Airway remodeling in asthma

Journal of Clinical Investigation

Volumn 104, Issue 8, 1999, Pages 1001-1005

  Elias, Jack A ^a   Zhu, Zhou ^a   Chupp, Geoffrey ^a   Homer, Robert J ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Pathol and Lab Medicine Service   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 11; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 9;

AIRWAY; ASTHMA; CELL HYPERPLASIA; HISTOPATHOLOGY; HUMAN; IMMUNOMODULATION; IMMUNOPATHOGENESIS; INFLAMMATION; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EID: 0032749366     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/jci8124     Document Type: Review

References (46)

1. Lange, P., Parner, J., Vestbo, J., Schnohr, P., and Jensen, G. 1998. A 15-year follow-up study of ventilatory function in adults with asthma. N. Engl. J. Med. 339:1194-1200.
2. Peat, J.K., Woolcock, A.J., and Cullen, K. 1987 Rate of decline of lung function in subjects with asthma. Eur. J. Respir. Dis. 70:171-179.
3. Holgate, S.T., Wilson, J.R., and Howarth, P.H. 1992. New insights into airway inflammation by endobronchial biopsy. Am. Rev. Respir. Dis. 145:S2-S6.
4. Bradding, P., Redington, A.E., and Holgate, S.T. 1997. Airway wall remodelling in the pathogenesis of asthma: cytokine expression in the airways. In Airway wall remodelling in asthma. A.G. Stewart, editor. CRC Press. Boca Raton, FL. 29-63.
5. Robinson, D.S., et al. 1992. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298-304.
6. Wills-Karp, M., et al. 1998. Interleukin-13: central mediator of allergic asthma. Science. 282:2258-2260.
7. Nicolaides, N.C., et al. 1997. Interleukin 9: a candidate gene for asthma. Proc. Natl. Acad. Sci. USA. 94:13175-13180.
8. Hamid, Q., et al. 1991. Expression of mRNA for inrerleukin-5 in mucosal bronchial biopsies from asthma. J. Clin. Invest. 87:1541-1546.
9. Huber, H.L., and Koessler, K.K. 1922. The pathology of bronchial asthma. Arch. Intern. Med. 30:689-760.
10. James, A.J. 1997. Relationship between airway wall thickness and airway hyperresponsiveness. In Airway wall remodelling in asthma. A.G. Stewart, editor. CRC Press. Boca Raton, FL. 1-27.
11. Kuwano, K., et al. 1993. Small airways dimensions in asthma and chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 148:1220-1225.
12. Pare, P.D., Roberts, C.R., Bai, T.R., and Wiggs, B.J. 1997. The functional consequences of airway remodelling in asthma. Monaldi Arch. Chest Dis. 52:589-598.
13. Fredberg, J.J. 1998. Airway smooth muscle in asthma: flirting with disaster. Eur. Respir. J. 12:1252-1256.
14. Jeffery, P.K., et al. 1992. Effects of treatment on airway inflammation and thickness of basement membrane reticular collagen in asthma: a quantitative light and electron microscopic study. Am. Rev. Respir. Dis. 145:890-899.
15. Roche, W.R., Williams, J.H., Beasley, R., and Holgate, S.T. 1989. Subepithelial fibrosis in the bronchi of asthmatics. Lancet. 1:520-524.
16. Minshall, E.M., et al. 1997. Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma. Am. J. Respir. Cell Mol. Biol. 17:326-333.
17. Chetta, A., et al. 1997. Airways remodeling is a distinctive feature of asthma and is related to severity of disease. Chest. 111:852-857.
18. Boulet, L.-P., Belanger, M., and Carrier, G. 1995. Airway responsiveness and bronchial-wall thickening in asthma with or without fixed airflow obstruction. Am. J. Respir. Crit. Care Med. 152:865-871.
19. Hoshino, M., Nakamura, Y., and Sim, J.J. 1998. Expression of growth factors and remodelling of the airway wall in bronchial asthma. Thorax. 53:21-27.
20. Chu, H.W., et al. 1998. Collagen deposition in large airways may not differentiate severe asthma from milder forms of the disease. Am. J. Respir. Crit. Care Med. 158:1936-1944.
21. Heard, B.E., and Hossain, S. 1973. Hyperplasia of bronchial muscle in asthma. J. Pathol. 110:319-331.
22. Ebina, M., Takahashi, T., Chiba, T., and Motomiya, M. 1993. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. Am. Rev. Respir. Dis. 48:720-726.
23. Tang, W., et al. 1996. Targeted expression of IL-11 in the murine airway causes airways obstruction, bronchial remodeling and lymphocytic inflammation. J. Clin. Invest. 98:2845-2853.
24. Brewster, C.E.P., et al. 1990. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am. J. Respir. Cell Mol. Biol. 3:507-511.
25. Gizycki, M.J., Adelroth, E., Rogers, A.V., O'Byrne, P.M., and Jeffery, P.K. 1997. Myofibroblast involvement in the allergen-induced late response in mild atopic asthma. Am. J. Respir. Cell Mol. Biol. 16:664-673.
26. Aikawa, X, Shimura, S, Sasaki, H., Ebina, M., and Takashima, T. 1992. Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack. Chest. 101:916-921.
27. Kim, K.C., et al. 1997. Airway goblet cell mucin: its structure and regulation of secretion. Eur. Resfir. J. 10:2644-2649.
28. Vignola, A.M., et al. 1997. Transforming growth factor-β expression in mucosal biopsies in asthma and chronic bronchitis. Am. J. Respir. Crit. Care Med. 156:591-599.
29. Ohno, I., et al. 1996. Transforming growth factor beta 1 (TGF beta 1) gene expression by eosinophils in asthmatic airway inflammation. Am. J. Respir. Cell Mol. Biol. 15:404-409.
30. Vignola, A.M., et al. 1998. Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am. J. Respir. Crit. Care Med. 158:1945-1950.
31. Hoshino, M., Nakamura, Y., Sim, J., Shimojo, J., and Isogai, S. 1998. Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation. J. Allergy Clin. Immunol. 102:783-788.
32. Mautino, G., et al. 1999. Increased expression of tissue inhibitor of metalloproteinase-1 and loss of correlation with matrix metalloproteinase-9 by macrophages in asthma. Lab. Invest. 79:39-47.
33. Uhl, E.W., et al. 1996. Parainfluenza virus-induced persistence of airway inflammation, fibrosis, and dysfunction associated with TGF-beta 1 expression in brown Norway rats. Am. J. Respir. Crit. Care Med. 154:1834-1842.
34. Blyth, D.I., Pedrick, M.S., Savage, T.J., Hessel, E.M., and Fattah, D. 1996. Lung inflammation and epithelial changes in a murine model of atopic asthma. Am. J. Respir. Cell Mol. Biol. 14:425-438.
35. DiCosmo, B.F., et al. 1994. Airway targeted interleukin-6 in transgenic mice: uncoupling of airway inflammation and bronchial hyperreactivity. J. Clin. Invest. 94:2028-2035.
36. Leng, S., and Elias, J.A. 1997. Interleukin-11. Int. J. Biochem. Cell Biol. 29:1059-1062.
37. Einarsson, O., Geba, G.P., Zhu, Z., Landry, M., and Elias, J.A. 1996. Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness. J. Clin. Invest. 97:915-924.
38. Minshall, E.M., et al. 1999. Interleukin 11 mRNA expression is increased in severe asthma: localization to eosinophils. J. Allergy Clin. Immunol. 103:558. (Abstr.)
39. Zhu, Z., et al. 1999. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities and eotaxin production. J. Clin. Invest. 103:779-788.
40. Temann, U.-A., Geba, G.P., Rankin, J.A., and Flavell, RA 1998. Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia and bronchial hyperresponsiveness. J. Exp. Med. 188:1307-1320.
41. Rankin, J.A., et al. 1996. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc. Natl. Acad. Sci. USA 93:7821-7825.
42. Lee, JJ., et al. 1997. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J. Exp. Med. 185:2143-2156.
43. Jain-Vora, S., Wert, S.E, Temann, U-A., Rankin, J.A., and Whitsett, J.A. 1997. Interleukin-4 alters epithelial cell differentiation and surfactant homeostasis in the postnatal mouse lung. Am. J. Respir. Cell Mol. Biol. 17:541-551.
44. Vignola, A.M., et al. 1998. Airway inflammation in mild intermittent and in persistent asthma. Am. J. Respir. Crit. Care Med. 157:403-409.
45. Barnes, P.J. 1996. Pathophysiology of asthma. Br. J. Clin. Pharmacol. 42:3-10.
46. Saetta, M. 1995. Airway wall remodeling after cessation of exposure to isocyanates in sensitized asthmatic subjects. Am. J. Respir. Crit. Care Med. 151:489-494.