Identification of sequence variants and analysis of the role of the glycogen synthase kinase 3 β gene and promoter in late onset Alzheimer's disease

Molecular Psychiatry

Volumn 6, Issue 3, 2001, Pages 320-324

  Russ, C ^a   Lovestone, S ^a   Powell, J F ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Association; Polymorphism; Promoter; SNPs; Tau

Indexed keywords

APOLIPOPROTEIN E; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; PRESENILIN 1; TAU PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; GENE FREQUENCY; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; ONSET AGE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; SINGLE NUCLEOTIDE POLYMORPHISM;

AGE OF ONSET; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; DNA PRIMERS; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; HUMANS; MIDDLE AGED; PHOSPHORYLATION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROMOTER REGIONS (GENETICS); TAU PROTEINS;

EID: 0035062230     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000852     Document Type: Article

References (30)

1. Molecular genetics of Alzheimer's disease
2. Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA
3. Tau protein function in living cells
4. Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells
5. Modulation of PHF-like tau phosphorylation in cultured neurones and transfected cells
6. Glycogen synthase kinase-3β phosphorylates tau protein at multiple sites in intact cells
7. Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain
8. Physiology and pathology of tau protein kinases in relation to Alzheimer's disease
9. Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3β and cyclin-dependent kinase 5, a component of TPK II
10. Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
11. Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex
12. Diabetes mellitus and the risk of dementia: The Rotterdam Study
13. Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cAMP-dependent protein kinase and phosphorylase kinase
14. Isolation and chromosomal mapping of glycogen synthase kinase-3alpha; and -3beta; encoding genes
15. Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch
16. Glycogen synthase kinase-3: Functions in oncogenesis and development
17. Expression analysis of glycogen synthase kinase-3 in human tissues
18. Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter
19. The Fe65 and X11 families of proteins: Proteins that interact with the Alzheimer's disease amyloid precursor protein
20. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease
21. A radiation hybrid map of the human genome
22. DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene
23. The Camberwell Dementia Case Register
24. Base-calling of automated sequencer traces using phred. II. Error probabilities
25. Base-calling of automated sequencer traces using phred. I. Accuracy assessment
26. PolyPhred: Automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing
27. Consed: A graphical tool for sequence finishing
28. Linkage disequilibrium between alleles at marker loci
29. Discordant patterns of linkage disequilibrium of the peptide-transporter loci within the HLA class II region
30. STATCALC: An integrated statistics system for the Apple II microcomputer