Genomic instability in cancer

Novartis Foundation Symposium

Volumn 240, Issue , 2001, Pages 133-142

  Rockwell, Sara ^a   Yuan, Jianling ^a   Peretz, Shani ^a   Glazer, Peter M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL HYPOXIA; CHROMOSOME ABERRATION; DNA REPAIR; DNA REPLICATION; EXTRACELLULAR SPACE; GENE AMPLIFICATION; GENETICS; HUMAN; METABOLISM; NEOPLASM; PATHOPHYSIOLOGY; PH; PHYSIOLOGY; REVIEW;

CELL HYPOXIA; CHROMOSOME ABERRATIONS; DNA REPAIR; DNA REPLICATION; EXTRACELLULAR SPACE; GENE AMPLIFICATION; HUMAN; HYDROGEN-ION CONCENTRATION; NEOPLASMS; SUPPORT, NON-U.S. GOV'T;

EID: 0035230283     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (35)

1. Brizel DM, Scully SP, Harrelson JM et al 1996 Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 56:941-943
2. Brizel DM, Sibley GS, Prosnitz LR, Scher RL, Dewhirst MW 1997 Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 38: 285-289
3. Cheng KC, Cahill DS, Kasai H, Nishimura S, Loeb LA 1992 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions. J Biol Chem 267:166-172
4. Coquelle A, Toledo F, Stern S, Bieth A, Debatisse M 1998 A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs. Mol Cell 2:259-265
5. Cuvier C, Jang A, Hill RP 1997 Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L+B) secretion. Clin Exp Metastasis 15:19-25
6. Foster PL 1992 Directed mutation: between unicorns and goats. J Bacteriol 174:1711-1716
7. Goncharova EI, Nádas A, Rossman TG 1996 Serum deprivation, but not inhibition of growth per se, induces a hypermutable state in Chinese hamster G12 cells. Cancer Res 56:752-756
8. Graeber TG, Osmanian C, Jacks T et al 1996 Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379:88-91
9. Hahn P, Kapp LN, Morgan WF, Painter RB 1986 Chromosomal changes without DNA overproduction in hydroxyurea-treated mammalian cells: implications for gene amplification. Cancer Res 46:4607-4612
10. Heacock CS, Sutherland RM 1990 Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism. Br J Cancer 62:217-225
11. Hill RP 1990 Tumor progression: potential role of unstable genomic changes. Cancer Metastasis Rev 9:137-147
12. Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P 1996 Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56:4509-4515
13. Jain RK 1995 Whitaker Lecture: Delivery of molecules, particles and cells to solid tumors. Ann Biomed Eng 24:457-473
14. Koong AC, Denko NC Hudson KM et al 2000 Candidate genes for the hypoxic tumor phenotype. Cancer Res 60:883-887
15. Loeb LA 1991 Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 51:3075-3079
16. Moulder JE, Rockwell S 1987 Tumor hypoxia: its impact on cancer therapy. Cancer Metastasis Rev 5:313-341
17. Nowell PC 1976 The clonal evolution of tumor cell populations. Science 194:23-28
18. Peretz S, Kim C, Rockwell S et al 1999 Tumor hypoxia induces and selects for overexpression of the IGF-1 receptor: implications for tumour progression and radioresistance. Proc Am Assoc Cancer Res 45:105 (abstr)
19. Pettersen EO, Juul NO, Ronning OW 1986 Regulation of protein metabolism of human cells during and after acute hypoxia. Cancer Res 46:4346-4351
20. Reynolds TY, Rockwell S, Glazer PM 1996 Genetic instability induced by the tumor microenvironment. Cancer Res 56:5754-5757
21. Rice GC, Hoy C, Schimke RT 1986 Transient hypoxia enhances the frequency of dihydrofblate reductase gene amplification in Chinese hamster ovary cells. Proc Natl Acad Sci USA 83: 5978-5982
22. Rice GC, Ling V, Schimke RT 1987 Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistance. Proc Natl Acad Sci USA 84:9261-9264
23. Rockwell S 2001 Hypoxia and drug resistance. In: J. R. Bertino (ed) Encyclopedia of Cancer, 2nd edn. Academic Press, New York
24. Rockwell S, Knisely JPS 1997 Hypoxia and angiogenesis in experimental tumor models: Therapeutic implications. In: Goldberg, ID Rosen, EM (eds) Regulation of Angiogenesis. Birkhauser Verlag, Basel, p 335-356
25. Rofstad EK, Johnsen NM, Lyng H 1996 Hypoxia-induced tetraploidisation of a diploid human melanoma cell line invitro. Br J Cancer 27:S136-S139
26. Rotin D, Robinson B, Tannock IF 1986 Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors. Cancer Res 46:2821 2826
27. Russo CA, Weber TK, Volpe CM et al 1995 An anoxia inducible endonuclease and enhanced DNA breakage as contributors to genomic instability in cancer. Cancer Res 55:1122-1128
28. Schimke RT, Sherwood SW, Hill AB, Johnston RN 1986 Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications. Proc Natl Acad Sci USA 83:2157-2161
29. Schlappack OK, Zimmermann A, Hill RP 1991 Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells. Br J Cancer 64:663-670
30. Stoler DL, Anderson GR, Russo CA, Spina AM, Beerman TA 1992 Anoxia-inducible endonuclease activity as a potential basis of the genomic instability of cancer cells. Cancer Res 52:4372-4378
31. Welbourn CR, Goldman G, Paterson IS, Valeri CR, Shepro D, Hechtman HB 1991 Pathophysiology of ischaemia reperfusion injury: central role of the neutrophil. Br J Surg 78:651-655
32. Wilkinson JK, Sandhu JW, Beneman JD, Tucker JD, Birnboim HC 1995 Hprt mutants in a transplantable murine tumour arise more frequently in vivo than in vitro. Br J Cancer 72:1234-1240
33. Young SD, Marshall RS, Hill RP 1988 Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc Natl Acad Sci USA 85:9533-9537
34. Yuan J, Glazer PM 1998 Mutagenesis induced by the tumor microenvironment. Mutat Res 400:439-446
35. Yuan J, Narayanan L, Rockwell S, Glazer PM 2000 Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res 60: 4372-4376