-
1
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
J. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
2
-
-
0035949487
-
Presenilin, Notch, and the genesis and treatment of Alzheimer's disease
-
D.J. Selkoe Presenilin, Notch, and the genesis and treatment of Alzheimer's disease Proc. Natl. Acad. Sci. USA 98 2001 11039 11041
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 11039-11041
-
-
Selkoe, D.J.1
-
3
-
-
0038664363
-
Reconstitution of gamma-secretase activity
-
D. Edbauer, E. Winkler, J.T. Regula, B. Pesold, H. Steiner, and C. Haass Reconstitution of gamma-secretase activity Nat. Cell Biol. 5 2003 486 488
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 486-488
-
-
Edbauer, D.1
Winkler, E.2
Regula, J.T.3
Pesold, B.4
Steiner, H.5
Haass, C.6
-
4
-
-
18444417998
-
Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
-
R. Francis, G. McGrath, J. Zhang, D.A. Ruddy, M. Sym, J. Apfeld, M. Nicoll, M. Maxwell, B. Hai, M.C. Ellis, A.L. Parks, W. Xu, J. Li, M. Gurney, R.L. Myers, C.S. Himes, R. Hiebsch, C. Ruble, J.S. Nye, and D. Curtis aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation Dev. Cell 3 2002 85 97
-
(2002)
Dev. Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
Ruddy, D.A.4
Sym, M.5
Apfeld, J.6
Nicoll, M.7
Maxwell, M.8
Hai, B.9
Ellis, M.C.10
Parks, A.L.11
Xu, W.12
Li, J.13
Gurney, M.14
Myers, R.L.15
Himes, C.S.16
Hiebsch, R.17
Ruble, C.18
Nye, J.S.19
Curtis, D.20
more..
-
5
-
-
0037154158
-
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
-
C. Goutte, M. Tsunozaki, V.A. Hale, and J.R. Priess APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos Proc. Natl. Acad. Sci. USA 99 2002 775 779
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 775-779
-
-
Goutte, C.1
Tsunozaki, M.2
Hale, V.A.3
Priess, J.R.4
-
6
-
-
4444264297
-
Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles
-
I. Hayashi, Y. Urano, R. Fukuda, N. Isoo, T. Kodama, T. Hamakubo, T. Tomita, and T. Iwatsubo Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles J. Biol. Chem. 279 2004 38040 38046
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 38040-38046
-
-
Hayashi, I.1
Urano, Y.2
Fukuda, R.3
Isoo, N.4
Kodama, T.5
Hamakubo, T.6
Tomita, T.7
Iwatsubo, T.8
-
7
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
-
G. Yu, M. Nishimura, S. Arawaka, D. Levitan, L. Zhang, A. Tandon, Y.Q. Song, E. Rogaeva, F. Chen, T. Kawarai, A. Supala, L. Levesque, H. Yu, D.S. Yang, E. Holmes, P. Milman, Y. Liang, D.M. Zhang, D.H. Xu, C. Sato, E. Rogaev, M. Smith, C. Janus, Y. Zhang, R. Aebersold, L.S. Farrer, S. Sorbi, A. Bruni, P. Fraser, and P. St George-Hyslop Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing Nature 407 2000 48 54
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.5
Tandon, A.6
Song, Y.Q.7
Rogaeva, E.8
Chen, F.9
Kawarai, T.10
Supala, A.11
Levesque, L.12
Yu, H.13
Yang, D.S.14
Holmes, E.15
Milman, P.16
Liang, Y.17
Zhang, D.M.18
Xu, D.H.19
Sato, C.20
Rogaev, E.21
Smith, M.22
Janus, C.23
Zhang, Y.24
Aebersold, R.25
Farrer, L.S.26
Sorbi, S.27
Bruni, A.28
Fraser, P.29
St George-Hyslop, P.30
more..
-
8
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
-
M.S. Wolfe, W. Xia, B.L. Ostaszewski, T.S. Diehl, W.T. Kimberly, and D.J. Selkoe Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity Nature 398 1999 513 517
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
9
-
-
0033615580
-
The presenilins in Alzheimer's disease-proteolysis holds the key
-
C. Haass, and B. De Strooper The presenilins in Alzheimer's disease-proteolysis holds the key Science 286 1999 916 919
-
(1999)
Science
, vol.286
, pp. 916-919
-
-
Haass, C.1
De Strooper, B.2
-
10
-
-
15844425969
-
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
G. Thinakaran, D.R. Borchelt, M.K. Lee, H.H. Slunt, L. Spitzer, G. Kim, T. Ratovitsky, F. Davenport, C. Nordstedt, M. Seeger, J. Hardy, A.I. Levey, S.E. Gandy, N.A. Jenkins, N.G. Copeland, D.L. Price, and S.S. Sisodia Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo Neuron 17 1996 181 190
-
(1996)
Neuron
, vol.17
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
Kim, G.6
Ratovitsky, T.7
Davenport, F.8
Nordstedt, C.9
Seeger, M.10
Hardy, J.11
Levey, A.I.12
Gandy, S.E.13
Jenkins, N.A.14
Copeland, N.G.15
Price, D.L.16
Sisodia, S.S.17
-
11
-
-
0035937153
-
The role of presenilins in gamma-secretase activity
-
M.S. Wolfe, and C. Haass The role of presenilins in gamma-secretase activity J. Biol. Chem. 276 2001 5413 5416
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 5413-5416
-
-
Wolfe, M.S.1
Haass, C.2
-
12
-
-
0141733241
-
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin
-
M.J. LaVoie, P.C. Fraering, B.L. Ostaszewski, W. Ye, W.T. Kimberly, M.S. Wolfe, and D.J. Selkoe Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin J. Biol. Chem. 278 2003 37213 37222
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 37213-37222
-
-
Lavoie, M.J.1
Fraering, P.C.2
Ostaszewski, B.L.3
Ye, W.4
Kimberly, W.T.5
Wolfe, M.S.6
Selkoe, D.J.7
-
13
-
-
3042520872
-
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: Identification of nicastrin mutants that selectively interact with APH-1
-
K. Shirotani, D. Edbauer, M. Kostka, H. Steiner, and C. Haass Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1 J. Neurochem. 89 2004 1520 1527
-
(2004)
J. Neurochem.
, vol.89
, pp. 1520-1527
-
-
Shirotani, K.1
Edbauer, D.2
Kostka, M.3
Steiner, H.4
Haass, C.5
-
14
-
-
12544255206
-
A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1
-
S.H. Kim, and S.S. Sisodia A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1 J. Biol. Chem. 280 2005 1992 2001
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 1992-2001
-
-
Kim, S.H.1
Sisodia, S.S.2
-
15
-
-
0142250857
-
Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: Interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates
-
S. Baulac, M.J. LaVoie, W.T. Kimberly, J. Strahle, M.S. Wolfe, D.J. Selkoe, and W. Xia Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates Neurobiol. Dis. 14 2003 194 204
-
(2003)
Neurobiol. Dis.
, vol.14
, pp. 194-204
-
-
Baulac, S.1
Lavoie, M.J.2
Kimberly, W.T.3
Strahle, J.4
Wolfe, M.S.5
Selkoe, D.J.6
Xia, W.7
-
16
-
-
14844286856
-
Gamma-secretase complex assembly within the early secretory pathway
-
A. Capell, D. Beher, S. Prokop, H. Steiner, C. Kaether, M.S. Shearman, and C. Haass Gamma-secretase complex assembly within the early secretory pathway J. Biol. Chem. 280 2005 6471 6478
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 6471-6478
-
-
Capell, A.1
Beher, D.2
Prokop, S.3
Steiner, H.4
Kaether, C.5
Shearman, M.S.6
Haass, C.7
-
17
-
-
3843122101
-
The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities
-
Y. Gu, N. Sanjo, F. Chen, H. Hasegawa, A. Petit, X. Ruan, W. Li, C. Shier, T. Kawarai, G. Schmitt-Ulms, D. Westaway, P. St George-Hyslop, and P.E. Fraser The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities J. Biol. Chem. 279 2004 31329 31336
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 31329-31336
-
-
Gu, Y.1
Sanjo, N.2
Chen, F.3
Hasegawa, H.4
Petit, A.5
Ruan, X.6
Li, W.7
Shier, C.8
Kawarai, T.9
Schmitt-Ulms, G.10
Westaway, D.11
St George-Hyslop, P.12
Fraser, P.E.13
-
18
-
-
0038652102
-
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2
-
W.T. Kimberly, M.J. LaVoie, B.L. Ostaszewski, W. Ye, M.S. Wolfe, and D.J. Selkoe Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2 Proc. Natl. Acad. Sci. USA 100 2003 6382 6387
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 6382-6387
-
-
Kimberly, W.T.1
Lavoie, M.J.2
Ostaszewski, B.L.3
Ye, W.4
Wolfe, M.S.5
Selkoe, D.J.6
-
19
-
-
0037659067
-
Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals
-
T. Li, G. Ma, H. Cai, D.L. Price, and P.C. Wong Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals J. Neurosci. 23 2003 3272 3277
-
(2003)
J. Neurosci.
, vol.23
, pp. 3272-3277
-
-
Li, T.1
Ma, G.2
Cai, H.3
Price, D.L.4
Wong, P.C.5
-
20
-
-
0242321947
-
Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin
-
O. Nyabi, M. Bentahir, K. Horre, A. Herreman, N. Gottardi-Littell, C. Van Broeckhoven, P. Merchiers, K. Spittaels, W. Annaert, and B. De Strooper Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin J. Biol. Chem. 278 2003 43430 43436
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 43430-43436
-
-
Nyabi, O.1
Bentahir, M.2
Horre, K.3
Herreman, A.4
Gottardi-Littell, N.5
Van Broeckhoven, C.6
Merchiers, P.7
Spittaels, K.8
Annaert, W.9
De Strooper, B.10
-
21
-
-
0032568821
-
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
-
G. Yu, F. Chen, G. Levesque, M. Nishimura, D.M. Zhang, L. Levesque, E. Rogaeva, D. Xu, Y. Liang, M. Duthie, P.H. St George-Hyslop, and P.E. Fraser The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin J. Biol. Chem. 273 1998 16470 16475
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 16470-16475
-
-
Yu, G.1
Chen, F.2
Levesque, G.3
Nishimura, M.4
Zhang, D.M.5
Levesque, L.6
Rogaeva, E.7
Xu, D.8
Liang, Y.9
Duthie, M.10
St George-Hyslop, P.H.11
Fraser, P.E.12
-
22
-
-
0035823039
-
Homodimerization of presenilin N-terminal fragments is affected by mutations linked to Alzheimer's disease
-
S. Cervantes, R. Gonzalez-Duarte, and G. Marfany Homodimerization of presenilin N-terminal fragments is affected by mutations linked to Alzheimer's disease FEBS Lett. 505 1 2001 81 86
-
(2001)
FEBS Lett.
, vol.505
, Issue.1
, pp. 81-86
-
-
Cervantes, S.1
Gonzalez-Duarte, R.2
Marfany, G.3
-
23
-
-
4344632844
-
Functional implications of the presenilin dimerization: Reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins
-
S. Cervantes, C.A. Saura, E. Pomares, R. Gonzalez-Duarte, and G. Marfany Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins J. Biol. Chem. 279 2004 36519 36529
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 36519-36529
-
-
Cervantes, S.1
Saura, C.A.2
Pomares, E.3
Gonzalez-Duarte, R.4
Marfany, G.5
-
25
-
-
0036565893
-
Identification of a novel family of presenilin homologues
-
C.P. Ponting, M. Hutton, A. Nyborg, M. Baker, K. Jansen, and T.E. Golde Identification of a novel family of presenilin homologues Hum. Mol. Genet. 11 2002 1037 1044
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 1037-1044
-
-
Ponting, C.P.1
Hutton, M.2
Nyborg, A.3
Baker, M.4
Jansen, K.5
Golde, T.E.6
-
26
-
-
0037150672
-
Identification of signal peptide peptidase, a presenilin-type aspartic protease
-
A. Weihofen, K. Binns, M. Lemberg, K. Ashman, and B. Martoglio Identification of signal peptide peptidase, a presenilin-type aspartic protease Science 296 2002 2215 2218
-
(2002)
Science
, vol.296
, pp. 2215-2218
-
-
Weihofen, A.1
Binns, K.2
Lemberg, M.3
Ashman, K.4
Martoglio, B.5
-
27
-
-
2442446430
-
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor
-
A.C. Nyborg, A.Y. Kornilova, K. Jansen, T.B. Ladd, M.S. Wolfe, and T.E. Golde Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor J. Biol. Chem. 279 2004 15153 15160
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 15153-15160
-
-
Nyborg, A.C.1
Kornilova, A.Y.2
Jansen, K.3
Ladd, T.B.4
Wolfe, M.S.5
Golde, T.E.6
-
28
-
-
0242331600
-
A presenilin dimer at the core of the gamma-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis
-
E.H. Schroeter, M.X. Ilagan, A.L. Brunkan, S. Hecimovic, Y.M. Li, M. Xu, H.D. Lewis, M.T. Saxena, B. De Strooper, A. Coonrod, T. Tomita, T. Iwatsubo, C.L. Moore, A. Goate, M.S. Wolfe, M. Shearman, and R. Kopan A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis Proc. Natl. Acad. Sci. USA 100 2003 13075 13080
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 13075-13080
-
-
Schroeter, E.H.1
Ilagan, M.X.2
Brunkan, A.L.3
Hecimovic, S.4
Li, Y.M.5
Xu, M.6
Lewis, H.D.7
Saxena, M.T.8
De Strooper, B.9
Coonrod, A.10
Tomita, T.11
Iwatsubo, T.12
Moore, C.L.13
Goate, A.14
Wolfe, M.S.15
Shearman, M.16
Kopan, R.17
-
29
-
-
15244341378
-
Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein
-
O. Berezovska, A. Lleo, L.D. Herl, M.P. Frosch, E.A. Stern, B.J. Bacskai, and B.T. Hyman Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein J. Neurosci. 25 2005 3009 3017
-
(2005)
J. Neurosci.
, vol.25
, pp. 3009-3017
-
-
Berezovska, O.1
Lleo, A.2
Herl, L.D.3
Frosch, M.P.4
Stern, E.A.5
Bacskai, B.J.6
Hyman, B.T.7
-
30
-
-
12144290191
-
Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein
-
H. Laudon, P.M. Mathews, H. Karlstrom, A. Bergman, M.R. Farmery, R.A. Nixon, B. Winblad, S.E. Gandy, U. Lendahl, J. Lundkvist, and J. Naslund Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein J. Neurochem. 89 2004 44 53
-
(2004)
J. Neurochem.
, vol.89
, pp. 44-53
-
-
Laudon, H.1
Mathews, P.M.2
Karlstrom, H.3
Bergman, A.4
Farmery, M.R.5
Nixon, R.A.6
Winblad, B.7
Gandy, S.E.8
Lendahl, U.9
Lundkvist, J.10
Naslund, J.11
-
31
-
-
0035374675
-
Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2
-
E.K. Choi, N.F. Zaidi, J.S. Miller, A.C. Crowley, D.E. Merriam, C. Lilliehook, J.D. Buxbaum, and W. Wasco Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2 J. Biol. Chem. 276 2001 19197 19204
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 19197-19204
-
-
Choi, E.K.1
Zaidi, N.F.2
Miller, J.S.3
Crowley, A.C.4
Merriam, D.E.5
Lilliehook, C.6
Buxbaum, J.D.7
Wasco, W.8
-
32
-
-
0034989501
-
Commentary: Abeta N-terminal isoforms: Critical contributors in the course of AD pathophysiology
-
T.L. Tekirian Commentary: abeta N-terminal isoforms: critical contributors in the course of AD pathophysiology J. Alzheimers Dis. 3 2001 241 248
-
(2001)
J. Alzheimers Dis.
, vol.3
, pp. 241-248
-
-
Tekirian, T.L.1
-
33
-
-
0141644224
-
FRET determinations using multiphoton fluorescence lifetime imaging microscopy (FLIM) to characterize amyloid-beta plaques
-
B.J. Bacskai, J. Skoch, G.A. Hickey, R. Allen, and B.T. Hyman FRET determinations using multiphoton fluorescence lifetime imaging microscopy (FLIM) to characterize amyloid-beta plaques J. Biomed. Opt. 8 2003 368 375
-
(2003)
J. Biomed. Opt.
, vol.8
, pp. 368-375
-
-
Bacskai, B.J.1
Skoch, J.2
Hickey, G.A.3
Allen, R.4
Hyman, B.T.5
-
34
-
-
0038117200
-
Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging
-
O. Berezovska, P. Ramdya, J. Skoch, M.S. Wolfe, B.J. Bacskai, and B.T. Hyman Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging J. Neurosci. 23 2003 4560 4566
-
(2003)
J. Neurosci.
, vol.23
, pp. 4560-4566
-
-
Berezovska, O.1
Ramdya, P.2
Skoch, J.3
Wolfe, M.S.4
Bacskai, B.J.5
Hyman, B.T.6
-
35
-
-
7044254509
-
Nonsteroidal anti-inflammatory drugs lower Abeta(42) and change presenilin 1 conformation
-
A. Lleo, O. Berezovska, L. Herl, S. Raju, A. Deng, B.J. Bacskai, M.P. Frosch, M. Irizarry, and B.T. Hyman Nonsteroidal anti-inflammatory drugs lower Abeta(42) and change presenilin 1 conformation Nat. Med. 10 2004 1065 1066
-
(2004)
Nat. Med.
, vol.10
, pp. 1065-1066
-
-
Lleo, A.1
Berezovska, O.2
Herl, L.3
Raju, S.4
Deng, A.5
Bacskai, B.J.6
Frosch, M.P.7
Irizarry, M.8
Hyman, B.T.9
-
36
-
-
0344824698
-
Activated Notch1 associates with a presenilin-1/gamma-secretase docking site
-
P. Ramdya, J. Skoch, B.J. Bacskai, B.T. Hyman, and O. Berezovska Activated Notch1 associates with a presenilin-1/gamma-secretase docking site J. Neurochem. 87 2003 843 850
-
(2003)
J. Neurochem.
, vol.87
, pp. 843-850
-
-
Ramdya, P.1
Skoch, J.2
Bacskai, B.J.3
Hyman, B.T.4
Berezovska, O.5
-
37
-
-
0347093518
-
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex
-
P.C. Fraering, M.J. LaVoie, W. Ye, B.L. Ostaszewski, W.T. Kimberly, D.J. Selkoe, and M.S. Wolfe Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex Biochemistry 43 2004 323 333
-
(2004)
Biochemistry
, vol.43
, pp. 323-333
-
-
Fraering, P.C.1
Lavoie, M.J.2
Ye, W.3
Ostaszewski, B.L.4
Kimberly, W.T.5
Selkoe, D.J.6
Wolfe, M.S.7
-
38
-
-
0343819757
-
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
-
Y.M. Li, M.T. Lai, M. Xu, Q. Huang, J. DiMuzio-Mower, M.K. Sardana, X.P. Shi, K.C. Yin, J.A. Shafer, and S.J. Gardell Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state Proc. Natl. Acad. Sci. USA 97 2000 6138 6143
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6138-6143
-
-
Li, Y.M.1
Lai, M.T.2
Xu, M.3
Huang, Q.4
Dimuzio-Mower, J.5
Sardana, M.K.6
Shi, X.P.7
Yin, K.C.8
Shafer, J.A.9
Gardell, S.J.10
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