Mitotic checkpoint, aneuploidy and cancer

Advances in Experimental Medicine and Biology

Volumn 570, Issue , 2005, Pages 477-499

  Yen, Tim J ^a   Kao, Gary D ^b  

^a FOX CHASE CANCER CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; BUB1 RELATED PROTEIN; BUB3 PROTEIN; PROTEIN; PROTEIN MAD2; RAE1 PROTEIN; UNCLASSIFIED DRUG;

ANAPHASE; ANEUPLOIDY; CANCER; CANCER THERAPY; CELL CYCLE; CELL FUNCTION; CENTROMERE; CHROMOSOME SEGREGATION; GENE EXPRESSION; GENE MUTATION; GENETIC LINKAGE; HUMAN; MITOSIS; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; REVIEW; TUMOR PROMOTION;

EID: 34548682055     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/1-4020-3764-3_17     Document Type: Review

References (89)

1. Andrews, P.D., E. Knatko, W.J. Moore, and J.R. Swedlow. 2003. Mitotic mechanics: the auroras come into view. Curr Opin Cell Biol. 15:672-83.
2. Andrews, P.D., Y. Ovechkina, N. Morrice, M. Wagenbach, K. Duncan, L. Wordeman, and J.R. Swedlow. 2004. Aurora B regulates MCAK at the mitotic centromere. Dev Cell. 6:253-68.
3. Babu, J.R., K.B. Jeganathan, D.J. Baker, X. Wu, N. Kang-Decker, and J.M. van Deursen. 2003. Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol. 160:341-53.
4. Baker, D.J., K.B. Jeganathan, J.D. Cameron, M. Thompson, S. Juneja, A. Kopecka, R. Kumar, R.B. Jenkins, P.C. de Groen, P. Roche, and J.M. van Deursen. 2004. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet. 36:744-9.
5. Biggins, S., and C.E. Walczak. 2003. Captivating capture: how microtubules attach to kinetochores. Curr Biol. 13:R449-60.
6. Cahill, D.P., L.T. da Costa, E.B. Carson-Walter, K.W. Kinzler, B. Vogelstein, and C. Lengauer. 1999. Characterization of MAD2B and other mitotic spindle checkpoint genes. Genomics. 58:181-7.
7. Cahill, D.P., C. Lengauer, J. Yu, G.J. Riggins, J.K. Willson, S.D. Markowitz, K.W. Kinzler, and B. Vogelstein. 1998. Mutations of mitotic checkpoint genes in human cancers. Nature. 392:300-3.
8. Chan, G.K., and T.J. Yen. 2003. The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit. Prog Cell Cycle Res. 5:431-9.
9. Chen, R.H., J.C. Waters, E.D. Salmon, and A.W. Murray. 1996. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science. 274:242-6.
10. Cimini, D., B. Howell, P. Maddox, A. Khodjakov, F. Degrassi, and E.D. Salmon. 2001. Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J Cell Biol. 153:517-27.
11. Clute, P., and J. Pines. 1999. Temporal and spatial control of cyclin B1 destruction in metaphase. Nat Cell Biol. 1:82-7.
12. Crown, J., M. O'Leary, and W.S. Ooi. 2004. Docetaxel and paclitaxel in the treatment of breast cancer: a review of clinical experience. Oncologist. 9 Suppl 2:24-32.
13. Dai, W., Q. Wang, T. Liu, M. Swamy, Y. Fang, S. Xie, R. Mahmood, Y.M. Yang, M. Xu, and C.V. Rao. 2004. Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. Cancer Res. 64:440-5.
14. David, G., G.M. Turner, Y. Yao, A. Protopopov, and R.A. DePinho. 2003. mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells. Genes Dev. 17:2396-405.
15. DeLuca, J.G., B.J. Howell, J.C. Canman, J.M. Hickey, G. Fang, and E.D. Salmon. 2003. Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores. Curr Biol. 13:2103-9.
16. den Elzen, N., and J. Pines. 2001. Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase. J Cell Biol. 153:121-36.
17. Ditchfield, C., V.L. Johnson, A. Tighe, R. Ellston, C. Haworth, T. Johnson, A. Mortlock, N. Keen, and S.S. Taylor. 2003. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol. 161:267-80.
18. Dobles, M., V. Liberal, M.L. Scott, R. Benezra, and P.K. Sorger. 2000. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell. 101:635-45.
19. Edmonson, J.H., L.P. Ebbert, A.G. Nascimento, S.H. Jung, H. McGaw, and J.B. Gerstner. 1996. Phase II study of docetaxel in advanced soft tissue sarcomas. Am J Clin Oncol. 19:574-6.
20. Fang, G., H. Yu, and M.W. Kirschner. 1998. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev. 12:1871-83.
21. Fodde, R., J. Kuipers, C. Rosenberg, R. Smits, M. Kielman, C. Gaspar, J.H. van Es, C. Breukel, J. Wiegant, R.H. Giles, and H. Clevers. 2001. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat Cell Biol. 3:433-8.
22. Geley, S., E. Kramer, C. Gieffers, J. Gannon, J.M. Peters, and T. Hunt. 2001. Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. J Cell Biol. 153:137-48.
23. Gemma, A., Y. Hosoya, M. Seike, K. Uematsu, F. Kurimoto, S. Hibino, A. Yoshimura, M. Shibuya, S. Kudoh, and M. Emi. 2001. Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers. Lung Cancer. 32:289-95.
24. Gorbsky, G.J., R.H. Chen, and A.W. Murray. 1998. Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase. J Cell Biol. 141:1193-205.
25. Hanks S, Coleman K, Reid S, Plaja A, Firth H, Fitzpatrick D, Kidd A, Mehes K, Nash R, Robin N, Shannon N, Tolmie J, Swansbury J, Irrthum A, Douglas J,Rahman N. 2004. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet. 36 (11):1159-61.
26. Hartmann, J.T., and C. Bokemeyer. 1999. Chemotherapy for renal cell carcinoma. Anticancer Res. 19:1541-3.
27. Hauf, S., R.W. Cole, S. LaTerra, C. Zimmer, G. Schnapp, R. Walter, A. Heckel, J. van Meel, C.L. Rieder, and J.M. Peters. 2003. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol. 161:281-94.
28. Hernando, E., I. Orlow, V. Liberal, G. Nohales, R. Benezra, and C. Cordon-Cardo. 2001. Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer. Int J Cancer. 95:223-7.
29. Hoffman, D.B., C.G. Pearson, T.J. Yen, B.J. Howell, and E.D. Salmon. 2001. Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores. Mol Biol Cell. 12:1995-2009.
30. Howell, B.J., D.B. Hoffman, G. Fang, A.W. Murray, and E.D. Salmon. 2000. Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells. J Cell Biol. 150:1233-50.
31. Imai, Y., Y. Shiratori, N. Kato, T. Inoue, and M. Omata. 1999. Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers. Jpn J Cancer Res. 90:837-40.
32. Johnson, V.L., M.I. Scott, S.V. Holt, D. Hussein, and S.S. Taylor. 2004. Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. J Cell Sci. 117:1577-89.
33. Kaplan, K.B., A.A. Burds, J.R. Swedlow, S.S. Bekir, P.K. Sorger, and I.S. Nathke. 2001. A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat Cell Biol. 3:429-32.
34. King, R.W., J.M. Peters, S. Tugendreich, M. Rolfe, P. Hieter, and M.W. Kirschner. 1995. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell. 81:279-88.
35. Kops, G.J., D.R. Foltz, and D.W. Cleveland. 2004. Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. Proc Natl Acad Sci U S A. 101:8699-704.
36. Lan, W., X. Zhang, S.L. Kline-Smith, S.E. Rosasco, G.A. Barrett-Wilt, J. Shabanowitz, D.F. Hunt, C.E. Walczak, and P.T. Stukenberg. 2004. Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr Biol. 14:273-86.
37. Lee, E.A., M.K. Keutmann, M.L. Dowling, E. Harris, G. Chan, and G.D. Kao. 2004. Inactivation of the mitotic checkpoint as a determinant of the efficacy of microtubuletargeted drugs in killing human cancer cells. Mol Cancer Ther. 3:661-9.
38. Lee, H., A.H. Trainer, L.S. Friedman, F.C. Thistlethwaite, M.J. Evans, B.A. Ponder, and A.R. Venkitaraman. 1999. Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2. Mol Cell. 4:1-10.
39. Lengauer, C., K.W. Kinzler, and B. Vogelstein. 1998. Genetic instabilities in human cancers. Nature. 396:643-9.
40. Li, X., and R.B. Nicklas. 1995. Mitotic forces control a cell-cycle checkpoint. Nature. 373:630-2.
41. Li, Y., and R. Benezra. 1996. Identification of a human mitotic checkpoint gene: hsMAD2. Science. 274:246-8.
42. Liu, S.T., J.C. Hittle, S.A. Jablonski, M.S. Campbell, K. Yoda, and T.J. Yen. 2003. Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis. Nat Cell Biol. 5:341-5.
43. Loeb, L.A. 1991. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 51:3075-9.
44. Luo, X., G. Fang, M. Coldiron, Y. Lin, H. Yu, M.W. Kirschner, and G. Wagner. 2000. Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. Nat Struct Biol. 7:224-9.
45. Luo, X., Z. Tang, G. Xia, K. Wassmann, T. Matsumoto, J. Rizo, and H. Yu. 2004. The Mad2 spindle checkpoint protein has two distinct natively folded states. Nat Struct Mol Biol. 11:338-45.
46. Martin-Lluesma, S., V.M. Stucke, and E.A. Nigg. 2002. Role of hec1 in spindle checkpoint signaling and kinetochore recruitment of mad1/mad2. Science. 297:2267-70.
47. Masuda, A., K. Maeno, T. Nakagawa, H. Saito, and T. Takahashi. 2003. Association between mitotic spindle checkpoint impairment and susceptibility to the induction of apoptosis by anti-microtubule agents in human lung cancers. Am J Pathol. 163:1109-16.
48. McEwen, B.F., G.K. Chan, B. Zubrowski, M.S. Savoian, M.T. Sauer, and T.J. Yen. 2001. CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells. Mol Biol Cell. 12:2776-89.
49. McGuire, W.P., J.A. Blessing, D. Moore, S.S. Lentz, and G. Photopulos. 1996. Paclitaxel has moderate activity in squamous cervix cancer. A Gynecologic Oncology Group study. J Clin Oncol. 14:792-5.
50. Meraldi, P., V.M. Draviam, and P.K. Sorger. 2004. Timing and checkpoints in the regulation of mitotic progression. Dev Cell. 7:45-60.
51. Modesti, M., and R. Kanaar. 2001. Homologous recombination: from model organisms to human disease. Genome Biol. 2:REVIEWS1014.
52. Musio, A., C. Montagna, D. Zambroni, E. Indino, O. Barbieri, L. Citti, A. Villa, T. Ried, and P. Vezzoni. 2003. Inhibition of BUB1 Results in Genomic Instability and Anchorage-independent Growth of Normal Human Fibroblasts. Cancer Res. 63:2855-63.
53. Nicklas, R.B. 1997. How cells get the right chromosomes. Science. 275:632-7.
54. Nicklas, R.B., and S.C. Ward. 1994. Elements of error correction in mitosis: microtubule capture, release, and tension. J Cell Biol. 126:1241-53.
55. Nowak, A.K., N.R. Wilcken, M.R. Stockler, A. Hamilton, and D. Ghersi. 2004. Systematic review of taxane-containing versus non-taxane-containing regimens for adjuvant and neoadjuvant treatment of early breast cancer. Lancet Oncol. 5:372-80.
56. Ohshima, K., S. Haraoka, S. Yoshioka, M. Hamasaki, T. Fujiki, J. Suzumiya, C. Kawasaki, M. Kanda, and M. Kikuchi. 2000. Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma. Cancer Lett. 158:141-50.
57. Orr-Weaver, T.L., and R.A. Weinberg. 1998. A checkpoint on the road to cancer. Nature. 392:223-4.
58. Pan, J., and R.H. Chen. 2004. Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae. Genes Dev. 18:1439-51.
59. Patel, S.R., N.E. Papadopoulos, C. Plager, K.A. Linke, S.H. Moseley, C.H. Spirindonidis, and R. Benjamin. 1996. Phase II study of paclitaxel in patients with previously treated osteosarcoma and its variants. Cancer. 78:741-4.
60. Percy, M.J., K.A. Myrie, C.K. Neeley, J.N. Azim, S.P. Ethier, and E.M. Petty. 2000. Expression and mutational analyses of the human MAD2L1 gene in breast cancer cells. Genes Chromosomes Cancer. 29:356-62.
61. Petrylak, D.P., and R. de Wit. 2002. Editorial: the coming revolution in the treatment of prostate cancer patients. Semin Urol Oncol. 20:1-3.
62. Piccart, M.J., K. Bertelsen, G. Stuart, J. Cassidy, C. Mangioni, E. Simonsen, K. James, S. Kaye, I. Vergote, R. Blom, R. Grimshaw, R. Atkinson, K. Swenerton, C. Trope, M. Nardi, J. Kaern, S. Tumolo, P. Timmers, J.A. Roy, F. Lhoas, B. Lidvall, M. Bacon, A. Birt, J. Andersen, B. Zee, J. Paul, S. Pecorelli, B. Baron, and W. McGuire. 2003. Long-term follow-up confirms a survival advantage of the paclitaxel-cisplatin regimen over the cyclophosphamide-cisplatin combination in advanced ovarian cancer. Int J Gynecol Cancer. 13 Suppl 2:144-8.
63. Picus, J., and M. Schultz. 1999. Docetaxel (Taxotere) as monotherapy in the treatment of hormone-refractory prostate cancer: preliminary results. Semin Oncol. 26:14-8.
64. Pihan, G.A., and S.J. Doxsey. 1999. The mitotic machinery as a source of genetic instability in cancer. Semin Cancer Biol. 9:289-302.
65. Putkey, F.R., T. Cramer, M.K. Morphew, A.D. Silk, R.S. Johnson, J.R. McIntosh, and D.W. Cleveland. 2002. Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev Cell. 3:351-65.
66. Reis, R.M., M. Nakamura, J. Masuoka, T. Watanabe, S. Colella, Y. Yonekawa, P. Kleihues, and H. Ohgaki. 2001. Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas. Acta Neuropathol (Berl). 101:297-304.
67. Rieder, C.L., and E.D. Salmon. 1994. Motile kinetochores and polar ejection forces dictate chromosome position on the vertebrate mitotic spindle. J Cell Biol. 124:223-33.
68. Rigas, J.R. 2004. Taxane-platinum combinations in advanced non-small cell lung cancer: a review. Oncologist. 9 Suppl 2:16-23.
69. Ru, H.Y., R.L. Chen, W.C. Lu, and J.H. Chen. 2002. hBUB1 defects in leukemia and lymphoma cells. Oncogene. 21:4673-9.
70. Sato, M., Y. Sekido, Y. Horio, M. Takahashi, H. Saito, J.D. Minna, K. Shimokata, and Y. Hasegawa. 2000. Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer. Jpn J Cancer Res. 91:504-9.
71. Schaar, B.T., G.K.T. Chan, P. Maddox, E.D. Salmon, and T.J. Yen. 1997. CENP-E function at kinetochores is essential for chromosome alignment. J. Cell Biol. 139:1373-1382.
72. Shannon, K.B., J.C. Canman, and E.D. Salmon. 2002. Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension. Mol Biol Cell. 13:3706-19.
73. Shepherd, F.A. 2004. Current paradigms in first-line treatment of non-small-cell lung cancer. Oncology (Huntingt). 18:13-20.
74. Shichiri, M., K. Yoshinaga, H. Hisatomi, K. Sugihara, and Y. Hirata. 2002. Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. Cancer Res. 62:13-7.
75. Skibbens, R.V., and P. Hieter. 1998. Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery. Annu Rev Genet. 32:307-37.
76. Skoufias, D.A., P.R. Andreassen, F.B. Lacroix, L. Wilson, and R.L. Margolis. 2001. Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints. Proc Natl Acad Sci U S A. 98:4492-7.
77. Sudakin, V., G.K. Chan, and T.J. Yen. 2001. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J Cell Biol. 154:925-36.
78. Sudakin, V., D. Ganoth, A. Dahan, H. Heller, J. Hershko, F.C. Luca, J.V. Ruderman, and A. Hershko. 1995. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol Biol Cell. 6:185-97.
79. Takahashi, T., N. Haruki, S. Nomoto, A. Masuda, S. Saji, and H. Osada. 1999. Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers. Oncogene. 18:4295-300.
80. Tanaka, T.U., N. Rachidi, C. Janke, G. Pereira, M. Galova, E. Schiebel, M.J. Stark, and K. Nasmyth. 2002. Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell. 108:317-29.
81. Thompson, L.H., and D. Schild. 2002. Recombinational DNA repair and human disease. Mutat Res. 509:49-78.
82. Tighe, A., V.L. Johnson, M. Albertella, and S.S. Taylor. 2001. Aneuploid colon cancer cells have a robust spindle checkpoint. Embo Rep. 2:609-14.
83. Tsukasaki, K., C.W. Miller, E. Greenspun, S. Eshaghian, H. Kawabata, T. Fujimoto, M. Tomonaga, C. Sawyers, J.W. Said, and H.P. Koeffler. 2001. Mutations in the mitotic check point gene, MAD1L1, in human cancers. Oncogene. 20:3301-5.
84. Wang, X., J.R. Babu, J.M. Harden, S.A. Jablonski, M.H. Gazi, W.L. Lingle, P.C. de Groen, T.J. Yen, and J.M. van Deursen. 2001. The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. J Biol Chem. 276:26559-67.
85. Wang, X., D.Y. Jin, R.W. Ng, H. Feng, Y.C. Wong, A.L. Cheung, and S.W. Tsao. 2002. Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells. Cancer Res. 62:1662-8.
86. Wang, X., D.Y. Jin, Y.C. Wong, A.L. Cheung, A.C. Chun, A.K. Lo, Y. Liu, and S.W. Tsao. 2000. Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells. Carcinogenesis. 21:2293-7.
87. Waters, J.C., R.H. Chen, A.W. Murray, and E.D. Salmon. 1998. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J Cell Biol. 141:1181-91.
88. Weaver, B.A., Z.Q. Bonday, F.R. Putkey, G.J. Kops, A.D. Silk, and D.W. Cleveland. 2003. Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J Cell Biol. 162:551-63.
89. Yao, X., A. Abrieu, Y. Zheng, K.F. Sullivan, and D.W. Cleveland. 2000. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Nat Cell Biol. 2:484-91.