Physicochemical and biological evaluation of P792, a rapid-clearance blood-pool agent for magnetic resonance imaging

Investigative Radiology

Volumn 36, Issue 8, 2001, Pages 445-454

  Port, Marc ^a   Corot, Claire ^a   Raynal, Isabelle ^a   Idee, Jean Marc ^a   Dencausse, Anne ^a   Lancelot, Eric ^a   Meyer, Dominique ^a   Bonnemain, Bruno ^a   Lautrou, Jean ^a  

^a Laboratoire Guerbet   (France)

Author keywords

Biocompatibility; Clinical indications; MRI blood pool contrast agent; Pharmacokinetics; Relaxivity; Tolerance

Indexed keywords

ACETIC ACID; CONTRAST MEDIUM; GADOLINIUM; GADOMELITOL; HISTAMINE; HUMAN SERUM ALBUMIN; LEUKOTRIENE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG SAFETY; ENDOTHELIUM; GLOMERULUS FILTRATION RATE; HEMODYNAMICS; HISTAMINE RELEASE; MAGNETIC FIELD; MALE; MAST CELL; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN BINDING; RABBIT; RAT;

EID: 0034872851     PISSN: 00209996     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004424-200108000-00002     Document Type: Article

References (53)

1. Rationale and applications for macromolecular Gd-based contrast agents
2. Pilot MR evaluation of pharmacokinetics and relaxivity of specific blood pool agents for MR angiography
3. Agents de contraste en IRM
4. Macromolecular systems for chemotherapy and magnetic resonance imaging
5. Blood pool contrast agents for cardiovascular MR imaging
6. Les produits à rémanence vasculaire: Définition et applications potentielles
7. P760 and P775: MRI contrast agents characterized by new pharmacokinetic properties
8. Physical, chemical and biological evaluations of P760: A new gadolinium complex characterized by a low rate of interstitial diffusion
9. Contrast-enhanced MRI of brain tumor in rats using a new medium molecular size contrast agent
10. Preclinical profile of the monodisperse iodinated macromolecular blood pool agent P743
11. Tumor characterization with dynamic contrast enhanced MRI using MR contrast agents of various molecular weights
12. Comparison of two blood pool contrast agents for 0.5 T MR angiography: Experimental study in rabbits
13. Albumin labeled with Gd-DOTA: An intravascular contrast enhancing agent for magnetic resonance blood pool imaging: Preparation and characterization
14. Physical and chemical properties of superparamagnetic iron oxide MR contrast agents: Ferumoxides, ferumostran, ferumoxsil
15. Physical, chemical and biological evaluation of CMD-A2-Gd-DOTA
16. Gd-DTPA cascade polymer: Potential blood pool contrast agent for MR Imaging
17. In vivo and in vitro evaluation of Gd-DTPA polylysine as a macromolecular agent for magnetic resonance imaging
18. Kinetic characterization of CMD A2 Gd-DOTA as an intravascular contrast agent for myocardial perfusion measurement with MRI
19. MS325-albumin-targeted contrast agent for MR angiography
20. MS325: A small molecular vascular imaging agent for magnetic resonance imaging
21. P792: A rapid clearance blood pool agent for magnetic resonance imaging: Preliminary results
22. 2O
23. Validation of the general purpose Tripos 5.2 force field
24. Iterative partial equalization of orbital electronegativity: A rapid access to atomic charges
25. Measurement of spin relaxation in complex systems
26. Physicochemical characterization of MS325, a new gadolinium complex by multinuclear relaxometry
27. Stability of MRI paramagnetic contrast media: A proton relaxometric protocol for transmetallation assessment
28. Renal effects of radiocontrast agents in rats: A new model of acute renal failure
29. Excretion of urinary N-acetyl-β-D-glucosaminidase isoenzymes after renal transplantation in the rat
30. Macrocyclic polyamino carboxylate complexes of Gd III as magnetic resonance imaging contrast agents
31. Stabilities of trivalent metal ion complexes of the tetraacetate derivatives of 12-, 13- and 14-membered tetraazamacrocycles
32. Physicochemical properties of gadoteridol and other magnetic resonance contrast agents
33. Gadolinium III chelates as MRI contrast agents: Structure, dynamics and applications
34. Lanthanides III chelate for NMR biomedical applications
35. Relaxometry animal biodistribution and magnetic resonance imaging studies of some new gadolinium III macrocyclic phosphonate and phosphonate monoester complexes
36. Dendrimer-based metal chelates: A new class of magnetic resonance imaging contrast agents
37. Pharmacokinetics of three gadolinium chelates with different molecular sizes shortly after intravenous injection in rabbits
38. Gadobenate dimeglumine (Gd-BOPTA): An overview
39. Gd(III) complexes as contrast agents for magnetic resonance imaging: A proton relaxation enhancement study of the interaction with human serum albumin
40. Structure activity relationship of macrocyclic and linear gadolinium chelates: Investigations of transmetallation effect in the zinc-dependent metallopeptidase angiotensin converting enzyme
41. Comparison of plasma and peritoneal concentration of various categories of MRI blood pool agents in a murine experimental pharmacokinetic model
42. Endothelial transport of macromolecules: Transcytosis and endocytosis
43. Safety of approved MR contrast media for intravenous injection
44. Reliability of experimental models of iodinated contrast media induced acute renal failure: From methodological considerations to pathophysiology
45. Hemodynamic tolerance of intravascular contrast agents for magnetic resonance imaging
46. Coronary arteries
47. Coronary MR angiography
48. The role of angiogenesis in tumor growth
49. Angiogenesis imaging
50. In vitro monitoring of tumor angiogenesis with MR imaging
51. Assessment of angiogenesis by MRI
52. MRI characterization of tumors and grading angiogenesis using macromolecular contrast media: Status report