The thermodynamic landscape of testosterone binding to cytochrome P450 3A4: Ligand binding and spin state equilibria

Biochemistry

Volumn 44, Issue 4, 2005, Pages 1353-1366

  Roberts, Arthur G ^a   Campbell, A Patricia ^a   Atkins, William M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION; ABSORPTION SPECTROSCOPY; CATALYSIS; DRUG PRODUCTS; ELECTRON SPIN RESONANCE SPECTROSCOPY; MATHEMATICAL MODELS; METABOLISM; REACTION KINETICS; SUBSTRATES; THERMODYNAMICS; TITRATION;

ABSORBANCE SPECTROSCOPY; CYTOCHROMES; FERRIC SPIN STATE; TESTOSTERONE;

ENZYMES;

CYTOCHROME P450 3A4; TESTOSTERONE;

AEROBIC METABOLISM; ARTICLE; BINDING AFFINITY; CATALYSIS; COMPLEX FORMATION; ELECTRON SPIN RESONANCE; ENZYME BINDING; ENZYME SUBSTRATE; LIGAND BINDING; MICHAELIS CONSTANT; MONITORING; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; THERMODYNAMICS; TITRIMETRY;

COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; ELECTRON SPIN RESONANCE SPECTROSCOPY; ESCHERICHIA COLI; HEME; HUMANS; KINETICS; LIGANDS; MODELS, CHEMICAL; PROTEIN BINDING; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY; SUBSTRATE SPECIFICITY; TESTOSTERONE; THERMODYNAMICS;

EID: 13444287729     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0481390     Document Type: Article

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