메뉴 건너뛰기




Volumn 111, Issue 7, 2003, Pages

The age of cancer: Telomeres, checkpoints, and longevity

Author keywords

[No Author keywords available]

Indexed keywords

RNA DIRECTED DNA POLYMERASE; TELOMERASE;

EID: 0037380710     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (31)

References (76)
  • 1
    • 0037724456 scopus 로고    scopus 로고
    • American Cancer Society. Atlanta, Georgia, USA
    • 2002. Cancer facts and figures 2002. American Cancer Society. Atlanta, Georgia, USA. 1-14.
    • (2002) Cancer Facts and Figures 2002 , pp. 1-14
  • 2
    • 0003884696 scopus 로고    scopus 로고
    • US Department of Health and Human Services, Administration on Aging. Washington, DC, USA
    • 2002. A profile of older Americans: 2002. US Department of Health and Human Services, Administration on Aging. Washington, DC, USA. 1-14.
    • (2002) A Profile of Older Americans: 2002 , pp. 1-14
  • 3
    • 0034962026 scopus 로고    scopus 로고
    • Mutant and genetically modified mice as models for studying the relationship between aging and carcinogenesis
    • Anisimov, V.N. 2001. Mutant and genetically modified mice as models for studying the relationship between aging and carcinogenesis. Mech. Ageing Dev. 122:1221-1255.
    • (2001) Mech. Ageing Dev. , vol.122 , pp. 1221-1255
    • Anisimov, V.N.1
  • 4
    • 0036494673 scopus 로고    scopus 로고
    • The Mouse Tumor Biology Database: A public resource for cancer genetics and pathology of the mouse
    • Naf, D., Krupke, D.M., Sundberg, J.P., Eppig, J.T., and Bult, C.J. 2002. The Mouse Tumor Biology Database: a public resource for cancer genetics and pathology of the mouse. Cancer Res. 62:1235-1240.
    • (2002) Cancer Res. , vol.62 , pp. 1235-1240
    • Naf, D.1    Krupke, D.M.2    Sundberg, J.P.3    Eppig, J.T.4    Bult, C.J.5
  • 5
    • 0037178761 scopus 로고    scopus 로고
    • Connecting chromosomes, crisis, and cancer
    • Maser, R.S., and DePinho, R.A. 2002. Connecting chromosomes, crisis, and cancer. Science. 297:565-569.
    • (2002) Science , vol.297 , pp. 565-569
    • Maser, R.S.1    DePinho, R.A.2
  • 6
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D., and Weinberg, R.A. 2000. The hallmarks of cancer. Cell. 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 7
    • 0001352834 scopus 로고    scopus 로고
    • On the origin of multiple mutations in human cancers
    • Jackson, A.L., and Loeb, L.A. 1998. On the origin of multiple mutations in human cancers. Semin. Cancer Biol. 8:421-429.
    • (1998) Semin. Cancer Biol. , vol.8 , pp. 421-429
    • Jackson, A.L.1    Loeb, L.A.2
  • 8
    • 0031987280 scopus 로고    scopus 로고
    • Estimation of mutation frequencies in normal mammalian cells and the development of cancer
    • Turker, M.S. 1998. Estimation of mutation frequencies in normal mammalian cells and the development of cancer. Semin. Cancer Biol. 8:407-419.
    • (1998) Semin. Cancer Biol. , vol.8 , pp. 407-419
    • Turker, M.S.1
  • 9
    • 0035522894 scopus 로고    scopus 로고
    • Two genetic hits (more or less) to cancer
    • Knudson, A.G. 2001. Two genetic hits (more or less) to cancer. Nat. Rev. Cancer. 1:157-162.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 157-162
    • Knudson, A.G.1
  • 10
    • 0034682721 scopus 로고    scopus 로고
    • Cellular senescence: Mitotic clock or culture shock?
    • Sherr, C.J., and DePinho, R.A. 2000. Cellular senescence: mitotic clock or culture shock? Cell. 102:407-410.
    • (2000) Cell , vol.102 , pp. 407-410
    • Sherr, C.J.1    DePinho, R.A.2
  • 11
    • 0024443804 scopus 로고
    • Solid tumor cytogenetics. Progress since 1979
    • Atkin, N.B. 1989. Solid tumor cytogenetics. Progress since 1979. Cancer Genet. Cytogenet. 40:3-12.
    • (1989) Cancer Genet. Cytogenet. , vol.40 , pp. 3-12
    • Atkin, N.B.1
  • 12
    • 33646065584 scopus 로고
    • Uber asymmetrische zellteilung in eithelkrebsen und deren biologische bedeutung
    • von Hansemann, D. 1890. Uber asymmetrische Zellteilung in Eithelkrebsen und deren biologische Bedeutung. Virchows Arch. Path. Anat. 119:299-326.
    • (1890) Virchows Arch. Path. Anat. , vol.119 , pp. 299-326
    • Von Hansemann, D.1
  • 14
    • 33747830026 scopus 로고
    • Artificial transmutation of the gene
    • Muller, H.J. 1927. Artificial transmutation of the gene. Science. 46:84-87.
    • (1927) Science , vol.46 , pp. 84-87
    • Muller, H.J.1
  • 15
    • 0000049842 scopus 로고
    • The remaking of chromosomes
    • Muller, H.J. 1938. The remaking of chromosomes. Collecting Net. 13:181-198.
    • (1938) Collecting Net , vol.13 , pp. 181-198
    • Muller, H.J.1
  • 16
    • 0001294157 scopus 로고
    • The stability of broken ends of chromosomes in zea mays
    • McClintock, B. 1941. The stability of broken ends of chromosomes in zea mays. Genetics. 26:234-282.
    • (1941) Genetics , vol.26 , pp. 234-282
    • McClintock, B.1
  • 17
    • 0031939872 scopus 로고    scopus 로고
    • Telomerase activity, cell proliferation, and cancer
    • Greider, C.W. 1998. Telomerase activity, cell proliferation, and cancer. Proc. Natl. Acad Sci. U. S. A. 95:90-2.
    • (1998) Proc. Natl. Acad Sci. U. S. A. , vol.95 , pp. 90-92
    • Greider, C.W.1
  • 18
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley, C.B., Futcher, A.B., and Greider, C.W. 1990. Telomeres shorten during ageing of human fibroblasts. Nature. 345:458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 19
    • 0025143252 scopus 로고
    • Telomere reduction in human colorectal carcinoma and with ageing
    • Hastie, N.D., et al. 1990. Telomere reduction in human colorectal carcinoma and with ageing. Nature. 346:866-868.
    • (1990) Nature , vol.346 , pp. 866-868
    • Hastie, N.D.1
  • 20
    • 0026460896 scopus 로고
    • Telomere length predicts replicative capacity of human fibroblasts
    • Allsopp, R.C., et al. 1992. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 89:10114-10118.
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 10114-10118
    • Allsopp, R.C.1
  • 21
    • 0029013631 scopus 로고
    • Telomerase activity associated with acquisition of malignancy in human colorectal cancer
    • Chadeneau, C., Hay, K., Hirte, H.W., Gallinger, S., and Bacchetti, S. 1995. Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res. 55:2533-2536.
    • (1995) Cancer Res. , vol.55 , pp. 2533-2536
    • Chadeneau, C.1    Hay, K.2    Hirte, H.W.3    Gallinger, S.4    Bacchetti, S.5
  • 22
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar, A.G., et al. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science. 279:349-352.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1
  • 23
    • 0036118368 scopus 로고    scopus 로고
    • Enumeration of the simian virus 40 early region elements necessary for human cell transformation
    • Hahn, W.C., et al. 2002. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol. Cell. Biol. 22:2111-2123.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 2111-2123
    • Hahn, W.C.1
  • 24
    • 0025029030 scopus 로고
    • Hypervariable ultra-long telomeres in mice
    • Kipling, D., and Cooke, H.J. 1990. Hypervariable ultra-long telomeres in mice. Nature. 347:400-402.
    • (1990) Nature , vol.347 , pp. 400-402
    • Kipling, D.1    Cooke, H.J.2
  • 26
    • 0029941676 scopus 로고    scopus 로고
    • Telomerase activation in mouse mammary tumors: Lack of detectable telomere shortening and evidence for regulation oftelomerase RNA with cell proliferation
    • Broccoli, D., Godley, L.A., Donehower, L.A., Varmus, H.E., and de Lange, T. 1996. Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation oftelomerase RNA with cell proliferation. Mol. Cell. Biol. 16:3765-3772.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3765-3772
    • Broccoli, D.1    Godley, L.A.2    Donehower, L.A.3    Varmus, H.E.4    De Lange, T.5
  • 27
    • 0032473931 scopus 로고    scopus 로고
    • Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation
    • Greenberg, R.A., Allsopp, R.C., Chin, L., Morin, G.B., and DePinho, R.A. 1998. Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene. 16:1723-1730.
    • (1998) Oncogene , vol.16 , pp. 1723-1730
    • Greenberg, R.A.1    Allsopp, R.C.2    Chin, L.3    Morin, G.B.4    DePinho, R.A.5
  • 28
    • 0030931491 scopus 로고    scopus 로고
    • Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
    • Blasco, M.A., et al. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 91:25-34.
    • (1997) Cell , vol.91 , pp. 25-34
    • Blasco, M.A.1
  • 29
    • 0032499210 scopus 로고    scopus 로고
    • Essential role of mouse telomerase in highly proliferative organs
    • Lee, H.W., et al. 1998. Essential role of mouse telomerase in highly proliferative organs. Nature. 392:569-574.
    • (1998) Nature , vol.392 , pp. 569-574
    • Lee, H.W.1
  • 30
    • 0033525558 scopus 로고    scopus 로고
    • Longevity, stress response, and cancer in aging telomerase-deficient mice
    • Rudolph, K.L., et al. 1999. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell. 96:701-712.
    • (1999) Cell , vol.96 , pp. 701-712
    • Rudolph, K.L.1
  • 31
    • 0033553516 scopus 로고    scopus 로고
    • p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • Chin, L., et al. 1999. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell. 97:527-538.
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1
  • 32
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter, C.M., et al. 1992. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1921-1929.
    • (1992) EMBO J. , vol.11 , pp. 1921-1929
    • Counter, C.M.1
  • 33
    • 0034978564 scopus 로고    scopus 로고
    • Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
    • Rudolph, K.L., Millard, M., Bosenberg, M.W., and DePinho, R.A. 2001. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat. Genet. 28:155-159.
    • (2001) Nat. Genet. , vol.28 , pp. 155-159
    • Rudolph, K.L.1    Millard, M.2    Bosenberg, M.W.3    DePinho, R.A.4
  • 34
    • 0037224923 scopus 로고    scopus 로고
    • Telomere-based crisis: Functional differences between relomerase activation and ALT in tumor progression
    • Chang, S., Khoo, C.M., Naylor, M.L., Maser, R.S., and DePinho, R.A. 2003. Telomere-based crisis: functional differences between relomerase activation and ALT in tumor progression. Genes Dev. 17:88-100.
    • (2003) Genes Dev. , vol.17 , pp. 88-100
    • Chang, S.1    Khoo, C.M.2    Naylor, M.L.3    Maser, R.S.4    DePinho, R.A.5
  • 35
    • 84965187257 scopus 로고
    • The age distribution of cancer and a multi-stage theory of carcinogenesis
    • Armitage, P., and Doll, R. 1954. The age distribution of cancer and a multi-stage theory of carcinogenesis. Br. J. Cancer. 8:1-12.
    • (1954) Br. J. Cancer , vol.8 , pp. 1-12
    • Armitage, P.1    Doll, R.2
  • 36
    • 0027254069 scopus 로고
    • How many mutations are required for tumorigenesis? Implications from human cancer data
    • Renan, M.J. 1993. How many mutations are required for tumorigenesis? Implications from human cancer data. Mol. Carcinog. 7:139-146.
    • (1993) Mol. Carcinog. , vol.7 , pp. 139-146
    • Renan, M.J.1
  • 37
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • Artandi, S.E., et al. 2000. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature. 406:641-645.
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1
  • 38
    • 0000839280 scopus 로고    scopus 로고
    • Telomere dysfunction provokes regional amplification and deletion in cancer genomes
    • O'Hagan, R.C., et al. 2002. Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell. 2:149-155.
    • (2002) Cancer Cell , vol.2 , pp. 149-155
    • O'Hagan, R.C.1
  • 39
    • 0030838976 scopus 로고    scopus 로고
    • Genetic alterations in primary breast cancers and their metastases: Direct comparison using modified comparative genomic hybridization
    • Nishizaki, T., et al. 1997. Genetic alterations in primary breast cancers and their metastases: direct comparison using modified comparative genomic hybridization. Genes Chromosomes Cancer. 19:267-272.
    • (1997) Genes Chromosomes Cancer , vol.19 , pp. 267-272
    • Nishizaki, T.1
  • 40
    • 0032980789 scopus 로고    scopus 로고
    • Comparative genomic hybridization of ductal carcinoma in situ of the breast: Evidence of multiple genetic pathways
    • Buerger, H., et al. 1999. Comparative genomic hybridization of ductal carcinoma in situ of the breast: evidence of multiple genetic pathways. J. Pathol. 187:396-402.
    • (1999) J. Pathol. , vol.187 , pp. 396-402
    • Buerger, H.1
  • 41
    • 0032969473 scopus 로고    scopus 로고
    • Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastases
    • Al-Mulla, F., Keith, W.N., Pickford, I.R., Going, J.J., and Birnie, G.D. 1999. Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastases. Genes Chromosomes Cancer. 24:306-314.
    • (1999) Genes Chromosomes Cancer , vol.24 , pp. 306-314
    • Al-Mulla, F.1    Keith, W.N.2    Pickford, I.R.3    Going, J.J.4    Birnie, G.D.5
  • 42
    • 0034016185 scopus 로고    scopus 로고
    • Genome changes and gene expression in human solid tumors
    • Gray, J.W., and Collins, C. 2000. Genome changes and gene expression in human solid tumors. Carcinogenesis. 21:443-452.
    • (2000) Carcinogenesis , vol.21 , pp. 443-452
    • Gray, J.W.1    Collins, C.2
  • 43
    • 0032531003 scopus 로고    scopus 로고
    • Close correlation between telomerase expression and adenomatous polyp progression in multistep colorectal carcinogenesis
    • Tang, R., Cheng, A.-J., Wang, J.-Y., and Wang, T.-C.V. 1998. Close correlation between telomerase expression and adenomatous polyp progression in multistep colorectal carcinogenesis. Cancer Res. 58:4052-4054.
    • (1998) Cancer Res. , vol.58 , pp. 4052-4054
    • Tang, R.1    Cheng, A.-J.2    Wang, J.-Y.3    Wang, T.-C.V.4
  • 44
    • 18644370262 scopus 로고    scopus 로고
    • Chromosomal instability in ulcerative colitis is related to telomere shortening
    • O'Sullivan, J.N., et al. 2002. Chromosomal instability in ulcerative colitis is related to telomere shortening. Nat. Genet. 32:280-284.
    • (2002) Nat. Genet. , vol.32 , pp. 280-284
    • O'Sullivan, J.N.1
  • 45
    • 0035940501 scopus 로고    scopus 로고
    • Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors
    • Gisselsson, D., et al. 2001. Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc. Natl. Acad. Sci. U. S. A. 98:12683-12688.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 12683-12688
    • Gisselsson, D.1
  • 46
    • 0033518188 scopus 로고    scopus 로고
    • A telomerase component is defective in the human disease dyskeratosis congenita
    • Mitchell, J.R., Wood, E., and Collins, K. 1999. A telomerase component is defective in the human disease dyskeratosis congenita. Nature. 402:551-555.
    • (1999) Nature , vol.402 , pp. 551-555
    • Mitchell, J.R.1    Wood, E.2    Collins, K.3
  • 47
    • 0035960043 scopus 로고    scopus 로고
    • The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
    • Vulliamy, T., et al. 2001. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature. 413:432-435.
    • (2001) Nature , vol.413 , pp. 432-435
    • Vulliamy, T.1
  • 48
    • 0034681457 scopus 로고    scopus 로고
    • Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery
    • Rudolph, K.L., Chang, S., Millard, M., Schreiber-Agus, N., and DePinho, R.A. 2000. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science. 287:1253-1258.
    • (2000) Science , vol.287 , pp. 1253-1258
    • Rudolph, K.L.1    Chang, S.2    Millard, M.3    Schreiber-Agus, N.4    DePinho, R.A.5
  • 49
    • 0028201293 scopus 로고
    • Activation of telomerase in a human tumor
    • de Lange, T. 1994. Activation of telomerase in a human tumor. Proc. Natl. Acad. Sci. U. S. A. 91:2882-2885.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 2882-2885
    • De Lange, T.1
  • 50
    • 0033620609 scopus 로고    scopus 로고
    • Two MAD tails: What the recent knockouts of Mad1 and Mxil tell us about the MYC/MAX/MAD network
    • Foley, K.P., and Eisenman, R.N. 1999. Two MAD tails: what the recent knockouts of Mad1 and Mxil tell us about the MYC/MAX/MAD network. Biochim. Biophys. Acta. 1423:M37-M47.
    • (1999) Biochim. Biophys. Acta , vol.1423
    • Foley, K.P.1    Eisenman, R.N.2
  • 52
    • 0031054261 scopus 로고    scopus 로고
    • Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis
    • Miura, N., et al. 1997. Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis. Cancer Genet. Cytogenet. 93:56-62.
    • (1997) Cancer Genet. Cytogenet. , vol.93 , pp. 56-62
    • Miura, N.1
  • 53
    • 10544224540 scopus 로고    scopus 로고
    • Telomere length in human liver diseases
    • Urabe, Y., et al. 1996. Telomere length in human liver diseases. Liver. 16:293-297.
    • (1996) Liver , vol.16 , pp. 293-297
    • Urabe, Y.1
  • 54
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R.A. 1995. The retinoblastoma protein and cell cycle control. Cell. 81:323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 55
    • 0027251720 scopus 로고
    • Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
    • Debbas, M., and White, E. 1993. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev. 7:546-554.
    • (1993) Genes Dev. , vol.7 , pp. 546-554
    • Debbas, M.1    White, E.2
  • 56
    • 0027934570 scopus 로고
    • p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
    • Morgenbesser, S.D., Williams, B.O., Jacks, T., and DePinho, R.A. 1994. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature. 371:72-74.
    • (1994) Nature , vol.371 , pp. 72-74
    • Morgenbesser, S.D.1    Williams, B.O.2    Jacks, T.3    DePinho, R.A.4
  • 57
    • 0028169994 scopus 로고
    • p53-dependent apoptosis suppresses tumor growth and progression in vivo
    • Symonds, H., et al. 1994. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell. 78:703-711.
    • (1994) Cell , vol.78 , pp. 703-711
    • Symonds, H.1
  • 58
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • Kim, N.W., et al. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science. 266:2011-2015.
    • (1994) Science , vol.266 , pp. 2011-2015
    • Kim, N.W.1
  • 59
    • 0030070054 scopus 로고    scopus 로고
    • Differential regulation of telomerase activity and telomerase RNA during multistage tumorigenesis
    • Blasco, M.A., Rizen, M., Greider, C.W., and Hanahan, D. 1996. Differential regulation of telomerase activity and telomerase RNA during multistage tumorigenesis. Nat. Genet. 12:200-204.
    • (1996) Nat. Genet. , vol.12 , pp. 200-204
    • Blasco, M.A.1    Rizen, M.2    Greider, C.W.3    Hanahan, D.4
  • 60
    • 0000146723 scopus 로고    scopus 로고
    • Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse
    • Greenberg, R.A., et al. 1999. Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell. 97:515-525.
    • (1999) Cell , vol.97 , pp. 515-525
    • Greenberg, R.A.1
  • 61
    • 0033614998 scopus 로고    scopus 로고
    • Creation of human tumour cells with defined genetic elements
    • Hahn, W.C., et al. 1999. Creation of human tumour cells with defined genetic elements. Nature. 400:464-468.
    • (1999) Nature , vol.400 , pp. 464-468
    • Hahn, W.C.1
  • 62
    • 0034175962 scopus 로고    scopus 로고
    • Flipping the oncogene switch: Illumination of tumor maintenance and regression
    • Chin, L., and DePinho, R.A. 2000. Flipping the oncogene switch: illumination of tumor maintenance and regression. Trends Genet. 16:147-150.
    • (2000) Trends Genet. , vol.16 , pp. 147-150
    • Chin, L.1    DePinho, R.A.2
  • 63
    • 0030728468 scopus 로고    scopus 로고
    • Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
    • Kamijo, T., et al. 1997. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell. 91:649-659.
    • (1997) Cell , vol.91 , pp. 649-659
    • Kamijo, T.1
  • 64
    • 0032549704 scopus 로고    scopus 로고
    • The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
    • Pomerantz, J., et al. 1998. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell. 92:713-723.
    • (1998) Cell , vol.92 , pp. 713-723
    • Pomerantz, J.1
  • 65
    • 0026693776 scopus 로고
    • Myc family oncoproteins function through a common pathway to transform normal cells in culture: Cross-interference by Max and trans-acting dominant mutants
    • Mukherjee, B., Morgenbesser, S.D., and DePinho, R.A. 1992. Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants. Genes Dev. 6:1480-1492.
    • (1992) Genes Dev. , vol.6 , pp. 1480-1492
    • Mukherjee, B.1    Morgenbesser, S.D.2    DePinho, R.A.3
  • 66
    • 0032482421 scopus 로고    scopus 로고
    • Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth
    • Schreiber-Agus, N., et al. 1998. Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth. Nature. 393:483-487.
    • (1998) Nature , vol.393 , pp. 483-487
    • Schreiber-Agus, N.1
  • 67
    • 0030959244 scopus 로고    scopus 로고
    • Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
    • Alland, L., et al. 1997. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature. 387:49-55.
    • (1997) Nature , vol.387 , pp. 49-55
    • Alland, L.1
  • 68
    • 0029993450 scopus 로고    scopus 로고
    • Role of the INK4a locus in tumor suppression and cell mortality
    • Serrano, M., et al. 1996. Role of the INK4a locus in tumor suppression and cell mortality. Cell. 85:27-37.
    • (1996) Cell , vol.85 , pp. 27-37
    • Serrano, M.1
  • 69
    • 0035817688 scopus 로고    scopus 로고
    • Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
    • Sharpless, N.E., et al. 2001. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature. 413:86-91.
    • (2001) Nature , vol.413 , pp. 86-91
    • Sharpless, N.E.1
  • 70
    • 0033614962 scopus 로고    scopus 로고
    • Essential role for oncogenic Ras in tumour maintenance
    • Chin, L., et al. 1999. Essential role for oncogenic Ras in tumour maintenance. Nature. 400:468-472.
    • (1999) Nature , vol.400 , pp. 468-472
    • Chin, L.1
  • 71
    • 0033001621 scopus 로고    scopus 로고
    • Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion
    • Pelengaris, S., Littlewood, T., Khan, M., Elia, G., and Evan, G. 1999. Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol. Cell. 3:565-577.
    • (1999) Mol. Cell , vol.3 , pp. 565-577
    • Pelengaris, S.1    Littlewood, T.2    Khan, M.3    Elia, G.4    Evan, G.5
  • 72
    • 0037013147 scopus 로고    scopus 로고
    • Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
    • Pelengaris, S., Khan, M., and Evan, G.I. 2002. Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell. 109:321-334.
    • (2002) Cell , vol.109 , pp. 321-334
    • Pelengaris, S.1    Khan, M.2    Evan, G.I.3
  • 73
    • 0037025201 scopus 로고    scopus 로고
    • Sustained loss of a neoplastic phenotype by brief inactivation of MYC
    • Jain, M., et al. 2002. Sustained loss of a neoplastic phenotype by brief inactivation of MYC. Science. 297:102-104.
    • (2002) Science , vol.297 , pp. 102-104
    • Jain, M.1
  • 74
    • 0033180211 scopus 로고    scopus 로고
    • Reversible tumorigenesis by MYC in hematopoietic lineages
    • Felsher, D.W., and Bishop, J.M. 1999. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol. Cell. 4:199-207.
    • (1999) Mol. Cell , vol.4 , pp. 199-207
    • Felsher, D.W.1    Bishop, J.M.2
  • 75
    • 0033616602 scopus 로고    scopus 로고
    • Transient excess of MYC activity can elicit genomic instability and tumorigenesis
    • Felsher, D.W., and Bishop, J.M. 1999. Transient excess of MYC activity can elicit genomic instability and tumorigenesis. Proc Natl. Acad. Sci. U. S. A. 96:3940-3944.
    • (1999) Proc Natl. Acad. Sci. U. S. A. , vol.96 , pp. 3940-3944
    • Felsher, D.W.1    Bishop, J.M.2
  • 76
    • 0035893318 scopus 로고    scopus 로고
    • Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
    • Fisher, G.H., et al. 2001. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev. 15:3249-3262.
    • (2001) Genes Dev. , vol.15 , pp. 3249-3262
    • Fisher, G.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.