Association between glycogen synthase kinase-3β genetic polymorphism and late-onset Alzheimer's disease

Dementia and Geriatric Cognitive Disorders

Volumn 21, Issue 4, 2006, Pages 228-232

  Mateo, Ignacio ^a   Infante, Jon ^a   Llorca, Javier ^b   Rodríguez, Eloy ^a   Berciano, José ^a   Combarros, Onofre ^a  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^b UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

Alzheimer's disease; Gene polymorphism; Glycogen synthase kinase 3 ; Saitohin; Tau

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN DERIVATIVE; SAITOHIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; PROMOTER REGION; RISK ASSESSMENT; SPAIN;

AGE FACTORS; AGE OF ONSET; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; CATCHMENT AREA (HEALTH); CODON; FEMALE; GENOTYPE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MALE; MIDDLE AGED; PHOSPHORYLATION; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); SPAIN; TAU PROTEINS;

EID: 33645720958     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000091044     Document Type: Article

References (11)

1. Stoothoff WH, Johnson GVW : Tau phosphorylation: physiological and pathological consequences. Biochim Biophys Acta 2005;1739:280-297.
2. Ferrer I, Barrachina M, Puig B: Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease. Pick's disease, progressive supranuclear palsy and corticobasal degeneration. Acta Neuropathol 2002;104:583-591.
3. Lucas JJ, Hernández F, Gómez-Ramos P, Morán MA, Hen R, Avila J: Decreased nuclear β-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3β conditional transgenic mice. EMBO J 2001;20:27-39.
4. Russ C, Lovestone S, Powell JF: Identification of sequence variants and analysis of the role of the glycogen synthase kinase 3 beta gene and promoter in late onset Alzheimer's disease. Mol Psychiatry 2001;6:320-324.
5. Hernández F, Pérez M, Lucas JJ, Mata AM, Bhat R, Avila J: Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease. J Biol Chem 2004;279:3801-3806.
6. Schraen-Maschke S, Dhaenens CM, Delacourte A, Sablonnière B: Microtubule-associated protein tau gene: a risk factor in human neurodegenerative diseases. Neurobiol Dis 2004;15:449-460.
7. Myers AJ, Kaleem M, Marlowe L, Pittman AM, Lees AJ, Fung HC, Duckworth J, Leung D, Gibson A, Morris CM, de Silva R, Hardy J: The H1c haplotype at the MAPT locus is associated with Alzheimer's disease. Hum Mol Genet 2005;14:2399-2404.
8. Conrad C, Vianna C, Freeman M, Davies P: A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease. Proc Natl Acad Sci USA 2002;99:7751-7756.
9. Combarros O, Rodero L, Infante J, Palacio E, Llorca J, Fernández-Viadero C, Peña N, Berciano J: Age-dependent association between the Q7R polymorphism in the Saitohin gene and sporadic Alzheimer's disease. Dement Geriatr Cogn Disord 2003;16:132-135.
10. McKhaan G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDA-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:934-944.
11. Lau KF, Miller CCJ, Anderton BH, Shaw PC: Molecular cloning and characterization of the human glycogen syntase kinase-3β promoter. Genomics 1999;60:121-128.