메뉴 건너뛰기




Volumn 9, Issue 3, 1999, Pages 368-373

Telomerase: Dr Jekyll or Mr Hyde?

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

EID: 0033151958     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(99)80055-0     Document Type: Article
Times cited : (49)

References (61)
  • 1
    • 0025731583 scopus 로고
    • Structure and function of telomeres
    • Blackburn EH: Structure and function of telomeres. Nature 1991. 350:569-573.
    • (1991) Nature , vol.350 , pp. 569-573
    • Blackburn, E.H.1
  • 2
    • 0029563009 scopus 로고
    • Telomeres: Beginning to understand the end
    • Zakian VA: Telomeres: Beginning to understand the end. Science 1995, 270:1601-1607.
    • (1995) Science , vol.270 , pp. 1601-1607
    • Zakian, V.A.1
  • 3
    • 0030272689 scopus 로고    scopus 로고
    • Telomerase and cancer: Revisiting the telomere hypothesis
    • Autexier C, Greider CW: Telomerase and cancer: Revisiting the telomere hypothesis. Trends Biochem Sci 1996, 21:387-391.
    • (1996) Trends Biochem Sci , vol.21 , pp. 387-391
    • Autexier, C.1    Greider, C.W.2
  • 4
    • 0032567975 scopus 로고    scopus 로고
    • Telomeres and senescence: The history, the experiment, the future
    • Greider CW: Telomeres and senescence: The history, the experiment, the future. Curr Biol 1998, 8:R178-R181.
    • (1998) Curr Biol , vol.8
    • Greider, C.W.1
  • 5
    • 0025787643 scopus 로고
    • Telomere loss: Mitotic clock or genetic time bomb?
    • Harley CB: Telomere loss: Mitotic clock or genetic time bomb? Mutat Res 1991, 256:271-282.
    • (1991) Mutat Res , vol.256 , pp. 271-282
    • Harley, C.B.1
  • 6
    • 0029894237 scopus 로고    scopus 로고
    • Telomere length regulation
    • Greider CW: Telomere length regulation. Annu Rev Biochem 1996, 65:337-365.
    • (1996) Annu Rev Biochem , vol.65 , pp. 337-365
    • Greider, C.W.1
  • 7
    • 0032522443 scopus 로고    scopus 로고
    • The telomerase reverse transcriptase: Components and regulation
    • Nugent CI, Lundblad V: The telomerase reverse transcriptase: Components and regulation. Genes Dev 1998, 12:1073-1085.
    • (1998) Genes Dev , vol.12 , pp. 1073-1085
    • Nugent, C.I.1    Lundblad, V.2
  • 8
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay JW, Bacchetti S: A survey of telomerase activity in human cancer. Eur J Cancer 1997, 33:787-791.
    • (1997) Eur J Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 9
    • 0030474816 scopus 로고    scopus 로고
    • Structure, function, and replication of Saccharomyces cerevisiae telomeres
    • Zakian VA: Structure, function, and replication of Saccharomyces cerevisiae telomeres. Annu Rev Genet 1996, 30:141-172.
    • (1996) Annu Rev Genet , vol.30 , pp. 141-172
    • Zakian, V.A.1
  • 10
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • HayfLick L: The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965, 37:614-636.
    • (1965) Exp Cell Res , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 11
    • 0028958708 scopus 로고
    • Telomeres and telomerase in aging and cancer
    • Harley CB, Villeponteau B: Telomeres and telomerase in aging and cancer. Curr Opin Genet Dev 1995, 5:249-255.
    • (1995) Curr Opin Genet Dev , vol.5 , pp. 249-255
    • Harley, C.B.1    Villeponteau, B.2
  • 12
    • 0027944347 scopus 로고
    • TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
    • Singer MS, Gottschling DE: TLC1: Template RNA component of Saccharomyces cerevisiae telomerase. Science 1994, 266:404-409.
    • (1994) Science , vol.266 , pp. 404-409
    • Singer, M.S.1    Gottschling, D.E.2
  • 13
    • 0030781067 scopus 로고    scopus 로고
    • Functionally interacting telomerase RNAs in the yeast telomerase complex
    • Prescott J, Blackburn EH: functionally interacting telomerase RNAs in the yeast telomerase complex. Genes Dev 1997, 11:2790-2800.
    • (1997) Genes Dev , vol.11 , pp. 2790-2800
    • Prescott, J.1    Blackburn, E.H.2
  • 14
    • 0029155795 scopus 로고
    • Telomerase in yeast
    • Cohn M, Blackburn EH: Telomerase in yeast Science 1995, 269:396-400.
    • (1995) Science , vol.269 , pp. 396-400
    • Cohn, M.1    Blackburn, E.H.2
  • 15
    • 0030881688 scopus 로고    scopus 로고
    • Three ever shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity
    • Lingner J, Cech TR, Hughes TR, Lundblad V: Three ever shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc Natl Acad Sci USA 1997, 94:11190-11195.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11190-11195
    • Lingner, J.1    Cech, T.R.2    Hughes, T.R.3    Lundblad, V.4
  • 17
    • 0032576733 scopus 로고    scopus 로고
    • Reconstitution of human telomerase activity in vitro
    • Beattie TL, Zhou W, Robinson MO, Harrington L: Reconstitution of human telomerase activity in vitro. Curr Biol, 1998, 8:177-180. This and the previous report [16•] demonstrate that the TER RNA subunit and the TERT protein subunit are, by themselves, sufficient for core telomerase catalysis. This report further demonstrates that a large portion of the TER RNA subunit of telomerase is not required for core telomerase activity.
    • (1998) Curr Biol , vol.8 , pp. 177-180
    • Beattie, T.L.1    Zhou, W.2    Robinson, M.O.3    Harrington, L.4
  • 18
    • 0032555261 scopus 로고    scopus 로고
    • The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex
    • Collins K, Gandhi L: The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex. Proc Natl Acad Sci USA 1998, 95:8485-8490.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8485-8490
    • Collins, K.1    Gandhi, L.2
  • 20
    • 0029761161 scopus 로고    scopus 로고
    • Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines
    • Bestilny LJ, Brown CB, Miura Y, Robertson LD, Riabowol KT: Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines. Cancer Res 1996. 56:3796-3802.
    • (1996) Cancer Res , vol.56 , pp. 3796-3802
    • Bestilny, L.J.1    Brown, C.B.2    Miura, Y.3    Robertson, L.D.4    Riabowol, K.T.5
  • 21
    • 0030070054 scopus 로고    scopus 로고
    • Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis
    • Blasco MA, Rizen M, Greider CW, Hanahan D: Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Nat Genet 1996, 12:200-204.
    • (1996) Nat Genet , vol.12 , pp. 200-204
    • Blasco, M.A.1    Rizen, M.2    Greider, C.W.3    Hanahan, D.4
  • 25
    • 0010045614 scopus 로고    scopus 로고
    • Extension of lifespan by introduction of telomerase into normal human cells
    • Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, LichtSteiner S, Wright WE: Extension of lifespan by introduction of telomerase into normal human cells. Science 1998, 279:349-352. Together with [28••], demonstrates that expression of TERT is sufficient to extend the lifespan of at least some cell types, providing the first direct support for the telomere hypothesis of replicative senescence.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Ouellette, M.2    Frolkis, M.3    Holt, S.E.4    Chiu, C.P.5    Morin, G.B.6    Harley, C.B.7    Shay, J.W.8    Lichtsteiner, S.9    Wright, W.E.10
  • 27
    • 0032440891 scopus 로고    scopus 로고
    • Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
    • Counter CM, Hahn WC, WEi W, Caddle SD, Beijersbergen RL, Lansdorp PM, Sedivy JM, Weinberg RA: Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci USA 1998, 95:14723-14728. Together with [30••], demonstrates that expression of TERT is sufficient to immortalize at least some post M1 SV40 T-Ag transformed cells.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14723-14728
    • Counter, C.M.1    Hahn, W.C.2    Wei, W.3    Caddle, S.D.4    Beijersbergen, R.L.5    Lansdorp, P.M.6    Sedivy, J.M.7    Weinberg, R.A.8
  • 28
    • 0032567967 scopus 로고    scopus 로고
    • Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
    • Vaziri H, Benchimol S: Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol 1998, 8:279-282. See annotation [25••].
    • (1998) Curr Biol , vol.8 , pp. 279-282
    • Vaziri, H.1    Benchimol, S.2
  • 29
    • 0032487675 scopus 로고    scopus 로고
    • Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
    • Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA, Klingelhutz AJ: Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998, 396:84-88. This report highlights the cell specificity in telomerase-mediated replicative lifespan extension. Whereas epithelial cells require inactivation of pRb in order for exogenous telomerase activity to extend the cell's replicative potential, fibroblasts were immortalized by telomerase alone.
    • (1998) Nature , vol.396 , pp. 84-88
    • Kiyono, T.1    Foster, S.A.2    Koop, J.I.3    McDougall, J.K.4    Galloway, D.A.5    Klingelhutz, A.J.6
  • 30
    • 0033616762 scopus 로고    scopus 로고
    • Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
    • Zhu J, Wang H, Bishop JM, Blackburn EH: Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci USA 1999, 96:3723-3728. See annotation [27••]. A further demonstration that telomere lengthening is not necessary for telomerase-mediated replicative lifespan extension, supporting a role for telomerase in telomere stabilization in addition to its role in the synthesis of telomeric DNA.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3723-3728
    • Zhu, J.1    Wang, H.2    Bishop, J.M.3    Blackburn, E.H.4
  • 31
    • 0032924343 scopus 로고    scopus 로고
    • Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
    • Morales CP, Holt SE, Ouellette M, Kaur KJ, VAN Y, Wilson KS, White MA, Wright WE, Shay JW: Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet 1999, 21:115-118. Together with [32••], demonstrates that cells expressing exogenous telomerase and maintained in culture long-term (i.e. telomerase-immortalized cells) retain normal growth controls (serum dependence, anchorage dependence, and contact inhibition), and a normal karyotype. This study further demonstrates that inactivation of p53 and pRb are not sufficient to confer anchorage-independent growth to telomerase-immortalized cells.
    • (1999) Nat Genet , vol.21 , pp. 115-118
    • Morales, C.P.1    Holt, S.E.2    Ouellette, M.3    Kaur, K.J.4    Van, Y.5    Wilson, K.S.6    White, M.A.7    Wright, W.E.8    Shay, J.W.9
  • 32
    • 0032923742 scopus 로고    scopus 로고
    • Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
    • Jiang XR, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl GM, Tlsty TD et al.: Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet 1999. 21:111-114. See annotation [31••]. This study further demonstrates that telomerase-immortalized cells are not tumorigenic in vivo.
    • (1999) Nat Genet , vol.21 , pp. 111-114
    • Jiang, X.R.1    Jimenez, G.2    Chang, E.3    Frolkis, M.4    Kusler, B.5    Sage, M.6    Beeche, M.7    Bodnar, A.G.8    Wahl, G.M.9    Tlsty, T.D.10
  • 33
    • 0024973811 scopus 로고
    • A mutant with a defect in telomere elongation leads to senescence in yeast
    • Lundblad V, Szostak JW: A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 1989, 57:633-643.
    • (1989) Cell , vol.57 , pp. 633-643
    • Lundblad, V.1    Szostak, J.W.2
  • 34
    • 0030455861 scopus 로고    scopus 로고
    • Sequence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
    • Lendvay TS, Morris DK, Sah J, BalasuBramanian B, Lundblad V: Sequence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 1996, 144:1399-1412.
    • (1996) Genetics , vol.144 , pp. 1399-1412
    • Lendvay, T.S.1    Morris, D.K.2    Sah, J.3    Balasubramanian, B.4    Lundblad, V.5
  • 35
    • 0032514694 scopus 로고    scopus 로고
    • Rap1 protein regulates telomere turnover in yeast
    • KrAuskopf A, Blackburn EH: Rap1 protein regulates telomere turnover in yeast. Proc Natl Acad Sci USA 1998, 95:12486-12491.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 12486-12491
    • Krauskopf, A.1    Blackburn, E.H.2
  • 36
    • 0031036351 scopus 로고    scopus 로고
    • A protein-counting mechanism for telomere length regulation in yeast
    • Marcand S, Gilson E, Shore D: A protein-counting mechanism for telomere length regulation in yeast. Science 1997, 275:986-990.
    • (1997) Science , vol.275 , pp. 986-990
    • Marcand, S.1    Gilson, E.2    Shore, D.3
  • 37
    • 0029102354 scopus 로고
    • Runaway telomere elongation caused by telomerase RNA gene mutations
    • McEachern MJ, Blackburn EH: Runaway telomere elongation caused by telomerase RNA gene mutations. Nature 1995, 376:403-409.
    • (1995) Nature , vol.376 , pp. 403-409
    • McEachern, M.J.1    Blackburn, E.H.2
  • 38
    • 0029746495 scopus 로고    scopus 로고
    • Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase
    • McEachern MJ, Blackburn EH: Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev 1996, 10:1822-1834.
    • (1996) Genes Dev , vol.10 , pp. 1822-1834
    • McEachern, M.J.1    Blackburn, E.H.2
  • 39
    • 0030297546 scopus 로고    scopus 로고
    • Telomeres and telomerase: A simple picture becomes complex
    • Lundblad V, Wright WE: Telomeres and telomerase: A simple picture becomes complex. Cell 1996, 87:369-375.
    • (1996) Cell , vol.87 , pp. 369-375
    • Lundblad, V.1    Wright, W.E.2
  • 40
    • 3543142313 scopus 로고    scopus 로고
    • Two modes of survival of fission yeast without telomerase
    • Nakamura TM, Cooper JP, Cech TR: Two modes of survival of fission yeast without telomerase. Science 1998, 282:493-496.
    • (1998) Science , vol.282 , pp. 493-496
    • Nakamura, T.M.1    Cooper, J.P.2    Cech, T.R.3
  • 41
    • 0031038170 scopus 로고    scopus 로고
    • Regulation of telomere length and function by a myb-domain protein in fission yeast
    • Promisel Cooper J, Nimmo ER, Allshire RC, Cech TR: Regulation of telomere length and function by a myb-domain protein in fission yeast. Nature 1997, 385:744-747.
    • (1997) Nature , vol.385 , pp. 744-747
    • Promisel Cooper, J.1    Nimmo, E.R.2    Allshire, R.C.3    Cech, T.R.4
  • 42
    • 0031027618 scopus 로고    scopus 로고
    • Control of telomere length by the human telomeric protein TRF1
    • Van Steensel B, De Lange T: Control of telomere length by the human telomeric protein TRF1. Nature 1997, 385:740-743.
    • (1997) Nature , vol.385 , pp. 740-743
    • Van Steensel, B.1    De Lange, T.2
  • 43
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • Van Steensel B, SmogorzewskA A, De Lange T: TRF2 protects human telomeres from end-to-end fusions. Cell 1998, 92:401-413. Demonstrates that TRF2 plays a key role in protecting the telomeres from end-to-end fusions and that (TTAGGG)-repeat DNA is not sufficient for the integrity and function of human telomeres.
    • (1998) Cell , vol.92 , pp. 401-413
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 44
    • 0029743764 scopus 로고    scopus 로고
    • Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats
    • KrAuskopf A, Blackburn EH: Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature 1996, 383:354-357.
    • (1996) Nature , vol.383 , pp. 354-357
    • Krauskopf, A.1    Blackburn, E.H.2
  • 45
    • 0032553473 scopus 로고    scopus 로고
    • Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
    • SMith S, Giriat I, Schmitt A, De Lange T: Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 1998, 282:1484 1487.
    • (1998) Science , vol.282 , pp. 14841487
    • Smith, S.1    Giriat, I.2    Schmitt, A.3    De Lange, T.4
  • 46
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB, Bacchetti S: Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 1992, 11:1921-1929.
    • (1992) EMBO J , vol.11 , pp. 1921-1929
    • Counter, C.M.1    Avilion, A.A.2    LeFeuvre, C.E.3    Stewart, N.G.4    Greider, C.W.5    Harley, C.B.6    Bacchetti, S.7
  • 47
    • 0028198679 scopus 로고
    • Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes
    • Counter CM, Botelho FM, Wang P, Harley CB, Bacchetti S: Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J Virol 1994, 68:3410-3414.
    • (1994) J Virol , vol.68 , pp. 3410-3414
    • Counter, C.M.1    Botelho, F.M.2    Wang, P.3    Harley, C.B.4    Bacchetti, S.5
  • 48
    • 0028140264 scopus 로고
    • Restoration of telomeres in human papiliomavirus-immortalized human anogenital epithelial cells
    • Klingelhutz AJ, Barber SA, Smith PP, Dyer K, McDougall JK: Restoration of telomeres in human papiliomavirus-immortalized human anogenital epithelial cells. Mol Cell Biol 1994, 14:961-969.
    • (1994) Mol Cell Biol , vol.14 , pp. 961-969
    • Klingelhutz, A.J.1    Barber, S.A.2    Smith, P.P.3    Dyer, K.4    McDougall, J.K.5
  • 49
    • 0033593814 scopus 로고    scopus 로고
    • Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice
    • Hande MP, SampEr E, LansdorP P, Blasco MA: Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J Cell Biol 1999, 144:589-601.
    • (1999) J Cell Biol , vol.144 , pp. 589-601
    • Hande, M.P.1    Samper, E.2    Lansdorp, P.3    Blasco, M.A.4
  • 50
    • 0031029377 scopus 로고    scopus 로고
    • Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro
    • Prescott J, Blackburn EH: Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro. Genes Dev 1997, 11:528-540.
    • (1997) Genes Dev , vol.11 , pp. 528-540
    • Prescott, J.1    Blackburn, E.H.2
  • 54
    • 0033104511 scopus 로고    scopus 로고
    • -/- embryos is associated with failure to close the neural tube
    • -/- embryos is associated with failure to close the neural tube. EMBO J 1999, 18:1172-1181. First demonstration of a clear developmental defect in mice lacking telomerase. mTR knockout mice have an increased frequency of death in utero that correlates with both telomere shortening and a failure to close the neural tube.
    • (1999) EMBO J , vol.18 , pp. 1172-1181
    • Herrera, E.1    Samper, E.2    Blasco, M.A.3
  • 55
    • 0030697342 scopus 로고    scopus 로고
    • Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
    • Bryan TM, Englezou A, DaLLa-Pozza L, Dunham MA, Reddel RR: Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat Med 1997, 3:1271-1274.
    • (1997) Nat Med , vol.3 , pp. 1271-1274
    • Bryan, T.M.1    Englezou, A.2    Dalla-Pozza, L.3    Dunham, M.A.4    Reddel, R.R.5
  • 56
    • 0027266758 scopus 로고
    • An alternative pathway for yeast telomere maintenance rescues est1 -senescence
    • Lundblad V, Blackburn EH: An alternative pathway for yeast telomere maintenance rescues est1 -senescence. Cell 1993, 73:347-360.
    • (1993) Cell , vol.73 , pp. 347-360
    • Lundblad, V.1    Blackburn, E.H.2
  • 57
    • 0033074324 scopus 로고    scopus 로고
    • Comparison of screening methods in the detection of bladder cancer
    • Ramakumar S, Bhuiyan J, Besse JA, Roberts SG, Wollan PC, Blut ML, O'Kane DJ: Comparison of screening methods in the detection of bladder cancer. J Urol 1999, 161:388-394. A comparison of the sensitivity and specificity of a variety of methods for detecting bladder malignancy in cells present in urine samples. Urinary telomerase showed the highest level of sensitivity and specificity as a predictor of bladder cancer.
    • (1999) J Urol , vol.161 , pp. 388-394
    • Ramakumar, S.1    Bhuiyan, J.2    Besse, J.A.3    Roberts, S.G.4    Wollan, P.C.5    Blut, M.L.6    O'Kane, D.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.