Topological alteration of the CYP3A4 active site by the divalent cation Mg2+

Drug Metabolism and Disposition

Volumn 28, Issue 10, 2000, Pages 1198-1201

  Schrag, Michael L ^a   Wienkers, Larry C ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; DIVALENT CATION; IRON COMPLEX; MAGNESIUM ION; METAL COMPLEX; PROTOPORPHYRIN; TRIAZOLAM;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG HYDROXYLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; ISOMER; LYMPHOBLAST; MICHAELIS CONSTANT; OXIDATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REACTION ANALYSIS; REACTION TIME; STEREOCHEMISTRY;

BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HYDROXYLATION; IMINES; KINETICS; MAGNESIUM; MIXED FUNCTION OXYGENASES; OXIDATION-REDUCTION; PROTEIN CONFORMATION; PROTOPORPHYRINS; PYRENES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY; TRIAZOLAM;

EID: 0033815031     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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