Senescence as an anticancer mechanism

Journal of Clinical Oncology

Volumn 25, Issue 14, 2007, Pages 1852-1857

  Hornsby, Peter J ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; PROTEIN P21; PROTEIN P53;

ANTINEOPLASTIC ACTIVITY; CANCER INHIBITION; CELL CYCLE; CELL CYCLE ARREST; CELL DEATH; CELL DIVISION; DNA DAMAGE; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; HETEROCHROMATIN; HUMAN; ONCOGENE; ONCOGENE RAS; PRIORITY JOURNAL; REVIEW; SENESCENCE; TELOMERE;

AGED; BETA-GALACTOSIDASE; CELL AGING; CELL CYCLE; DNA DAMAGE; GENE EXPRESSION; GENES, TUMOR SUPPRESSOR; HUMANS; NEOPLASMS; TELOMERE;

EID: 34249818455     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2006.10.3101     Document Type: Review

References (81)

1. Prescott JC, Blackburn EH: Telomerase: Dr Jekyll or Mr Hyde? Curr Opin Genet Dev 9:368-373, 1999
2. Harrington L, Robinson MO: Telomere dysfunction: Multiple paths to the same end. Oncogene 21:592-597, 2002
3. Shay JW, Wright WE: Senescence and immortalization: Role of telomeres and telomerase. Carcinogenesis 26:867-874, 2005
4. Campisi J: Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors. Cell 120:513-522, 2005
5. von Zglinicki T, Saretzki G, Ladhoff J, et al: Human cell senescence as a DNA damage response. Mech Ageing Dev 126:111-117, 2005
6. Toussaint O, Remade J, Dierick JF, et al: From the Hayflick mosaic to the mosaics of ageing: Role of stress-induced premature senescence in human ageing. Int J Biochem Cell Biol 34:1415-1429, 2002
7. Shay JW, Roninson IB: Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23:2919-2933, 2004
8. Kahlem P, Dorken B, Schmitt CA: Cellular senescence in cancer treatment: Friend or foe? J Clin Invest 113:169-174, 2004
9. Ben-Porath I, Weinberg RA: When cells get stressed: An integrative view of cellular senescence. J Clin Invest 113:8-13, 2004
10. Schmitt CA: Senescence, apoptosis and therapy: Cutting the lifelines of cancer. Nat Rev Cancer 3:286-295, 2003
11. Roninson IB: Tumor cell senescence in cancer treatment. Cancer Res 63:2705-2715, 2003
12. Beausejour CM, Krtolica A, Galimi F, et al: Reversal of human cellular senescence: Roles of the p53 and p16 pathways. EMBO J 22:4212-4222, 2003
13. Bavik C, Coleman I, Dean JP, et al: The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms. Cancer Res 66:794-802, 2006
14. Hayflick L: Cell aging. Annu Rev Gerontol Geriatr 1:26-67, 1980
15. Herbig U, Ferreira M, Condel L, et al: Cellular senescence in aging primates. Science 311:1257, 2006
16. Hornsby PJ: Cellular senescence and tissue aging in vivo. J Gerontol 57:B251-B256, 2002
17. Serrano M, Lin AW, Mccurrach ME, et al: Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16 INK4A. Cell 88:593-602, 1997
18. Collado M, Serrano M: The power and the promise of oncogene-induced senescence markers. Nat Rev Cancer 6:472-476, 2006
19. Mooi WJ, Peeper DS: Oncogene-induced cell senescence: Halting on the road to cancer. N Engl J Med 355:1037-1046, 2006
20. Chin L, Tam A, Pomerantz J, et al: Essential role for oncogenic Ras in tumour maintenance. Nature 400:468-472, 1999
21. Benanti JA, Galloway DA: Normal human fibroblasts are resistant to RAS-induced senescence. Mol Cell Biol 24:2842-2852, 2004
22. Deng Q, Liao R, Wu BL, et al: High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. J Biol Chem 279:1050-1059, 2004
23. Pollock PM, Harper UL, Hansen KS, et al: High frequency of BRAF mutations in nevi. Nat Genet 33:19-20, 2003
24. Michaloglou C, Vredeveld LC, Soengas MS, et al: BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436:720-724, 2005
25. Frame FM, Rogoff HA, Pickering MT, et al: E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts. Oncogene 25:3258-3266, 2006
26. Abulaiti A, Fikaris AJ, Tsygankova OM, et al: Ras induces chromosome instability and abrogation of the DNA damage response. Cancer Res 66:10505-10512, 2006
27. Gorgoulis VG, Vassiliou LV, Karakaidos P, et al: Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434:907-913, 2005
28. Bartkova J, Horejsi Z, Koed K, et al: DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434:864-870, 2005
29. Davis T, Baird DM, Haughton MF, et al: Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor. J Gerontol 60A:1386-1393, 2005
30. Hong S, Pusapati RV, Powers JT, et al: Oncogenes and the DNA damage response: Myc and E2F1 engage the ATM signaling pathway to activate p53 and induce apoptosis. Cell Cycle 5:801-803, 2006
31. Robles SJ, Adami GR: Agents that cause DNA double strand breaks lead to p16(INK4A) enrichment and the premature senescence of normal fibroblasts. Oncogene 16:1113-1123, 1998
32. Parrinello S, Samper E, Krtolica A, et al: Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 5:741-747, 2003
33. Pilch DR, Sedelnikova OA, Redon C, et al: Characteristics of gamma-H2AX foci at DNA double-strand breaks sites. Biochem Cell Biol 81:123-129, 2003
34. Petrini JH, Stracker TH: The cellular response to DNA double-strand breaks: Defining the sensors and mediators. Trends Cell Biol 13:458-462, 2003
35. Vidanes GM, Bonilla CY, Toczyski DP: Complicated tails: Histone modifications and the DNA damage response. Cell 121:973-976, 2005
36. Thiriet C, Hayes JJ: Chromatin in need of a fix: Phosphorylation of H2AX connects chromatin to DNA repair. Mol Cell 18:617-622, 2005
37. Noda A, Ning Y, Venable SF, et al: Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 211:90-98, 1994
38. Smith JR, Pereira-Smith OM: Replicative senescence: Implications for in vivo aging and tumor suppression. Science 273:63-67, 1996
39. Alcorta DA, Xiong Y, Phelps D, et al: Involvement of the cyclin-dependent kinase inhibitor p16 INK4a in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci U S A 93:13742-13747, 1996
40. Krishnamurthy J, Torrice C, Ramsey MR, et al: Ink4a/Arf expression is a biomarker of aging. J Clin Invest 114:1299-1307, 2004
41. Ohtani N, Zebedee Z, Huot TJ, et al: Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature 409:1067-1070, 2001
42. Shapiro GI, Edwards CD, Ewen ME, et al: P16INK4A participates in a G1 arrest checkpoint in response to DNA damage. Mol Cell Biol 18:378-387, 1998
43. Jacobs JJ, de Lange T: Significant role for p16INK4a in p53-independent telomere-directed senescence. Curr Biol 14:2302-2308, 2004
44. Jacobs JJ, de Lange T: P16INK4a as a second effector of the telomere damage pathway. Cell Cycle 4:1364-1368, 2005
45. Iwasa H, Han J, Ishikawa F: Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 8:131-144, 2003
46. Bulavin DV, Fornace AJ Jr: P38 MAP kinase's emerging role as a tumor suppressor. Adv Cancer Res 92:95-118, 2004
47. Roux PP, Blenis J: ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 68:320-344, 2004
48. Zarubin T, Han J: Activation and signaling of the p38 MAP kinase pathway. Cell Res 15:11-18, 2005
49. Schulz VP, Zakian VA, Ogburn CE, et al: Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Hum Genet 97:750-754, 1996
50. Szekely AM, Bleichert F, Numann A, et al: Werner protein protects nonproliferating cells from oxidative DNA damage. Mol Cell Biol 25:10492-10506, 2005
51. Narita M, Nunez S, Heard E, et al: Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113:703-716, 2003
52. Park IK, Morrison SJ, Clarke MF: Bmi1, stem cells, and senescence regulation. J Clin Invest 113:175-179, 2004
53. Schulz L, Tyler J: Heterochromatin focuses on senescence. Mol Cell 17:168-170, 2005
54. Bakkenist CJ, Drissi R, Wu J, et al: Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. Cancer Res 64:3748-3752, 2004
55. West MD, Pereira-Smith OM, Smith JR: Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity. Exp Cell Res 184:138-147, 1989
56. Millis AJ, Hoyle M, McCue HM, et al: Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts. Exp Cell Res 201:373-379, 1992
57. Shelton DN, Chang E, Whittier PS, et al: Microarray analysis of replicative senescence. Curr Biol 9:939-945, 1999
58. Coussens LM, Werb Z: Inflammation and cancer. Nature 420:860-867, 2002
59. Krtolica A, Parrinello S, Lockett S, et al: Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging. Proc Natl Acad Sci U S A 98:12072-12077, 2001
60. Liu D, Hornsby PJ: Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion. Cancer Res 67:3117-3126, 2007
61. Dimri GP, Lee XH, Basile G, et al: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 92:9363-9367, 1995
62. Lee BY, Han JA, Im JS, et al: Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. Aging Cell 5:187-195, 2006
63. Romanov SR, Kozakiewicz BK, Holst CR, et al: Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature 409:633-637, 2001
64. Sjoblom T, Jones S, Wood LD, et al: The consensus coding sequences of human breast and colorectal cancers. Science 314:268-274, 2006
65. Roninson IB, Broude EV, Chang BD: If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat 4:303-313, 2001
66. Guiducci C, Cerone MA, Bacchetti S: Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability. Oncogene 20:714-725, 2001
67. Gisselsson D, Jonson T, Petersen A, et al: Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc Natl Acad Sci U S A 98:12683-12688, 2001
68. Gisselsson D, Bjork J, Hoglund M, et al: Abnormal nuclear shape in solid tumors reflects mitotic instability. Am J Pathol 158:199-206, 2001
69. Maser RS, DePinho RA: Connecting chromosomes, crisis, and cancer. Science 297:565-569, 2002
70. DePinho RA, Wong KK: The age of cancer: Telomeres, checkpoints, and longevity. J Clin Invest 111:S9-S14, 2003
71. Gisselsson D: Chromosome instability in cancer: How, when, and why? Adv Cancer Res 87:1-29, 2003
72. Sun B, Chen M, Hawks CL, et al: The minimal set of genetic alterations required for conversion of primary human fibroblasts to cancer cells in the subrenal capsule assay. Neoplasia 7:585-593, 2005
73. Hiyama E, Hiyama K, Yokoyama T, et al: Correlating telomerase activity levels with human neuroblastoma outcomes. Nat Med 1:249-255, 1995
74. Gordon KE, Ireland H, Roberts M, et al: High levels of telomere dysfunction bestow a selective disadvantage during the progression of human oral squamous cell carcinoma. Cancer Res 63:458-467, 2003
75. Neumann AA, Reddel RR: Telomere maintenance and cancer: Look, no telomerase. Nat Rev Cancer 2:879-884, 2002
76. Chang S, Khoo CM, Naylor ML, et al: Telomere-based crisis: Functional differences between telomerase activation and ALT in tumor progression. Genes Dev 17:88-100, 2003
77. Wright WE, Shay JW: Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology. Nat Med 6:849-851, 2000
78. Hornsby PJ: Mouse and human cells versus oxygen. Sci Aging Knowledge Environ 30:PE21, 2003
79. Hornsby PJ: Replicative senescence and cancer, in Balducci L, Extermann M (eds): Biological Basis of Geriatric Oncology. New York, NY, Springer, 2005, pp 53-73
80. Hornsby PJ: Cell proliferation in mammalian aging, in Masoro EJ, Austad SN (eds): Handbook of the Biology of Aging (ed 5). San Diego, CA, Academic Press, 2001, pp 207-266
81. Campisi J: Cancer and ageing: Rival demons? Nat Rev Cancer 3:339-349, 2003