Assessment of a rapid clearance blood pool MR contrast medium (P792) for assays of microvascular characteristics in experimental breast tumors with correlations to histopathology

Magnetic Resonance in Medicine

Volumn 45, Issue 5, 2001, Pages 880-886

  Turetschek, Karl ^a   Floyd, Eugenia ^a   Shames, David M ^a   Roberts, Timothy P L ^a   Preda, Anda ^a   Novikov, Viktor ^a   Corot, Claire ^a   Carter, Wayne O ^a   Brasch, Robert C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Breast neoplasm; Contrast media; Histologic tumor grade; Magnetic resonance imaging; Microvascular permeability

Indexed keywords

BLOOD; BLOOD VESSELS; DIAGNOSIS; MAGNETIC RESONANCE IMAGING; MEDICAL IMAGING; TUMORS;

BREAST NEOPLASM; CONTRAST AGENT; CONTRAST MEDIUM; DIAGNOSTIC POTENTIAL; MICROVASCULAR; MOLECULAR SIZE; TUMOR GRADES; TWO-COMPARTMENT MODELS;

CONTRAST MEDIA;

CONTRAST MEDIUM; GADOLINIUM PENTETATE ALBUMIN; GADOMELITOL; TUMOR MARKER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD; BLOOD VESSEL PERMEABILITY; BLOOD VOLUME; BREAST TUMOR; CANCER GRADING; COMPARTMENT MODEL; CONTRAST ENHANCEMENT; DRUG CLEARANCE; FEMALE; HISTOPATHOLOGY; MICROVASCULATURE; NONHUMAN; RAT; SPECTROMETER; TUMOR VASCULARIZATION;

EID: 0035029877     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1117     Document Type: Article

References (40)

1. Correlation of dynamic contrast-enhanced MR imaging with histologic tumor grade: Comparison of macromolecular and small-molecular contrast media
2. Measurement of capillary permeability to macromolecules by dynamic magnetic resonance imaging - A quantitative noninvasive technique
3. Characterization of N-ethyl-N-nitrosourea-induced malignant and benign breast tumors in rats by using three MR contrast agents
4. Regional comparison of tumor vascularity and permeability parameters measured by albumin-Gd-DTPA and Gd-DTPA
5. Assessing tumor angiogenesis using macromolecular MR imaging contrast media
6. Microvascular permeability of normal and neoplastic tissues
7. Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules
8. Transport of molecules across tumor vasculature
9. Differentiation of alveolitis and pulmonary fibrosis with a macromolecular MR imaging contrast agent
10. Contrast enhanced MR imaging of tumor capillary permeability: Effect of irradiation on delivery of chemotherapy
11. Arthritic temporomandibular joint: Correlation of macromolecular contrast-enhanced MR imaging parameters and histopathologic findings
12. Histologic confirmation of microvascular hyperpermeability to macromolecular MR contrast medium in reperfused myocardial infarction
13. Non-invasive assessment of wound healing angiogenesis with contrast enhanced MRI
14. Albumin labeled with Gd-DTPA. An intravascular contrast-enhancing agent for magnetic resonance blood pool and perfusion imaging
15. P760 and P775: MRI contrast agents characterized by new pharmacokinetic properties
16. Comparison of plasma and peritoneal concentrations of various categories of MRI blood pool agents in a murine experimental pharmakokinetic model
17. Diverse spectrum of tumors in male Sprague Dawley rats following single high doses of N-ethyl-N-nitrosurea (ENU)
18. Neoplasms induced with high single doses of N-ethyl-N-nitrosurea in 30 day-old Sprague Dawley rats, with special emphasis in mammary neoplasia
19. FLASH imaging: Rapid NMR imaging using low flip angle pulses
20. Chemical, physicochemical and biological evaluation of P792: A rapid clearance blood pool agent for MRI
21. Albumin labeled with Gd-DTPA: An intravascular contrast enhancing agent for magnetic resonance blood pool imaging: Preparation and characterization
22. Comparison of the contrast-enhancing properties of albumin-(Gd-DTPA) and Gd-DTPA at 2.0 T: An experimental study in rats
23. Physiologic measurements by contrast-enhanced MR imaging: Expectations and limitations
24. Tissue distribution and magnetic resonance spin lattice relaxation effects of gadolinium-DTPA
25. Relaxation of water protons in the intra- and extracellular regions of blood containing Gd(DTPA)
26. Histologic grading and prognosis in breast cancer
27. Transport of molecules in the tumor interstitium: A review
28. Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors
29. The role of angiogenesis in tumor growth
30. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma
31. Quantification of capillary permeability to macromolecular magnetic resonance imaging contrast media in experimental mammary adenocarcinomas
32. Mammary carcinoma model: Correlation of macromolecular contrast-enhanced MR imaging characterizations of tumor microvasculature and histologic capillary density
33. Prostate cancer tumor grade differentiation with dynamic contrast-enhanced MR imaging in the rat: Comparison of macromolecular and small-molecular contrast media-preliminary experience
34. Magnetic resonance imaging in ovarian cancer demonstrating altered microvascular permeability following inhibition of vascular endothelial growth factor
35. MRI characterization of microvessels in experimental breast tumors using a particulate contrast agent with histopathologic correlation
36. MRI enhancement and microvascular density in gliomas. Correlation with tumor cell proliferation
37. Angiogenesis in ductal breast carcinoma. Comparison of microvessel density between primary tumour and lymph node metastasis
38. Tumor angiogenesis in stage IB cervical cancer: Correlation of microvessel density with survival
39. Immunohistochemical determination of tumor angiogenesis measured by the maximal microvessel density in human prostate cancer