S. C., M. Krieger, T. Brunner, and C. A. Dahinden. 1992. Monocyte chemotactic protein lisa potent activator of human basophils. J. Exp. Med. 175:1271-1275.
49. Schweizer, R. C., B. A. C. Welmers, J. A. M. Raaijtnakers, P. Zanen, J.-W. J. Lammers, and L. Koenderman. 1994. RANTES- and interleukin-8-induced responses in normal human eosinophils: effects of priming with interleukin-5. Blood 83:3697-3704.
50. Poulter, L., G. Janossy, C. Power, S. Sreenan, and C. Burke. 1994. Immunological/physiological relationship in asthma: potential regulation by lung macrophages. Immunol. Today 15:258-261.
51. Guo, C.-B., M. C. Liu, S. J. Galli, B. S. Bochner, A. Kagey-Sobotka, and L. M. Lichtenstein. 1994. Identification of IgE-bearing cells in the late-phase response to antigen in the lung as basophils. Am. J. Respir. Cell Mol. Biol. 10:384-390.
52. Kimura, I., Y. Tanizaki, K. Saito, K. Takahashi, N. Ueda, and S. Sato. 1975. Appearance of basophils in sputum of patients with bronchial asthma. Clin. Allergy 5:95-98.
53. Van Damme, J., P. Proost, J.-P. Lenaerts, and G. Opdenakker. 1992. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. J. Exp. Med. 176:59-65.
54. Schall, T. J., K. Bacon, K. J. Toy, and D. V. Goeddel. 1990. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 347:669-671.
55. Loetscher, P., M. Seitz, I. Clark-Lewis, M. Baggiolini, and M. Moser. 1994. Monocyte chemotactic proteins MCP-1, MCP-2, and MCP-3 are major atiractants for human CD4+ and CD8+ T lymphocytes. FASEB J. 8:1055-1060.
56. Taub, D. D., P. Proost, W. J. Murphy, M. Anver, D. L. Longo, J. Van Damme, and J. J. Oppenheim. 1995. Monocyte chemotactic protein-1 (MCP-1), -2 and -3 are chemotactic for human T lymphocytes. J. Clin. Invest. 95:1370-1376.
57. Allavena, P., G. Bianchi, D. Zhou, J. Van Damme, P. Jilek, S. Sozzani, and A. Mantovani. 1994. Induction of natural killer cell migration by monocyte chemotactic protein-1, -2 and -3. Eur. J. Immunol. 24:3233-3236.
58. Lukacs, N. W., R. M. Stricter, C. L. Shaklee, S. W. Chensue, and S. L. Kunkel. 1995. Macrophage inflammatory protein-1 a influences eosinophil recruitment in antigen-specific airway inflammation. Eur. J. Immunol. 25:245-251.
59. Jose, P. J., D. A. Griffiths-Johnson, P. D. Collins, D. T. Walsh, R. Moqbel, N. F. Totty, O. Truong, J. J. Hsuan, and T. J. Williams. 1994. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J. Exp. Med. 179:881-887.
60. Ponath, P. D., S. Qin, D. J. Ringler, I. Clark-Lewis, J. Wang, N. Kassam, H. Smith, X. Shi, J.-A. Gonzalo, W. Newman, J.-C. Guterrez-Ramos, and C. R. Mackay. 1996. Cloning of the human eosinophil chemoattractant, eotaxin: expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J. Clin. Invest. 97:604-612.
61. Garcia-Zepeda, E. A., M. E. Rothenberg, R. T. Ownbey, J. Celestin, P. Leder, and A. D. Luster. 1996. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nature Med. 2:449-456.