-
1
-
-
0034681260
-
Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
-
Brown MS, Ye J, Rawson RB, Goldstein JL: Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 2000, 100(4):391-398.
-
(2000)
Cell
, vol.100
, Issue.4
, pp. 391-398
-
-
Brown, M.S.1
Ye, J.2
Rawson, R.B.3
Goldstein, J.L.4
-
2
-
-
0034671686
-
Notch Signaling: From the Outside In
-
Mumm JS, Kopan R: Notch Signaling: From the Outside In. Dev Biol 2000, 228(2): 151-165.
-
(2000)
Dev Biol
, vol.228
, Issue.2
, pp. 151-165
-
-
Mumm, J.S.1
Kopan, R.2
-
3
-
-
0035576260
-
Intramembrane proteolysis of signal peptides: An essential step in the generation of HLA-E epitopes
-
Lemberg MK, Bland FA, Weihofen A, Braud VM, Martoglio B: Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes. J Immunol 2001, 167(11):6441-6446.
-
(2001)
J Immunol
, vol.167
, Issue.11
, pp. 6441-6446
-
-
Lemberg, M.K.1
Bland, F.A.2
Weihofen, A.3
Braud, V.M.4
Martoglio, B.5
-
4
-
-
0035913908
-
Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases
-
Urban S, Lee JR, Freeman M: Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell 2001, 107(2):173-182.
-
(2001)
Cell
, vol.107
, Issue.2
, pp. 173-182
-
-
Urban, S.1
Lee, J.R.2
Freeman, M.3
-
5
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe DJ: Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001, 81 (2):741-766.
-
(2001)
Physiol Rev
, vol.81
, Issue.2
, pp. 741-766
-
-
Selkoe, D.J.1
-
6
-
-
24044513994
-
Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling
-
Sun Y, Lowther W, Kato K, Bianco C, Kenney N, Strizzi L, Raafat D, Hirota M, Khan NI, Bargo S, Jones B, Salomon D, Callahan R: Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling. Oncogens 2005, 24(34):5365-5374.
-
(2005)
Oncogens
, vol.24
, Issue.34
, pp. 5365-5374
-
-
Sun, Y.1
Lowther, W.2
Kato, K.3
Bianco, C.4
Kenney, N.5
Strizzi, L.6
Raafat, D.7
Hirota, M.8
Khan, N.I.9
Bargo, S.10
Jones, B.11
Salomon, D.12
Callahan, R.13
-
7
-
-
20544460148
-
Notch/ gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
-
van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H: Notch/ gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 2005, 435(7044):959-963.
-
(2005)
Nature
, vol.435
, Issue.7044
, pp. 959-963
-
-
van Es, J.H.1
van Gijn, M.E.2
Riccio, O.3
van den Born, M.4
Vooijs, M.5
Begthel, H.6
Cozijnsen, M.7
Robine, S.8
Winton, D.J.9
Radtke, F.10
Clevers, H.11
-
8
-
-
2642539953
-
Intramembrane proteolysis and endoplasmic reticulum retention of hepatitis C virus core protein
-
Okamoto K, Moriishi K, Miyamura T, Matsuura Y: Intramembrane proteolysis and endoplasmic reticulum retention of hepatitis C virus core protein. J Virol 2004, 78(12):6370-6380.
-
(2004)
J Virol
, vol.78
, Issue.12
, pp. 6370-6380
-
-
Okamoto, K.1
Moriishi, K.2
Miyamura, T.3
Matsuura, Y.4
-
9
-
-
0036565893
-
Identification of a novel family of presenilin homologues
-
Ponting CP, Hutton M, Nyborg A, Baker M, Jansen K, Golde TE: Identification of a novel family of presenilin homologues. Hum Mol Genet 2002, 11 (9): 1037-1044.
-
(2002)
Hum Mol Genet
, vol.11
, Issue.9
, pp. 1037-1044
-
-
Ponting, C.P.1
Hutton, M.2
Nyborg, A.3
Baker, M.4
Jansen, K.5
Golde, T.E.6
-
10
-
-
0036410505
-
Novel class of polytopic proteins with domains associated with putative protease activity
-
Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev El: Novel class of polytopic proteins with domains associated with putative protease activity. Biochemistry (Mosc) 2002, 67(7):826-835.
-
(2002)
Biochemistry (Mosc)
, vol.67
, Issue.7
, pp. 826-835
-
-
Grigorenko, A.P.1
Moliaka, Y.K.2
Korovaitseva, G.I.3
Rogaev, E.4
-
11
-
-
0037150672
-
Identification of signal peptide peptidase, a presenilin-type aspartic protease
-
Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B: Identification of signal peptide peptidase, a presenilin-type aspartic protease. Science 2002, 296(5576):2215-2218.
-
(2002)
Science
, vol.296
, Issue.5576
, pp. 2215-2218
-
-
Weihofen, A.1
Binns, K.2
Lemberg, M.K.3
Ashman, K.4
Martoglio, B.5
-
12
-
-
33749327877
-
Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase
-
Nyborg AC, Ladd TB, Jansen K, Kukar T, Golde TE: Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase. Foseb J 2006, 20(10):1671-1679.
-
(2006)
Foseb J
, vol.20
, Issue.10
, pp. 1671-1679
-
-
Nyborg, A.C.1
Ladd, T.B.2
Jansen, K.3
Kukar, T.4
Golde, T.E.5
-
13
-
-
33746608185
-
A gamma-secretase-like intramembrane cleavage of TNFalpha by the G×GD aspartyl protease SPPL2b
-
Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E, Bohland C, Imhof A, Martoglio B, Teplow DB, Haass C:A gamma-secretase-like intramembrane cleavage of TNFalpha by the G×GD aspartyl protease SPPL2b. Nat Cell Biol 2006, 8(8):894-896.
-
(2006)
Nat Cell Biol
, vol.8
, Issue.8
, pp. 894-896
-
-
Fluhrer, R.1
Grammer, G.2
Israel, L.3
Condron, M.M.4
Haffner, C.5
Friedmann, E.6
Bohland, C.7
Imhof, A.8
Martoglio, B.9
Teplow, D.B.10
Haass, C.11
-
14
-
-
33746618450
-
SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production
-
Friedmann E, Hauben E, Maylandt K, Schleeger S, Vreugde S, Lichtenthaler SF, Kuhn PH, Stauffer D, Rovelli G, Martoglio B: SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. Nat Cell Biol 2006, 8(8):843-848.
-
(2006)
Nat Cell Biol
, vol.8
, Issue.8
, pp. 843-848
-
-
Friedmann, E.1
Hauben, E.2
Maylandt, K.3
Schleeger, S.4
Vreugde, S.5
Lichtenthaler, S.F.6
Kuhn, P.H.7
Stauffer, D.8
Rovelli, G.9
Martoglio, B.10
-
15
-
-
0141994826
-
Intramembrane-cleaving aspartic proteases and disease: Presenilins, signal peptide peptidase and their homologs
-
Martoglio B, Golde TE: Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs. Hum Mol Genet 2003, 12 Spec No 2:R201-6.
-
(2003)
Hum Mol Genet
, vol.12
, Issue.SPEC 2
-
-
Martoglio, B.1
Golde, T.E.2
-
16
-
-
0042671326
-
Intramembrane proteolysis by presenilin and presenilin-like proteases
-
Xia W, Wolfe MS: Intramembrane proteolysis by presenilin and presenilin-like proteases. J Cell Sci 2003, 116(Pt 14):2839-2844.
-
(2003)
J Cell Sci
, vol.116
, Issue.PART 14
, pp. 2839-2844
-
-
Xia, W.1
Wolfe, M.S.2
-
17
-
-
0037930851
-
Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors
-
Weihofen A, Lemberg MK, Friedmann E, Rueeger H, Schmitz A, Paganetti P, Rovelli G, Martoglio B: Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors. J Biol Chem 2003, 278(19): 16528-16533.
-
(2003)
J Biol Chem
, vol.278
, Issue.19
, pp. 16528-16533
-
-
Weihofen, A.1
Lemberg, M.K.2
Friedmann, E.3
Rueeger, H.4
Schmitz, A.5
Paganetti, P.6
Rovelli, G.7
Martoglio, B.8
-
18
-
-
1842523970
-
Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes
-
Wang J, Brunkan AL, Hecimovic S, Walker E, Goate A: Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes. Neurobiol Dis 2004, 15(3):654-666.
-
(2004)
Neurobiol Dis
, vol.15
, Issue.3
, pp. 654-666
-
-
Wang, J.1
Brunkan, A.L.2
Hecimovic, S.3
Walker, E.4
Goate, A.5
-
19
-
-
0037418440
-
Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis
-
Golde TE, Eckman CB: Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis. Sci STKE 2003, 2003(172):RE4..
-
(2003)
Sci STKE
, vol.2003
, Issue.172
-
-
Golde, T.E.1
Eckman, C.B.2
-
20
-
-
1942436343
-
On the mechanism of SPP-catalysed intramembrane proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane
-
Lemberg MK, Martoglio B: On the mechanism of SPP-catalysed intramembrane proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane. FEBS Lett 2004, 564(3):213-218.
-
(2004)
FEBS Lett
, vol.564
, Issue.3
, pp. 213-218
-
-
Lemberg, M.K.1
Martoglio, B.2
-
21
-
-
0346788899
-
Intramembrane proteolysis and post-targeting functions of signal peptides
-
Martoglio B: Intramembrane proteolysis and post-targeting functions of signal peptides. Biochem Soc Trans 2003, 31(Pt 6): 1243-1247.
-
(2003)
Biochem Soc Trans
, vol.31
, Issue.PART 6
, pp. 1243-1247
-
-
Martoglio, B.1
-
22
-
-
5644240819
-
A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin
-
Nyborg AC, Jansen K, Ladd TB, Fauq A, Golde TE: A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin. J Biol Chem 2004, 279(41 ):43148-43156.
-
(2004)
J Biol Chem
, vol.279
, Issue.41
, pp. 43148-43156
-
-
Nyborg, A.C.1
Jansen, K.2
Ladd, T.B.3
Fauq, A.4
Golde, T.E.5
-
23
-
-
10944270703
-
Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins
-
Friedmann E, Lemberg MK, Weihofen A, Dev KK, Dengler U, Rovelli G. Martoglio B: Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. J Biol Chem 2004, 279(49):50790-50798.
-
(2004)
J Biol Chem
, vol.279
, Issue.49
, pp. 50790-50798
-
-
Friedmann, E.1
Lemberg, M.K.2
Weihofen, A.3
Dev, K.K.4
Dengler, U.5
Rovelli, G.6
Martoglio, B.7
-
24
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing [see comments]
-
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P: Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing [see comments]. Nature 2000, 407(6800):48- 54.
-
(2000)
Nature
, vol.407
, Issue.6800
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.5
Tandon, A.6
Song, Y.Q.7
Rogaeva, E.8
Chen, F.9
Kawarai, T.10
Supala, A.11
Levesque, L.12
Yu, H.13
Yang, D.S.14
Holmes, E.15
Milman, P.16
Liang, Y.17
Zhang, D.M.18
Xu, D.H.19
Sato, C.20
Rogaev, E.21
Smith, M.22
Janus, C.23
Zhang, Y.24
Aebersold, R.25
Farrer, L.S.26
Sorbi, S.27
Bruni, A.28
Fraser, P.29
St George-Hyslop, P.30
more..
-
25
-
-
18444417998
-
-
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, NyeJS, Curtis D: aph-1 and pen-2 are required for Notch pathway signaling, gamma- secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell 2002, 3(1):85-97.
-
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, NyeJS, Curtis D: aph-1 and pen-2 are required for Notch pathway signaling, gamma- secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell 2002, 3(1):85-97.
-
-
-
-
26
-
-
0038664363
-
Reconstitution of gamma-secretase activity
-
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C: Reconstitution of gamma-secretase activity. Nat Cell Biol 2003, 5:486-488.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 486-488
-
-
Edbauer, D.1
Winkler, E.2
Regula, J.T.3
Pesold, B.4
Steiner, H.5
Haass, C.6
-
27
-
-
0037468759
-
The role of presenilin cofactors in the gamma-secretase complex
-
Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T: The role of presenilin cofactors in the gamma-secretase complex. Nature 2003, 422(6930):438-441.
-
(2003)
Nature
, vol.422
, Issue.6930
, pp. 438-441
-
-
Takasugi, N.1
Tomita, T.2
Hayashi, I.3
Tsuruoka, M.4
Niimura, M.5
Takahashi, Y.6
Thinakaran, G.7
Iwatsubo, T.8
-
28
-
-
0038652102
-
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2
-
Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ: Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci U S A 2003, 100(11):6382-6387.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.11
, pp. 6382-6387
-
-
Kimberly, W.T.1
LaVoie, M.J.2
Ostaszewski, B.L.3
Ye, W.4
Wolfe, M.S.5
Selkoe, D.J.6
-
29
-
-
0037902542
-
APHI, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity
-
Marlow L, Canet RM, Haugabook SJ, Hardy JA, Lahiri DK, Sambamurti K: APHI, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity. Biochem Biophys Res Commun 2003, 305(3):502-509.
-
(2003)
Biochem Biophys Res Commun
, vol.305
, Issue.3
, pp. 502-509
-
-
Marlow, L.1
Canet, R.M.2
Haugabook, S.J.3
Hardy, J.A.4
Lahiri, D.K.5
Sambamurti, K.6
-
30
-
-
2442446430
-
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor
-
Nyborg AC, Kornilova AY, Jansen K, Ladd TB, Wolfe MS, Golde TE: Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor. J Biol Chem 2004, 279(15):15153- 15160.
-
(2004)
J Biol Chem
, vol.279
, Issue.15
, pp. 15153-15160
-
-
Nyborg, A.C.1
Kornilova, A.Y.2
Jansen, K.3
Ladd, T.B.4
Wolfe, M.S.5
Golde, T.E.6
-
31
-
-
4344632844
-
Functional implications of the presenilin dimerization: Reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins
-
Cervantes S, Saura CA, Pomares E, Gonzalez-Duarte R, Marfany G: Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins. J Biol Chem 2004, 279(35):36519-36529.
-
(2004)
J Biol Chem
, vol.279
, Issue.35
, pp. 36519-36529
-
-
Cervantes, S.1
Saura, C.A.2
Pomares, E.3
Gonzalez-Duarte, R.4
Marfany, G.5
-
32
-
-
0035823039
-
Homodimerization of presenilin N-terminal fragments is affected by mutations linked to Alzheimer's disease
-
Cervantes S, Gonzalez-Duarte R, Marfany G: Homodimerization of presenilin N-terminal fragments is affected by mutations linked to Alzheimer's disease. FEBS Lett 2001, 505(1):81-86.
-
(2001)
FEBS Lett
, vol.505
, Issue.1
, pp. 81-86
-
-
Cervantes, S.1
Gonzalez-Duarte, R.2
Marfany, G.3
-
33
-
-
0242331600
-
A presenilin dimer at the core of the gamma-secretase enzyme: Insights from parallel analysis of Notch I and APP proteolysis
-
Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, Shearman M, Kopan R: A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch I and APP proteolysis. Proc Natl Acad Sci USA 2003, 100(22):13075-13080.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.22
, pp. 13075-13080
-
-
Schroeter, E.H.1
Ilagan, M.X.2
Brunkan, A.L.3
Hecimovic, S.4
Li, Y.M.5
Xu, M.6
Lewis, H.D.7
Saxena, M.T.8
De Strooper, B.9
Coonrod, A.10
Tomita, T.11
Iwatsubo, T.12
Moore, C.L.13
Goate, A.14
Wolfe, M.S.15
Shearman, M.16
Kopan, R.17
-
34
-
-
0142039025
-
Oligomerization of human presenilin-1 fragments
-
Hebert SS, Godin C, Levesque G: Oligomerization of human presenilin-1 fragments. FEBS Lett 2003, 550(1-3):30-34.
-
(2003)
FEBS Lett
, vol.550
, Issue.1-3
, pp. 30-34
-
-
Hebert, S.S.1
Godin, C.2
Levesque, G.3
-
35
-
-
0037474505
-
Dimerization of presenilin-1 in vivo: Suggestion of novel regulatory mechanisms leading to higher order complexes
-
Hebert SS, Godin C, Tomiyama T, Mori H, Levesque G: Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes. Biochem Biophys Res Commun 2003, 301 (1): 119-126.
-
(2003)
Biochem Biophys Res Commun
, vol.301
, Issue.1
, pp. 119-126
-
-
Hebert, S.S.1
Godin, C.2
Tomiyama, T.3
Mori, H.4
Levesque, G.5
-
36
-
-
29644436238
-
Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy
-
Herl L, Lleo A, Thomas AV, Nyborg AC, Jansen K, Golde TE, Hyman BT, Berezovska O: Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy. Biochem Biophys Res Commun 2006, 340(2):668-674.
-
(2006)
Biochem Biophys Res Commun
, vol.340
, Issue.2
, pp. 668-674
-
-
Herl, L.1
Lleo, A.2
Thomas, A.V.3
Nyborg, A.C.4
Jansen, K.5
Golde, T.E.6
Hyman, B.T.7
Berezovska, O.8
-
37
-
-
33644839624
-
C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation
-
Wang J, Beher D, Nyborg AC, Shearman MS, Golde TE, Goate A: C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation, J Neurochem 2006, 96(1):218-227.
-
(2006)
J Neurochem
, vol.96
, Issue.1
, pp. 218-227
-
-
Wang, J.1
Beher, D.2
Nyborg, A.C.3
Shearman, M.S.4
Golde, T.E.5
Goate, A.6
-
38
-
-
28244456207
-
Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenlin in homologues SPPL2b and SPPL3
-
Krawitz P, Haffner C, Fluhrer R, Steiner H, Schmid B, Haass C: Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenlin in homologues SPPL2b and SPPL3. J Biol Chem 2005, 280(47):39515-39523.
-
(2005)
J Biol Chem
, vol.280
, Issue.47
, pp. 39515-39523
-
-
Krawitz, P.1
Haffner, C.2
Fluhrer, R.3
Steiner, H.4
Schmid, B.5
Haass, C.6
-
39
-
-
33745586176
-
Signal peptide peptidase: Biochemical properties and modulation by nonsteroidal antiinflammatory drugs
-
Sato T, Nyborg AC, Iwata N, Diehl TS, Saido TC, Golde TE, Wolfe MS: Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs. Biochemistry 2006, 45(28):8649-8656.
-
(2006)
Biochemistry
, vol.45
, Issue.28
, pp. 8649-8656
-
-
Sato, T.1
Nyborg, A.C.2
Iwata, N.3
Diehl, T.S.4
Saido, T.C.5
Golde, T.E.6
Wolfe, M.S.7
-
40
-
-
0038117200
-
Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging
-
Berezovska O, Randya P, Skoch J, Wolfe MS, Bacskai B, Hyman BT: Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging. J Neurosci 2003, 23(11):4560- 4566.
-
(2003)
J Neurosci
, vol.23
, Issue.11
, pp. 4560-4566
-
-
Berezovska, O.1
Randya, P.2
Skoch, J.3
Wolfe, M.S.4
Bacskai, B.5
Hyman, B.T.6
-
41
-
-
0141644224
-
Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques
-
Bacskai BJ, Skoch J, Hickey GA, Allen R, Hyman BT: Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques. J Biomed Opt 2003, 8(3):368-375.
-
(2003)
J Biomed Opt
, vol.8
, Issue.3
, pp. 368-375
-
-
Bacskai, B.J.1
Skoch, J.2
Hickey, G.A.3
Allen, R.4
Hyman, B.T.5
-
42
-
-
22844434140
-
Low density lipoprotein receptor-related protein (LRP) interacts with presenilin I and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase
-
Lleo A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CD, Berezovska O: Low density lipoprotein receptor-related protein (LRP) interacts with presenilin I and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. J Biol Chem 2005, 280(29):27303-27309.
-
(2005)
J Biol Chem
, vol.280
, Issue.29
, pp. 27303-27309
-
-
Lleo, A.1
Waldron, E.2
von Arnim, C.A.3
Herl, L.4
Tangredi, M.M.5
Peltan, I.D.6
Strickland, D.K.7
Koo, E.H.8
Hyman, B.T.9
Pietrzik, C.D.10
Berezovska, O.11
-
43
-
-
33745000693
-
Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals
-
Dev KK, Chatterjee S, Osinde M, Stauffer D, Morgan H, Kobialko M, Dengler U, Rueeger H, Martoglio B, Rovelli G: Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals. Eur J Pharmacol 2006, 540(1-3): 10-17.
-
(2006)
Eur J Pharmacol
, vol.540
, Issue.1-3
, pp. 10-17
-
-
Dev, K.K.1
Chatterjee, S.2
Osinde, M.3
Stauffer, D.4
Morgan, H.5
Kobialko, M.6
Dengler, U.7
Rueeger, H.8
Martoglio, B.9
Rovelli, G.10
-
44
-
-
20444429794
-
Drosophila signal Peptide peptidase is an essential protease for larval development
-
Casso DJ, Tanda S, Biehs B, Martoglio B, Kornberg TB: Drosophila signal Peptide peptidase is an essential protease for larval development. Genetics 2005, 170(1): 139-148.
-
(2005)
Genetics
, vol.170
, Issue.1
, pp. 139-148
-
-
Casso, D.J.1
Tanda, S.2
Biehs, B.3
Martoglio, B.4
Kornberg, T.B.5
-
45
-
-
33744543016
-
Cell-surface expression of a new splice variant of the mouse signal peptide peptidase
-
Urny J, Hermans-Borgmeyer I, Schaller HC: Cell-surface expression of a new splice variant of the mouse signal peptide peptidase. Biochim Biophys Acta 2006, 1759(3-4):1759-165.
-
(2006)
Biochim Biophys Acta
, vol.1759
, Issue.3-4
, pp. 1759-1165
-
-
Urny, J.1
Hermans-Borgmeyer, I.2
Schaller, H.C.3
-
46
-
-
0042786828
-
Expression of the presenilin-like signal peptide peptidase (SPP) in mouse adult brain and during development
-
Urny J, Hermans-Borgmeyer I, Gercken G, Chica Schaller H: Expression of the presenilin-like signal peptide peptidase (SPP) in mouse adult brain and during development. Gene Expr Patterns 2003, 3(5):685-691.
-
(2003)
Gene Expr Patterns
, vol.3
, Issue.5
, pp. 685-691
-
-
Urny, J.1
Hermans-Borgmeyer, I.2
Gercken, G.3
Chica Schaller, H.4
-
47
-
-
33644585599
-
Efficient cleavage by signal peptide peptidase requires residues within the signal peptide between the core and El proteins of hepatitis C virus strain J1
-
Hope RG, McElwee MJ, McLauchlan J: Efficient cleavage by signal peptide peptidase requires residues within the signal peptide between the core and El proteins of hepatitis C virus strain J1. J Gen Virol 2006, 87(Pt 3):623-627.
-
(2006)
J Gen Virol
, vol.87
, Issue.PART 3
, pp. 623-627
-
-
Hope, R.G.1
McElwee, M.J.2
McLauchlan, J.3
-
48
-
-
33749406620
-
Signal Peptide Peptidase Cleavage of GB Virus B Core Protein Is Required for Productive Infection in Vivo
-
Targett-Adams P, Schaller T, Hope G, Lanford RE, Lemon SM, Martin A, McLauchlan J: Signal Peptide Peptidase Cleavage of GB Virus B Core Protein Is Required for Productive Infection in Vivo. J Biol Chem 2006, 281 (39):29221-29227.
-
(2006)
J Biol Chem
, vol.281
, Issue.39
, pp. 29221-29227
-
-
Targett-Adams, P.1
Schaller, T.2
Hope, G.3
Lanford, R.E.4
Lemon, S.M.5
Martin, A.6
McLauchlan, J.7
-
49
-
-
0035921427
-
The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein
-
Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, Saftig P, De Strooper B, Annaert W: The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein. J Cell Biol 2001, 154(4):731-740.
-
(2001)
J Cell Biol
, vol.154
, Issue.4
, pp. 731-740
-
-
Cupers, P.1
Bentahir, M.2
Craessaerts, K.3
Orlans, I.4
Vanderstichele, H.5
Saftig, P.6
De Strooper, B.7
Annaert, W.8
-
50
-
-
0035407522
-
KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: Measurements in living cells using FRET
-
Majoul I, Straub M, Hell SW, Duden R, Soling HD: KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET. Dev Cell 2001, 1(1):139-153.
-
(2001)
Dev Cell
, vol.1
, Issue.1
, pp. 139-153
-
-
Majoul, I.1
Straub, M.2
Hell, S.W.3
Duden, R.4
Soling, H.D.5
-
51
-
-
15844425969
-
Endoproteolysis of presenilin I and accumulation of processed derivatives in vivo
-
Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey Al, Gandy SE, Jenkins NA, Copeland NG, Price DL, Sisodia SS: Endoproteolysis of presenilin I and accumulation of processed derivatives in vivo. Neuron 1996, 17(1):181-190.
-
(1996)
Neuron
, vol.17
, Issue.1
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
Kim, G.6
Ratovitsky, T.7
Davenport, F.8
Nordstedt, C.9
Seeger, M.10
Hardy, J.11
Levey, A.12
Gandy, S.E.13
Jenkins, N.A.14
Copeland, N.G.15
Price, D.L.16
Sisodia, S.S.17
-
52
-
-
7044254509
-
Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin I conformation
-
Lleo A, Berezovska O, Herl L, Raju S, Deng A, Bacskai BJ, Frosch MP, Irizarry M, Hyman BT: Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin I conformation. Nat Med 2004, 10(10):1065- 1066.
-
(2004)
Nat Med
, vol.10
, Issue.10
, pp. 1065-1066
-
-
Lleo, A.1
Berezovska, O.2
Herl, L.3
Raju, S.4
Deng, A.5
Bacskai, B.J.6
Frosch, M.P.7
Irizarry, M.8
Hyman, B.T.9
-
53
-
-
24044497252
-
The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACEI) substrate
-
von Arnim CA, Kinoshita A, Peltan ID, Tangredi MM, Herl L, Lee BM, Spoelgen R, Hshieh TT, Ranganathan S, Battey FD, Liu CX, Bacskai BJ, Sever S, Irizarry MC, Strickland DK, Hyman BT: The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACEI) substrate. J Biol Chem 2005, 280(18):17777-17785.
-
(2005)
J Biol Chem
, vol.280
, Issue.18
, pp. 17777-17785
-
-
von Arnim, C.A.1
Kinoshita, A.2
Peltan, I.D.3
Tangredi, M.M.4
Herl, L.5
Lee, B.M.6
Spoelgen, R.7
Hshieh, T.T.8
Ranganathan, S.9
Battey, F.D.10
Liu, C.X.11
Bacskai, B.J.12
Sever, S.13
Irizarry, M.C.14
Strickland, D.K.15
Hyman, B.T.16
-
54
-
-
15244341378
-
Familial Alzheimer's disease presenilin I mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein
-
Berezovska O, Lleo A, Herl LD, Frosch MP, Stern EA, Bacskai BJ, Hyman BT: Familial Alzheimer's disease presenilin I mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. J Neurosci 2005, 25(11):3009-3017.
-
(2005)
J Neurosci
, vol.25
, Issue.11
, pp. 3009-3017
-
-
Berezovska, O.1
Lleo, A.2
Herl, L.D.3
Frosch, M.P.4
Stern, E.A.5
Bacskai, B.J.6
Hyman, B.T.7
|