Chemokines in asthma: Cooperative interaction between chemokines and IL-13

Journal of Allergy and Clinical Immunology

Volumn 111, Issue 2, 2003, Pages 227-243

  Zimmermann, Nives ^a   Hershey, Gurjit Khurana ^a   Foster, Paul S ^b   Rothenberg, Marc E ^a,c  

^a Divisions of Allergy and Immunology   (Australia)

^b Biology and Environment   (Australia)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Asthma; Chemokine; Eotaxin; IL 13

Indexed keywords

ANTIASTHMATIC AGENT; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR ANTAGONIST; EOTAXIN; EOTAXIN 1 ANTIBODY; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5 ANTIBODY; MACROPHAGE INFLAMMATORY PROTEIN 2; MC 148; MONOCYTE CHEMOTACTIC PROTEIN 3; MONOKINE INDUCED BY INTERFERON GAMMA PROTEIN; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ALLERGY; CLINICAL TRIAL; CYTOKINE PRODUCTION; DRUG MECHANISM; EOSINOPHIL; GENE DELETION; GENETIC POLYMORPHISM; HUMAN; IMMUNOREGULATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION;

EID: 0037326942     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2003.139     Document Type: Article

References (133)

1. Zlotnik A, Yoshie O, Chemokines: a new classification system and their role in immunity. Immunity 2000;12:121-7.
2. Proost P, Wuyts A, Van Damme J. Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1. J Leukoc Biol 1996;59:67-74.
3. Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med 1996;2:449-56.
4. Stellato C, Collins P, Ponath PD, Soler D, Newman W, La RG, et al. Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines. J Clin Invest 1997;99:926-36.
5. Minshall EM, Cameron L, Lavigne F, Leung DY, Hamilos D, Garcia-Zepada EA, et al. Eotaxin mRNA and protein expression in chronic sinusitis and allergen-induced nasal responses in seasonal allergic rhinitis. Am J Respir Cell Mol Biol 1997;17:683-90.
6. Lilly CM, Nakamura H, Kesselman H, Nagler AC, Asano K, Garcia ZE, et al. Expression of eotaxin by human lung epithelial cells: induction by cytokines and inhibition by glucocorticoids. J Clin Invest 1997;99:1767-73.
7. Stellato C, Matsukura S, Fal A, White J, Beck LA, Proud D, et al. Differential regulation of epithelial-derived C-C chemokine expression by IL-4 and the glucocorticoid budesonide. J Immunol 1999;163:5624-32.
8. Schnyder B, Lugli S, Feng N, Etter H, Lutz RA, Ryffel B, et al. Interleukin-4 (IL-4) and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular cell adhesion molecule-1 induction in the absence of the common gamma chain. Blood 1996;87:4286-95.
9. Zurawski G, de Vries JE, Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today 1994;15:19-26.
10. Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998;282:2261-3.
11. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, et al. Interleukin-13: central mediator of allergic asthma. Science 1998;282:2258-61.
12. Minty Z, Chalon P, Deroeq JM, Dumont X, Guillemot JC, Kaghad M, et al. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature 1993;362:248-50.
13. Punnonen J, Aversa G, Cocks BG, McKenzie AN, Menon S, Zurawski G, et al. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci U S A 1993;90:3730-4.
14. Bochner BS, Klunk DA, Sterbinsky SA, Coffman RL, Schleimer RP. IL-13 selectively induces vascular cell adhesion molecule-I expression in human endothelial cells. J Immunol 1995;154:799-803.
15. Deiehmann K, Bardutsky J, Forster J, Heinzmann A, Kuehr J. Common polymorphisms in the coding part of the IL4-receptor gene. Biochem Biophys Acta 1997;231:696-7.
16. Mitsuyasu H, Izuhara K, Mao XQ, Gao PS, Arinobu Y, Enomoto T, et al. Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma. Nat Genet 1998;19:119-20.
17. Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. Association of atopy with a gain-of-function mutation in the interleukin-4 receptor α chain. N Engl J Med 1997;337:1720-5.
18. Matthews DJ, Hibbert L, Friedrich K, Minty A, Callard RE. X-SCID B cell responses to interleukin-4 and interleukin-13 are mediated by a receptor complex that includes the interleukin-4 receptor alpha chain (p140) but not the gamma c chain. Eur J Immunol 1997;27:116-21.
19. Miloux B, Laurent P, Bonnin O, Lupker J, Caput D, Vita N, et al. Cloning of the human IL-13R alphal chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex. FEBS Lett 1997;401:163-6.
20. Aman MJ, Tayebi N, Obiri NI, Puri RK, Modi WS, Leonard WJ, cDNA cloning and characterization of the human interleukin 13 receptor alpha chain. J Biol Chem 1996;271:29265-70.
21. Caput D, Laurent P, Kaghad M, Lelias JM, Lefort S, Vita N, et al. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. J Biol Chem 1996;271:16921-6.
22. Hilton DJ, Zhang JG, Metcalf D, Alexander WS, Nicola NA, Willson TA. Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc Natl Acad Sci U S A 1996;93:497-501.
23. Zhang JG, Hilton DJ, Willson TA, McFarlane C, Roberts BA, Moritz RL, et al. Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned 11-13 receptor and 11-4 receptor alpha-chains. J Biol Chem 1997;272:9474-80.
24. Guo J, Apiou F, Mellerin MP, Lebeau B, Jacques Y, Minvielle S. Chromosome mapping and expression of the human interleukin-13 receptor. Genomics 1997;42:141-5.
25. Mattes J, Yang M, Siqueira A, Clark K, MacKenzie J, McKenzie AN, et al. IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lung. J Immunol 2001;167:1683-92.
26. Takeda K, Kamanaka M, Tanaka T, Kishimoto T, Akira S. Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. J Immunol 1996;157:3220-2.
27. H2 cells. Immunity 1996;4:313-9.
28. Wills-Karp M. IL-12/IL-13 axis in allergic asthma. J Allergy Clin Immunol 2001;107:9-18.
29. Welham MJ, Learmonth L, Bone H, Schrader JW. Interleukin-13 signal transduction in lymphohemopoietic cells. Similarities and differences in signal transduction with interleukin-4 and insulin. J Biol Chem 1995;270:12286-96.
30. Akimoto T, Numata F, Tamura M, Takata Y, Higashida N, Takashi T, et al. Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J Exp Med 1998;187:1537-42.
31. Zimmermann N, Hogan SP, Mishra A, Brandt EB, Bodette TR, Pope SM, et al. Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpression. J Immunol 2000;165:5839-46.
32. Oravecz T, Pall M, Norcross MA. Beta-chemokine inhibition of monocytotropic HIV-1 infection. Interference with a postbinding fusion step. J Immunol 1996;157:1329-32.
33. Struyf S, Proost P, Schols D, De Clercq E, Opdenakker G, Lenaerts JP, et al. CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3. J Immunol 1999;162:4903-9.
34. Mochizuki M, Bartels J, Mallet AI, Christophers E, Schroder JM. IL-4 induces eotaxin: a possible mechanism of selective eosinophil recruitment in helminth infection and atopy. J Immunol 1998;160:60-8.
35. Culley FJ, Brown A, Conroy DM, Sabroe I, Pritchard DI, Williams TJ. Eotaxin is specifically cleaved by hookworm metalloproteases preventing its action in vitro and in vivo. J Immunol 2000;165:6447-53.
36. Murphy PM. The molecular biology of leukocyte chemoattractant receptors. Annu Rev Immunol 1994;12:593-633.
37. Gerard C, Gerard NP. The pro-inflammatory seven-transmembrane segment receptors of the leukocyte. Curr Opin Immunol 1994;6:140-5.
38. Loetscher P, Seitz M, Baggiolini M, Moser B, Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes. J Exp Med 1996;184:569-77.
39. Loetscher M, Gerber B, Loetscher P, Jones SA, Piah L, Clark-Lewis I, et al. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med 1996;184:963-9.
40. Sallusto F, Lenig D, Mackay CR, Lanzavecchia A. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 1998;187:875-83.
41. D'Amico G, Frascaroli G, Bianchi G, Transidico P, Doni A, Vecchi A, et al. Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys. Nat Immunol 2000;1:387-91.
42. Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M. Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5. Blood 2001;97:1920-4.
43. Blanpain C, Migcotte I, Lee B, Vakili J, Doranz BJ, Govaerts C, et al. CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood 1999;94:1899-905.
44. Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, et al. The ligands of CXC chemokine receptor 3, 1-TAC, Mig, and IP10, are natural antagonists for CCR3. J Biol Chem 2001;276:2986-91.
45. Fulkerson P, Zimmermann N, Brandt E, Muntel E, Kavanaugh J, Mishra A, et al. The chemokine monokine induced by IFN-γ (Mig, CXCL9) is a potent inhibitor of eosinophils in vitro and in vivo. J Allergy Clin Immunol 2003. In press.
46. Poznansky MC, Olszak IT, Foxall R, Evans RH, Luster AD, Seadden DT. Active movement of T cells away from a chemokine. Nat Med 2000;6:543-8.
47. Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, et al. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med 1996;183:2437-48.
48. Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS. Cloning, expression, and characterization of the human eosinophil eotaxin receptor. J Exp Med 1996;183:2349-54.
49. Luster AD, Rothenberg ME. Role of monocyte chemoattractant protein and eotaxin subfamily of chemokines in allergic inflammation. J Leukoc Biol 1997;62:620-33.
50. Youn BS, Zhang SM, Lee EK, Park DH, Broxmeyer HE, Murphy PM, et al. Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J Immunol 1997;159:5201-5.
51. Zhang S, Youn BS, Gao JL, Murphy PM, Kwon BS. Differential effects of leukotactin-1 and macrophage inflammatory protein-1alpha on neutrophils mediated by CCR1. J Immunol 1999;162:4938-42.
52. Heath H, Qin S, Rao P, Wu L, LaRosa G, Kassam N, et al. Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J Clin Invest 1997;99:178-84.
53. Warringa RAJ, Koenderman L, Kok PTM, Kreukniet J, Bruijnzeel PLB. Modulation and induction of eosinophil chemotaxis by granulocyte-macrophage colony-stimulating factor and interleukin-3. Blood 1991;77:2694-700.
54. Lamkhioued B, Renzi PM, Abi-Younes S, Garcia-Zepeda EA, Allakhverdi Z, Ghaffar O, et al. Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the sites of inflammation. J Immunol 1997;159:4593-601.
55. Sullivan SK, McGrath DA, Liao F, Boehme SA, Farber JM, Bacon KB. MIP-3alpha induces human eosinophil migration and activation of the mitogen-activated protein kinases (p42/p44 MAPK). J Leukoc Biol 1999;66:674-82.
56. Nagase H, Miyamasu M, Yamaguchi M, Fujisawa T, Ohta K, Yamamoto K, et al. Expression of CXCR4 in eosinophils: functional analyses and cytokine-mediated regulation. J Immunol 2000;164:5935-43.
57. Jinquan T, Quan S, Feili G, Larsen CG, Thestrup-Pedersen K. Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4. J Immunol 1999;162:4285-92.
58. Nagase H, Miyamasu M, Yamaguchi M, Kawasaki H, Ohta K, Yamamoto K, et al. Glucocorticoids preferentially upregulate functional CXCR4 expression in eosinophils. J Allergy Clin Immunol 2000;106:1132-9.
59. Uhing RJ, Gettys TW, Tomhave E, Synderman R, Didsbury JR. Differential regulation of cAMP by endogenous versus transfected formylpeptide chemoattractant receptors: implications for Gi-coupled receptor signalling. Biochem Biophys Res Commun 1992;183:1033-9.
60. Zimmermann N, Daugherty BL, Stark JM, Rothenberg ME. Molecular analysis of CCR-3 events in eosinophilic cells. J Immunol 2000;164:1055-64.
61. Ganju RK, Dutt P, Wu L, Newman W, Avraham H, Avraham S, et al. Beta-chemokine receptor CCR5 signals via the novel tyrosine kinase RAFTK. Blood 1998;91:791-7.
62. Boehme SA, Sullivan SK, Crowe PD, Santos M, Conlon PJ, Sriramarao P, et al. Activation of mitogen-activated protein kinase regulates eotaxin-induced eosinophil migration. J Immunol 1999;163:1611-8.
63. Kampen GT, Stafford S, Adachi T, Jinquan T, Quan S, Grant JA, et al. Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Blood 2000;95:1911-7.
64. El-Shazly A, Yamaguchi N, Masuyama K, Suda T, Ishikawa T. Novel association of the src family kinases, hck and c-fgr, with CCR3 receptor stimulation: a possible mechanism for eotaxin-induced human eosinophil chemotaxis. Biochem Biophys Res Commun 1999;264:163-70.
65. Zimmermann N, Coukright JJ, Rothenberg ME. CC chemokine receptor-3 undergoes prolonged ligand-induced internalization. J Biol Chem 1999;274:12611-8.
66. Zimmermann N, Rothenberg M. Receptor internalization is required for eotaxin-induced responses in human eosinophils. J Allergy Clin Immunol 2003;111:97-105.
67. Dulkys Y, Kluthe C, Buschermohle T, Barg I, Knoss S, Kapp A, et al. IL-3 induces down-regulation of CCR3 protein and mRNA in human eosinophils. J Immunol 2001;167:3443-53.
68. Daugherty BL, Springer MS. The beta-chemokine receptor genes CCRI (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21. Genomics 1997;41:294-5.
69. National Center for Biotechnology Information. Online Mendelian Inheritance in Man database. Available at http://www.ncbi.nlm.nih.gov/omim/. Accessed December 16, 2002.
70. Ahuja SK, Shetty A, Tiffany HL, Murphy PM. Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B. J Biol Chem 1994;269:26381-9.
71. Mummidi S, Ahuja SS, McDaniel BL, Ahuja SK. The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5′-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons. J Biol Chem 1997;272:30662-71.
72. Zimmermann N, Daugherty BL, Kavanaugh JL, El-Awar FY, Moulton EA, Rothenberg ME. Analysis of the CC chemokine receptor 3 gene reveals a complex 5′ exon organization, a functional role for untranslated exon 1, and a broadly active promoter with eosinophil-selective elements. Blood 2000;96:2346-54.
73. Zimmermann N, Bernstein JA, Rothenberg ME. Polymorphisms in the human CC chemokine receptor-3 gene. Biochim Biophys Acta 1998;1442:170-6.
74. Kato H, Tsuchiya N, Izumi S, Miyamasu M, Nakajima T, Kawasaki H, et al. New variations of human CC-chemokine receptors CCR3 and CCR4. Genes Immun 1999;1:97-104.
75. Bates P. Chemokine receptors and HIV-1: an attractive pair? Cell 1996;86:1-3.
76. Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, et al. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996;85:1135-48.
77. Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, Allikmets R, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 1996;273:1856-62.
78. Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, Horuk R, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996;86:367-77.
79. Samson M, Soularue P, Vassart G, Parmentier M. The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3. Genomics 1996;36:522-6.
80. Quillent C, Oberlin E, Braun J, Rousset D, Gonzalez-Canali G, Metais P, et al. HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR-5 gene. Lancet 1998;351:14-8.
81. Smith MW, Dean M, Carrington M, Winkler C, Huttley GA, Lomb DA, et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science 1997;277:959-65.
82. Gerard C, Rollins BJ. Chemokines and disease. Nat Immunol 2001;2:108-15.
83. Hogan SP, Mould AW, Young JM, Rothenberg ME, Ramsay AJ, Matthaei K, et al. Cellular and molecular regulation of eosinophil trafficking to the lung. Immunol Cell Biol 1998;76:454-60.
84. Dunn CJ, Elliott GA, Oostveen JA, Richards IM. Development of a prolonged eosinophil-rich inflammatory leukocyte infiltration in the guinea-pig asthmatic response to ovalbumin inhalation. Am Rev Respir Dis 1988;137:541-7.
85. Wegner CD, Gundel RH, Reilly P, Haynes N, Letts LG, Rothlein R. Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma. Science 1990;247:456-9.
86. Renz H, Smith HR, Henson JE, Ray BS, Irvin CG, Gelfand EW. Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse. J Allergy Clin Immunol 1992;89:1127-38.
87. Jose PJ, Adcock IM, Griffiths-Johnson DA, Berkman N, Wells TNC, Williams TJ, et al. Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea-pig lungs. Biochem Biophys Res Comm 1994;205:788-94.
88. Rothenberg ME, MacLean JA, Pearlman E, Luster AD, Leder P. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J Exp Med 1997;185:785-90.
89. Gonzalo JA, Lloyd CM, Wen D, Albar JP, Wells TN, Proudfoot A, et al. The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyper-responsiveness. J Exp Med 1998;188:157-67.
90. Mattes J, Yang M, Mahalingam S, Kuehr J, Webb DC, Simson L, et al. Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of cosinophilia and airways hyperreactivity in experimental asthma. J Exp Med 2002;195:1433-44.
91. Shi HZ, Humbles A, Gerard C, Jin Z, Weller PF. Lymph node trafficking and antigen presentation by endobronchial eosinophils. J Clin Invest 2000;105:945-53.
92. Medoff BD, Sauty A, Tager AM, Maclean JA, Smith RN, Mathew A, et al. IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol 2002;168:5278-86.
93. Blease K, Mehrad B, Standiford TJ, Lukacs NW, Kunkel SL, Chensue SW, et al. Airway remodeling is absent in CCR1-/- mice during chronic fungal allergic airway disease. J Immunol 2000;165:1564-72.
94. Blease K, Mehrad B, Standiford TJ, Lukacs NW, Gosling J, Boring L, et al. Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice. J Immunol 2000;165:2603-11.
95. MacLean JA, De Sanctis GT, Ackerman KG, Drazen JM, Sauty A, DeHaan E, et al. CC chemokine receptor-2 is not essential for the development of antigen-induced pulmonary eosinophilia and airway hyperresponsiveness. J Immunol 2000;165:6568-75.
96. Campbell EM, Charo IF, Kunkel SL, Strieter RM, Boring L, Gosling J, et al. Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in nomal but not CCR2-/- mice: the role of mast cells. J Immnuol 1999;163:2160-7.
97. Humbles AA, Lu B, Friend DS, Okinaga S, Lora J, Al-Garawi A, et al. The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc Natl Acad Sci U S A 2002;99:1479-84.
98. Ma W, Bryce PJ, Humbles AA, Laouini D, Yalcindag A, Alenius H, et al. CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J Clin Invest 2002;109:621-8.
99. Schuh JM, Power CA, Proudfoot AE, Kunkel SL, Lukacs NW, Hogaboam CM. Airway hyperresponsiveness, but not airway remodeling, is attenuated during chronic pulmonary allergic responses to Aspergillus in CCR4-/- mice. FASEB J 2002;16:1313-5.
100. Schuh JM, Blease K, Hogaboam CM. The role of CC chemokine receptor 5 (CCR5) and RANTES/CCL5 during chronic fungal asthma in mice. FASEB J 2002;16:228-30.
101. Lukaes NW, Prosser DM, Wiekowski M, Lira SA, Cook DN. Requirement for the chemokine receptor CCR6 in allergic pulmonary inflammation. J Exp Med 2001;194:551-5.
102. Chensue SW, Lukaes NW, Yang TY, Shang X, Frait KA, Kunkel SL, et al. Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. J Exp Med 2001;193:573-84.
103. De Sanctis GT, MacLean JA, Qin S, Wolyniec WW, Grasemann H, Yandava CN, et al. Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation. J Clin Invest 1999;103:507-15.
104. Ying S, Robinson DS, Meng Q, Rottman J, Kennedy R, Ringler DJ, et al. Enhanced expression of cotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Eur J Immunol 1997;27:3507-16.
105. Alam R, York J, Boyars M, Stafford S, Grant JA, Lee J, et al. Increased MCP-1, RANTES, and MIP-1alpha in bronchoalveolar lavage fluid of allergic asthmatic patients. Am J Respir Crit Care Med 1996;153(4 Pt 1):1398-404.
106. Ying S, Meng Q, Zeibecoglou K, Robinson DS, Macfarlane A, Humbert M, et al. Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (intrinsic) asthmatics. J Immunol 1999;163:6321-9.
107. Ying S, Robinson DS, Meng Q, Barata LT, McEuen AR, Buekley MG, et al. C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). J Immunol 1999;163:3976-84.
108. Berkman N, Ohnona S, Chung FK, Breuer R. Eotaxin-3 but not eotaxin gene expression is upregulated in asthmatics 24 hours after allergen challenge. Am J Respir Cell Mol Biol 2001;24:682-7.
109. Lilly CM, Woodruff PG, Camargo CA Jr, Nakamura H, Drazen JM, Nadel ES, et al. Elevated plasma eotaxin levels in patients with acute asthma. J Allergy Clin Immunol 1999;104(4 Pt 1):786-90.
110. Nickel RG, Casolaro V, Wahn U, Beyer K, Barnes KC, Plunkett BS, et al. Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES. J. Immunol 2000;164:1612-6.
111. Fryer AA, Spiteri MA, Bianco A, Hepple M, Jones PW, Strange RC, et al. The -403 G→ A promoter polymorphism in the RANTES gene is associated with atopy and asthma. Genes Immun 2000;1:509-14.
112. Nakamura H, Luster AD, Nakamura T, In KH, Sonna LA, Deykin A, et al. Variant eotaxin: its effects on the asthma phenotype. J Allergy Clin Immunol 2001;108:946-53.
113. Leckie MJ, ten Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000;356:2144-8.
114. Lloyd CM, Delaney T, Nguyen T, Tian J, Martinez AC, Coyle AJ, et al. CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. J Exp Med 2000;191:265-74.
115. Matthews AN, Friend DS, Zimmermann N, Sarafi MN, Luster AD, Pearlman E, et al. Eotaxin is required for the baseline level of tissue eosinophils. Proc Natl Acad Sci U S A 1998;95:6273-8.
116. Sabroe I, Conroy DM, Gerard NP, Li Y, Collins PD, Post TW, et al. Cloning and characterization of the guinea pig eosinophil eotaxin receptor, C-C chemokine receptor-3: blockade using a monoclonal antibody in vivo. J Immunol 1998;161:6139-47.
117. Heath H, Qin S, Rao P, Wu L, LaRosa G, Kassam N, et al. Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J Clin Invest 1997;99:178-84.
118. Proudfoot AE, Power CA, Hoogewerf AJ, Montjovent MO, Burlat F, Offord RE, et al. Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist. J Biol Chem 1996;271:2599-603.
119. Elsner J, Petering H, Hochstetter R, Kimmig D, Wells TN, Kapp A, et al. The CC chemokine antagonist Met-RANTES inhibits eosinophil effector functions through the chemokine receptors CCR1 and CCR3. Eur J Immunol 1997;27:2892-8.
120. Kips J, Palmans E, Proudfoot AEI, Tyers MD, Coyle AJ, Wells TNC, et al. The effect of Met-RANTES on the allergen-induced airway eosinophilia in an in vivo mouse model. Am J Respir Crit Care Med 1997;155:A733.
121. Moore PS, Boshoff C, Weiss RA, Chang Y. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 1996;274:1739-44.
122. Kledal TN, Rosenkilde MM, Coulin F, Simmons G, Johnsen AH, Alouani S, et al. A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science 1997;277:1656-9.
123. Luttichau HR, Stine J, Boesen TP, Johnsen AH, Chantry D, Gerstoft J, et al. A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum. J Exp Med 2000;191:171-80.
124. White JR, Lee JM, Young PR, Hertzberg RP, Jurewicz AJ, Chaikin MA, et al. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem 1998;273:10095-8.
125. Hesselgesser J, Ng HP, Liang M, Zheng W, May K, Bauman JG, et al. Identification and characterization of small molecule functional antagonists of the CCR1 chemokine receptor. J Biol Chem 1998;273:15687-92.
126. Bertrand CP, Ponath PD. CCR3 blockade as a new therapy for asthma. Expert Opin Investig Drugs 2000;9:43-52.
127. Sabroe I, Peck MJ, Van Keulen BJ, Jorritsma A, Simmons G, Clapham PR, et al. A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. J Biol Chem 2000;275:25985-92.
128. Rutledge BJ, Rayburn H, Rosenberg R, North RJ, Gladue RP, Corless CL, et al. High level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens. J Immunol 1995;155:4838-43.
129. Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999;103:779-88.
130. Pope SM, Brandt EB, Mishra A, Hogan SP, Zimmermann N, Matthaei KI, et al. Interleukin-13 induces eosinophil recruitment to the lung by an IL-5 and eotaxin dependent mechanism. J Allergy Clin immunol 2001;108:594-601.
131. Bandeira-Melo C, Sugiyama K, Woods LJ, Weller PF. Cutting edge: eotaxin elicits rapid vesicular transport-mediated release of preformed IL-4 from human eosinophils. J Immunol 2001;166:4813-7.
132. Schmid-Grendelmeier P, Altznauer F, Fischer B, Bizer C, Straumann A, Menz G, et al. Eosinophils express functional IL-13 in eosinophilic inflammatory diseases. J Immunol 2002;169:1021-7.
133. Bandeira-Melo C, Woods LJ, Phoofolo M, Weller PF. Intracrine cysteinyl leukotriene receptor-mediated signalling of eosinophil vesicular transport-mediated interleukin-4 secretion. J Exp Med 2002;196:841-50.