메뉴 건너뛰기




Volumn 24, Issue 6, 2007, Pages 1172-1185

Promise and progress for functional and molecular imaging of response to targeted therapies

Author keywords

DCE MRI; Diffusion Weighted MRI; FDG PET; HIF 1 ; Imaging biomarkers; PI3K AKT; Targeted therapies; VEGF

Indexed keywords

103D5R; 2 MORPHOLINO 8 PHENYLCHROMONE; 2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; ANTINEOPLASTIC AGENT; AP 23573; AP 23841; AXITINIB; BAY 579352; BEVACIZUMAB; CC 1779; EVEROLIMUS; FLUORODEOXYGLUCOSE F 18; HYPOXIA INDUCIBLE FACTOR 1; MONOCLONAL ANTIBODY DC101; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PX 478; PX 866; RAPAMYCIN; SEMAXANIB; SUNITINIB; UNCLASSIFIED DRUG; VANDETANIB; VASCULOTROPIN; VATALANIB; WORTMANNIN;

EID: 34249006601     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9250-3     Document Type: Review
Times cited : (60)

References (140)
  • 1
    • 3242679103 scopus 로고    scopus 로고
    • Phase I trial design for solid tumor studies of targeted, non-cytotoxic agents: Theory and practice
    • W. R. Parulekar, and E. A. Eisenhauer. Phase I trial design for solid tumor studies of targeted, non-cytotoxic agents: theory and practice. J. Natl. Cancer Inst. 96:990-997 (2004).
    • (2004) J. Natl. Cancer Inst. , vol.96 , pp. 990-997
    • Parulekar, W.R.1    Eisenhauer, E.A.2
  • 2
    • 0344438131 scopus 로고    scopus 로고
    • Molecular imaging and cancer
    • R. G. Blasberg. Molecular imaging and cancer. Mol. Cancer Ther. 2:335-343 (2003).
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 335-343
    • Blasberg, R.G.1
  • 4
    • 27844601569 scopus 로고    scopus 로고
    • Metabolite changes in HT-29 xenograft tumors following HIF-1alpha inhibition with PX-478 as studied by MR spectroscopy in vivo and ex vivo
    • 7
    • B. F. Jordan, K. Black, I. F. Robey, M. Runquist, G. Powis, and R. J. Gillies. Metabolite changes in HT-29 xenograft tumors following HIF-1alpha inhibition with PX-478 as studied by MR spectroscopy in vivo and ex vivo. NMR Biomed. 18(7):430-439 (2005).
    • (2005) NMR Biomed. , vol.18 , pp. 430-439
    • Jordan, B.F.1    Black, K.2    Robey, I.F.3    Runquist, M.4    Powis, G.5    Gillies, R.J.6
  • 5
    • 20444430874 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478
    • B. F. Jordan, M. Runquist, N. Raghunand, A. Baker, R. Williams, L. Kirkpatrick, G. Powis, and R. J. Gillies. Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478. Neoplasia 7:475-485 (2005).
    • (2005) Neoplasia , vol.7 , pp. 475-485
    • Jordan, B.F.1    Runquist, M.2    Raghunand, N.3    Baker, A.4    Williams, R.5    Kirkpatrick, L.6    Powis, G.7    Gillies, R.J.8
  • 8
    • 1942477407 scopus 로고    scopus 로고
    • Diffusion-weighted MRI and response to anti-cancer therapies
    • J. P. Galons, D. L. Morse, D. R. Jennings, and R. J. Gillies. Diffusion-weighted MRI and response to anti-cancer therapies. Isr. J. Chem. 43:91-101 (2003).
    • (2003) Isr. J. Chem. , vol.43 , pp. 91-101
    • Galons, J.P.1    Morse, D.L.2    Jennings, D.R.3    Gillies, R.J.4
  • 9
    • 0030753231 scopus 로고    scopus 로고
    • Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging
    • T. L. Chenevert, P. E. McKeever, and B. D. Ross. Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging. Clin. Cancer Res. 3:1457-1466 (1997).
    • (1997) Clin. Cancer Res. , vol.3 , pp. 1457-1466
    • Chenevert, T.L.1    McKeever, P.E.2    Ross, B.D.3
  • 15
    • 0346037048 scopus 로고    scopus 로고
    • Diffusion-weighted magnetic resonance imaging for monitoring diffusion changes in rectal carcinoma during combined, preoperative chemoradiation: Preliminary results of a prospective study
    • P. A. Hein, C. Kremser, W. Judmaier, J. Griebel, K. P. Pfeiffer, A. Kreczy, E. B. Hug, P. Lukas, and A. F. DeVries. Diffusion-weighted magnetic resonance imaging for monitoring diffusion changes in rectal carcinoma during combined, preoperative chemoradiation: preliminary results of a prospective study. Eur. J. Radiol. 45:214-222 (2003).
    • (2003) Eur. J. Radiol. , vol.45 , pp. 214-222
    • Hein, P.A.1    Kremser, C.2    Judmaier, W.3    Griebel, J.4    Pfeiffer, K.P.5    Kreczy, A.6    Hug, E.B.7    Lukas, P.8    Devries, A.F.9
  • 16
    • 33747834603 scopus 로고    scopus 로고
    • Osteosarcoma: Preliminary results of in vivo assessment of tumor necrosis after chemotherapy with diffusion- and perfusion-weighted magnetic resonance imaging
    • M. Uhl, U. Saueressig, M. van Buiren, U. Kontny, C. Niemeyer, G. Kohler, K. Ilyasov, and M. Langer. Osteosarcoma: preliminary results of in vivo assessment of tumor necrosis after chemotherapy with diffusion- and perfusion-weighted magnetic resonance imaging. Invest. Radiol. 41:618-623 (2006).
    • (2006) Invest. Radiol. , vol.41 , pp. 618-623
    • Uhl, M.1    Saueressig, U.2    Van Buiren, M.3    Kontny, U.4    Niemeyer, C.5    Kohler, G.6    Ilyasov, K.7    Langer, M.8
  • 19
    • 0033040644 scopus 로고    scopus 로고
    • Assessment of induced rat mammary tumour response to chemotherapy using the apparent diffusion coefficient of tissue water as determined by diffusion-weighted 1H-NMR spectroscopy in vivo
    • L. Lemaire, F. A. Howe, L. M. Rodrigues, and J. R. Griffiths. Assessment of induced rat mammary tumour response to chemotherapy using the apparent diffusion coefficient of tissue water as determined by diffusion-weighted 1H-NMR spectroscopy in vivo. Magma 8:20-26 (1999).
    • (1999) Magma , vol.8 , pp. 20-26
    • Lemaire, L.1    Howe, F.A.2    Rodrigues, L.M.3    Griffiths, J.R.4
  • 20
    • 0030047282 scopus 로고    scopus 로고
    • Early detection of treatment response by diffusion-weighted 1H-NMR spectroscopy in a murine tumour in vivo
    • M. Zhao, J. G. Pipe, J. Bonnett, and J. L. Evelhoch. Early detection of treatment response by diffusion-weighted 1H-NMR spectroscopy in a murine tumour in vivo. Br. J. Cancer 73:61-64 (1996).
    • (1996) Br. J. Cancer , vol.73 , pp. 61-64
    • Zhao, M.1    Pipe, J.G.2    Bonnett, J.3    Evelhoch, J.L.4
  • 21
    • 0031748452 scopus 로고    scopus 로고
    • Magnetic resonance imaging and spectroscopy of combretastatin A4 prodrug-induced disruption of tumour perfusion and energetic status
    • D. A. Beauregard, P. E. Thelwall, D. J. Chaplin, S. A. Hill, G. E. Adams, and K. M. Brindle. Magnetic resonance imaging and spectroscopy of combretastatin A4 prodrug-induced disruption of tumour perfusion and energetic status. Br. J. Cancer 77:1761-1767 (1998).
    • (1998) Br. J. Cancer , vol.77 , pp. 1761-1767
    • Beauregard, D.A.1    Thelwall, P.E.2    Chaplin, D.J.3    Hill, S.A.4    Adams, G.E.5    Brindle, K.M.6
  • 22
    • 0033140111 scopus 로고    scopus 로고
    • Early increases in breast tumor xenograft water mobility in response to paclitaxel therapy detected by non-invasive diffusion magnetic resonance imaging
    • J. P. Galons, M. I. Altbach, G. D. Paine-Murrieta, C. W. Taylor, and R. J. Gillies. Early increases in breast tumor xenograft water mobility in response to paclitaxel therapy detected by non-invasive diffusion magnetic resonance imaging. Neoplasia 1:113-117 (1999).
    • (1999) Neoplasia , vol.1 , pp. 113-117
    • Galons, J.P.1    Altbach, M.I.2    Paine-Murrieta, G.D.3    Taylor, C.W.4    Gillies, R.J.5
  • 27
    • 0035029877 scopus 로고    scopus 로고
    • Assessment of a rapid clearance blood pool MR contrast medium (P792) for assays of microvascular characteristics in experimental breast tumors with correlations to histopathology
    • K. Turetschek, E. Floyd, D. M. Shames, T. P. Roberts, A. Preda, V. Novikov, C. Corot, W. O. Carter, and R. C. Brasch. Assessment of a rapid clearance blood pool MR contrast medium (P792) for assays of microvascular characteristics in experimental breast tumors with correlations to histopathology. Magn. Reson. Med. 45:880-886 (2001).
    • (2001) Magn. Reson. Med. , vol.45 , pp. 880-886
    • Turetschek, K.1    Floyd, E.2    Shames, D.M.3    Roberts, T.P.4    Preda, A.5    Novikov, V.6    Corot, C.7    Carter, W.O.8    Brasch, R.C.9
  • 28
    • 0028277939 scopus 로고
    • Comparison of contrast enhanced CT and Mn-DPDP enhanced MRI for detection of focal hepatic lesions. Initial findings
    • B. A. Birnbaum, J. C. Weinreb, M. P. Fernandez, J. J. Brown, N. M. Rofsky, and S. W. Young. Comparison of contrast enhanced CT and Mn-DPDP enhanced MRI for detection of focal hepatic lesions. Initial findings. Clin. Imaging 18:21-27 (1994).
    • (1994) Clin. Imaging , vol.18 , pp. 21-27
    • Birnbaum, B.A.1    Weinreb, J.C.2    Fernandez, M.P.3    Brown, J.J.4    Rofsky, N.M.5    Young, S.W.6
  • 29
    • 27144500159 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in cirrhosis: Enhancement patterns at dynamic gadolinium- and superparamagnetic iron oxide-enhanced T1-weighted MR imaging
    • A. M. Lutz, J. K. Willmann, K. Goepfert, B. Marincek, and D. Weishaupt. Hepatocellular carcinoma in cirrhosis: enhancement patterns at dynamic gadolinium- and superparamagnetic iron oxide-enhanced T1-weighted MR imaging. Radiology 237:520-528 (2005).
    • (2005) Radiology , vol.237 , pp. 520-528
    • Lutz, A.M.1    Willmann, J.K.2    Goepfert, K.3    Marincek, B.4    Weishaupt, D.5
  • 30
    • 0037626078 scopus 로고    scopus 로고
    • Functional tumor imaging with dynamic contrast-enhanced magnetic resonance imaging
    • P. L. Choyke, A. J. Dwyer, and M. V. Knopp. Functional tumor imaging with dynamic contrast-enhanced magnetic resonance imaging. J. Magn. Reson. Imaging 17:509-520 (2003).
    • (2003) J. Magn. Reson. Imaging , vol.17 , pp. 509-520
    • Choyke, P.L.1    Dwyer, A.J.2    Knopp, M.V.3
  • 33
    • 15544383053 scopus 로고    scopus 로고
    • FDG-PET and beyond: Molecular breast cancer imaging
    • A. Quon, and S. S. Gambhir. FDG-PET and beyond: molecular breast cancer imaging. J. Clin. Oncol. 23:1664-1673 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 1664-1673
    • Quon, A.1    Gambhir, S.S.2
  • 35
    • 0034885978 scopus 로고    scopus 로고
    • Using positron emission tomography with [(18)F]FDG to predict tumor behavior in experimental colorectal cancer
    • B. M. Burt, J. L. Humm, D. A. Kooby, O. D. Squire, S. Mastorides, S. M. Larson, and Y. Fong. Using positron emission tomography with [(18)F]FDG to predict tumor behavior in experimental colorectal cancer. Neoplasia 3:189-195 (2001).
    • (2001) Neoplasia , vol.3 , pp. 189-195
    • Burt, B.M.1    Humm, J.L.2    Kooby, D.A.3    Squire, O.D.4    Mastorides, S.5    Larson, S.M.6    Fong, Y.7
  • 36
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • R. A. Gatenby, and R. J. Gillies. Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 4:891-899 (2004).
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 37
    • 0037441913 scopus 로고    scopus 로고
    • Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma
    • M. Kunkel, T. E. Reichert, P. Benz, H. A. Lehr, J. H. Jeong, S. Wieand, P. Bartenstein, W. Wagner, and T. L. Whiteside. Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma. Cancer 97:1015-1024 (2003).
    • (2003) Cancer , vol.97 , pp. 1015-1024
    • Kunkel, M.1    Reichert, T.E.2    Benz, P.3    Lehr, H.A.4    Jeong, J.H.5    Wieand, S.6    Bartenstein, P.7    Wagner, W.8    Whiteside, T.L.9
  • 38
    • 1642345520 scopus 로고    scopus 로고
    • Valuation of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography for gastric cancer
    • E. Mochiki, H. Kuwano, H. Katoh, T. Asao, N. Oriuchi, and K. Endo. Evaluation of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography for gastric cancer. World J. Surg. 28:247-253 (2004).
    • (2004) World J. Surg. , vol.28 , pp. 247-253
    • Mochiki, E.1    Kuwano, H.2    Katoh, H.3    Asao, T.4    Oriuchi, N.5    Endo, K.6
  • 40
    • 5444234387 scopus 로고    scopus 로고
    • Fluorodeoxyglucose-PET in the management of breast cancer
    • R. Kumar and A. Alavi. Fluorodeoxyglucose-PET in the management of breast cancer. Radiol. Clin. North Am. 42:1113-1122 (2004), ix.
    • (2004) Radiol. Clin. North Am. , vol.42 , pp. 1113-1122
    • Kumar, R.1    Alavi, A.2
  • 41
    • 0036160394 scopus 로고    scopus 로고
    • FDG-PET in staging and restaging non-small cell lung cancer after neoadjuvant chemoradiotherapy: Correlation with histopathology
    • J. S. Ryu, N. C. Choi, A. J. Fischman, T. J. Lynch, and D. J. Mathisen. FDG-PET in staging and restaging non-small cell lung cancer after neoadjuvant chemoradiotherapy: correlation with histopathology. Lung Cancer 35:179-187 (2002).
    • (2002) Lung Cancer , vol.35 , pp. 179-187
    • Ryu, J.S.1    Choi, N.C.2    Fischman, A.J.3    Lynch, T.J.4    Mathisen, D.J.5
  • 42
    • 0038354700 scopus 로고    scopus 로고
    • PET-FDG as predictor of therapy response in patients with colorectal carcinoma
    • A. Dimitrakopoulou-Strauss, L. G. Strauss, and J. Rudi. PET-FDG as predictor of therapy response in patients with colorectal carcinoma. Q. J. Nucl. Med. 47:8-13 (2003).
    • (2003) Q. J. Nucl. Med. , vol.47 , pp. 8-13
    • Dimitrakopoulou-Strauss, A.1    Strauss, L.G.2    Rudi, J.3
  • 43
  • 44
    • 0033762462 scopus 로고    scopus 로고
    • Comparison of Gadomer-17 and gadopentetate dimeglumine for differentiation of benign from malignant breast tumors with MR imaging
    • H. E. Daldrup-Link, D. M. Shames, M. Wendland, A. Muhler, A. Gossmann, W. Rosenau, and R. C. Brasch. Comparison of Gadomer-17 and gadopentetate dimeglumine for differentiation of benign from malignant breast tumors with MR imaging. Acad. Radiol. 7:934-944 (2000).
    • (2000) Acad. Radiol. , vol.7 , pp. 934-944
    • Daldrup-Link, H.E.1    Shames, D.M.2    Wendland, M.3    Muhler, A.4    Gossmann, A.5    Rosenau, W.6    Brasch, R.C.7
  • 45
    • 0033007860 scopus 로고    scopus 로고
    • Characterization of N-ethyl-N-nitrosourea-induced malignant and benign breast tumors in rats by using three MR contrast agents
    • M. Y. Su, Z. Wang, P. M. Carpenter, X. Lao, A. Muhler, and O. Nalcioglu. Characterization of N-ethyl-N-nitrosourea-induced malignant and benign breast tumors in rats by using three MR contrast agents. J. Magn. Reson. Imaging 9:177-186 (1999).
    • (1999) J. Magn. Reson. Imaging , vol.9 , pp. 177-186
    • Su, M.Y.1    Wang, Z.2    Carpenter, P.M.3    Lao, X.4    Muhler, A.5    Nalcioglu, O.6
  • 46
    • 0036197311 scopus 로고    scopus 로고
    • Evaluation of the anti-vascular effects of combretastatin in rodent tumours by dynamic contrast enhanced MRI
    • R. J. Maxwell, J. Wilson, V. E. Prise, B. Vojnovic, G. J. Rustin, M. A. Lodge, and G. M. Tozer. Evaluation of the anti-vascular effects of combretastatin in rodent tumours by dynamic contrast enhanced MRI. NMR Biomed. 15:89-98 (2002).
    • (2002) NMR Biomed. , vol.15 , pp. 89-98
    • Maxwell, R.J.1    Wilson, J.2    Prise, V.E.3    Vojnovic, B.4    Rustin, G.J.5    Lodge, M.A.6    Tozer, G.M.7
  • 47
    • 0036194959 scopus 로고    scopus 로고
    • Assessing changes in tumour vascular function using dynamic contrast-enhanced magnetic resonance imaging
    • C. Hayes, A. R. Padhani, and M. O. Leach. Assessing changes in tumour vascular function using dynamic contrast-enhanced magnetic resonance imaging. NMR Biomed. 15:154-163 (2002).
    • (2002) NMR Biomed. , vol.15 , pp. 154-163
    • Hayes, C.1    Padhani, A.R.2    Leach, M.O.3
  • 49
    • 3042719089 scopus 로고    scopus 로고
    • Tumor microvascular changes in antiangiogenic treatment: Assessment by magnetic resonance contrast media of different molecular weights
    • K. Turetschek, A. Preda, V. Novikov, R. C. Brasch, H. J. Weinmann, P. Wunderbaldinger, and T. P. Roberts. Tumor microvascular changes in antiangiogenic treatment: assessment by magnetic resonance contrast media of different molecular weights. J. Magn. Reson. Imaging 20:138-144 (2004).
    • (2004) J. Magn. Reson. Imaging , vol.20 , pp. 138-144
    • Turetschek, K.1    Preda, A.2    Novikov, V.3    Brasch, R.C.4    Weinmann, H.J.5    Wunderbaldinger, P.6    Roberts, T.P.7
  • 52
    • 16544368779 scopus 로고    scopus 로고
    • 18F-FDG kinetics in locally advanced breast cancer: Correlation with tumor blood flow and changes in response to neoadjuvant chemotherapy
    • J. Tseng, L. K. Dunnwald, E. K. Schubert, J. M. Link, S. Minoshima, M. Muzi, and D. A. Mankoff. 18F-FDG kinetics in locally advanced breast cancer: correlation with tumor blood flow and changes in response to neoadjuvant chemotherapy. J. Nucl. Med. 45:1829-1837 (2004).
    • (2004) J. Nucl. Med. , vol.45 , pp. 1829-1837
    • Tseng, J.1    Dunnwald, L.K.2    Schubert, E.K.3    Link, J.M.4    Minoshima, S.5    Muzi, M.6    Mankoff, D.A.7
  • 53
    • 33745954240 scopus 로고    scopus 로고
    • Diagnostics and biomarker development: Priming the pipeline
    • K. A. Phillips, S. Van Bebber, and A. M. Issa. Diagnostics and biomarker development: priming the pipeline. Nat. Rev. Drug Discov. 5:463-469 (2006).
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 463-469
    • Phillips, K.A.1    Bebber Van, S.2    Issa, A.M.3
  • 54
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • J. A. DiMasi, R. W. Hansen, and H. G. Grabowski. The price of innovation: new estimates of drug development costs. J. Health Econ. 22:151-185 (2003).
    • (2003) J. Health Econ. , vol.22 , pp. 151-185
    • Dimasi, J.A.1    Hansen, R.W.2    Grabowski, H.G.3
  • 55
    • 32944472716 scopus 로고    scopus 로고
    • Do oncologists believe new cancer drugs offer good value?
    • E. Nadler, B. Eckert, and P. J. Neumann. Do oncologists believe new cancer drugs offer good value? Oncologist 11:90-95 (2006).
    • (2006) Oncologist , vol.11 , pp. 90-95
    • Nadler, E.1    Eckert, B.2    Neumann, P.J.3
  • 56
    • 33744487875 scopus 로고    scopus 로고
    • Molecular imaging in cancer
    • R. Weissleder. Molecular imaging in cancer. Science 312:1168-1171 (2006).
    • (2006) Science , vol.312 , pp. 1168-1171
    • Weissleder, R.1
  • 58
    • 6044278144 scopus 로고    scopus 로고
    • Evaluating the efficiency of targeted designs for randomized clinical trials
    • R. Simon, and A. Maitournam. Evaluating the efficiency of targeted designs for randomized clinical trials. Clin. Cancer Res. 10:6759-6763 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6759-6763
    • Simon, R.1    Maitournam, A.2
  • 59
    • 23844457954 scopus 로고    scopus 로고
    • In vivo magnetic resonance spectroscopy in cancer
    • R. J. Gillies and D. L. Morse. In vivo magnetic resonance spectroscopy in cancer. Annu. Rev. Biomed. Eng. 7:287-326 (2005).
    • (2005) Annu. Rev. Biomed. Eng. , vol.7 , pp. 287-326
    • Gillies, R.J.1    Morse, D.L.2
  • 60
    • 0036441844 scopus 로고    scopus 로고
    • The value of improving the productivity of the drug development process: Faster times and better decisions
    • J. A. DiMasi. The value of improving the productivity of the drug development process: faster times and better decisions. Pharmacoeconomics 20:1-10 (2002).
    • (2002) Pharmacoeconomics , vol.20 , pp. 1-10
    • Dimasi, J.A.1
  • 62
    • 33746544343 scopus 로고    scopus 로고
    • New paradigms in anticancer therapy: Targeting multiple signaling pathways with kinase inhibitors
    • S. Faivre, S. Djelloul, and E. Raymond. New paradigms in anticancer therapy: targeting multiple signaling pathways with kinase inhibitors. Semin. Oncol. 33:407-420 (2006).
    • (2006) Semin. Oncol. , vol.33 , pp. 407-420
    • Faivre, S.1    Djelloul, S.2    Raymond, E.3
  • 63
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • S. R. Datta, A. Brunet, and M. E. Greenberg. Cellular survival: a play in three Akts. Genes Dev. 13:2905-2929 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 2905-2929
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 64
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • I. Vivanco, and C. L. Sawyers. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2:489-501 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 65
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • P. Blume-Jensenand, and T. Hunter. Oncogenic kinase signalling. Nature 411:355-365 (2001).
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensenand, P.1    Hunter, T.2
  • 66
    • 0141927222 scopus 로고    scopus 로고
    • Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer
    • N. Gao, Z. Zhang, B. H. Jiang, and X. Shi. Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer. Biochem. Biophys. Res. Commun. 310:1124-1132 (2003).
    • (2003) Biochem. Biophys. Res. Commun. , vol.310 , pp. 1124-1132
    • Gao, N.1    Zhang, Z.2    Jiang, B.H.3    Shi, X.4
  • 67
    • 13844273087 scopus 로고    scopus 로고
    • PI3K-Akt pathway: Its functions and alterations in human cancer
    • M. Osaki, M. Oshimura, and H. Ito. PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 9:667-676 (2004).
    • (2004) Apoptosis , vol.9 , pp. 667-676
    • Osaki, M.1    Oshimura, M.2    Ito, H.3
  • 69
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/Akt signalling pathway in human malignancy
    • K. M. Nicholson, and N. G. Anderson. The protein kinase B/Akt signalling pathway in human malignancy. Cell. Signal. 14:381-395 (2002).
    • (2002) Cell. Signal. , vol.14 , pp. 381-395
    • Nicholson, K.M.1    Anderson, N.G.2
  • 71
    • 0031913246 scopus 로고    scopus 로고
    • Mechanism of activation and function of protein kinase B
    • D. R. Alessi and P. Cohen. Mechanism of activation and function of protein kinase B. Curr. Opin. Genet. Dev. 8:5562 (1998).
    • (1998) Curr. Opin. Genet. Dev. , vol.8 , pp. 55-62
    • Alessi, D.R.1    Cohen, P.2
  • 72
    • 0032189381 scopus 로고    scopus 로고
    • Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
    • P. J. Coffer, J. Jin, and J. R. Woodgett. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem. J. 335:1-13 (1998).
    • (1998) Biochem. J. , vol.335 , pp. 1-13
    • Coffer, P.J.1    Jin, J.2    Woodgett, J.R.3
  • 74
    • 27144482397 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism
    • A. R. Gottschalk, A. Doan, J. L. Nakamura, D. Stokoe, and D. A. Haas-Kogan. Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism. Int. J. Radiat. Oncol. Biol. Phys. 63:1221-1227 (2005).
    • (2005) Int. J. Radiat. Oncol. Biol. Phys. , vol.63 , pp. 1221-1227
    • Gottschalk, A.R.1    Doan, A.2    Nakamura, J.L.3    Stokoe, D.4    Haas-Kogan, D.A.5
  • 75
    • 0034100051 scopus 로고    scopus 로고
    • In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002)
    • L. Hu, C. Zaloudek, G. B. Mills, J. Gray, and R. B. Jaffe. In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002). Clin. Cancer Res. 6:880-886 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 880-886
    • Hu, L.1    Zaloudek, C.2    Mills, G.B.3    Gray, J.4    Jaffe, R.B.5
  • 76
    • 0034792844 scopus 로고    scopus 로고
    • Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice
    • S. S. Ng, M. S. Tsao, T. Nicklee, and D. W. Hedley. Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice. Clin. Cancer Res. 7:3269-3275 (2001).
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3269-3275
    • Ng, S.S.1    Tsao, M.S.2    Nicklee, T.3    Hedley, D.W.4
  • 77
    • 0030814125 scopus 로고    scopus 로고
    • Radiosensitization of human tumor cells by the phosphatidylinositol3- kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay
    • K. E. Rosenzweig, M. B. Youmell, S. T. Palayoor, and B. D. Price. Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clin. Cancer Res. 3:1149-1156 (1997).
    • (1997) Clin. Cancer Res. , vol.3 , pp. 1149-1156
    • Rosenzweig, K.E.1    Youmell, M.B.2    Palayoor, S.T.3    Price, B.D.4
  • 80
    • 6944238452 scopus 로고    scopus 로고
    • Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway
    • L. A. DeGraffenried, L. Fulcher, W. E. Friedrichs, V. Grunwald, R. B. Ray, and M. Hidalgo. Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway. Ann. Oncol. 15:1510-1516 (2004).
    • (2004) Ann. Oncol. , vol.15 , pp. 1510-1516
    • Degraffenried, L.A.1    Fulcher, L.2    Friedrichs, W.E.3    Grunwald, V.4    Ray, R.B.5    Hidalgo, M.6
  • 83
    • 26644449670 scopus 로고    scopus 로고
    • The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells
    • Q. B. She, D. B. Solit, Q. Ye, K. E. O'Reilly, J. Lobo, and N. Rosen. The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells. Cancer Cell 8:287-297 (2005).
    • (2005) Cancer Cell , vol.8 , pp. 287-297
    • She, Q.B.1    Solit, D.B.2    Ye, Q.3    O'Reilly, K.E.4    Lobo, J.5    Rosen, N.6
  • 84
    • 0034901463 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology
    • G. L. Semenza. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol. Med. 7:345-350 (2001).
    • (2001) Trends Mol. Med. , vol.7 , pp. 345-350
    • Semenza, G.L.1
  • 85
    • 0036216692 scopus 로고    scopus 로고
    • HIF-1 and tumor progression: Pathophysiology and therapeutics
    • G. L. Semenza. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol. Med. 8:S62-S67 (2002).
    • (2002) Trends Mol. Med. , vol.8
    • Semenza, G.L.1
  • 86
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • G. L. Wang, B. H. Jiang, E. A. Rue, and G. L. Semenza. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. U. S. A. 92:5510-5514 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA. , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 89
    • 0142154635 scopus 로고    scopus 로고
    • Oxygen-dependent and -independent regulation of HIF-1alpha
    • Y. S. Chun, M. S. Kim, and J. W. Park. Oxygen-dependent and -independent regulation of HIF-1alpha. J. Korean Med. Sci. 17:581-588 (2002).
    • (2002) J. Korean Med. Sci. , vol.17 , pp. 581-588
    • Chun, Y.S.1    Kim, M.S.2    Park, J.W.3
  • 90
    • 0032493368 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
    • L. E. Huang, J. Gu, M. Schau, and H. F. Bunn. Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. U. S. A. 95:7987-7992 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA. , vol.95 , pp. 7987-7992
    • Huang, L.E.1    Gu, J.2    Schau, M.3    Bunn, H.F.4
  • 92
    • 4644275138 scopus 로고    scopus 로고
    • HIF-1: The knowns and unknowns of hypoxia sensing
    • A. Zagorska, and J. Dulak. HIF-1: the knowns and unknowns of hypoxia sensing. Acta Biochim. Pol. 51:563-585 (2004).
    • (2004) Acta Biochim. Pol. , vol.51 , pp. 563-585
    • Zagorska, A.1    Dulak, J.2
  • 93
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • K. L. Talks, H. Turley, K. C. Gatter, P. H. Maxwell, C. W. Pugh, P. J. Ratcliffe, and A. L. Harris. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 157:411-421 (2000).
    • (2000) Am. J. Pathol. , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5    Ratcliffe, P.J.6    Harris, L.7
  • 95
    • 18644366801 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors
    • I. F. Robey, A. D. Lien, S. J. Welsh, B. K. Baggett, and R. J. Gillies. Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia 7:324-330 (2005).
    • (2005) Neoplasia , vol.7 , pp. 324-330
    • Robey, I.F.1    Lien, A.D.2    Welsh, S.J.3    Baggett, B.K.4    Gillies, R.J.5
  • 96
    • 1642453685 scopus 로고    scopus 로고
    • Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling
    • K. Kasuno, S. Takabuchi, K. Fukuda, S. Kizaka-Kondoh, J. Yodoi, T. Adachi, G. L. Semenza, and K. Hirota. Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. J. Biol. Chem. 279:2550-2558 (2004). Epub 2003 Nov 4.
    • (2004) J. Biol. Chem. , vol.279 , pp. 2550-2558
    • Kasuno, K.1    Takabuchi, S.2    Fukuda, K.3    Kizaka-Kondoh, S.4    Yodoi, J.5    Adachi, T.6    Semenza, G.L.7    Hirota, K.8
  • 97
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • R. Fukuda, K. Hirota, F. Fan, Y. D. Jung, L. M. Ellis, and G. L. Semenza. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J. Biol. Chem. 277:38205-38211 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6
  • 98
    • 0037008770 scopus 로고    scopus 로고
    • Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
    • C. Treins, S. Giorgetti-Peraldi, J. Murdaca, G. L. Semenza, and E. Van Obberghen. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J. Biol. Chem. 277:27975-27981 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 27975-27981
    • Treins, C.1    Giorgetti-Peraldi, S.2    Murdaca, J.3    Semenza, G.L.4    Obberghen Van, E.5
  • 99
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • E. Laughner, P. Taghavi, K. Chiles, P. C. Mahon, and G. L. Semenza. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol. Cell Biol. 21:3995-4004 (2001).
    • (2001) Mol. Cell Biol. , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 100
    • 0038375038 scopus 로고    scopus 로고
    • Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1
    • R. Fukuda, B. Kelly, and G. L. Semenza. Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. Cancer Res. 63:2330-2334 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 2330-2334
    • Fukuda, R.1    Kelly, B.2    Semenza, G.L.3
  • 102
    • 0034213146 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1alpha in brain tumors: Association with angiogenesis, invasion, and progression
    • D. Zagzag, H. Zhong, J. M. Scalzitti, E. Laughner, J. W. Simons, and G. L. Semenza. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer 88:2606-2618 (2000).
    • (2000) Cancer , vol.88 , pp. 2606-2618
    • Zagzag, D.1    Zhong, H.2    Scalzitti, J.M.3    Laughner, E.4    Simons, J.W.5    Semenza, G.L.6
  • 103
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • G. L. Semenza. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3:721-732 (2003).
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 104
  • 105
    • 4444369682 scopus 로고    scopus 로고
    • Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha
    • S. Welsh, R. Williams, L. Kirkpatrick, G. Paine-Murrieta, and G. Powis. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol. Cancer Ther. 3:233-244 (2004).
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 233-244
    • Welsh, S.1    Williams, R.2    Kirkpatrick, L.3    Paine-Murrieta, G.4    Powis, G.5
  • 107
    • 33645415479 scopus 로고    scopus 로고
    • Tumor angiogenesis: Pathophysiology and implications for contrast-enhanced MRI and CT assessment
    • C. A. Cuenod, L. Fournier, D. Balvay, and J. M. Guinebretiere. Tumor angiogenesis: pathophysiology and implications for contrast-enhanced MRI and CT assessment. Abdom. Imaging 31:188-193 (2006).
    • (2006) Abdom. Imaging , vol.31 , pp. 188-193
    • Cuenod, C.A.1    Fournier, L.2    Balvay, D.3    Guinebretiere, J.M.4
  • 108
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • D. Hanahan, and J. Folkman. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86:353-364 (1996).
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 110
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • P. Carmeliet and R. K. Jain. Angiogenesis in cancer and other diseases. Nature 407:249-257 (2000).
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 113
    • 0023905973 scopus 로고
    • Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis
    • W. Risau and V. Lemmon. Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis. Dev. Biol. 125:441-450 (1988).
    • (1988) Dev. Biol. , vol.125 , pp. 441-450
    • Risau, W.1    Lemmon, V.2
  • 114
    • 0031729982 scopus 로고    scopus 로고
    • Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis
    • V. Goede, T. Schmidt, S. Kimmina, D. Kozian, and H. G. Augustin. Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis. Lab. Invest. 78:1385-1394 (1998).
    • (1998) Lab. Invest. , vol.78 , pp. 1385-1394
    • Goede, V.1    Schmidt, T.2    Kimmina, S.3    Kozian, D.4    Augustin, H.G.5
  • 115
    • 3142682314 scopus 로고    scopus 로고
    • Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice
    • Z. Zhou, J. Wang, R. Cao, H. Morita, R. Soininen, K. M. Chan, B. Liu, Y. Cao, and K. Tryggvason. Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice. Cancer Res. 64:4699-4702 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 4699-4702
    • Zhou, Z.1    Wang, J.2    Cao, R.3    Morita, H.4    Soininen, R.5    Chan, K.M.6    Liu, B.7    Cao, Y.8    Tryggvason, K.9
  • 116
    • 0030044984 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, a potent and selective angiogenic agent
    • K. A. Thomas. Vascular endothelial growth factor, a potent and selective angiogenic agent. J. Biol. Chem. 271:603-606 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 603-606
    • Thomas, K.A.1
  • 117
    • 0033117167 scopus 로고    scopus 로고
    • Extracellular matrix-driven matrix metalloproteinase production in endothelial cells: Implications for angiogenesis
    • T. L. Haas, and J. A. Madri. Extracellular matrix-driven matrix metalloproteinase production in endothelial cells: implications for angiogenesis. Trends Cardiovasc. Med. 9:70-77 (1999).
    • (1999) Trends Cardiovasc. Med. , vol.9 , pp. 70-77
    • Haas, T.L.1    Madri, J.A.2
  • 118
    • 0032963472 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression
    • J. E. Nor, J. Christensen, D. J. Mooney, and P. J. Polverini. Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am. J. Pathol. 154:375-384 (1999).
    • (1999) Am. J. Pathol. , vol.154 , pp. 375-384
    • Nor, J.E.1    Christensen, J.2    Mooney, D.J.3    Polverini, P.J.4
  • 119
  • 120
    • 0038104888 scopus 로고    scopus 로고
    • Structural response of microcirculatory networks to changes in demand: Information transfer by shear stress
    • A. R. Pries, B. Reglin, and T. W. Secomb. Structural response of microcirculatory networks to changes in demand: information transfer by shear stress. Am. J. Physiol. Heart Circ. Physiol. 284:H2204-H2212 (2003).
    • (2003) Am. J. Physiol. Heart Circ. Physiol. , vol.284
    • Pries, A.R.1    Reglin, B.2    Secomb, T.W.3
  • 123
    • 8844224030 scopus 로고    scopus 로고
    • Microenvironmental and cellular consequences of altered blood flow in tumours
    • N. Raghunand, R. A. Gatenby, and R. J. Gillies. Microenvironmental and cellular consequences of altered blood flow in tumours. Br. J. Radiol. 76:S11-S22 (2003).
    • (2003) Br. J. Radiol. , vol.76
    • Raghunand, N.1    Gatenby, R.A.2    Gillies, R.J.3
  • 124
    • 0034075041 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients
    • J. C. Lee, N. H. Chow, S. T. Wang, and S. M. Huang. Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients. Eur. J. Cancer 36:748-753 (2000).
    • (2000) Eur. J. Cancer , vol.36 , pp. 748-753
    • Lee, J.C.1    Chow, N.H.2    Wang, S.T.3    Huang, S.M.4
  • 125
    • 33751094077 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces proliferation of breast cancer cells and inhibits the anti-proliferative activity of anti-hormones
    • Y. Liang, R. A. Brekken, and S. M. Hyder. Vascular endothelial growth factor induces proliferation of breast cancer cells and inhibits the anti-proliferative activity of anti-hormones. Endocr. Relat. Cancer 13:905-919 (2006).
    • (2006) Endocr. Relat. Cancer , vol.13 , pp. 905-919
    • Liang, Y.1    Brekken, R.A.2    Hyder, S.M.3
  • 126
    • 33745550002 scopus 로고    scopus 로고
    • The balance of VEGF-C and VEGFR-3 mRNA is a predictor of lymph node metastasis in non-small cell lung cancer
    • H. Takizawa, K. Kondo, H. Fujino, K. Kenzaki, T. Miyoshi, S. Sakiyama, and A. Tangoku. The balance of VEGF-C and VEGFR-3 mRNA is a predictor of lymph node metastasis in non-small cell lung cancer. Br. J. Cancer 95:75-79 (2006).
    • (2006) Br. J. Cancer , vol.95 , pp. 75-79
    • Takizawa, H.1    Kondo, K.2    Fujino, H.3    Kenzaki, K.4    Miyoshi, T.5    Sakiyama, S.6    Tangoku, A.7
  • 127
    • 15244340228 scopus 로고    scopus 로고
    • VEGF, FGF2, TGFB1 and TGFBR1 mRNA expression levels correlate with the malignant transformation of the uterine cervix
    • G. Soufla, S. Sifakis, S. Baritaki, A. Zafiropoulos, E. Koumantakis, and D. A. Spandidos. VEGF, FGF2, TGFB1 and TGFBR1 mRNA expression levels correlate with the malignant transformation of the uterine cervix. Cancer Lett. 221:105-118 (2005).
    • (2005) Cancer Lett. , vol.221 , pp. 105-118
    • Soufla, G.1    Sifakis, S.2    Baritaki, S.3    Zafiropoulos, A.4    Koumantakis, E.5    Spandidos, D.A.6
  • 128
    • 27944490875 scopus 로고    scopus 로고
    • VEGF as a therapeutic target in cancer
    • N. Ferrara. VEGF as a therapeutic target in cancer. Oncology 69:11-16 (2005).
    • (2005) Oncology , vol.69 , pp. 11-16
    • Ferrara, N.1
  • 129
    • 33747587367 scopus 로고    scopus 로고
    • New targeted therapy for rare stomach, kidney cancers
    • FDA.
    • FDA. New targeted therapy for rare stomach, kidney cancers. FDA Consum. 40:5 (2006).
    • (2006) FDA Consum. , vol.40 , pp. 5
  • 132
    • 23844516785 scopus 로고    scopus 로고
    • PTK787/ZK222584, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, reduces uptake of the contrast agent GdDOTA by murine orthotopic B16/BL6 melanoma tumours and inhibits their growth in vivo
    • M. Rudin, P. M. McSheehy, P. R. Allegrini, M. Rausch, D. Baumann, M. Becquet, K. Brecht, J. Brueggen, S. Ferretti, F. Schaeffer, C. Schnell, and J. Wood. PTK787/ZK222584, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, reduces uptake of the contrast agent GdDOTA by murine orthotopic B16/BL6 melanoma tumours and inhibits their growth in vivo. NMR Biomed. 18:308-321 (2005).
    • (2005) NMR Biomed. , vol.18 , pp. 308-321
    • Rudin, M.1    McSheehy, P.M.2    Allegrini, P.R.3    Rausch, M.4    Baumann, D.5    Becquet, M.6    Brecht, K.7    Brueggen, J.8    Ferretti, S.9    Schaeffer, F.10    Schnell, C.11    Wood, J.12
  • 134
    • 26244450843 scopus 로고    scopus 로고
    • Heterogeneity in the angiogenic response of a BT474 human breast cancer to a novel vascular endothelial growth factor-receptor tyrosine kinase inhibitor: Assessment by voxel analysis of dynamic contrast-enhanced MRI
    • K. L. Li, L. J. Wilmes, R. G. Henry, M. G. Pallavicini, J. W. Park, D. D. Hu-Lowe, T. M. McShane, D. R. Shalinsky, Y. J. Fu, R. C. Brasch, and N. M. Hylton. Heterogeneity in the angiogenic response of a BT474 human breast cancer to a novel vascular endothelial growth factor-receptor tyrosine kinase inhibitor: assessment by voxel analysis of dynamic contrast-enhanced MRI. J. Magn. Reson. Imaging 22:511-519 (2005).
    • (2005) J. Magn. Reson. Imaging , vol.22 , pp. 511-519
    • Li, K.L.1    Wilmes, L.J.2    Henry, R.G.3    Pallavicini, M.G.4    Park, J.W.5    Hu-Lowe, D.D.6    McShane, T.M.7    Shalinsky, D.R.8    Fu, Y.J.9    Brasch, R.C.10    Hylton, N.M.11
  • 136
    • 33748752619 scopus 로고    scopus 로고
    • A phase II study of high-dose bevacizumab in combination with irinotecan, 5-fluorouracil, leucovorin, as initial therapy for advanced colorectal cancer: Results from the eastern cooperative oncology group study E2200
    • B. Giantonio, D. Levy, P. O'Dwyer, N. Meropol, P. Catalano, and A. Benson, 3rd. A phase II study of high-dose bevacizumab in combination with irinotecan, 5-fluorouracil, leucovorin, as initial therapy for advanced colorectal cancer: results from the eastern cooperative oncology group study E2200. Ann. Oncol. 17:1399-1403 (2006).
    • (2006) Ann. Oncol. , vol.17 , pp. 1399-1403
    • Giantonio, B.1    Levy, D.2    O'Dwyer, P.3    Meropol, N.4    Catalano, P.5    Benson III, A.6
  • 138
    • 7044253187 scopus 로고    scopus 로고
    • MRI monitoring of Avastin antiangiogenesis therapy using B22956/1, a new blood pool contrast agent, in an experimental model of human cancer
    • A. Preda, V. Novikov, M. Moglich, K. Turetschek, D. M. Shames, R. C. Brasch, F. M. Cavagna, and T. P. Roberts. MRI monitoring of Avastin antiangiogenesis therapy using B22956/1, a new blood pool contrast agent, in an experimental model of human cancer. J. Magn. Reson. Imaging 20:865-873 (2004).
    • (2004) J. Magn. Reson. Imaging , vol.20 , pp. 865-873
    • Preda, A.1    Novikov, V.2    Moglich, M.3    Turetschek, K.4    Shames, D.M.5    Brasch, R.C.6    Cavagna, F.M.7    Roberts, T.P.8
  • 139
    • 33646675851 scopus 로고    scopus 로고
    • MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy
    • W. B. Pope, A. Lai, P. Nghiemphu, P. Mischel, and T. F. Cloughesy. MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy. Neurology 66:1258-1260 (2006).
    • (2006) Neurology , vol.66 , pp. 1258-1260
    • Pope, W.B.1    Lai, A.2    Nghiemphu, P.3    Mischel, P.4    Cloughesy, T.F.5
  • 140
    • 3242711422 scopus 로고    scopus 로고
    • Complete radiological and metabolic response of metastatic renal cell carcinoma to SU5416 (semaxanib) in a patient with probable von Hippel-Lindau syndrome
    • R. R. Jennens, M. A. Rosenthal, G. J. Lindeman, and M. Michael. Complete radiological and metabolic response of metastatic renal cell carcinoma to SU5416 (semaxanib) in a patient with probable von Hippel-Lindau syndrome. Urol. Oncol. 22:193-196 (2004).
    • (2004) Urol. Oncol. , vol.22 , pp. 193-196
    • Jennens, R.R.1    Rosenthal, M.A.2    Lindeman, G.J.3    Michael, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.