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Volumn 113, Issue 2, 2004, Pages 169-174

Cellular senescence in cancer treatment: Friend or foe?

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA GALACTOSIDASE; CELL DNA; CYCLIN DEPENDENT KINASE 4; PROTEIN P16; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; DNA; PROTEIN P16INK4A;

EID: 85047694328     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI20784     Document Type: Review
Times cited : (104)

References (55)
  • 1
    • 0037013154 scopus 로고    scopus 로고
    • A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
    • Schmitt, C.A., et al. 2002. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell. 109:335-346.
    • (2002) Cell , vol.109 , pp. 335-346
    • Schmitt, C.A.1
  • 2
    • 0037086268 scopus 로고    scopus 로고
    • DNA damage is able to induce senescence in tumor cells in vitro and in vivo
    • te Poele, R.H., Okorokov, A.L., Jardine, L., Cummings, J., and Joel, S.P. 2002. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res. 62:1876-1883.
    • (2002) Cancer Res. , vol.62 , pp. 1876-1883
    • Te Poele, R.H.1    Okorokov, A.L.2    Jardine, L.3    Cummings, J.4    Joel, S.P.5
  • 3
    • 0035736138 scopus 로고    scopus 로고
    • If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells
    • Roninson, I.B., Broude, E.V., and Chang, B.D. 2001. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist. Updat. 4:303-313.
    • (2001) Drug Resist. Updat. , vol.4 , pp. 303-313
    • Roninson, I.B.1    Broude, E.V.2    Chang, B.D.3
  • 4
    • 0032485213 scopus 로고    scopus 로고
    • Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
    • Robles, S.J., and Adami, G.R. 1998. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene. 16:1113-1123.
    • (1998) Oncogene , vol.16 , pp. 1113-1123
    • Robles, S.J.1    Adami, G.R.2
  • 5
    • 17444388849 scopus 로고    scopus 로고
    • A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents
    • Chang, B.D., et al. 1999. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res. 59:3761-3767.
    • (1999) Cancer Res. , vol.59 , pp. 3761-3767
    • Chang, B.D.1
  • 6
    • 0035219571 scopus 로고    scopus 로고
    • Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening
    • Suzuki, K., et al. 2001. Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening. Radiat. Res. 155:248-253.
    • (2001) Radiat. Res. , vol.155 , pp. 248-253
    • Suzuki, K.1
  • 7
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick, L., and Moorhead, P.S. 1961. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25:585-621.
    • (1961) Exp. Cell Res. , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 8
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri, G.P., et al. 1995. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U. S. A. 92:9363-9367.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 9363-9367
    • Dimri, G.P.1
  • 9
    • 0000962421 scopus 로고    scopus 로고
    • Control of replicative senescence
    • S.A.J. Rowe, editor. Academic Press. New York, New York, USA
    • Campisi, J., Dimri, G., and Hara, E. 1996. Control of replicative senescence. In Handbook of the biology of aging. S.A.J. Rowe, editor. Academic Press. New York, New York, USA. 121-149.
    • (1996) Handbook of the Biology of Aging , pp. 121-149
    • Campisi, J.1    Dimri, G.2    Hara, E.3
  • 11
    • 0031586589 scopus 로고    scopus 로고
    • The tumor suppressor protein p16INK4a
    • Serrano, M. 1997. The tumor suppressor protein p16INK4a. Exp. Cell Res. 237:7-13.
    • (1997) Exp. Cell Res. , vol.237 , pp. 7-13
    • Serrano, M.1
  • 12
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • Narita, M., et al. 2003. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell. 113:703-716.
    • (2003) Cell , vol.113 , pp. 703-716
    • Narita, M.1
  • 13
    • 0032427628 scopus 로고    scopus 로고
    • The role of ATM in DNA damage responses and cancer
    • Canman, C.E., and Lim, D.S. 1998. The role of ATM in DNA damage responses and cancer. Oncogene. 17:3301-3308.
    • (1998) Oncogene , vol.17 , pp. 3301-3308
    • Canman, C.E.1    Lim, D.S.2
  • 14
    • 0034659730 scopus 로고    scopus 로고
    • DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling
    • Tee, A.R., and Proud, C.G. 2000. DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling. Oncogene. 19:3021-3031.
    • (2000) Oncogene , vol.19 , pp. 3021-3031
    • Tee, A.R.1    Proud, C.G.2
  • 15
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham, R.T. 2001. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15:2177-2196.
    • (2001) Genes Dev. , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 16
    • 0035313706 scopus 로고    scopus 로고
    • DNA-PK, ATM and ATR as sensors of DNA damage: Variations on a theme?
    • Durocher, D., and Jackson, S.P. 2001. DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr. Opin. Cell Biol. 13:225-231.
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 225-231
    • Durocher, D.1    Jackson, S.P.2
  • 17
    • 0037178748 scopus 로고    scopus 로고
    • Interfaces between the detection, signaling, and repair of DNA damage
    • Rouse, J., and Jackson, S.P. 2002. Interfaces between the detection, signaling, and repair of DNA damage. Science. 297:547-551.
    • (2002) Science , vol.297 , pp. 547-551
    • Rouse, J.1    Jackson, S.P.2
  • 19
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A.J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 20
    • 0032530486 scopus 로고    scopus 로고
    • DNA damage activates p53 through a phosphorylation-acetylation cascade
    • Sakaguchi, K., et al. 1998. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 12:2831-2841.
    • (1998) Genes Dev. , vol.12 , pp. 2831-2841
    • Sakaguchi, K.1
  • 21
  • 22
    • 0033118933 scopus 로고    scopus 로고
    • DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization
    • Shieh, S.Y., Taya, Y., and Prives, C. 1999. DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization. EMB0 J. 18:1815-1823.
    • (1999) EMB0 J. , vol.18 , pp. 1815-1823
    • Shieh, S.Y.1    Taya, Y.2    Prives, C.3
  • 23
    • 0034710870 scopus 로고    scopus 로고
    • Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage
    • Chao, C., Saito, S., Anderson, C.W., Appella, E., and Xu, Y. 2000. Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc. Natl. Acad. Sci. U. S. A. 97:11936-11941.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 11936-11941
    • Chao, C.1    Saito, S.2    Anderson, C.W.3    Appella, E.4    Xu, Y.5
  • 24
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden, K.H., and Lu, X. 2002. Live or let die: the cell's response to p53. Nat. Rev. Cancer. 2:594-604.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 25
    • 0034664733 scopus 로고    scopus 로고
    • p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
    • Oda, K., et al. 2000. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell. 102:849-862.
    • (2000) Cell , vol.102 , pp. 849-862
    • Oda, K.1
  • 26
    • 18244379872 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
    • D'Orazi, G., et al. 2002. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat. Cell Biol. 4:11-19.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 11-19
    • D'Orazi, G.1
  • 27
    • 0034114544 scopus 로고    scopus 로고
    • Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage
    • Webley, K., et al. 2000. Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage. Mol. Cell. Biol. 20:2803-2808.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2803-2808
    • Webley, K.1
  • 28
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano, M., Lin, A.W., McCurrach, M.E., Beach, D., and Lowe, S.W. 1997. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 88:593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 29
    • 0031594707 scopus 로고    scopus 로고
    • p16INK4A participates in a G1 arrest checkpoint in response to DNA damage
    • Shapiro, G.I., Edwards, C.D., Ewen, M.E., and Rollins, B.J. 1998. p16INK4A participates in a G1 arrest checkpoint in response to DNA damage. Mol. Cell. Biol. 18:378-387.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 378-387
    • Shapiro, G.I.1    Edwards, C.D.2    Ewen, M.E.3    Rollins, B.J.4
  • 30
    • 0034616913 scopus 로고    scopus 로고
    • Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage
    • Agami, R., and Bernards, R. 2000. Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage. Cell. 102:55-66.
    • (2000) Cell , vol.102 , pp. 55-66
    • Agami, R.1    Bernards, R.2
  • 31
    • 0034523993 scopus 로고    scopus 로고
    • Differential gene expression in p53-mediated G(1) arrest of human fibroblasts after gamma-irradiation or N-phosphoacetyl-L-aspartate treatment
    • Seidita, G., Polizzi, D., Costanzo, G., Costa, S., and Di Leonardo, A. 2000. Differential gene expression in p53-mediated G(1) arrest of human fibroblasts after gamma-irradiation or N-phosphoacetyl-L-aspartate treatment. Carcinogenesis. 21:2203-2210.
    • (2000) Carcinogenesis , vol.21 , pp. 2203-2210
    • Seidita, G.1    Polizzi, D.2    Costanzo, G.3    Costa, S.4    Di Leonardo, A.5
  • 32
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A., and Jacks, T. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 362:847-849.
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 34
    • 0037309193 scopus 로고    scopus 로고
    • Chemotherapy response and resistance
    • Lee, S., and Schmitt, C.A. 2003. Chemotherapy response and resistance. Curr. Opin. Genet. Dev. 13:90-96.
    • (2003) Curr. Opin. Genet. Dev. , vol.13 , pp. 90-96
    • Lee, S.1    Schmitt, C.A.2
  • 35
    • 18444380541 scopus 로고    scopus 로고
    • INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence
    • Brookes, S., et al. 2002. INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J. 21:2936-2945.
    • (2002) EMBO J. , vol.21 , pp. 2936-2945
    • Brookes, S.1
  • 36
    • 0029023626 scopus 로고
    • Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved
    • Wang, E. 1995. Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Res. 55:2284-2292.
    • (1995) Cancer Res. , vol.55 , pp. 2284-2292
    • Wang, E.1
  • 37
    • 0035940459 scopus 로고    scopus 로고
    • The tumor-infiltrating B cell response in medullary breast cancer is oligoclonal and directed against the autoantigen actin exposed on the surface of apoptotic cancer cells
    • Hansen, M.H., Nielsen, H., and Ditzel, H.J. 2001. The tumor-infiltrating B cell response in medullary breast cancer is oligoclonal and directed against the autoantigen actin exposed on the surface of apoptotic cancer cells. Proc. Natl. Acad. Sci. U. S. A. 98:12659-12664.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 12659-12664
    • Hansen, M.H.1    Nielsen, H.2    Ditzel, H.J.3
  • 38
    • 0038820117 scopus 로고    scopus 로고
    • Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal
    • Lauber, K., et al. 2003. Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell. 113:717-730.
    • (2003) Cell , vol.113 , pp. 717-730
    • Lauber, K.1
  • 39
    • 0024536234 scopus 로고
    • Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages
    • Savill, J.S., et al. 1989. Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. J. Clin. Invest. 83:865-875.
    • (1989) J. Clin. Invest. , vol.83 , pp. 865-875
    • Savill, J.S.1
  • 40
    • 0031716156 scopus 로고    scopus 로고
    • Senescent human neutrophil binding to thrombospondin (TSP): Evidence for a TSP-independent pathway of phagocytosis by macrophages
    • Murphy, J.F., McGregor, J.L., and Leung, L.L. 1998. Senescent human neutrophil binding to thrombospondin (TSP): evidence for a TSP-independent pathway of phagocytosis by macrophages. Br. J. Haematol. 102:957-964.
    • (1998) Br. J. Haematol. , vol.102 , pp. 957-964
    • Murphy, J.F.1    McGregor, J.L.2    Leung, L.L.3
  • 41
    • 0042206639 scopus 로고    scopus 로고
    • Association of increased autophagic inclusions labeled for beta-galactosidase with fibroblastic aging
    • Gerland, L.M., et al. 2003. Association of increased autophagic inclusions labeled for beta-galactosidase with fibroblastic aging. Exp. Gerontol. 38:887-895.
    • (2003) Exp. Gerontol. , vol.38 , pp. 887-895
    • Gerland, L.M.1
  • 42
    • 0030842655 scopus 로고    scopus 로고
    • Cell-cycle arrest versus cell death in cancer therapy
    • Waldman, T., et al. 1997. Cell-cycle arrest versus cell death in cancer therapy. Nat. Med. 3:1034-1036.
    • (1997) Nat. Med. , vol.3 , pp. 1034-1036
    • Waldman, T.1
  • 43
    • 0035834121 scopus 로고    scopus 로고
    • Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
    • Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.Y., and Campisi, J. 2001. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl. Acad. Sci. U. S. A. 98:12072-12077.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 12072-12077
    • Krtolica, A.1    Parrinello, S.2    Lockett, S.3    Desprez, P.Y.4    Campisi, J.5
  • 44
    • 0041966056 scopus 로고    scopus 로고
    • Reversal of human cellular senescence: Roles of the p53 and p16 pathways
    • Beausejour, C.M., et al. 2003. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J. 22:4212-4222.
    • (2003) EMBO J. , vol.22 , pp. 4212-4222
    • Beausejour, C.M.1
  • 45
    • 0037686707 scopus 로고    scopus 로고
    • Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53
    • Dirac, A.M., and Bernards, R. 2003. Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53. J. Biol. Chem. 278:11731-11734.
    • (2003) J. Biol. Chem. , vol.278 , pp. 11731-11734
    • Dirac, A.M.1    Bernards, R.2
  • 46
    • 0038342441 scopus 로고    scopus 로고
    • Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
    • Sage, J., Miller, A.L., Perez-Mancera, P.A., Wysocki, J.M., and Jacks, T. 2003. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature. 424:223-228.
    • (2003) Nature , vol.424 , pp. 223-228
    • Sage, J.1    Miller, A.L.2    Perez-Mancera, P.A.3    Wysocki, J.M.4    Jacks, T.5
  • 47
    • 0042929916 scopus 로고    scopus 로고
    • pRb inactivation in senescent cells leads to an E2F-dependent apoptosis requiring p73
    • Alexander, K., Yang, H.S., and Hinds, P.W. 2003. pRb inactivation in senescent cells leads to an E2F-dependent apoptosis requiring p73. Mol. Cancer Res. 1:716-728.
    • (2003) Mol. Cancer Res. , vol.1 , pp. 716-728
    • Alexander, K.1    Yang, H.S.2    Hinds, P.W.3
  • 48
    • 0033569423 scopus 로고    scopus 로고
    • INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
    • Schmitt, C.A., McCurrach, M.E., de Stanchina, E., Wallace-Brodeur, R.R., and Lowe, S.W. 1999. INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes Dev. 13:2670-2677.
    • (1999) Genes Dev. , vol.13 , pp. 2670-2677
    • Schmitt, C.A.1    McCurrach, M.E.2    De Stanchina, E.3    Wallace-Brodeur, R.R.4    Lowe, S.W.5
  • 49
    • 0034727833 scopus 로고    scopus 로고
    • Genomic aberrations and survival in chronic lymphocytic leukemia
    • Dohner, H., et al. 2000. Genomic aberrations and survival in chronic lymphocytic leukemia. N. Engl. J. Med. 343:1910-1916.
    • (2000) N. Engl. J. Med. , vol.343 , pp. 1910-1916
    • Dohner, H.1
  • 50
    • 0033826530 scopus 로고    scopus 로고
    • Genetic analysis of chemoresistance in primary murine lymphomas
    • Schmitt, C.A., Rosenthal, C.T., and Lowe, S.W. 2000. Genetic analysis of chemoresistance in primary murine lymphomas. Nat. Med. 6:1029-1035.
    • (2000) Nat. Med. , vol.6 , pp. 1029-1035
    • Schmitt, C.A.1    Rosenthal, C.T.2    Lowe, S.W.3
  • 51
    • 0042125511 scopus 로고    scopus 로고
    • Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer
    • Chang, J.C., et al. 2003. Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer. Lancet. 362:362-369.
    • (2003) Lancet , vol.362 , pp. 362-369
    • Chang, J.C.1
  • 52
    • 0344305439 scopus 로고    scopus 로고
    • Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukaemia
    • Holleman, A., Den Boer, M.L., Kazemier, K.M., Janka-Schaub, G.E., and Pieters, R. 2003. Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukaemia. Blood. 102:4541-4546.
    • (2003) Blood , vol.102 , pp. 4541-4546
    • Holleman, A.1    Den Boer, M.L.2    Kazemier, K.M.3    Janka-Schaub, G.E.4    Pieters, R.5
  • 53
    • 0036897350 scopus 로고    scopus 로고
    • Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner
    • doi:10.1172/JCI200216588
    • Lodygin, D., Menssen, A., and Hermeking, H. 2002. Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner. J. Clin. Invest. 110:1717-1727. doi:10.1172/ JCI200216588.
    • (2002) J. Clin. Invest. , vol.110 , pp. 1717-1727
    • Lodygin, D.1    Menssen, A.2    Hermeking, H.3
  • 54
    • 0035925574 scopus 로고    scopus 로고
    • Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4
    • Soni, R., et al. 2001. Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. J. Natl. Cancer Inst. 93:436-446.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 436-446
    • Soni, R.1
  • 55
    • 0038032792 scopus 로고    scopus 로고
    • RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells
    • Hall, A.H., and Alexander, K.A. 2003. RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells. J. Virol. 77:6066-6069.
    • (2003) J. Virol. , vol.77 , pp. 6066-6069
    • Hall, A.H.1    Alexander, K.A.2


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