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Volumn 2, Issue 11, 2002, Pages 879-884

Telomere maintenance and cancer - Look, no telomerase

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE LENGTHENING OF TELOMERE INHIBITOR; ANTINEOPLASTIC AGENT; TELOMERASE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; ENZYME INHIBITOR; RAD52 PROTEIN; RAD52 PROTEIN, HUMAN; RAD52 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; TUMOR PROTEIN;

EID: 0036832737     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc929     Document Type: Review
Times cited : (136)

References (83)
  • 1
    • 0013462065 scopus 로고
    • n, present at the telomeres of human chromosomes
    • n, present at the telomeres of human chromosomes. Proc. Natl Acad. Sci. USA 85, 6622-6626 (1988).
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 6622-6626
    • Moyzis, R.K.1
  • 2
    • 0025731583 scopus 로고
    • Structure and function of telomeres
    • Blackburn, E. H. Structure and function of telomeres. Nature 350, 569-573 (1991).
    • (1991) Nature , vol.350 , pp. 569-573
    • Blackburn, E.H.1
  • 3
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • de Lange, T. Protection of mammalian telomeres, Oncogene 21, 532-540 (2002).
    • (2002) Oncogene , vol.21 , pp. 532-540
    • De Lange, T.1
  • 4
    • 0029953557 scopus 로고    scopus 로고
    • Evidence for a new step in telomere maintenance
    • Wellinger, R. J., Ethier, K., Labrecque, P. & Zakian, V. A. Evidence for a new step in telomere maintenance. Cell 85, 423-433 (1996).
    • (1996) Cell , vol.85 , pp. 423-433
    • Wellinger, R.J.1    Ethier, K.2    Labrecque, P.3    Zakian, V.A.4
  • 5
    • 0031000884 scopus 로고    scopus 로고
    • Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
    • Makarov, V. L., Hirose, Y. & Langmore, J. P. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88, 657-666 (1997).
    • (1997) Cell , vol.88 , pp. 657-666
    • Makarov, V.L.1    Hirose, Y.2    Langmore, J.P.3
  • 6
    • 0030731928 scopus 로고    scopus 로고
    • Normal human chromosomes have long G-rich telomeric overhangs at one end
    • Wright, W. E., Tesmer, V. M., Huffman, K. E., Levene, S. D. & Shay, J. W. Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev. 11, 2801-2809 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 2801-2809
    • Wright, W.E.1    Tesmer, V.M.2    Huffman, K.E.3    Levene, S.D.4    Shay, J.W.5
  • 7
    • 0033553536 scopus 로고    scopus 로고
    • Mammalian telomeres end in a large duplex loop
    • Griffith, J. D. et al. Mammalian telomeres end in a large duplex loop. Cell 91, 503-514 (1999).
    • (1999) Cell , vol.91 , pp. 503-514
    • Griffith, J.D.1
  • 8
    • 0015184804 scopus 로고
    • Principle of marginotomy in template synthesis of polynucleotides
    • Olovnikov, A. M. [Principle of marginotomy in template synthesis of polynucleotides]. Doklady Akademii. Nauk. SSR 201, 1496-1499 (1971).
    • (1971) Doklady Akademii. Nauk. SSR , vol.201 , pp. 1496-1499
    • Olovnikov, A.M.1
  • 9
    • 0015515155 scopus 로고
    • Origin of concatemeric T7 DNA
    • Watson, J. D. Origin of concatemeric T7 DNA. Nature New Biol. 239, 197-201 (1972).
    • (1972) Nature New Biol. , vol.239 , pp. 197-201
    • Watson, J.D.1
  • 11
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley, C. B., Futcher, A. B. & Greider, C. W. Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460 (1990).
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 12
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick, L. & Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621 (1961).
    • (1961) Exp. Cell Res. , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 13
    • 0019973132 scopus 로고
    • Induction of immortality is an early prerequisite event in malignant transformation of mammalian cells by carcinogens
    • Newbold, R. F., Overell, R. W. & Connell, J. R. Induction of immortality is an early prerequisite event in malignant transformation of mammalian cells by carcinogens. Nature 299, 633-635 (1982).
    • (1982) Nature , vol.299 , pp. 633-635
    • Newbold, R.F.1    Overell, R.W.2    Connell, J.R.3
  • 14
    • 0023007274 scopus 로고
    • Suppression of tumor growth by senescence in virally transformed human fibroblasts
    • O'Brien, W., Stenman, G. & Sager R. Suppression of tumor growth by senescence in virally transformed human fibroblasts. Proc. Natl Acad. Sci. USA 83, 8659-8663 (1986).
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 8659-8663
    • O'Brien, W.1    Stenman, G.2    Sager, R.3
  • 15
    • 0021999501 scopus 로고
    • Neoplastic transformation of human epidermal keratinocytes by AD12-SV40 and Kirsten sarcoma viruses
    • Rhim, J. S. et al. Neoplastic transformation of human epidermal keratinocytes by AD12-SV40 and Kirsten sarcoma viruses. Science 227, 1250-1252 (1985).
    • (1985) Science , vol.227 , pp. 1250-1252
    • Rhim, J.S.1
  • 16
    • 0024204746 scopus 로고
    • Human bronchial epithelial cells neoplastically transformed by v-Ki-ras: Altered response to inducers of terminal squamous differentiation
    • Reddel, R. R. et al. Human bronchial epithelial cells neoplastically transformed by v-Ki-ras: altered response to inducers of terminal squamous differentiation. Oncogene Res. 3, 401-408 (1988).
    • (1988) Oncogene Res. , vol.3 , pp. 401-408
    • Reddel, R.R.1
  • 17
    • 0002889389 scopus 로고
    • SV40-induced transformation of human diploid cells: Crisis and recovery
    • Girardi, A. J., Jensen, F. C. & Koprowski, H. SV40-induced transformation of human diploid cells: crisis and recovery. J. Cell. Comp. Physiol. 65, 69-84 (1965).
    • (1965) J. Cell. Comp. Physiol. , vol.65 , pp. 69-84
    • Girardi, A.J.1    Jensen, F.C.2    Koprowski, H.3
  • 18
    • 0021815615 scopus 로고
    • Establishment and characterization of a permanent pSV ori-transformed ataxia-telangiectasia cell line
    • Murnane, J. P., Fuller, L. F. & Painter, R. B. Establishment and characterization of a permanent pSV ori-transformed ataxia-telangiectasia cell line. Exp. Cell Res. 158, 119-126 (1985).
    • (1985) Exp. Cell Res. , vol.158 , pp. 119-126
    • Murnane, J.P.1    Fuller, L.F.2    Painter, R.B.3
  • 19
    • 0028322713 scopus 로고
    • SV40-induced immortalization of human cells
    • Bryan, T. M. & Reddel, R. R. SV40-induced immortalization of human cells. Crit. Rev. Oncogenesis 5, 831-857 (1994).
    • (1994) Crit. Rev. Oncogenesis , vol.5 , pp. 831-857
    • Bryan, T.M.1    Reddel, R.R.2
  • 20
    • 0142237266 scopus 로고
    • Limited and unlimited growth of SV40-transformed cells from human diploid MRC-5 fibroblasts
    • Huschtscha, L. I. & Holliday, R. Limited and unlimited growth of SV40-transformed cells from human diploid MRC-5 fibroblasts. J. Cell Sci. 83, 77-99 (1988).
    • (1988) J. Cell Sci. , vol.83 , pp. 77-99
    • Huschtscha, L.I.1    Holliday, R.2
  • 21
    • 0024426688 scopus 로고
    • Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen
    • Shay, J. W. & Wright, W. E. Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen. Exp. Cell Res. 184, 109-118 (1989).
    • (1989) Exp. Cell Res. , vol.184 , pp. 109-118
    • Shay, J.W.1    Wright, W.E.2
  • 23
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter, C. M. et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11, 1921-1929 (1992).
    • (1992) EMBO J. , vol.11 , pp. 1921-1929
    • Counter, C.M.1
  • 24
    • 0015844590 scopus 로고
    • A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
    • Olovnikov, A. M. A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J. Theor. Biol. 41, 181-190 (1973).
    • (1973) J. Theor. Biol. , vol.41 , pp. 181-190
    • Olovnikov, A.M.1
  • 26
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider, C. W. & Blackburn, E. H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43, 405-413 (1985).
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 27
    • 0033019840 scopus 로고    scopus 로고
    • Telomerase activity is sufficient to allow transformed cells to escape from crisis
    • Halvorsen, T. L., Leibowitz, G. & Levine, F. Telomerase activity is sufficient to allow transformed cells to escape from crisis. Mol. Cell Biol. 19, 1864-1870 (1999).
    • (1999) Mol. Cell Biol. , vol.19 , pp. 1864-1870
    • Halvorsen, T.L.1    Leibowitz, G.2    Levine, F.3
  • 28
    • 0032440891 scopus 로고    scopus 로고
    • Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
    • Counter, C. M. et al. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc. Natl Acad. Sci. USA 95, 14723-14728 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 14723-14728
    • Counter, C.M.1
  • 29
    • 0033614998 scopus 로고    scopus 로고
    • Creation of human tumour cells with defined genetic elements
    • Hahn, W. C. et al. Creation of human tumour cells with defined genetic elements. Nature 400, 464-468 (1999).
    • (1999) Nature , vol.400 , pp. 464-468
    • Hahn, W.C.1
  • 30
    • 0028007237 scopus 로고
    • Telomere dynamics in an immortal human cell line
    • Murnane, J. P., Sabatier, L., Marder, B. A. & Morgan, W. F. Telomere dynamics in an immortal human cell line. EMBO J. 13, 4953-4962 (1994).
    • (1994) EMBO J. , vol.13 , pp. 4953-4962
    • Murnane, J.P.1    Sabatier, L.2    Marder, B.A.3    Morgan, W.F.4
  • 31
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • Kim, N. W. et al. Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2015 (1994).
    • (1994) Science , vol.266 , pp. 2011-2015
    • Kim, N.W.1
  • 32
    • 0029162563 scopus 로고
    • Telomere elongation in immortal human cells without detectable telomerase activity
    • Bryan, T. M., Englezou, A., Gupta, J., Bacchetti, S. & Reddel, R. R. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14, 4240-4248 (1995).
    • (1995) EMBO J. , vol.14 , pp. 4240-4248
    • Bryan, T.M.1    Englezou, A.2    Gupta, J.3    Bacchetti, S.4    Reddel, R.R.5
  • 33
    • 0030990049 scopus 로고    scopus 로고
    • Telomere dynamics and telomerase activity in in vitro immortalised human cells
    • Bryan, T. M. & Reddel, R. R. Telomere dynamics and telomerase activity in in vitro immortalised human cells. Eur. J. Cancer. 33, 767-773 (1997).
    • (1997) Eur. J. Cancer , vol.33 , pp. 767-773
    • Bryan, T.M.1    Reddel, R.R.2
  • 34
    • 0030916582 scopus 로고    scopus 로고
    • The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit
    • Bryan, T. M., Marusic, L., Bacchetti, S., Namba, M. & Reddel, R. R. The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit. Hum. Mol. Genet 6, 921-926 (1997).
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 921-926
    • Bryan, T.M.1    Marusic, L.2    Bacchetti, S.3    Namba, M.4    Reddel, R.R.5
  • 35
    • 0033593814 scopus 로고    scopus 로고
    • Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice
    • Hande, M. P., Samper, E., Lansdorp, P. & Blasco, M. A. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J. Cell Biol. 144, 589-601 (1999).
    • (1999) J. Cell Biol. , vol.144 , pp. 589-601
    • Hande, M.P.1    Samper, E.2    Lansdorp, P.3    Blasco, M.A.4
  • 36
    • 0032514373 scopus 로고    scopus 로고
    • Telomerase activity during spontaneous immortalization of Li-Fraumeni syndrome skin fibroblasts
    • Gollahon, L. S. et al. Telomerase activity during spontaneous immortalization of Li-Fraumeni syndrome skin fibroblasts Oncogene 17, 709-717 (1998).
    • (1998) Oncogene , vol.17 , pp. 709-717
    • Gollahon, L.S.1
  • 37
    • 0033199695 scopus 로고    scopus 로고
    • Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body
    • Yeager, T. R. et al. Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res. 59, 4175-4179 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 4175-4179
    • Yeager, T.R.1
  • 38
    • 0030697342 scopus 로고    scopus 로고
    • Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
    • Bryan, T. M., Englezou, A., Dalla-Pozza, L., Dunham, M. A. & Reddel, R. R. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nature Med. 3, 1271-1274 (1997).
    • (1997) Nature Med. , vol.3 , pp. 1271-1274
    • Bryan, T.M.1    Englezou, A.2    Dalla-Pozza, L.3    Dunham, M.A.4    Reddel, R.R.5
  • 39
    • 0037148281 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres in mammalian cells
    • Henson, J. D., Neumann, A. A., Yeager, T. R. & Reddel, R. R. Alternative lengthening of telomeres in mammalian cells. Oncogene 21, 598-610 (2002).
    • (2002) Oncogene , vol.21 , pp. 598-610
    • Henson, J.D.1    Neumann, A.A.2    Yeager, T.R.3    Reddel, R.R.4
  • 40
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay, J. W. & Bacchetti, S. A survey of telomerase activity in human cancer. Eur. J. Cancer 33, 787-791 (1997).
    • (1997) Eur. J. Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 41
    • 0034012226 scopus 로고    scopus 로고
    • The role of senescence and immortalization in carcinogenesis
    • Reddel, R. R. The role of senescence and immortalization in carcinogenesis. Carcinogenesis 21, 477-484 (2000).
    • (2000) Carcinogenesis , vol.21 , pp. 477-484
    • Reddel, R.R.1
  • 42
    • 0035444984 scopus 로고    scopus 로고
    • Telomere maintenance by telomerase and by recombination can coexist in human cells
    • Cerone, M. A., Londono-Vallejo, J. A. & Bacchetti, S. Telomere maintenance by telomerase and by recombination can coexist in human cells. Hum. Mol. Genet. 10, 1945-1952 (2001).
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1945-1952
    • Cerone, M.A.1    Londono-Vallejo, J.A.2    Bacchetti, S.3
  • 43
    • 0035445809 scopus 로고    scopus 로고
    • Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathway
    • Grobelny, J. V., Kulp-McEliece, M. & Broccoli, D. Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathway. Hum. Mol. Genet. 10, 1953-1961 (2001).
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1953-1961
    • Grobelny, J.V.1    Kulp-McEliece, M.2    Broccoli, D.3
  • 44
    • 0034998040 scopus 로고    scopus 로고
    • Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM 847 cells
    • Perrem, K., Colgin, L. M., Neumann, A. A. Yeager, T. R. & Reddel, R. R. Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells. Mol. Cell. Biol. 21, 3862-3875 (2001)
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3862-3875
    • Perrem, K.1    Colgin, L.M.2    Neumann, A.A.3    Yeager, T.R.4    Reddel, R.R.5
  • 45
    • 0035943603 scopus 로고    scopus 로고
    • Telomerase can inhibit the recombination-based pathway of telomere maintenance in human cells
    • Ford, L. P. et al. Telomerase can inhibit the recombination-based pathway of telomere maintenance in human cells. J. Biol. Chem. 276, 32198-32203 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 32198-32203
    • Ford, L.P.1
  • 46
    • 18644373013 scopus 로고    scopus 로고
    • Telomerase contributes to tumorigenesis by a telomere length-independent mechanism
    • Stewart, S. A. et al. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc. Natl Acad. Sci. USA 99, 12606-12611 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 12606-12611
    • Stewart, S.A.1
  • 47
    • 0033568462 scopus 로고    scopus 로고
    • Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
    • Zhang, X., Mar V., Zhou, W., Harrington, L. & Robinson, M. O. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev. 13, 2388-2399 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 2388-2399
    • Zhang, X.1    Mar, V.2    Zhou, W.3    Harrington, L.4    Robinson, M.O.5
  • 48
    • 0032828652 scopus 로고    scopus 로고
    • Inhibition of telomerase limits the growth of human cancer cells
    • Hahn, W. C. et al. Inhibition of telomerase limits the growth of human cancer cells. Nature Med. 5, 1164-1170 (1999).
    • (1999) Nature Med. , vol.5 , pp. 1164-1170
    • Hahn, W.C.1
  • 49
    • 0033455559 scopus 로고    scopus 로고
    • Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
    • Herbert, B.-S. et al. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc. Natl Acad. Sci. USA 96, 14276-14281 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 14276-14281
    • Herbert, B.-S.1
  • 50
    • 4243937106 scopus 로고    scopus 로고
    • A highly selective telomerase inhibitor limiting human cancer cell proliferation
    • Damm, K. et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J. 20, 6958-6968 (2001).
    • (2001) EMBO J. , vol.20 , pp. 6958-6968
    • Damm, K.1
  • 51
    • 0037148271 scopus 로고    scopus 로고
    • Telomerase in the human organism
    • Collins, K. & Mitchell, J. R. Telomerase in the human organism. Oncogene 21, 564-579 (2002).
    • (2002) Oncogene , vol.21 , pp. 564-579
    • Collins, K.1    Mitchell, J.R.2
  • 52
    • 0033754823 scopus 로고    scopus 로고
    • Dyskeratosis congenita in all its forms
    • Dokal, I. Dyskeratosis congenita in all its forms. Br. J. Haematol. 110, 768-779 (2000).
    • (2000) Br. J. Haematol. , vol.110 , pp. 768-779
    • Dokal, I.1
  • 53
    • 0343750697 scopus 로고    scopus 로고
    • Impaired germinal center reaction in mice with short telomeres
    • Herrera, E., Martinez, C. & Blasco, M. A. Impaired germinal center reaction in mice with short telomeres. EMBO J. 19, 472-481 (2000).
    • (2000) EMBO J. , vol.19 , pp. 472-481
    • Herrera, E.1    Martinez, C.2    Blasco, M.A.3
  • 55
    • 0035822079 scopus 로고    scopus 로고
    • Defects in mismatch repair promote telomerase-independent proliferation
    • Rizki, A. & Lundblad, V. Defects in mismatch repair promote telomerase-independent proliferation. Nature 411, 713-716 (2001).
    • (2001) Nature , vol.411 , pp. 713-716
    • Rizki, A.1    Lundblad, V.2
  • 56
    • 0037047068 scopus 로고    scopus 로고
    • The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
    • Nautiyal, S., DeRisi, J. L. & Blackburn, E. H. The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA 99, 9316-9321 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 9316-9321
    • Nautiyal, S.1    DeRisi, J.L.2    Blackburn, E.H.3
  • 57
    • 0033513079 scopus 로고    scopus 로고
    • Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae
    • Teng, S.-C. & Zakian, V. A. Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae. Mol. Cell. Biol. 19, 8083-8093 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 8083-8093
    • Teng, S.-C.1    Zakian, V.A.2
  • 58
    • 0034077143 scopus 로고    scopus 로고
    • Telomere maintenance in telomerase-deficient mouse embryonic stem cells: Characterization of an amplified telomeric DNA
    • Niida, H. et al. Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA. Mol. Cell. Biol. 20, 4115-4127 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4115-4127
    • Niida, H.1
  • 59
    • 0033636907 scopus 로고    scopus 로고
    • Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process
    • Teng, S.-C., Chang, J., McCowan, B. & Zakian, V. A. Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process. Mol. Cell 6, 947-952 (2000).
    • (2000) Mol. Cell , vol.6 , pp. 947-952
    • Teng, S.-C.1    Chang, J.2    McCowan, B.3    Zakian, V.A.4
  • 60
    • 0032959506 scopus 로고    scopus 로고
    • RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase
    • Le, S., Moore, J. K., Haber, J. E. & Greider, C. W. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase. Genetics 152, 143-152 (1999).
    • (1999) Genetics , vol.152 , pp. 143-152
    • Le, S.1    Moore, J.K.2    Haber, J.E.3    Greider, C.W.4
  • 61
    • 0035131699 scopus 로고    scopus 로고
    • Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events
    • Chen, Q., Ijpma, A. & Greider, C. W. Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events. Mol. Cell. Biol. 21, 1819-1827 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1819-1827
    • Chen, Q.1    Ijpma, A.2    Greider, C.W.3
  • 62
    • 0035936559 scopus 로고    scopus 로고
    • SGS1 is required for telomere elongation in the absence of telomerase
    • Huang, P.-H. et al. SGS1 is required for telomere elongation in the absence of telomerase. Curr. Biol. 11, 125-129 (2001).
    • (2001) Curr. Biol. , vol.11 , pp. 125-129
    • Huang, P.-H.1
  • 63
    • 0035853104 scopus 로고    scopus 로고
    • Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase
    • Cohen, H. & Sinclair, D. A. Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase. Proc. Natl Acad. Sci. USA 98, 3174-3179 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 3174-3179
    • Cohen, H.1    Sinclair, D.A.2
  • 64
    • 0035865143 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae WRN homolog Sgs1 p parlicipates in telomere maintenance in cells lacking telomerase
    • Johnson, F. B. et al. The Saccharomyces cerevisiae WRN homolog Sgs1 p parlicipates in telomere maintenance in cells lacking telomerase. EMBO J. 20, 905-913 (2001).
    • (2001) EMBO J. , vol.20 , pp. 905-913
    • Johnson, F.B.1
  • 65
    • 0031262792 scopus 로고    scopus 로고
    • Immortalized cells with no detectable telomerase activity. A review
    • Reddel, R. R., Bryan, T. M. & Murnane, J. P. Immortalized cells with no detectable telomerase activity. A review. Biochemistry 62, 1254-1262 (1997).
    • (1997) Biochemistry , vol.62 , pp. 1254-1262
    • Reddel, R.R.1    Bryan, T.M.2    Murnane, J.P.3
  • 66
    • 0034503110 scopus 로고    scopus 로고
    • ALT-associated PML bodies are present in viable cells and are enriched in cells in the G2/M phase of the cell cycle
    • Grobelny, J. V., Godwin, A. K. & Broccoli, D. ALT-associated PML bodies are present in viable cells and are enriched in cells in the G2/M phase of the cell cycle. J. Cell Sci. 113, 4577-4585 (2000).
    • (2000) J. Cell Sci. , vol.113 , pp. 4577-4585
    • Grobelny, J.V.1    Godwin, A.K.2    Broccoli, D.3
  • 67
    • 0035969107 scopus 로고    scopus 로고
    • Cellular proteins locaiized at and interacting within ND10/PML nuclear bodies/PODs suggest functions of a nuclear depot
    • Negorev, D. & Maul, G. G. Cellular proteins locaiized at and interacting within ND10/PML nuclear bodies/PODs suggest functions of a nuclear depot. Oncogene 20, 7234-7242 (2001).
    • (2001) Oncogene , vol.20 , pp. 7234-7242
    • Negorev, D.1    Maul, G.G.2
  • 69
    • 0036510162 scopus 로고    scopus 로고
    • Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells
    • Varley, H., Pickett, H. A., Foxon, J. L., Reddel, R. R. & Royle, N. J. Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells. Nature Genet. 30, 301-305 (2002).
    • (2002) Nature Genet. , vol.30 , pp. 301-305
    • Varley, H.1    Pickett, H.A.2    Foxon, J.L.3    Reddel, R.R.4    Royle, N.J.5
  • 70
    • 0036269549 scopus 로고    scopus 로고
    • Recombinational telomere elongation promoted by DNA circles
    • Natarajan, S. & McEachern, M. J. Recombinational telomere elongation promoted by DNA circles. Mol. Cell. Biol. 22, 4512-4521 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 4512-4521
    • Natarajan, S.1    McEachern, M.J.2
  • 71
    • 0032577927 scopus 로고    scopus 로고
    • Extra-chromosome telomere repeat DNA in telomerase-negative immortalized cell lines
    • Tokutake, Y. et al. Extra-chromosome telomere repeat DNA in telomerase-negative immortalized cell lines. Biochem. Biophys. Res. Commun. 247, 765-772 (1998).
    • (1998) Biochem. Biophys. Res. Commun. , vol.247 , pp. 765-772
    • Tokutake, Y.1
  • 72
    • 0032551708 scopus 로고    scopus 로고
    • Release of telomeric DNA from chromosomes in immortal human cells lacking telomerase activity
    • Ogino, H. et al. Release of telomeric DNA from chromosomes in immortal human cells lacking telomerase activity. Biochem. Biophys. Res. Commun. 248, 223-227 (1998).
    • (1998) Biochem. Biophys. Res. Commun. , vol.248 , pp. 223-227
    • Ogino, H.1
  • 73
    • 0036011002 scopus 로고    scopus 로고
    • Extrachromosomal RNA-DNA complex containing long telomeric repeats in chironomids
    • Rosen, M., Kamnert, I. & Edstrom, J. E. Extrachromosomal RNA-DNA complex containing long telomeric repeats in chironomids. Insect Mol. Biol. 11, 167-174 (2002).
    • (2002) Insect Mol. Biol. , vol.11 , pp. 167-174
    • Rosen, M.1    Kamnert, I.2    Edstrom, J.E.3
  • 74
    • 0033519630 scopus 로고    scopus 로고
    • Repression of an alternative mechanism for lengthening of telomeres in somatic cell hybrids
    • Perrem, K. et al. Repression of an alternative mechanism for lengthening of telomeres in somatic cell hybrids. Oncogene 18, 3383-3390 (1999).
    • (1999) Oncogene , vol.18 , pp. 3383-3390
    • Perrem, K.1
  • 75
    • 0032851592 scopus 로고    scopus 로고
    • Telomerase activity in hybrids between telomerase-negative and telomerase-positive immortal human cells is repressed in the different complementation groups but not in the same complementation group of immortality
    • Ishii, Y., Tsuyama, N., Maeda, S., Tahara, H. & Ide, T. Telomerase activity in hybrids between telomerase-negative and telomerase-positive immortal human cells is repressed in the different complementation groups but not in the same complementation group of immortality. Mech. Ageing Dev. 110, 175-193 (1999).
    • (1999) Mech. Ageing Dev. , vol.110 , pp. 175-193
    • Ishii, Y.1    Tsuyama, N.2    Maeda, S.3    Tahara, H.4    Ide, T.5
  • 76
    • 0035902614 scopus 로고    scopus 로고
    • Domain structure and dynamics in the helical filaments formed by RecA and Rad 51 on DNA
    • Yu, X., Jacobs, S. A., West, S. C., Ogawa, T. & Egelman, E. H. Domain structure and dynamics in the helical filaments formed by RecA and Rad51 on DNA. Proc. Natl Acad. Sci. USA 98, 8419-8424 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 8419-8424
    • Yu, X.1    Jacobs, S.A.2    West, S.C.3    Ogawa, T.4    Egelman, E.H.5
  • 77
    • 0030737816 scopus 로고    scopus 로고
    • Chromosome end elongation by recombination in the mosquito Anopheles gambiae
    • Roth, C. W., Kobeski, F., Walter, M. F. & Biessmann, H. Chromosome end elongation by recombination in the mosquito Anopheles gambiae. Mol. Cell. Biol. 17, 5176-5183 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5176-5183
    • Roth, C.W.1    Kobeski, F.2    Walter, M.F.3    Biessmann, H.4
  • 78
    • 0029980065 scopus 로고    scopus 로고
    • Terminal long tandem repeats in chromosomes form Chironomus pallidivittatus
    • López, C. C., Nielsen, L. & Edström, J.-E. Terminal long tandem repeats in chromosomes form Chironomus pallidivittatus. Mol. Cell. Biol. 16, 3285-3290 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3285-3290
    • López, C.C.1    Nielsen, L.2    Edström, J.-E.3
  • 79
    • 0025316079 scopus 로고
    • Addition of teiomere-associated HeT DNA sequences 'heals' broken chromosome ends in Drosophila
    • Biessmann, H. et al. Addition of teiomere-associated HeT DNA sequences 'heals' broken chromosome ends in Drosophila. Cell 61, 663-673 (1990).
    • (1990) Cell , vol.61 , pp. 663-673
    • Biessmann, H.1
  • 80
    • 0028959218 scopus 로고
    • The unusual telomeres of Drosophila
    • Mason, J. M. & Biessmann, H. The unusual telomeres of Drosophila. Trends Genet. 11, 58-62 (1995).
    • (1995) Trends Genet. , vol.11 , pp. 58-62
    • Mason, J.M.1    Biessmann, H.2
  • 81
    • 0036674425 scopus 로고    scopus 로고
    • Telomerase beyond telomeres
    • Blasco, M. A. Telomerase beyond telomeres. Nature Rev. Cancer 2, 627-633 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 627-633
    • Blasco, M.A.1
  • 82
    • 0035963271 scopus 로고    scopus 로고
    • Alternative lengthening of telomeresis associated with chromosomal instability in osteosarcomas
    • Scheel, C. et al. Alternative lengthening of telomeresis associated with chromosomal instability in osteosarcomas. Oncogene 20, 3835-3844 (2001).
    • (2001) Oncogene , vol.20 , pp. 3835-3844
    • Scheel, C.1
  • 83
    • 0037148275 scopus 로고    scopus 로고
    • Telomere maintenance without telomerase
    • Lundblad, V. Telomere maintenance without telomerase. Oncogene 21, 522-531 (2002).
    • (2002) Oncogene , vol.21 , pp. 522-531
    • Lundblad, V.1


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