APH1, PEN2, and Nicastrin increase Aβ levels and γ-secretase activity

Biochemical and Biophysical Research Communications

Volumn 305, Issue 3, 2003, Pages 502-509

  Marlow, Laura ^a   Canet, Rosa M ^a,b   Haugabook, Sharie J ^a   Hardy, John A ^b   Lahiri, Debomoy K ^c   Sambamurti, Kumar ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amyloid; APH 1; APP; Intramembrane proteolysis; Nicastrin; Notch; PEN 2; Presenilin; Regulated proteolysis; Secretosome; Secretase

Indexed keywords

AMYLOID BETA PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; GAMMA SECRETASE; ISOPROTEIN; OLIGOMER; PRESENILIN 1; PRESENILIN 2; PRESENILIN ENHANCER 2; PROTEIN; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BIOGENESIS; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME REGULATION; ENZYME STRUCTURE; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC CODE; HUMAN; HUMAN CELL; KNOCKOUT GENE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENILE PLAQUE;

EID: 0037902542     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00797-6     Document Type: Article

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