메뉴 건너뛰기




Volumn 60, Issue 11, 2005, Pages 1386-1393

Prevention of accelerated cell aging in Werner Syndrome using a p38 mitogen-activated protein kinase inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLIN DEPENDENT KINASE INHIBITOR 1; DIMETHYL SULFOXIDE; DNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; SYNAPTOPHYSIN;

EID: 29144451333     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/60.11.1386     Document Type: Article
Times cited : (82)

References (36)
  • 1
    • 0032825111 scopus 로고    scopus 로고
    • What geriatricians should know about the Werner syndrome
    • Martin GM, Oshima J, Gray MD, Poot M. What geriatricians should know about the Werner syndrome. J Am Geriatr Soc. 1999;47:1136-1144.
    • (1999) J Am Geriatr Soc , vol.47 , pp. 1136-1144
    • Martin, G.M.1    Oshima, J.2    Gray, M.D.3    Poot, M.4
  • 2
    • 4444281968 scopus 로고    scopus 로고
    • What can progeroid syndromes tell us about human aging?
    • Kipling D, Davis T, Ostler EL, Faragher RG. What can progeroid syndromes tell us about human aging? Science. 2004;305:1426-1431.
    • (2004) Science , vol.305 , pp. 1426-1431
    • Kipling, D.1    Davis, T.2    Ostler, E.L.3    Faragher, R.G.4
  • 3
    • 0022335895 scopus 로고
    • A comparison of adult and childhood progerias: Werner syndrome and Hutchinson-Gilford progeria syndrome
    • Brown WT, Kieras FJ, Houck GE Jr, Dutkowski R, Jenkins EC. A comparison of adult and childhood progerias: Werner syndrome and Hutchinson-Gilford progeria syndrome. Adv Exp Med Biol. 1985;190:229-244.
    • (1985) Adv Exp Med Biol , vol.190 , pp. 229-244
    • Brown, W.T.1    Kieras, F.J.2    Houck Jr., G.E.3    Dutkowski, R.4    Jenkins, E.C.5
  • 4
    • 15844409553 scopus 로고    scopus 로고
    • Positional cloning of the Werner's syndrome gene
    • Yu CE, Oshima J, Fu YH, et al. Positional cloning of the Werner's syndrome gene. Science. 1996;272:258-262.
    • (1996) Science , vol.272 , pp. 258-262
    • Yu, C.E.1    Oshima, J.2    Fu, Y.H.3
  • 5
    • 0035880025 scopus 로고    scopus 로고
    • Unwinding the molecular basis of the Werner syndrome
    • Shen J, Loeb LA. Unwinding the molecular basis of the Werner syndrome. Mech Ageing Dev. 2001;122:921-944.
    • (2001) Mech Ageing Dev , vol.122 , pp. 921-944
    • Shen, J.1    Loeb, L.A.2
  • 6
    • 0031060263 scopus 로고    scopus 로고
    • Chromosome instability syndromes: Lessons for carcinogenesis
    • Meyn MS. Chromosome instability syndromes: lessons for carcinogenesis. Curr Top Microbiol Immunol. 1997;221:71-148.
    • (1997) Curr Top Microbiol Immunol , vol.221 , pp. 71-148
    • Meyn, M.S.1
  • 7
    • 0019444282 scopus 로고
    • Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts
    • Salk D, Bryant E, Au K, Hoehn H, Martin GM. Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts. Hum Genet. 1981;58:310-316.
    • (1981) Hum Genet , vol.58 , pp. 310-316
    • Salk, D.1    Bryant, E.2    Au, K.3    Hoehn, H.4    Martin, G.M.5
  • 8
    • 0021171248 scopus 로고
    • Werner's syndrome: An underdiagnosed disorder resembling premature aging
    • Tollefsbol TO, Cohen HJ. Werner's syndrome: an underdiagnosed disorder resembling premature aging. Age. 1984;7:75-88.
    • (1984) Age , vol.7 , pp. 75-88
    • Tollefsbol, T.O.1    Cohen, H.J.2
  • 10
    • 0017668626 scopus 로고
    • A retarded rate of DNA replication and normal level of DNA repair in Werner's syndrome fibroblasts in culture
    • Fujiwara Y, Higashikawa T, Tatsumi M. A retarded rate of DNA replication and normal level of DNA repair in Werner's syndrome fibroblasts in culture. J Cell Physiol. 1977;92:365-374.
    • (1977) J Cell Physiol , vol.92 , pp. 365-374
    • Fujiwara, Y.1    Higashikawa, T.2    Tatsumi, M.3
  • 11
    • 0020306698 scopus 로고
    • Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblasts
    • Takeuchi F, Hanaoka F, Goto M, Yamada M, Miyamoto T. Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblasts. Exp Gerontol. 1982;17:473-480.
    • (1982) Exp Gerontol , vol.17 , pp. 473-480
    • Takeuchi, F.1    Hanaoka, F.2    Goto, M.3    Yamada, M.4    Miyamoto, T.5
  • 12
    • 0026702210 scopus 로고
    • Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines
    • Poot M, Hoehn H, Runger TM, Martin GM. Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp Cell Res. 1992;202:267-273.
    • (1992) Exp Cell Res , vol.202 , pp. 267-273
    • Poot, M.1    Hoehn, H.2    Runger, T.M.3    Martin, G.M.4
  • 14
    • 0031057892 scopus 로고    scopus 로고
    • Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells
    • Huot J, Houle F, Marceau F, Landry J. Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells. Circ Res. 1997;80:383-392.
    • (1997) Circ Res , vol.80 , pp. 383-392
    • Huot, J.1    Houle, F.2    Marceau, F.3    Landry, J.4
  • 15
    • 0031056783 scopus 로고    scopus 로고
    • Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27
    • Guay J, Lambert H, Gingras-Bretan G, Lavoie JN, Huot J, Landry J. Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27. J Cell Sci. 1997;110:357-368.
    • (1997) J Cell Sci , vol.110 , pp. 357-368
    • Guay, J.1    Lambert, H.2    Gingras-Bretan, G.3    Lavoie, J.N.4    Huot, J.5    Landry, J.6
  • 16
    • 0036242247 scopus 로고    scopus 로고
    • Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
    • Wang W, Chen JX, Liao R, et al. Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol. 2002;22:3389-3403.
    • (2002) Mol Cell Biol , vol.22 , pp. 3389-3403
    • Wang, W.1    Chen, J.X.2    Liao, R.3
  • 17
    • 0346463059 scopus 로고    scopus 로고
    • High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts
    • Deng Q, Liao R, Wu BL, Sun P. High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. J Biol Chem. 2004;279:1050-1059.
    • (2004) J Biol Chem , vol.279 , pp. 1050-1059
    • Deng, Q.1    Liao, R.2    Wu, B.L.3    Sun, P.4
  • 18
    • 0037119470 scopus 로고    scopus 로고
    • The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation
    • Kim GY, Mercer SE, Ewton DZ, Yan Z, Jin K, Friedman E. The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation. J Biol Chem. 2002;277:29792-19802.
    • (2002) J Biol Chem , vol.277 , pp. 29792-119802
    • Kim, G.Y.1    Mercer, S.E.2    Ewton, D.Z.3    Yan, Z.4    Jin, K.5    Friedman, E.6
  • 19
    • 0036731380 scopus 로고    scopus 로고
    • Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence
    • Haq R, Brenton JD, Takahashi M, et al. Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. Cancer Res. 2002;62:5076-5082.
    • (2002) Cancer Res , vol.62 , pp. 5076-5082
    • Haq, R.1    Brenton, J.D.2    Takahashi, M.3
  • 20
    • 0345932931 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway
    • Iwasa H, Han J, Ishikawa F. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells. 2003;8:131-144.
    • (2003) Genes Cells , vol.8 , pp. 131-144
    • Iwasa, H.1    Han, J.2    Ishikawa, F.3
  • 21
    • 0033987424 scopus 로고    scopus 로고
    • Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
    • Wyllie FS, Jones CJ, Skinner JW, et al. Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts. Nat Genet. 2000;24:16-17.
    • (2000) Nat Genet , vol.24 , pp. 16-17
    • Wyllie, F.S.1    Jones, C.J.2    Skinner, J.W.3
  • 22
    • 0037383795 scopus 로고    scopus 로고
    • Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms
    • Davis T, Singhrao SK, Wyllie FS, et al. Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms. J Cell Sci. 2003;116:1349-1357.
    • (2003) J Cell Sci , vol.116 , pp. 1349-1357
    • Davis, T.1    Singhrao, S.K.2    Wyllie, F.S.3
  • 23
    • 0037313185 scopus 로고    scopus 로고
    • Extensive allelic variation and ultrashort telomeres in senescent human cells
    • Baird DM, Rowson J, Wynford-Thomas D, Kipling D. Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet. 2003;33:203-207.
    • (2003) Nat Genet , vol.33 , pp. 203-207
    • Baird, D.M.1    Rowson, J.2    Wynford-Thomas, D.3    Kipling, D.4
  • 24
    • 0028295472 scopus 로고
    • The expression of proliferation-dependent antigens during the lifespan of normal and progeroid human fibroblasts in culture
    • Kill IR, Faragher RG, Lawrence K, Shall S. The expression of proliferation-dependent antigens during the lifespan of normal and progeroid human fibroblasts in culture. J Cell Sci. 1994;107:571-579.
    • (1994) J Cell Sci , vol.107 , pp. 571-579
    • Kill, I.R.1    Faragher, R.G.2    Lawrence, K.3    Shall, S.4
  • 25
    • 4744371424 scopus 로고    scopus 로고
    • Morphological adjustment of senescent cells by modulating caveolin-1 status
    • Cho KA, Ryu SJ, Oh YS, et al. Morphological adjustment of senescent cells by modulating caveolin-1 status. J Biol Chem. 2004;279:42270-42278.
    • (2004) J Biol Chem , vol.279 , pp. 42270-42278
    • Cho, K.A.1    Ryu, S.J.2    Oh, Y.S.3
  • 26
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science. 1998;279:349-352.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Ouellette, M.2    Frolkis, M.3
  • 27
    • 0029971241 scopus 로고    scopus 로고
    • Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells
    • Schulz VP, Zakian VA, Ogburn CE, et al. Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Hum Genet. 1996;97:750-754.
    • (1996) Hum Genet , vol.97 , pp. 750-754
    • Schulz, V.P.1    Zakian, V.A.2    Ogburn, C.E.3
  • 28
    • 3543130605 scopus 로고    scopus 로고
    • Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells
    • Baird DM, Davis T, Rowson J, Jones CJ, Kipling D. Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells. Hum Mol Genet. 2004;13:1515-1524.
    • (2004) Hum Mol Genet , vol.13 , pp. 1515-1524
    • Baird, D.M.1    Davis, T.2    Rowson, J.3    Jones, C.J.4    Kipling, D.5
  • 30
    • 0029924534 scopus 로고    scopus 로고
    • From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: The telomere loss/DNA damage model of cell aging
    • Vaziri H, Benchimol S. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging. Exp Gerontol. 1996;31:295-301.
    • (1996) Exp Gerontol , vol.31 , pp. 295-301
    • Vaziri, H.1    Benchimol, S.2
  • 31
    • 3242739250 scopus 로고    scopus 로고
    • Investigation of the signaling pathways involved in the proliferative life span barriers in Werner syndrome fibroblasts
    • Davis T, Faragher RG, Jones CJ, Kipling D. Investigation of the signaling pathways involved in the proliferative life span barriers in Werner syndrome fibroblasts. Ann N Y Acad Sci. 2004;1019:274-277.
    • (2004) Ann N Y Acad Sci , vol.1019 , pp. 274-277
    • Davis, T.1    Faragher, R.G.2    Jones, C.J.3    Kipling, D.4
  • 32
    • 0142123097 scopus 로고    scopus 로고
    • Gene expression profiling in Werner syndrome closely resembles that of normal aging
    • Kyng KJ, May A, Kolvraa S, Bohr VA. Gene expression profiling in Werner syndrome closely resembles that of normal aging. Proc Natl Acad Sci U S A. 2003;100:12259-12264.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12259-12264
    • Kyng, K.J.1    May, A.2    Kolvraa, S.3    Bohr, V.A.4
  • 33
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev. 2001;81:807-869.
    • (2001) Physiol Rev , vol.81 , pp. 807-869
    • Kyriakis, J.M.1    Avruch, J.2
  • 34
    • 0037083375 scopus 로고    scopus 로고
    • MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha
    • Ge B, Gram H, Di Padova F, et al. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science. 2002;295:1291-1294.
    • (2002) Science , vol.295 , pp. 1291-1294
    • Ge, B.1    Gram, H.2    Di Padova, F.3
  • 35
    • 3543043128 scopus 로고    scopus 로고
    • Essential role of limiting telomeres in the pathogenesis of Werner syndrome
    • Chang S, Multani AS, Cabrera NG, et al. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet. 2004;36:877-882.
    • (2004) Nat Genet , vol.36 , pp. 877-882
    • Chang, S.1    Multani, A.S.2    Cabrera, N.G.3
  • 36
    • 3342918498 scopus 로고    scopus 로고
    • The p38 MAP kinase pathway as a therapeutic target in inflammatory disease
    • Saklatvala J. The p38 MAP kinase pathway as a therapeutic target in inflammatory disease. Curr Opin Pharmacol. 2004;4:372-377. 1394-1398
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 372-377
    • Saklatvala, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.