Thermodynamics of ligand binding to P450 2B4 and P450eryF studied by isothermal titration calorimetry

Drug Metabolism Reviews

Volumn 39, Issue 2-3, 2007, Pages 539-556

  Muralidhara, B K ^a   Halpert, James R ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Allostery; Drug metabolism; Drug drug interactions; Heat capacity; Isothermal titration calorimetry; P450 flexibility; Structure based drug design; Thermodynamic signatures

Indexed keywords

1 (2 (BENZYLOXY)ETHYL) IMIDAZOLE; 1 (4 CHLOROPHENYL)IMIDAZOLE; 1 BENZYLIMIDAZOLE; 1 PHENYLIMIDAZOLE; 4 (4 CHLOROPHENYL)IMIDAZOLE; 4 PHENYLIMIDAZOLE; 4 PHENYLOPYRIDINE; BIFONAZOLE; CYTOCHROME P450; CYTOCHROME P450 2B4; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; IMIDAZOLE; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; BINDING AFFINITY; BINDING SITE; CONFORMATION; DRUG BINDING; DRUG DESIGN; DRUG METABOLISM; ENTROPY; HEAT EXCHANGE; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; MOLECULAR DYNAMICS; REVIEW; STOICHIOMETRY; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CALORIMETRY; GATA1 TRANSCRIPTION FACTOR; HUMANS; LIGANDS; PROTEIN BINDING; THERMODYNAMICS;

EID: 34548394914     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.1080/03602530701498182     Document Type: Review

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