Genetic variation in CTNNA3 encoding alpha-3 catenin and Alzheimer's disease

Neuroscience Letters

Volumn 358, Issue 3, 2004, Pages 220-222

  Blomqvist, Mia E L ^a   Andreasen, Niels ^b   Bogdanovic, Nenad ^b   Blennow, Kaj ^c   Brookes, Anthony J ^a   Prince, Jonathan A ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Alpha 3 catenin; Alzheimer's disease; CTNNA3; Genetic variation; Linkage disequilibrium

Indexed keywords

ALPHA 3 CATENIN; ALPHA CATENIN; UNCLASSIFIED DRUG;

ALLELE; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC CODE; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

AGE OF ONSET; ALPHA CATENIN; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; CHROMOSOMES, HUMAN, PAIR 10; CYTOSKELETAL PROTEINS; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; PEPTIDE FRAGMENTS; POLYMORPHISM, GENETIC; SENILE PLAQUES; TAU PROTEINS; VARIATION (GENETICS);

EID: 1642334902     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.01.032     Document Type: Article

References (16)

1. Andreasen N., Minthon L., Davidsson P., Vanmechelen E., Vanderstichele H., Winblad B., Blennow K. Evaluation of CSF-tau and CSF-Abeta42 as diagnostic markers for Alzheimer disease in clinical practice. Arch. Neurol. 58:2001;373-379.
2. Bertram L., Blacker D., Mullin K., Keeney D., Jones J., Basu S., Yhu S., McInnis M.G., Go R.C., Vekrellis K., Selkoe D.J., Saunders A.J., Tanzi R.E. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science. 290:2000;2302-2303.
3. Ertekin-Taner N., Graff-Radford N., Younkin L.H., Eckman C., Baker M., Adamson J., Ronald J., Blangero J., Hutton M., Younkin S.G. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science. 290:2000;2303-2304.
4. Ertekin-Taner N., Ronald J., Asahara H., Younkin L., Hella M., Jain S., Gnida E., Younkin S., Fadale D., Ohyagi Y., Singleton A., Scanlin L., De Andrade M., Petersen R., Graff-Radford N., Hutton M., Younkin S. Fine mapping of the α-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Hum. Mol. Genet. 12:2003;3133-3143.
5. Goate A., Chartier-Harlin M.C., Mullan M., Brown J., Crawford F., Fidani L., Giuffra L., Haynes A., Irving N., James L., Mant R., Newton P., Rooke K., Roques P., Talbot C., Pericak-Vance M., Roses A., Williamson R., Rossor M., Owen M., Hardy J. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 349:1991;704-706.
6. Kehoe P.G., Katzov H., Feuk L., Bennet A.M., Johansson B., Wiman B., de Faire U., Cairns N.J., Wilcock G.K., Brookes A.J., Blennow K., Prince J.A. Haplotypes extending across ACE are associated with Alzheimer's disease. Hum. Mol. Genet. 12:2003;859-867.
7. Kehoe P.G., Russ C., McIlory S., Williams H., Holmans P., Holmes C., Liolitsa D., Vahidassr D., Powell J., McGleenon B., Liddell M., Plomin R., Dynan K., Williams N., Neal J., Cairns N.J., Wilcock G., Passmore P., Lovestone S., Williams J., Owen M.J. Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease. Nat. Genet. 21:1999;71-72.
8. Kehoe P., Wavrant-De Vrieze F., Crook R., Wu W.S., Holmans P., Fenton I., Spurlock G., Norton N., Williams H., Williams N., Lovestone S., Perez-Tur J., Hutton M., Chartier-Harlin M.C., Shears S., Roehl K., Booth J., Van Voorst W., Ramic D., Williams J., Goate A., Hardy J., Owen M.J. A full genome scan for late onset Alzheimer's disease. Hum. Mol. Genet. 8:1999;237-245.
9. Li Y.J., Scott W.K., Hedges D.J., Zhang F., Gaskell P.C., Nance M.A., Watts R.L., Hubble J.P., Koller W.C., Pahwa R., Stern M.B., Hiner B.C., Jankovic J., Allen F.A. Jr, Goetz C.G., Mastaglia F., Stajich J.M., Gibson R.A., Middleton L.T., Saunders A.M., Scott B.L., Small G.W., Nicodemus K.K., Reed A.D., Schmechel D.E., Welsh-Bohmer K.A., Conneally P.M., Roses A.D., Gilbert J.R., Vance J.M., Haines J.L., Pericak-Vance M.A. Age at onset in two common neurodegenerative diseases is genetically controlled. Am. J. Hum. Genet. 70:2002;985-993.
10. Myers A., Holmans P., Marshall H., Kwon J., Meyer D., Ramic D., Shears S., Booth J., DeVrieze F.W., Crook R., Hamshere M., Abraham R., Tunstall N., Rice F., Carty S., Lillystone S., Kehoe P., Rudrasingham V., Jones L., Lovestone S., Perez-Tur J., Williams J., Owen M.J., Hardy J., Goate A.M. Susceptibility locus for Alzheimer's disease on chromosome 10. Science. 290:2000;2304-2305.
11. Prince J.A., Feuk L., Emahazion T., Jobs M., Howell W.M., Brookes A.J. Robust and accurate single nucleotide polymorphism genotyping by dynamic allele specific hyrbidization (DASH): design criteria and assay validation. Genome Res. 11:2001;152-162.
12. Prince J.A., Feuk L., Gu H.F., Johansson B., Gatz M., Blennow K., Brookes A.J. Genetic variation in a haplotype block spanning IDE influences Alzheimer disease. Hum. Mutat. 22:2003;363-371.
13. Rogaev E.I., Sherrington R., Rogaeva E.A., Levesque G., Ikeda M., Liang Y., Chi H., Lin C., Holman K., Tsuda T., Mar L., Sorbi S., Nacmias B., Piacentini S., Chumakov I., Cohen D., Lannfelt L., Fraser P.E., Rommens J.M., St. George-Hyslop P.H. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature. 376:1995;775-778.
14. Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin J.-F., Bruni A.C., Montesi M.P., Sorbi S., Rainero I., Pinessi L., Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P., Polinsky R.J., Wasco W., Da Silva H.A.R., Haines J.L., Pericak-Vance M.A., Tanzi R.E., Roses A.D., Fraser P.E., Rommens J.M., St. George-Hyslop P.H. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375:1995;754-760.
15. Strittmatter W.J., Saunders A.M., Schmechel D., Pericak-Vance M., Enghild J., Salvesen G.S., Roses A.D. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. 90:1993;1977-1981.
16. Wimo A., Winblad B., Aguero-Torres H., von Strauss E. The magnitude of dementia occurrence in the world. Alzheimer Dis. Assoc. Disord. 17:2003;63-67.