메뉴 건너뛰기




Volumn 33, Issue 4, 2006, Pages 407-420

New Paradigms in Anticancer Therapy: Targeting Multiple Signaling Pathways With Kinase Inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

AP 23573; BEVACIZUMAB; CARBOPLATIN; CETUXIMAB; CISPLATIN; ERLOTINIB; EVEROLIMUS; FLUOROURACIL; FOLINIC ACID; GEFITINIB; GEMCITABINE; IMATINIB; IRINOTECAN; MIDOSTAURIN; PACLITAXEL; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN SERINE KINASE; PROTEIN TYROSINE KINASE; SORAFENIB; SUNITINIB; TAMOXIFEN; TEMSIROLIMUS; TRASTUZUMAB;

EID: 33746544343     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2006.04.005     Document Type: Article
Times cited : (238)

References (134)
  • 1
    • 18544385341 scopus 로고    scopus 로고
    • Receptor-targeted cancer therapy
    • Richter M., and Zhang H. Receptor-targeted cancer therapy. DNA Cell Biol 24 (2005) 271-282
    • (2005) DNA Cell Biol , vol.24 , pp. 271-282
    • Richter, M.1    Zhang, H.2
  • 2
    • 33746520768 scopus 로고    scopus 로고
    • Scientific basis of cancer chemotherapy
    • Perry M.C. (Ed), Lippincott Williams & Wilkins, Philadelphia, PA
    • Schwarz J.K., and Yarbro J.W. Scientific basis of cancer chemotherapy. In: Perry M.C. (Ed). The Chemotherapy Source Book (ed 3) (2001), Lippincott Williams & Wilkins, Philadelphia, PA 1-6
    • (2001) The Chemotherapy Source Book (ed 3) , pp. 1-6
    • Schwarz, J.K.1    Yarbro, J.W.2
  • 3
    • 84984568414 scopus 로고    scopus 로고
    • The history of targeted therapy for cancer, in K.K. S
    • Harrington K.J. (Ed), Oxford University Press, New York, NY
    • Bagshawe K.D. The history of targeted therapy for cancer, in K.K. S. In: Harrington K.J. (Ed). Targeted Therapy for Cancer (2003), Oxford University Press, New York, NY 3-16
    • (2003) Targeted Therapy for Cancer , pp. 3-16
    • Bagshawe, K.D.1
  • 5
    • 13844316734 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors and the dawn of molecular cancer therapeutics
    • Tibes R., Trent J., and Kurzrock R. Tyrosine kinase inhibitors and the dawn of molecular cancer therapeutics. Annu Rev Pharmacol Toxicol 45 (2005) 357-384
    • (2005) Annu Rev Pharmacol Toxicol , vol.45 , pp. 357-384
    • Tibes, R.1    Trent, J.2    Kurzrock, R.3
  • 6
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H., Fehrenbacher L., Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350 (2004) 2335-2342
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 7
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat Med 9 (2003) 669-676
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 8
    • 1642533527 scopus 로고    scopus 로고
    • Cetuximab. In the treatment of metastatic colorectal cancer
    • Reynolds N.A., and Wagstaff A.J. Cetuximab. In the treatment of metastatic colorectal cancer. Drugs 64 (2004) 109-118
    • (2004) Drugs , vol.64 , pp. 109-118
    • Reynolds, N.A.1    Wagstaff, A.J.2
  • 9
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D., Humblet Y., Siena S., et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351 (2004) 337-345
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 10
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon D.J., Leyland-Jones B., Shak S., et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344 (2001) 783-792
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 11
    • 0037285971 scopus 로고    scopus 로고
    • Growth factor receptors in breast cancer. Potential for therapeutic intervention
    • Nahta R., Hortobagyi G.N., and Esteva F.J. Growth factor receptors in breast cancer. Potential for therapeutic intervention. Oncologist 8 (2003) 5-17
    • (2003) Oncologist , vol.8 , pp. 5-17
    • Nahta, R.1    Hortobagyi, G.N.2    Esteva, F.J.3
  • 12
    • 12144287534 scopus 로고    scopus 로고
    • United States Food and Drug Administration Drug Approval summary. Gefitinib (ZD1839; Iressa) tablets
    • Cohen M.H., Williams G.A., Sridhara R., et al. United States Food and Drug Administration Drug Approval summary. Gefitinib (ZD1839; Iressa) tablets. Clin Cancer Res 10 (2004) 1212-1218
    • (2004) Clin Cancer Res , vol.10 , pp. 1212-1218
    • Cohen, M.H.1    Williams, G.A.2    Sridhara, R.3
  • 13
    • 25144488564 scopus 로고    scopus 로고
    • Approval summary for erlotinib for treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen
    • Johnson J.R., Cohen M., Sridhara R., et al. Approval summary for erlotinib for treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen. Clin Cancer Res 11 (2005) 6414-6421
    • (2005) Clin Cancer Res , vol.11 , pp. 6414-6421
    • Johnson, J.R.1    Cohen, M.2    Sridhara, R.3
  • 14
    • 10744220743 scopus 로고    scopus 로고
    • Approval summary. Imatinib mesylate capsules for treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase
    • Johnson J.R., Bross P., Cohen M., et al. Approval summary. Imatinib mesylate capsules for treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase. Clin Cancer Res 9 (2003) 1972-1979
    • (2003) Clin Cancer Res , vol.9 , pp. 1972-1979
    • Johnson, J.R.1    Bross, P.2    Cohen, M.3
  • 15
    • 0036795899 scopus 로고    scopus 로고
    • Approval summary. Imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors
    • Dagher R., Cohen M., Williams G., et al. Approval summary. Imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors. Clin Cancer Res 8 (2002) 3034-3038
    • (2002) Clin Cancer Res , vol.8 , pp. 3034-3038
    • Dagher, R.1    Cohen, M.2    Williams, G.3
  • 16
    • 0036094117 scopus 로고    scopus 로고
    • Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia
    • Cohen M.H., Williams G., Johnson J.R., et al. Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia. Clin Cancer Res 8 (2002) 935-942
    • (2002) Clin Cancer Res , vol.8 , pp. 935-942
    • Cohen, M.H.1    Williams, G.2    Johnson, J.R.3
  • 17
    • 1642447060 scopus 로고    scopus 로고
    • The role of EGFR inhibitors in nonsmall cell lung cancer
    • Ciardiello F., De Vita F., Orditura M., et al. The role of EGFR inhibitors in nonsmall cell lung cancer. Curr Opin Oncol 16 (2004) 130-135
    • (2004) Curr Opin Oncol , vol.16 , pp. 130-135
    • Ciardiello, F.1    De Vita, F.2    Orditura, M.3
  • 18
    • 2342492317 scopus 로고    scopus 로고
    • Review of epidermal growth factor receptor biology
    • Herbst R.S. Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys 59 (2004) 21-26
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , pp. 21-26
    • Herbst, R.S.1
  • 19
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer. Correlation with clinical response to gefitinib therapy
    • Paez J.G., Janne P.A., Lee J.C., et al. EGFR mutations in lung cancer. Correlation with clinical response to gefitinib therapy. Science 304 (2004) 1497-1500
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 20
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T.J., Bell D.W., Sordella R., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350 (2004) 2129-2139
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 21
    • 0022406444 scopus 로고
    • Amplification of a novel v-erbB-related gene in a human mammary carcinoma
    • King C.R., Kraus M.H., and Aaronson S.A. Amplification of a novel v-erbB-related gene in a human mammary carcinoma. Science 229 (1985) 974-976
    • (1985) Science , vol.229 , pp. 974-976
    • King, C.R.1    Kraus, M.H.2    Aaronson, S.A.3
  • 22
    • 37049183697 scopus 로고
    • Human breast cancer. Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon D.J., Clark G.M., Wong S.G., et al. Human breast cancer. Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235 (1987) 177-182
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 23
    • 0027517374 scopus 로고
    • Clinical significance of HER-2/neu oncogene amplification in primary breast cancer
    • The South Australian Breast Cancer Study Group
    • Seshadri R., Firgaira F.A., Horsfall D.J., et al., The South Australian Breast Cancer Study Group. Clinical significance of HER-2/neu oncogene amplification in primary breast cancer. J Clin Oncol 11 (1993) 1936-1942
    • (1993) J Clin Oncol , vol.11 , pp. 1936-1942
    • Seshadri, R.1    Firgaira, F.A.2    Horsfall, D.J.3
  • 24
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    • Heinrich M.C., Corless C.L., Demetri G.D., et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 21 (2003) 4342-4349
    • (2003) J Clin Oncol , vol.21 , pp. 4342-4349
    • Heinrich, M.C.1    Corless, C.L.2    Demetri, G.D.3
  • 25
    • 0242670019 scopus 로고    scopus 로고
    • PDGFRA activating mutations in gastrointestinal stromal tumors
    • Heinrich M.C., Corless C.L., Duensing A., et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 299 (2003) 708-710
    • (2003) Science , vol.299 , pp. 708-710
    • Heinrich, M.C.1    Corless, C.L.2    Duensing, A.3
  • 27
    • 2342557044 scopus 로고    scopus 로고
    • Targeted therapies for non-small-cell lung cancer. Biology, rationale, and preclinical results from a radiation oncology perspective
    • Raben D., Helfrich B., and Bunn Jr. P.A. Targeted therapies for non-small-cell lung cancer. Biology, rationale, and preclinical results from a radiation oncology perspective. Int J Radiat Oncol Biol Phys 59 (2004) 27-38
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , pp. 27-38
    • Raben, D.1    Helfrich, B.2    Bunn Jr., P.A.3
  • 28
    • 1542315370 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumours and their response to treatment with the tyrosine kinase inhibitor imatinib
    • Mechtersheimer G., Egerer G., Hensel M., et al. Gastrointestinal stromal tumours and their response to treatment with the tyrosine kinase inhibitor imatinib. Virchows Arch 444 (2004) 108-118
    • (2004) Virchows Arch , vol.444 , pp. 108-118
    • Mechtersheimer, G.1    Egerer, G.2    Hensel, M.3
  • 29
    • 1942473596 scopus 로고    scopus 로고
    • Biology of gastrointestinal stromal tumors. KIT mutations and beyond
    • Duensing A., Heinrich M.C., Fletcher C.D., et al. Biology of gastrointestinal stromal tumors. KIT mutations and beyond. Cancer Invest 22 (2004) 106-116
    • (2004) Cancer Invest , vol.22 , pp. 106-116
    • Duensing, A.1    Heinrich, M.C.2    Fletcher, C.D.3
  • 30
    • 1242293090 scopus 로고    scopus 로고
    • Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy. focus on NSCLC
    • Langer C.J. Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy. focus on NSCLC. Int J Radiat Oncol Biol Phys 58 (2004) 991-1002
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 991-1002
    • Langer, C.J.1
  • 31
    • 1042287070 scopus 로고    scopus 로고
    • Novel treatments in non-small cell lung cancer
    • Leslie W.T., and Bonomi P.D. Novel treatments in non-small cell lung cancer. Hematol Oncol Clin North Am 18 (2004) 245-267
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 245-267
    • Leslie, W.T.1    Bonomi, P.D.2
  • 32
    • 0036817873 scopus 로고    scopus 로고
    • Targeting intracellular signal transduction. A new paradigm for a brave new world of molecularly targeted therapeutics
    • Beeram M., and Patnaik A. Targeting intracellular signal transduction. A new paradigm for a brave new world of molecularly targeted therapeutics. Hematol Oncol Clin North Am 16 (2002) 1089-1100
    • (2002) Hematol Oncol Clin North Am , vol.16 , pp. 1089-1100
    • Beeram, M.1    Patnaik, A.2
  • 33
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 34
    • 2942670180 scopus 로고    scopus 로고
    • PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma
    • Ostman A. PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Cytokine Growth Factor Rev 15 (2004) 275-286
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 275-286
    • Ostman, A.1
  • 35
    • 20444430119 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor (PDGFR). A target for anticancer therapeutics
    • Board R., and Jayson G.C. Platelet-derived growth factor receptor (PDGFR). A target for anticancer therapeutics. Drug Resist Updat 8 (2005) 75-83
    • (2005) Drug Resist Updat , vol.8 , pp. 75-83
    • Board, R.1    Jayson, G.C.2
  • 36
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • Erber R., Thurnher A., Katsen A.D., et al. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J 18 (2004) 338-340
    • (2004) FASEB J , vol.18 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3
  • 37
    • 0033761908 scopus 로고    scopus 로고
    • Endothelial cell survival and apoptosis in the tumor vasculature
    • Liu W., Ahmad S.A., Reinmuth N., et al. Endothelial cell survival and apoptosis in the tumor vasculature. Apoptosis 5 (2000) 323-328
    • (2000) Apoptosis , vol.5 , pp. 323-328
    • Liu, W.1    Ahmad, S.A.2    Reinmuth, N.3
  • 38
    • 33746537537 scopus 로고    scopus 로고
    • Drug resistance
    • Perry M.C. (Ed), Lippincott Williams & Wilkins, Philadelphia, PA
    • Goldie J. Drug resistance. In: Perry M.C. (Ed). The Chemotherapy Source Book (ed 3) (2001), Lippincott Williams & Wilkins, Philadelphia, PA 1-6
    • (2001) The Chemotherapy Source Book (ed 3) , pp. 1-6
    • Goldie, J.1
  • 39
    • 24644523246 scopus 로고    scopus 로고
    • Resistance to tyrosine kinase inhibitors. Calling on extra forces
    • Cools J., Maertens C., and Marynen P. Resistance to tyrosine kinase inhibitors. Calling on extra forces. Drug Resist Updat 8 (2005) 119-129
    • (2005) Drug Resist Updat , vol.8 , pp. 119-129
    • Cools, J.1    Maertens, C.2    Marynen, P.3
  • 40
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature. An emerging concept in antiangiogenic therapy
    • Jain R.K. Normalization of tumor vasculature. An emerging concept in antiangiogenic therapy. Science 307 (2005) 58-62
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 41
    • 10944242667 scopus 로고    scopus 로고
    • Antiangiogenic therapy. Creating a unique "window" of opportunity
    • Lin M.I., and Sessa W.C. Antiangiogenic therapy. Creating a unique "window" of opportunity. Cancer Cell 6 (2004) 529-531
    • (2004) Cancer Cell , vol.6 , pp. 529-531
    • Lin, M.I.1    Sessa, W.C.2
  • 42
    • 25844490498 scopus 로고    scopus 로고
    • Clinical trials of intracellular signal transductions inhibitors for breast cancer-A strategy to overcome endocrine resistance
    • Johnston S.R. Clinical trials of intracellular signal transductions inhibitors for breast cancer-A strategy to overcome endocrine resistance. Endocr Relat Cancer 12 suppl 1 (2005) S145-S157
    • (2005) Endocr Relat Cancer , vol.12 , Issue.SUPPL. 1
    • Johnston, S.R.1
  • 43
    • 0242721012 scopus 로고    scopus 로고
    • The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro
    • Gee J.M., Harper M.E., Hutcheson I.R., et al. The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro. Endocrinology 144 (2003) 5105-5117
    • (2003) Endocrinology , vol.144 , pp. 5105-5117
    • Gee, J.M.1    Harper, M.E.2    Hutcheson, I.R.3
  • 45
    • 0036402628 scopus 로고    scopus 로고
    • BAY 43-9006. Early clinical data in patients with advanced solid malignancies
    • Hotte S.J., and Hirte H.W. BAY 43-9006. Early clinical data in patients with advanced solid malignancies. Curr Pharm Des 8 (2002) 2249-2253
    • (2002) Curr Pharm Des , vol.8 , pp. 2249-2253
    • Hotte, S.J.1    Hirte, H.W.2
  • 46
    • 4644259265 scopus 로고    scopus 로고
    • Kinase inhibition with BAY 43-9006 in renal cell carcinoma
    • Ahmad T., and Eisen T. Kinase inhibition with BAY 43-9006 in renal cell carcinoma. Clin Cancer Res 10 (2004) 6388S-6392S
    • (2004) Clin Cancer Res , vol.10
    • Ahmad, T.1    Eisen, T.2
  • 47
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G., Song S., Meyer-Morse N., et al. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 111 (2003) 1287-1295
    • (2003) J Clin Invest , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3
  • 48
    • 14644446018 scopus 로고    scopus 로고
    • A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
    • Pietras K., and Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol 23 (2005) 939-952
    • (2005) J Clin Oncol , vol.23 , pp. 939-952
    • Pietras, K.1    Hanahan, D.2
  • 49
    • 18144399578 scopus 로고    scopus 로고
    • mTOR-targeted therapy of cancer with rapamycin derivatives
    • Vignot S., Faivre S., Aguirre D., et al. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol 16 (2005) 525-537
    • (2005) Ann Oncol , vol.16 , pp. 525-537
    • Vignot, S.1    Faivre, S.2    Aguirre, D.3
  • 50
    • 4644239244 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition
    • Dutcher J.P. Mammalian target of rapamycin inhibition. Clin Cancer Res 10 (2004) 6382S-6387S
    • (2004) Clin Cancer Res , vol.10
    • Dutcher, J.P.1
  • 51
    • 0035657643 scopus 로고    scopus 로고
    • Protein kinase C inhibitors as novel anticancer drugs
    • Goekjian P.G., and Jirousek M.R. Protein kinase C inhibitors as novel anticancer drugs. Expert Opin Investig Drugs 10 (2001) 2117-2140
    • (2001) Expert Opin Investig Drugs , vol.10 , pp. 2117-2140
    • Goekjian, P.G.1    Jirousek, M.R.2
  • 52
    • 14944352767 scopus 로고    scopus 로고
    • Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants
    • Debiec-Rychter M., Cools J., Dumez H., et al. Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants. Gastroenterology 128 (2005) 270-279
    • (2005) Gastroenterology , vol.128 , pp. 270-279
    • Debiec-Rychter, M.1    Cools, J.2    Dumez, H.3
  • 53
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T., Butterfield C.E., Kraling B.M., et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 60 (2000) 1878-1886
    • (2000) Cancer Res , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kraling, B.M.3
  • 54
    • 0031952212 scopus 로고    scopus 로고
    • Paclitaxel/carboplatin administration along with antiangiogenic therapy in non-small-cell lung and breast carcinoma models
    • Herbst R.S., Takeuchi H., and Teicher B.A. Paclitaxel/carboplatin administration along with antiangiogenic therapy in non-small-cell lung and breast carcinoma models. Cancer Chemother Pharmacol 41 (1998) 497-504
    • (1998) Cancer Chemother Pharmacol , vol.41 , pp. 497-504
    • Herbst, R.S.1    Takeuchi, H.2    Teicher, B.A.3
  • 55
    • 0030920374 scopus 로고    scopus 로고
    • Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents
    • Kakeji Y., and Teicher B.A. Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents. Invest New Drugs 15 (1997) 39-48
    • (1997) Invest New Drugs , vol.15 , pp. 39-48
    • Kakeji, Y.1    Teicher, B.A.2
  • 56
    • 20944448672 scopus 로고    scopus 로고
    • Trimodal cancer treatment. Beneficial effects of combined antiangiogenesis, radiation, and chemotherapy
    • Huber P.E., Bischof M., Jenne J., et al. Trimodal cancer treatment. Beneficial effects of combined antiangiogenesis, radiation, and chemotherapy. Cancer Res 65 (2005) 3643-3655
    • (2005) Cancer Res , vol.65 , pp. 3643-3655
    • Huber, P.E.1    Bischof, M.2    Jenne, J.3
  • 57
    • 0037312485 scopus 로고    scopus 로고
    • Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma
    • Inoue K., Chikazawa M., Fukata S., et al. Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma. Clin Cancer Res 9 (2003) 886-899
    • (2003) Clin Cancer Res , vol.9 , pp. 886-899
    • Inoue, K.1    Chikazawa, M.2    Fukata, S.3
  • 58
    • 0036790060 scopus 로고    scopus 로고
    • Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy
    • Pietras K., Rubin K., Sjoblom T., et al. Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy. Cancer Res 62 (2002) 5476-5484
    • (2002) Cancer Res , vol.62 , pp. 5476-5484
    • Pietras, K.1    Rubin, K.2    Sjoblom, T.3
  • 59
    • 0035214416 scopus 로고    scopus 로고
    • Metronomic scheduling. The future of chemotherapy?
    • Gasparini G. Metronomic scheduling. The future of chemotherapy?. Lancet Oncol 2 (2001) 733-740
    • (2001) Lancet Oncol , vol.2 , pp. 733-740
    • Gasparini, G.1
  • 60
    • 0034048358 scopus 로고    scopus 로고
    • Less is more, regularly. Metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice
    • Hanahan D., Bergers G., and Bergsland E. Less is more, regularly. Metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J Clin Invest 105 (2000) 1045-1047
    • (2000) J Clin Invest , vol.105 , pp. 1045-1047
    • Hanahan, D.1    Bergers, G.2    Bergsland, E.3
  • 61
    • 0035394833 scopus 로고    scopus 로고
    • Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo. A role for altered tumor angiogenesis
    • Viloria-Petit A., Crombet T., Jothy S., et al. Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo. A role for altered tumor angiogenesis. Cancer Res 61 (2001) 5090-5101
    • (2001) Cancer Res , vol.61 , pp. 5090-5101
    • Viloria-Petit, A.1    Crombet, T.2    Jothy, S.3
  • 62
    • 0029888125 scopus 로고    scopus 로고
    • Overexpression of HER2 modulates bcl-2, bcl-XL, and tamoxifen-induced apoptosis in human MCF-7 breast cancer cells
    • Kumar R., Mandal M., Lipton A., et al. Overexpression of HER2 modulates bcl-2, bcl-XL, and tamoxifen-induced apoptosis in human MCF-7 breast cancer cells. Clin Cancer Res 2 (1996) 1215-1219
    • (1996) Clin Cancer Res , vol.2 , pp. 1215-1219
    • Kumar, R.1    Mandal, M.2    Lipton, A.3
  • 63
    • 2942652871 scopus 로고    scopus 로고
    • Mechanisms of tamoxifen resistance. Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
    • Shou J., Massarweh S., Osborne C.K., et al. Mechanisms of tamoxifen resistance. Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J Natl Cancer Inst 96 (2004) 926-935
    • (2004) J Natl Cancer Inst , vol.96 , pp. 926-935
    • Shou, J.1    Massarweh, S.2    Osborne, C.K.3
  • 64
    • 1642406972 scopus 로고    scopus 로고
    • Synergistic interactions between tamoxifen and trastuzumab (Herceptin)
    • Argiris A., Wang C.X., Whalen S.G., et al. Synergistic interactions between tamoxifen and trastuzumab (Herceptin). Clin Cancer Res 10 (2004) 1409-1420
    • (2004) Clin Cancer Res , vol.10 , pp. 1409-1420
    • Argiris, A.1    Wang, C.X.2    Whalen, S.G.3
  • 65
    • 0037373326 scopus 로고    scopus 로고
    • Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells
    • Knowlden J.M., Hutcheson I.R., Jones H.E., et al. Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 144 (2003) 1032-1044
    • (2003) Endocrinology , vol.144 , pp. 1032-1044
    • Knowlden, J.M.1    Hutcheson, I.R.2    Jones, H.E.3
  • 66
    • 0842286818 scopus 로고    scopus 로고
    • Additive antitumour effect of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) and the antioestrogen fulvestrant (Faslodex, ICI 182,780) in breast cancer cells
    • Okubo S., Kurebayashi J., Otsuki T., et al. Additive antitumour effect of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) and the antioestrogen fulvestrant (Faslodex, ICI 182,780) in breast cancer cells. Br J Cancer 90 (2004) 236-244
    • (2004) Br J Cancer , vol.90 , pp. 236-244
    • Okubo, S.1    Kurebayashi, J.2    Otsuki, T.3
  • 67
    • 23744502215 scopus 로고    scopus 로고
    • Gefitinib, an EGFR tyrosine kinase inhibitor, directly inhibits the function of P-glycoprotein in multidrug resistant cancer cells
    • Kitazaki T., Oka M., Nakamura Y., et al. Gefitinib, an EGFR tyrosine kinase inhibitor, directly inhibits the function of P-glycoprotein in multidrug resistant cancer cells. Lung Cancer 49 (2005) 337-343
    • (2005) Lung Cancer , vol.49 , pp. 337-343
    • Kitazaki, T.1    Oka, M.2    Nakamura, Y.3
  • 68
    • 4644329144 scopus 로고    scopus 로고
    • Gefitinib reverses breast cancer resistance protein-mediated drug resistance
    • Yanase K., Tsukahara S., Asada S., et al. Gefitinib reverses breast cancer resistance protein-mediated drug resistance. Mol Cancer Ther 3 (2004) 1119-1125
    • (2004) Mol Cancer Ther , vol.3 , pp. 1119-1125
    • Yanase, K.1    Tsukahara, S.2    Asada, S.3
  • 69
    • 5644264888 scopus 로고    scopus 로고
    • Gefitinib enhances the antitumor activity and oral bioavailability of irinotecan in mice
    • Stewart C.F., Leggas M., Schuetz J.D., et al. Gefitinib enhances the antitumor activity and oral bioavailability of irinotecan in mice. Cancer Res 64 (2004) 7491-7499
    • (2004) Cancer Res , vol.64 , pp. 7491-7499
    • Stewart, C.F.1    Leggas, M.2    Schuetz, J.D.3
  • 70
    • 13944269488 scopus 로고    scopus 로고
    • Gefitinib ("Iressa," ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance
    • Nakamura Y., Oka M., Soda H., et al. Gefitinib ("Iressa," ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance. Cancer Res 65 (2005) 1541-1546
    • (2005) Cancer Res , vol.65 , pp. 1541-1546
    • Nakamura, Y.1    Oka, M.2    Soda, H.3
  • 71
    • 20244365941 scopus 로고    scopus 로고
    • The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation
    • Beuvink I., Boulay A., Fumagalli S., et al. The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 120 (2005) 747-759
    • (2005) Cell , vol.120 , pp. 747-759
    • Beuvink, I.1    Boulay, A.2    Fumagalli, S.3
  • 72
    • 15044350672 scopus 로고    scopus 로고
    • PKC 412 sensitizes U1810 non-small cell lung cancer cells to DNA damage
    • Hemstrom T.H., Joseph B., Schulte G., et al. PKC 412 sensitizes U1810 non-small cell lung cancer cells to DNA damage. Exp Cell Res 305 (2005) 200-213
    • (2005) Exp Cell Res , vol.305 , pp. 200-213
    • Hemstrom, T.H.1    Joseph, B.2    Schulte, G.3
  • 73
    • 22344446415 scopus 로고    scopus 로고
    • Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer
    • Boulay A., Rudloff J., Ye J., et al. Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer. Clin Cancer Res 11 (2005) 5319-5328
    • (2005) Clin Cancer Res , vol.11 , pp. 5319-5328
    • Boulay, A.1    Rudloff, J.2    Ye, J.3
  • 74
    • 15744372810 scopus 로고    scopus 로고
    • KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
    • Pao W., Wang T.Y., Riely G.J., et al. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med 2 (2005) e17
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Wang, T.Y.2    Riely, G.J.3
  • 75
    • 0141960451 scopus 로고    scopus 로고
    • Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/Akt pathway signaling
    • She Q.B., Solit D., Basso A., and Moasser M.M. Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/Akt pathway signaling. Clin Cancer Res 9 (2003) 4340-4346
    • (2003) Clin Cancer Res , vol.9 , pp. 4340-4346
    • She, Q.B.1    Solit, D.2    Basso, A.3    Moasser, M.M.4
  • 76
    • 0037616593 scopus 로고    scopus 로고
    • Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors
    • Bianco R., Shin I., Ritter C.A., et al. Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. Oncogene 22 (2003) 2812-2822
    • (2003) Oncogene , vol.22 , pp. 2812-2822
    • Bianco, R.1    Shin, I.2    Ritter, C.A.3
  • 77
    • 6944235337 scopus 로고    scopus 로고
    • Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt activity
    • deGraffenried L.A., Friedrichs W.E., Russell D.H., et al. Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt activity. Clin Cancer Res 10 (2004) 8059-8067
    • (2004) Clin Cancer Res , vol.10 , pp. 8059-8067
    • deGraffenried, L.A.1    Friedrichs, W.E.2    Russell, D.H.3
  • 78
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer. A phase III trial-INTACT 1
    • Giaccone G., Herbst R.S., Manegold C., et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer. A phase III trial-INTACT 1. J Clin Oncol 22 (2004) 777-784
    • (2004) J Clin Oncol , vol.22 , pp. 777-784
    • Giaccone, G.1    Herbst, R.S.2    Manegold, C.3
  • 79
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer. A phase III trial-INTACT 2
    • Herbst R.S., Giaccone G., Schiller J.H., et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer. A phase III trial-INTACT 2. J Clin Oncol 22 (2004) 785-794
    • (2004) J Clin Oncol , vol.22 , pp. 785-794
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.H.3
  • 80
    • 17844372539 scopus 로고    scopus 로고
    • Critical update and emerging trends in epidermal growth factor receptor targeting in cancer
    • Baselga J., and Arteaga C.L. Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J Clin Oncol 23 (2005) 2445-2459
    • (2005) J Clin Oncol , vol.23 , pp. 2445-2459
    • Baselga, J.1    Arteaga, C.L.2
  • 81
    • 1542503756 scopus 로고    scopus 로고
    • Combining the anti-EGFR agent gefitinib with chemotherapy in non-small-cell lung cancer. How do we go from INTACT to impact?
    • Baselga J. Combining the anti-EGFR agent gefitinib with chemotherapy in non-small-cell lung cancer. How do we go from INTACT to impact?. J Clin Oncol 22 (2004) 759-761
    • (2004) J Clin Oncol , vol.22 , pp. 759-761
    • Baselga, J.1
  • 82
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I., and Sawyers C.L. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2 (2002) 489-501
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 83
    • 16444379884 scopus 로고    scopus 로고
    • Bcl-2 and CCND1/CDK4 expression levels predict the cellular effects of mTOR inhibitors in human ovarian carcinoma
    • Aguirre D., Boya P., Bellet D., et al. Bcl-2 and CCND1/CDK4 expression levels predict the cellular effects of mTOR inhibitors in human ovarian carcinoma. Apoptosis 9 (2004) 797-805
    • (2004) Apoptosis , vol.9 , pp. 797-805
    • Aguirre, D.1    Boya, P.2    Bellet, D.3
  • 84
    • 2942735384 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
    • Raymond E., Alexandre J., Faivre S., et al. Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 22 (2004) 2336-2347
    • (2004) J Clin Oncol , vol.22 , pp. 2336-2347
    • Raymond, E.1    Alexandre, J.2    Faivre, S.3
  • 85
    • 0038688097 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of CCI-779, a novel cytostatic cell-cycle inhibitor, in combination with 5-fluorouracil and leucovorin in patients with advanced solid tumors
    • Punt C.J., Boni J., Bruntsch U., et al. Phase I and pharmacokinetic study of CCI-779, a novel cytostatic cell-cycle inhibitor, in combination with 5-fluorouracil and leucovorin in patients with advanced solid tumors. Ann Oncol 14 (2003) 931-937
    • (2003) Ann Oncol , vol.14 , pp. 931-937
    • Punt, C.J.1    Boni, J.2    Bruntsch, U.3
  • 86
    • 4544388665 scopus 로고    scopus 로고
    • The mTOR pathway in estrogen response. A potential for combining the rapamycin derivative RAD001 wih the aromatase inhibitor letrozole (Femara) in breast carcinoma
    • (abstr 5619)
    • Rudloff J., Boulay A., Zumstein-Mecker S., et al. The mTOR pathway in estrogen response. A potential for combining the rapamycin derivative RAD001 wih the aromatase inhibitor letrozole (Femara) in breast carcinoma. Proc Am Assoc Cancer Res 45 (2004) 1298 (abstr 5619)
    • (2004) Proc Am Assoc Cancer Res , vol.45 , pp. 1298
    • Rudloff, J.1    Boulay, A.2    Zumstein-Mecker, S.3
  • 87
    • 0029977949 scopus 로고    scopus 로고
    • Rapamycin resistance tied to defective regulation of p27Kip1
    • Luo Y., Marx S.O., Kiyokawa H., et al. Rapamycin resistance tied to defective regulation of p27Kip1. Mol Cell Biol 16 (1996) 6744-6751
    • (1996) Mol Cell Biol , vol.16 , pp. 6744-6751
    • Luo, Y.1    Marx, S.O.2    Kiyokawa, H.3
  • 88
    • 33746504210 scopus 로고    scopus 로고
    • A phase I/II trial of the oral mTOR-inhibitor everolimus (E, RAD001) and imatinib mesylate (IM) in patients (pts) with gastrointestinal stromal tumor (GIST) refractory to IM
    • (abstr 3002)
    • van Oosterom A., Dumez H., Desai J., et al. A phase I/II trial of the oral mTOR-inhibitor everolimus (E, RAD001) and imatinib mesylate (IM) in patients (pts) with gastrointestinal stromal tumor (GIST) refractory to IM. Proc Am Assoc Cancer Res 45 (2004) 694 (abstr 3002)
    • (2004) Proc Am Assoc Cancer Res , vol.45 , pp. 694
    • van Oosterom, A.1    Dumez, H.2    Desai, J.3
  • 89
    • 0028811653 scopus 로고
    • Protein kinase C. Structure, function, and regulation
    • Newton A.C. Protein kinase C. Structure, function, and regulation. J Biol Chem 270 (1995) 28495-28498
    • (1995) J Biol Chem , vol.270 , pp. 28495-28498
    • Newton, A.C.1
  • 90
    • 0024416291 scopus 로고
    • The Albert Lasker Medical Awards. The family of protein kinase C for signal transduction
    • Nishizuka Y. The Albert Lasker Medical Awards. The family of protein kinase C for signal transduction. JAMA 262 (1989) 1826-1833
    • (1989) JAMA , vol.262 , pp. 1826-1833
    • Nishizuka, Y.1
  • 91
    • 0037710311 scopus 로고    scopus 로고
    • The isoform-specific regulation of apoptosis by protein kinase C
    • Gutcher I., Webb P.R., and Anderson N.G. The isoform-specific regulation of apoptosis by protein kinase C. Cell Mol Life Sci 60 (2003) 1061-1070
    • (2003) Cell Mol Life Sci , vol.60 , pp. 1061-1070
    • Gutcher, I.1    Webb, P.R.2    Anderson, N.G.3
  • 92
    • 0027322679 scopus 로고
    • Protein kinase C isoenzymes. Divergence in signal transduction?
    • Hug H., and Sarre T.F. Protein kinase C isoenzymes. Divergence in signal transduction?. Biochem J 291 (1993) 329-343
    • (1993) Biochem J , vol.291 , pp. 329-343
    • Hug, H.1    Sarre, T.F.2
  • 93
    • 0028189803 scopus 로고
    • Protein kinase C in signal transduction and carcinogenesis
    • Blumberg P.M., Acs G., Areces L.B., et al. Protein kinase C in signal transduction and carcinogenesis. Prog Clin Biol Res 387 (1994) 3-19
    • (1994) Prog Clin Biol Res , vol.387 , pp. 3-19
    • Blumberg, P.M.1    Acs, G.2    Areces, L.B.3
  • 94
    • 0031058595 scopus 로고    scopus 로고
    • Protein kinase C. A worthwhile target for anticancer drugs?
    • Caponigro F., French R.C., and Kaye S.B. Protein kinase C. A worthwhile target for anticancer drugs?. Anticancer Drugs 8 (1997) 26-33
    • (1997) Anticancer Drugs , vol.8 , pp. 26-33
    • Caponigro, F.1    French, R.C.2    Kaye, S.B.3
  • 95
    • 0035233927 scopus 로고    scopus 로고
    • Modulation of protein kinase C in antitumor treatment
    • Hofmann J. Modulation of protein kinase C in antitumor treatment. Rev Physiol Biochem Pharmacol 142 (2001) 1-96
    • (2001) Rev Physiol Biochem Pharmacol , vol.142 , pp. 1-96
    • Hofmann, J.1
  • 96
    • 0142106971 scopus 로고    scopus 로고
    • Protein kinase C. A target for anticancer drugs?
    • Mackay H.J., and Twelves C.J. Protein kinase C. A target for anticancer drugs?. Endocr Relat Cancer 10 (2003) 389-396
    • (2003) Endocr Relat Cancer , vol.10 , pp. 389-396
    • Mackay, H.J.1    Twelves, C.J.2
  • 97
    • 1342310067 scopus 로고    scopus 로고
    • Phase I study of PKC412 (N-benzoyl-staurosporine), a novel oral protein kinase C inhibitor, combined with gemcitabine and cisplatin in patients with non-small-cell lung cancer
    • Monnerat C., Henriksson R., Le Chevalier T., et al. Phase I study of PKC412 (N-benzoyl-staurosporine), a novel oral protein kinase C inhibitor, combined with gemcitabine and cisplatin in patients with non-small-cell lung cancer. Ann Oncol 15 (2004) 316-323
    • (2004) Ann Oncol , vol.15 , pp. 316-323
    • Monnerat, C.1    Henriksson, R.2    Le Chevalier, T.3
  • 99
    • 0037225829 scopus 로고    scopus 로고
    • Imatinib mesylate. In the treatment of gastrointestinal stromal tumours
    • Croom K.F., and Perry C.M. Imatinib mesylate. In the treatment of gastrointestinal stromal tumours. Drugs 63 (2003) 513-522
    • (2003) Drugs , vol.63 , pp. 513-522
    • Croom, K.F.1    Perry, C.M.2
  • 100
    • 8744288462 scopus 로고    scopus 로고
    • Imatinib mesylate acts in metastatic or unresectable gastrointestinal stromal tumor by targeting KIT receptors-A review
    • Sawaki A., and Yamao K. Imatinib mesylate acts in metastatic or unresectable gastrointestinal stromal tumor by targeting KIT receptors-A review. Cancer Chemother Pharmacol 54 suppl 1 (2004) S44-S49
    • (2004) Cancer Chemother Pharmacol , vol.54 , Issue.SUPPL. 1
    • Sawaki, A.1    Yamao, K.2
  • 101
    • 20844433223 scopus 로고    scopus 로고
    • Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib. randomised trial
    • Verweij J., Casali P.G., Zalcberg J., et al. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib. randomised trial. Lancet 364 (2004) 1127-1134
    • (2004) Lancet , vol.364 , pp. 1127-1134
    • Verweij, J.1    Casali, P.G.2    Zalcberg, J.3
  • 102
    • 34547438026 scopus 로고    scopus 로고
    • A phase I study of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) in patients with advanced solid malignancies
    • (abstr)
    • Lee C.P., Attard G., Poupard P.D., et al. A phase I study of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) in patients with advanced solid malignancies. Proc Am Soc Clin Oncol 23 (2005) 3054a (abstr)
    • (2005) Proc Am Soc Clin Oncol , vol.23
    • Lee, C.P.1    Attard, G.2    Poupard, P.D.3
  • 103
    • 18044387648 scopus 로고    scopus 로고
    • Raf kinase as a target for anticancer therapeutics
    • Sridhar S.S., Hedley D., and Siu L.L. Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther 4 (2005) 677-685
    • (2005) Mol Cancer Ther , vol.4 , pp. 677-685
    • Sridhar, S.S.1    Hedley, D.2    Siu, L.L.3
  • 104
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • Gilliland D.G., and Griffin J.D. The roles of FLT3 in hematopoiesis and leukemia. Blood 100 (2002) 1532-1542
    • (2002) Blood , vol.100 , pp. 1532-1542
    • Gilliland, D.G.1    Griffin, J.D.2
  • 105
    • 12144279435 scopus 로고    scopus 로고
    • Normal and oncogenic FLT3
    • Naoe T., and Kiyoi H. Normal and oncogenic FLT3. Cell Mol Life Sci 61 (2004) 2932-2938
    • (2004) Cell Mol Life Sci , vol.61 , pp. 2932-2938
    • Naoe, T.1    Kiyoi, H.2
  • 106
    • 14644415949 scopus 로고    scopus 로고
    • Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma
    • Rini B.I., and Small E.J. Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma. J Clin Oncol 23 (2005) 1028-1043
    • (2005) J Clin Oncol , vol.23 , pp. 1028-1043
    • Rini, B.I.1    Small, E.J.2
  • 107
    • 1442274808 scopus 로고    scopus 로고
    • p38 MAP kinase. A convergence point in cancer therapy
    • Olson J.M., and Hallahan A.R. p38 MAP kinase. A convergence point in cancer therapy. Trends Mol Med 10 (2004) 125-129
    • (2004) Trends Mol Med , vol.10 , pp. 125-129
    • Olson, J.M.1    Hallahan, A.R.2
  • 108
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm S.M., Carter C., Tang L., et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 64 (2004) 7099-7109
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 109
    • 13844267552 scopus 로고    scopus 로고
    • The Raf kinase inhibitor BAY 43-9006 reduces cellular uptake of platinum compounds and cytotoxicity in human colorectal carcinoma cell lines
    • Heim M., Scharifi M., Zisowsky J., et al. The Raf kinase inhibitor BAY 43-9006 reduces cellular uptake of platinum compounds and cytotoxicity in human colorectal carcinoma cell lines. Anticancer Drugs 16 (2005) 129-136
    • (2005) Anticancer Drugs , vol.16 , pp. 129-136
    • Heim, M.1    Scharifi, M.2    Zisowsky, J.3
  • 110
    • 33746521943 scopus 로고    scopus 로고
    • Ratain MJ, Eisen T, Stadler WM, et al: Final findings from a phase II, placebo-controlled, randomized discontinuation trial (RDT) of sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC). (Oral presentation) American Society of Clinical Oncology 41st Annual Meeting, Orlando, FL, May 13-17, 2005. Available at: www.asco.org
  • 111
    • 33746556975 scopus 로고    scopus 로고
    • Escudier B, Szczylik C, Eisen T, et al: Randomized phase III trial of the Raf kinase and VEGFR inhibitor sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC). (Oral presentation) American Society of Clinical Oncology 41st Annual Meeting, Orlando, FL, May 13-17, 2005. Available at: www.asco.org
  • 112
    • 33746491282 scopus 로고    scopus 로고
    • Posada EM, Gulley J, Arlen PM, et al: A phase II study of BAY 43-9006 in patients with androgen-independent prostate cancer (AIPC) with proteomic profiling. (Oral presentation) American Society of Clinical Oncology 41st Annual Meeting, Orlando, FL, May 13-17, 2005. Available at: www.asco.org
  • 113
    • 33746486502 scopus 로고    scopus 로고
    • Siu LL, Winquist E, Agulnik M, et al: A phase II study of BAY 43-9006 in patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) and nasopharyngeal cancer (NPC). (abstr 5566) American Society of Clinical Oncology 41st Annual Meeting, Orlando, FL, May 13-17, 2005. Available at: www.asco.org
  • 114
    • 33746550034 scopus 로고    scopus 로고
    • Flaherty KT, Redlinger M, Schuchter LM, et al: Phase I/II pharmacokinetic and pharmacodynamic trial of BAY 43-9006 alone in patients with metastatic melanoma. (abstr 3037) American Society of Clinical Oncology 41st Annual Meeting, Orlando, FL, May 13-17, 2005. Available at: www.asco.org
  • 115
    • 33746534621 scopus 로고    scopus 로고
    • Adjei AA, Mandrekar S, Marks RS, et al: A phase I study of BAY 43-9006 and gefitinib in patients with refractory or recurrent non-small-cell lung cancer (NSCLC). (abstr 3067) American Society of Clinical Oncology 41st Annual Meeting, Orlando, FL, May 13-17, 2005. Available at: www.asco.org
  • 116
    • 33746477247 scopus 로고    scopus 로고
    • Eisen T, Ahmad T, Gore ME, et al: Phase I trial of BAY 43-9006 (sorafenib) combined with dacarbazine (DTIC) in metastatic melanoma patients. (abstr 7508). American Society of Clinical Oncology 41st Annual Meeting, Orlando, FL, May 13-17, 2005. Available at: www.asco.org
  • 117
    • 33746501599 scopus 로고    scopus 로고
    • Steinbild S, Baas F, Gmehling D, et al: Phase I study of BAY 43-9006 (sorafenib), a Raf kinase and VEGFR inhibitor, combined with irinotecan (CPT-11) in advanced solid tumors. (abstr 3115) American Society of Clinical Oncology 41st Annual Meeting, Orlando, FL, May 13-17, 2005. Available at: www.asco.org
  • 118
    • 12444297983 scopus 로고    scopus 로고
    • The receptor tyrosine kinase inhibitor SU11248 impedes endothelial cell migration, tubule formation, and blood vessel formation in vivo, but has little effect on existing tumor vessels
    • Osusky K.L., Hallahan D.E., Fu A., et al. The receptor tyrosine kinase inhibitor SU11248 impedes endothelial cell migration, tubule formation, and blood vessel formation in vivo, but has little effect on existing tumor vessels. Angiogenesis 7 (2004) 225-233
    • (2004) Angiogenesis , vol.7 , pp. 225-233
    • Osusky, K.L.1    Hallahan, D.E.2    Fu, A.3
  • 119
    • 78650874372 scopus 로고    scopus 로고
    • SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
    • Abrams T.J., Lee L.B., Murray L.J., et al. SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther 2 (2003) 471-478
    • (2003) Mol Cancer Ther , vol.2 , pp. 471-478
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3
  • 120
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors. Determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel D.B., Laird A.D., Xin X., et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors. Determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 9 (2003) 327-337
    • (2003) Clin Cancer Res , vol.9 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 121
    • 9144274970 scopus 로고    scopus 로고
    • SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model
    • Murray L.J., Abrams T.J., Long K.R., et al. SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model. Clin Exp Metastasis 20 (2003) 757-766
    • (2003) Clin Exp Metastasis , vol.20 , pp. 757-766
    • Murray, L.J.1    Abrams, T.J.2    Long, K.R.3
  • 122
    • 0038204144 scopus 로고    scopus 로고
    • SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • O'Farrell A.M., Abrams T.J., Yuen H.A., et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 101 (2003) 3597-3605
    • (2003) Blood , vol.101 , pp. 3597-3605
    • O'Farrell, A.M.1    Abrams, T.J.2    Yuen, H.A.3
  • 123
    • 0041672482 scopus 로고    scopus 로고
    • SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models
    • Schueneman A.J., Himmelfarb E., Geng L., et al. SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res 63 (2003) 4009-4016
    • (2003) Cancer Res , vol.63 , pp. 4009-4016
    • Schueneman, A.J.1    Himmelfarb, E.2    Geng, L.3
  • 124
    • 33746540289 scopus 로고    scopus 로고
    • Data on file. Pfizer Inc, New York, NY, 2005
  • 125
    • 3042749217 scopus 로고    scopus 로고
    • The RET proto-oncogene. a potential target for molecular cancer therapy
    • Putzer B.M., and Drosten M. The RET proto-oncogene. a potential target for molecular cancer therapy. Trends Mol Med 10 (2004) 351-357
    • (2004) Trends Mol Med , vol.10 , pp. 351-357
    • Putzer, B.M.1    Drosten, M.2
  • 127
    • 18344380647 scopus 로고    scopus 로고
    • Molecular genetics of multiple endocrine neoplasia types 1 and 2
    • Marx S.J. Molecular genetics of multiple endocrine neoplasia types 1 and 2. Nat Rev Cancer 5 (2005) 367-375
    • (2005) Nat Rev Cancer , vol.5 , pp. 367-375
    • Marx, S.J.1
  • 128
    • 2442669093 scopus 로고    scopus 로고
    • Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with "standard of care" therapeutic agents for the treatment of breast cancer
    • Abrams T.J., Murray L.J., Pesenti E., et al. Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with "standard of care" therapeutic agents for the treatment of breast cancer. Mol Cancer Ther 2 (2003) 1011-1021
    • (2003) Mol Cancer Ther , vol.2 , pp. 1011-1021
    • Abrams, T.J.1    Murray, L.J.2    Pesenti, E.3
  • 129
    • 33644847440 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and first evidence of antitumor activity of sunitinib, a novel oral multi-target tyrosine kinase inhibitor, in patients with cancer
    • Faive S., Delbaldo C., Vera K., et al. Safety, pharmacokinetic, and first evidence of antitumor activity of sunitinib, a novel oral multi-target tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol 24 (2006) 25-35
    • (2006) J Clin Oncol , vol.24 , pp. 25-35
    • Faive, S.1    Delbaldo, C.2    Vera, K.3
  • 130
    • 33746515363 scopus 로고    scopus 로고
    • Demetri DG, van Oosterom A, Blackstein M, et al. Phase 3, multicenter, randomized, double-blind, placebo-controlled trial of SU11248 in patients (pts) following failure of imatinib for metastatic GIST. (Oral presentation) American Society of Clinical Oncology 41st Annual Meeting, Orlando, FL, May 13-17 2005. Available at: www.asco.org
  • 131
    • 33746481190 scopus 로고    scopus 로고
    • Motzer R, Rini BI, Michaelson M, et al: Phase 2 trials of SU11248 show antitumor activity in second-line therapy for patients with metastatic renal cell carcinoma (RCC). (Oral presentation) American Society of Clinical Oncology 41st Annual Meeting, Orlando, FL, May 13-17, 2005. Available at: www.asco.org
  • 132
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang J.C., Haworth L., Sherry R.M., et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 349 (2003) 427-434
    • (2003) N Engl J Med , vol.349 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 133
    • 33746522641 scopus 로고    scopus 로고
    • Miller KD, Burstein HJ, Elias AD, et al: Phase II study of SU11248, a multitargeted receptor tyrosine kinase inhibitor (TKI), in patients (pts) with previously treated metastatic breast cancer (MBC). (Oral presentation) American Society of Clinical Oncology 41st Annual Meeting, Orlando, FL, May 13-17, 2005. Available at: www.asco.org
  • 134
    • 33746483651 scopus 로고    scopus 로고
    • Kulke M, Lenz HJ, Meropol NJ, et al: A phase 2 study to evaluate the efficacy and safety of SU11248 in patients (pts) with unresectable neuroendocrine tumors (NETs). (Oral presentation) American Society of Clinical Oncology 41st Annual Meeting, Orlando, FL, May 13-17, 2005. Available at: www.asco.org


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.