Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients

American Journal of Respiratory and Critical Care Medicine

Volumn 160, Issue 1, 1999, Pages 216-220

  Montuschi, Paolo ^b   Corradi, Massimo ^b   Ciabattoni, Giovanni ^b   Nightingale, Julia ^b   Kharitonov, Sergei A ^b   Barnes, Peter J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; BECLOMETASONE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CARBON MONOXIDE; FLUTICASONE PROPIONATE; NITRIC OXIDE; PREDNISOLONE;

ADULT; ARTICLE; ASTHMA; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE SEVERITY; EXPIRED AIR; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION TEST; LUNG LAVAGE; MALE; ORAL DRUG ADMINISTRATION; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; SPIROMETRY;

EID: 0001058084     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.160.1.9809140     Document Type: Article

References (35)

1. Barnes, P. J. 1990. Reactive oxygen species and airway inflammation. Free Radic. Biol. Med. 9:235-243.
2. Kanazawa, H., N. Kurihara, K. Hirata, and T. Takeda. 1991. The role of free radicals in airway obstruction in asthmatic patients. Chest 100:1319-1322.
3. Sedgwick, J. B., K. M. Geiger, and W. W. Busse. 1990. Superoxide generation by hypodense eosinophils from patients with asthma. Am. Rev. Respir. Dis. 142:120-125.
4. Joseph, B. Z., J. M. Routes, and L. Borish. 1993. Activities of superoxide dismutases and NADPH oxidase in neutrophils obtained from asthmatic and normal donors. Inflammation 17:361-367.
5. Jarjour, N. N., W. W. Busse, and W. J. Calhoun. 1992. Enhanced production of oxygen radicals in nocturnal asthma. Am. Rev. Respir. Dis. 146:905-911.
6. Owen, S., D. Pearson, V. Suarez-Mendez, R. O'Driscoll, and A. Woodcock. 1991. Evidence of free radical activity in asthma. N. Engl. J. Med. 325:586-587.
7. Novak, Z., I. Nemeth, K. Gyurkovits, S. I. Varga, and B. Matkovics. 1991. Examination of the role of oxygen free radicals in bronchial asthma in childhood. Clin. Chim. Acta 201:147-252.
8. Rahman, I., D. Morrison, K. Donaldson, and W. McNee. 1996. Systemic oxidative stress in asthma, COPD, and smokers. Am. J. Respir. Crit. Care Med. 154:1055-1060.
9. Morrow, J. D., and L. J. Roberts, II. 1996. The isoprostanes: current knowledge and directions for future research. Biochem. Pharmacol. 51:1-9.
10. Morrow, J. D., J. A. Awad, H. J. Boss, I. A. Blair, and L. J. Roberts. 1992. Non-cyclooxygenase derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids. Proc. Natl. Acad. Sci. U.S.A. 89:10721-10725.
11. Morrow, J. D., K. E. Hill, R. F. Burk, T. M. Nammour, K. F. Badr, and L. J. Roberts, II. 1990. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free-radical-catalyzed mechanism. Proc. Natl. Acad. Sci. U.S.A 87:9383-9387.
12. Wang, Z., G. Ciabattoni, C. Creminon, J. Lawson, G. A. Fitzgerald, C. Patrono, and J. Maclouf. 1995. Immunological characterization of urinary 8-epi-prostaglandin F2 alpha excretion in man. J. Pharmacol. Exp. Ther. 275:94-100.
13. Morrow, J. D., B. Frei, A. W. Longmire, J. M. Gaziano, S. M. Lynch, Y. Shyr, W. E. Strauss, J. A. Oates, and L. J. Roberts, II. 1995. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. N. Engl. J. Med. 332:1198-1203.
14. Morrow, J. D., K. P. Moore, J. A. Awad, M. D. Ravenscraft, G. Marini, K. F. Badr, R. Williams, and L. J. Roberts, II. 1993. Marked overproduction of non-cyclooxygenase derived prostanoids (F2-isoprostanes) in the hepatorenal syndrome. J. Lipid Mediat. 6:417-420.
15. Stein, C. M., S. B. Tanner, J. A. Awad, L. J. Roberts, II, and J. D. Morrow. 1996. Evidence for a free radical-mediated injury (isoprostane overproduction) in scleroderma. Arthritis Rheum. 39:1146-1150.
16. Montuschi, P., G. Ciabattoni, P. Paredi, R. M. du Bois, P. Pantelidis, S. A. Kharitonov, and P. J. Barnes. 1998. 8-Isoprostane as a biomarker of oxidative stress in interstitial lung disease. Am. J. Respir. Crit. Care Med. 158:1524-1527.
17. 2α-III, an index of oxidant stress. Am. Rev. Respir. Dis. 158:1709-1714.
18. American Thoracic Society. 1987. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am. Rev. Respir. Dis. 136:225-244.
19. National Institutes of Health: National Heart, Lung, and Blood Institute. 1997. Guidelines for the diagnosis and management of asthma. National Institutes of Health, Washington, DC. Publication No. 97-4051.
20. Loukides, S., I. Horvath, T. Wodehouse, P. J. Cole, and P. J. Barnes. 1998. Elevated levels of expired breath hydrogen peroxide in bronchiectasis. Am. J. Respir. Crit. Care Med. 158:991-994.
21. Kharitonov, S. A., F. K. Chung, D. J. Evans, B. J. O'Connor, and P. J. Barnes. 1996. The elevated level of exhaled nitric oxide in asthmatic patients is mainly derived from the lower respiratory tract. Am. J. Respir. Crit. Care Med. 153:1773-1780.
22. Roberts, L. J., II, and J. D. Morrow. 1997. The generation and actions of isoprostanes. Biochim. Biophys. Acta 1345:121-135.
23. 2 alpha by human monocytes: discriminate production by reactive oxygen species and prostaglandin endoperoxide synthase-2. J. Biol. Chem. 271:8919-8924.
24. 2α. J. Biol. Chem. 270:9800-9808.
25. 2 alpha in vitro and in vivo via the cyclooxygenases. J. Pharmacol. Exp. Ther. 282:1658-1665.
26. Delanty, N., M. Reilly, D. Practicò, D. J. Fitzgerald, J. A. Lawson, and G. A. FitzGerald. 1996. 8-Epi-PGF2α: specific analysis of an isoeicosanoid as an index of oxidant stress in vivo. Br. J. Clin. Pharmacol. 42:15-19.
27. Rahman, I., E. Skwarska, and W. McNee. 1997. Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease. Thorax 52:565-568.
28. Olopade, C. O., M. Zakkar, W. I. Swedler, and I. Rubenstein. 1997. Exhaled penthane levels in acute asthma. Chest 111:862-865.
29. Kharitonov, S. A., D. H. Yates, and P. J. Barnes. 1996. Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients. Am. J. Respir. Crit. Care. Med. 153:454-457.
30. Zayasu, K., K. Sekisawa, S. Okinaga, M. Yamaya, T. Ohrui, and H. Sasaki. 1997. Increased carbon monoxide in exhaled air of asthmatic patients. Am. J. Respir. Crit. Care Med. 156:1140-1143.
31. Horvath, I., L. E. Donnelly, A. Kiss, P. Paredi, S. A. Kharitonov, and P. J. Barnes. 1998. Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress. Thorax 53: 668-672.
32. Saleh, D., P. Ernst, S. Lim, P. J. Barnes, and A. Giaid. 1998. Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: effect of inhaled glucocorticoid. FASEB J. 12:929-937.
33. Yates, D. H., S. A. Kharitonov, P. S. Thomas, and P. J. Barnes. 1996. Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase. Am. J. Respir. Crit. Care Med. 154:247-250.
34. Choi, A. M., and J. Alam. 1996. Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am. J. Respir. Cell Mol. Biol. 15:9-19.
35. Jourdan, K. B., J. A. Mitchell, and T. W. Evans. 1997. Release of isoprostanes by human pulmonary artery in organ culture: a cyclo-oxygenase and nitric oxide dependent pathway. Biochem. Biophys. Res. Commun. 233:668-672.