Tumor necrosis factor receptor (TNFR) 1, but not TNFR2, mediates tumor necrosis factor-α-induced interleukin-6 and RANTES in human airway smooth muscle cells: Role of p38 and p42/44 mitogen-activated protein kinases

Molecular Pharmacology

Volumn 60, Issue 4, 2001, Pages 646-655

  Amrani, Y ^a   Ammit, A J ^a   Panettieri R A , Jr ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN P44; PROTEIN P55; PROTEIN P75; RANTES; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRACHEA MUSCLE;

ANTIGENS, CD; BRONCHI; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; GENE EXPRESSION; HUMANS; IMIDAZOLES; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; RANTES; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034815225     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. TNFα-induced secretion of RANTES and IL-6 from human airway smooth muscle cells: Modulation by cAMP
2. Activation of tumor necrosis factor receptor 1 in airway smooth muscle: A potential pathway that modulates bronchial hyper-responsiveness in asthma?
3. Activation of the p55 TNFR1 coupled to TRAF2 stimulates ICAM-1 expression by modulating a thapsigargin-sensitive pathway in human tracheal smooth muscle cells
4. Up-regulation of ICAM-1 by cytokines in human tracheal smooth muscle cells involves an NF-κB-dependent signaling pathway that is only partially sensitive to dexamethasone
5. Activation of the TNFα-p55 receptor induces myocyte proliferation and modulates agonist-evoked calcium transients in cultured human tracheal smooth muscle cells
6. Tumor necrosis factor-alpha mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression
7. Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 mitogen-activated protein kinase-dependent TNF-alpha gene expression
8. p55 and p75 tumor necrosis factor receptors are expressed and mediate common functions in synovial fibroblasts and other fibroblasts
9. 2-terminal kinase is required for intercellular adhesion molecule-1 expression mediated by interleukin-1β: Involvement of sequential activation of tyrosine kinase, nuclear factor-κB-inducing kinase, and IκB kinase 2
10. Airway smooth muscle cells: Contributing to and regulating airway mucosal inflammation?
11. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
12. p38 MAPK and NF-κB collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system
13. MAPKs: New JNK expands the group
14. Activation of Jun N-terminal kinase/stress-activated protein kinase pathway by tumor necrosis factor α leads to intercellular adhesion molecule-1 expression
15. p38 MAP kinase regulates TNFα-, IL-1β- and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cells
16. Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK- and p38 MAPK-dependent mechanisms
17. A role for p38mapk/HSP27 pathway in smooth muscle cell migration
18. Mitogen-activated protein kinases regulate cytokine gene expression in human airway myocytes
19. Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines. Regulation by T helper 2 cytokines and corticosteroids
20. p38 MAP kinase regulates IL-1β responses in cultured airway smooth muscle cells
21. Slow release of soluble TNF receptors by monocytes in vitro
22. Lipopolysaccharide enhances bradykinin-induced signal transduction via activation of Ras/Raf/MEK/MAPK in canine tracheal smooth muscle cells
23. PAF-induced RANTES production by human airway smooth muscle cells requires both p38 MAP kinase and erk
24. Tumor necrosis factor-α enhances mRNA expression and secretion of interleukin-6 in cultured human airway smooth muscle cells
25. Implication of TNF receptor-I-mediated extracellular signal-regulated kinases 1 and 2 (ERK1/2) activation in growth of AIDS-associated Kaposi's sarcoma cells: A possible role of a novel death domain protein MADD in TNF-α-induced ERK1/2 activation in Kaposi's sarcoma cells
26. Regulation of neutrophil apoptosis by tumor necrosis factor-α: Requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro
27. The p38 signal transduction pathway activation and function
28. MAPK superfamily activation in human airway smooth muscle: Mitogenesis requires prolonged p42/p44 activation
29. Mitogen-activated signaling and cell cycle regulation in airway smooth muscle
30. 1 promoter activity in cultured airway smooth-muscle cells
31. A human airway smooth muscle cell line that retains physiological responsiveness
32. p38 mitogen-activated protein kinase regulates endothelial VCAM-1 expression at the post-transcriptional level
33. The platelet-derived growth factor receptor stimulation of p42/p44 mitogen-activated protein kinase in airway smooth muscle involves a G-protein-mediated tyrosine phosphorylation of Gab1
34. H202 and tumor necrosis factor-α activate intercellular adhesion molecule-1 (ICAM-1) gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter
35. Triggering of the human interleukin-6 gene by interferon-γ and tumor necrosis factor-α in monocytic cells involves cooperation between interferon regulatory factor-1, NF-κB and Sp1 transcription factors
36. Tumor necrosis factor ́ modulates mitogenic responses of human cultured airway smooth muscle
37. The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from TNFα- or IL-1β-stimulated rheumatoid synovial fibroblasts
38. Two TNF receptors
39. Ligand passing: The 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor
40. Tumor necrosis factor receptor and Fas signaling mechanisms