Site-directed mutagenesis of cytochrome P450eryF: Implications for substrate oxidation, cooperativity, and topology of the active site

Chemical Research in Toxicology

Volumn 15, Issue 6, 2002, Pages 843-853

  Khan, Kishore K ^a   He, You Ai ^a   He, You Qun ^a   Halpert, James R ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CYTOCHROME P450; CYTOCHROME P450ERYF; GLYCINE; HETEROCYCLIC COMPOUND; ISOENZYME; ISOLEUCINE; LEUCINE; PHENANTHRENE DERIVATIVE; PHENYLALANINE; PYRROLE DERIVATIVE; QUINOLINE DERIVATIVE; SERINE; TESTOSTERONE; TRYPTOPHAN; UNCLASSIFIED DRUG; 7 BENZYLOXYQUINOLINE; 7-BENZYLOXYQUINOLINE; ERYTHOMYCIN A BIOSYNTHESIS HYDROLASE; LIGAND; MIXED FUNCTION OXIDASE; N PHENYLPROTOPORPHYRIN; N-PHENYLPROTOPORPHYRIN IX; PROTOPORPHYRIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME LOCALIZATION; ENZYME SUBSTRATE; HYDROXYLATION; NONHUMAN; OXIDATION; SITE DIRECTED MUTAGENESIS; SPECTROSCOPY; BINDING SITE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERISM; KINETICS; METABOLISM; OXIDATION REDUCTION REACTION; SPECTROPHOTOMETRY; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ISOMERISM; KINETICS; LIGANDS; MIXED FUNCTION OXYGENASES; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; PROTOPORPHYRINS; QUINOLINES; SPECTROPHOTOMETRY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TESTOSTERONE;

BACTERIA (MICROORGANISMS);

EID: 0035998284     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx025539k     Document Type: Article

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