Low GSK-3 activity in frontal cortex of schizophrenic patients

Schizophrenia Research

Volumn 52, Issue 1-2, 2001, Pages 101-105

  Kozlovsky, N ^a   Belmaker, R H ^a   Agam, G ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Enzyme activity; Frontal cortex; Glycogen synthase kinase 3; Occipital cortex; Postmortem brain; Protein levels

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; PROTEIN KINASE;

ANALYTIC METHOD; ARTICLE; BRAIN LEVEL; BRAIN REGION; CELL FUNCTION; CITRIC ACID CYCLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE CLASSIFICATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MALE; NERVE CELL DIFFERENTIATION; OCCIPITAL CORTEX; PRIORITY JOURNAL; PROTEIN ANALYSIS; SCHIZOPHRENIA;

BIPOLAR DISORDER; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; DEPRESSIVE DISORDER, MAJOR; FEMALE; FRONTAL LOBE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; HUMANS; MALE; OCCIPITAL LOBE; REFERENCE VALUES; SCHIZOPHRENIA;

EID: 0035476357     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(00)00174-2     Document Type: Article

References (30)

1. Hippocampal pyramidal cell orientation in schizophrenia
2. Neurodevelopmental abnormalities in schizophrenia: Insights from neuropathology
3. Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia
4. Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia
5. Glucogen synthase kinase 3b facilitates staurosporine- and heat-shock induced apoptosis: Protection by lithium
6. Significant reductions in synapsin but not synaptophysin specific activity in the brains of some schizophrenics
7. New morphological and neuropathological findings in schizophrenia: A neurodevelopmental perspective
8. The neurodevelopmental theory of schizophrenia: Evidence concerning structure and neuropsychology
9. Schizophrenia and the hippocampus: The embryological hypothesis extended
10. Abnormalities of Wnt signalling in schizophrenia - Evidence for neurodevelopmental abnormality
11. Alterations in hippocampal non-phosphorylated MAP2 protein expression in schizophrenia
12. Implication of cyclin-dependent kinases and glycogen synthase kinase 3 in the phosphorylation of microtubule-associated protein 1B in developing neuronal cells
13. Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia
14. CNS signal transduction in the pathophysiology and pharmacology of affective disorders and schizophrenia
15. Further studies of elevated cerebrospinal fluid neuronal cell adhesion molecule in schizophrenia
16. Decreased GSK-3b immunoreactivity in postmortem frontal cortex of schizophrenic patients
17. Developmental expression and localization of glycogen synthase kinase-3beta in rat brain
18. Inhibition of GSK-3 beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium
19. Identification of two protein kinases that phosphorylate the neural cell-adhesion molecule
20. Increased expression of Wnt-1 in schizophrenic brains
21. WNTs modulate cell fate and behavior during vertebrate development
22. An assay for glycogen synthase kinase 3 (GSK-3) for use in crude cell extracts
23. Increased levels of GAP-43 protein in schizophrenic brain tissues demonstrated by a novel immunodetection method
24. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
25. The Stanley Foundation brain collection and neuropathology consortium
26. Use of a synthetic peptide as a selective substrate for glycogen synthase kinase 3
27. On the plausibility of the neurodevelopmental hypothesis of schizophrenia
28. Dysfunction of protein kinase FA/GSK-3 alpha in lymphocytes of patients with schizophrenic disorder
29. Immunological and biochemical study on tissue and subcellular distributions of protein kinase FA a simplified and efficient procedure for high quantity purification from brain
30. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis