Association study of the human FZD3 locus with schizophrenia

Biological Psychiatry

Volumn 54, Issue 11, 2003, Pages 1298-1301

  Yang, Jianzhong ^a   Si, Tianmei ^a   Ling, Yansu ^a   Ruan, Yan ^a   Han, Yonghua ^a   Wang, Xiling ^a   Zhang, Hongyan ^a   Kong, Qingmei ^a   Li, Xueni ^a   Liu, Cui ^a   Zhang, Darong ^a   Zhou, Mo ^a   Yu, Yaqin ^b   Liu, Shuzeng ^b   Shu, Liang ^a   Ma, Dalong ^c   Wei, Jun ^b   Zhang, Dai ^a  

^a PEKING UNIVERSITY SIXTH HOSPITAL   (China)

^b JILIN UNIVERSITY   (China)

^c PEKING UNIVERSITY   (China)

Author keywords

Association study; Chromosome 8p; FZD3 gene; Schizophrenia; Single nucleotide polymorphisms; Wnt family

Indexed keywords

FZD3 PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ARTICLE; CHI SQUARE TEST; CHROMOSOME 8P; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; FZD3 GENE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 10744230060     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(03)00291-9     Document Type: Article

References (21)

1. Arnold S.E. Neurodevelopmental abnormalities in schizophrenia Insights from neuropathology . Dev Psychopathol. 11:1999;439-456.
2. Beasley C., Cotter D., Khan N., Pollard C., Sheppard P., Varndell I., et al. Glycogen synthase kinase-3beta immunoreactivity is reduced in the prefrontal cortex in schizophrenia. Neurosci Lett. 20:2001;117-120.
3. Bloom F.E. Advancing a neurodevelopmental origin for schizophrenia. Arch Gen Psychiatry. 50:1993;224-227.
4. Chiano M.N., Clayton D.G. Fine genetic mapping using haplotype analysis and the missing data problem. Ann Human Genet. 62:1998;55-60.
5. Cotter D., Kerwin R., al-Sarraji S., Brion J.P., Chadwich A., Lovestone S. Abnormalities of Wnt signaling in schizophrenia - evidence for neurodevelopmental abnormality. NeuroReport. 9:1998;1379-1383.
6. Hall A.C., Lucas F.R., Salinas P.C. Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling. Cell. 100:2000;525-535.
7. Kendler K.S., MacLean C.J., O'Neill F.A., Burke J., Murphy B., Duke F., et al. Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish study of high-density schizophrenia Families. Am J Psychiatry. 153:1996;1534-1540.
8. Lee K.J., Jessell T.M. The specification of dorsal cell fates in the vertebrate central nervous system. Annu Rev Neurosci. 22:1999;261-294.
9. Lieberman J.A. Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective. Biol Psychiatry. 15:(46):1999;729-739.
10. McMahon A.P., Bradley A. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell. 62:1991;1073-1085.
11. Miyaoka T., Seno H., Ishino H. Increased expression of Wnt-1 in schizophrenic brains. Schizophr Res. 38:1999;1-6.
12. Murry R.M. Neurodevelopmental schizophrenia The rediscovery of dementia praecox . Br J Psychiatry. 165:(suppl):1994;6-12.
13. Patapoutian A., Reichardt L.F. Roles of Wnt proteins in neural development and maintenance. Curr Opin Neurobiol. 10:2000;392-399.
14. Pulver A.E., Lasseter V.K., Kasch L., Wolyniec P., Nestadt G., Blouin J.L., et al. Schizophrenia A genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes . Am J Med Genet. 60:1995;252-260.
15. Pulver A.E., Mulle J., Swartz K.L., Blouin J.-L., Dombroski B., Liang K.-Y., et al. Genetic heterogeneity in schizophrenia Stratification of genome scan data using co-segregating related phenotypes . Mol Psychiatry. 5:2000;650-653.
16. Sala C.F., Formenti E., Terstappen G.C., Caricasole A. Identification, gene structure, and expression of human frizzled-3 (FZD3). Biochem Biophys Res Commun. 273:2000;27-34.
17. Additional support for schizophrenia linkage on chromosomes 6 and 8 A multicenter study. Schizophrenia Linkage Collaborative Group for chromosomes 3, 6 and 8 . Am J Med Genet. 67:1996;580-594.
18. Sokol S.Y. Wnt signaling and dorso-ventral axis specification in vertebrates. Curr Opin Genet Dev. 9:1999;405-410.
19. Spielman R.S., McGinnis R.E., Ewens W.J. Transmission tests for linkage disequilibrium The insulin gene region and insulin-dependent diabetes mellitus (IDDM) . Am J Hum Genet. 52:1993;506-516.
20. Wang Y., Thekdi N., Smallwood P.M., Macke J.P., Nathans J. Frizzled-3 is required for the development of major fiber tracts in the rostral CNS. J Neurosci. 22:2002;8563-8573.
21. Weinberger D.R. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry. 44:1987;660-669.