Conformational flexibility of mammalian cytochrome P450 2B4 in binding imidazole inhibitors with different ring chemistry and side chains: Solution thermodynamics and molecular modeling

Journal of Biological Chemistry

Volumn 281, Issue 12, 2006, Pages 8051-8061

  Muralidhara, B K ^a   Negi, Surendra ^a   Chin, Christopher C ^a   Braun, Werner ^a   Halpert, James R ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALORIMETRY; ENTROPY; ISOTHERMS; MOLECULAR DYNAMICS; SPECTROSCOPIC ANALYSIS; STOICHIOMETRY; THERMODYNAMICS;

CALORIMETRIC TITRATIONS; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR MODELING;

CYTOLOGY;

1 [2 (BENZYLOXY)ETHYL]IMIDAZOLE; 1 BENZYLIMIDAZOLE; 4 (4 CHLOROPHENYL)IMIDAZOLE; 4 PHENYLIMIDAZOLE; CYTOCHROME P450 2B; CYTOCHROME P450 2B4; IMIDAZOLE; UNCLASSIFIED DRUG; 1 (2 (BENZYLOXY)ETHYL)IMIDAZOLE; 1-(2-(BENZYLOXY)ETHYL)IMIDAZOLE; 1-BENZYLIMIDAZOLE; 4(5)-PHENYLIMIDAZOLE; ACRYLAMIDE DERIVATIVE; CYTOCHROME P 450 CYP2B4 (RABBIT); CYTOCHROME P-450 CYP2B4 (RABBIT); IMIDAZOLE DERIVATIVE; LIGAND; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CALORIMETRY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG INHIBITION; ENZYME INHIBITION; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPECTROSCOPY; THERMODYNAMICS; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HEAT; KINETICS; PROTEIN BINDING; PROTEIN CONFORMATION; RABBIT; SPECTROPHOTOMETRY; STATISTICAL MODEL; TEMPERATURE; TIME; ULTRACENTRIFUGATION; X RAY CRYSTALLOGRAPHY;

MAMMALIA;

ACRYLAMIDES; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HEAT; IMIDAZOLES; INHIBITORY CONCENTRATION 50; KINETICS; LIGANDS; MODELS, MOLECULAR; MODELS, STATISTICAL; PROTEIN BINDING; PROTEIN CONFORMATION; RABBITS; SPECTROPHOTOMETRY; TEMPERATURE; THERMODYNAMICS; TIME FACTORS; ULTRACENTRIFUGATION;

EID: 33646357912     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M509696200     Document Type: Article

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