Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21

Nature Genetics

Volumn 20, Issue 1, 1998, Pages 70-73

  Blouin, Jean Louis ^a   Dombroski, Beth A ^b   Nath, Swapan K ^c   Lasseter, Virginia K ^d   Wolyniec, Paula S ^d   Nestadt, Gerald ^d   Thornquist, Mary ^d   Ullrich, Gail ^d   McGrath, John ^d   Kasch, Laura ^d   Lamacz, Malgorzata ^d   Thomas, Marion G ^d   Gehrig, Corinne ^a   Radhakrishna, Uppala ^a   Snyder, Sarah E ^b   Balk, Katherine G ^b   Neufeld, Karin ^d   Swartz, Karen L ^d   DeMarchi, Nicola ^e   Papadimitriou, George N ^f   Dikeos, Dimitris G ^f   Stefanis, Costas N ^f   Chakravarti, Aravinda ^c   Childs, Barton ^d   Housman, David E ^g   Kazazian, Haig H ^b   Antonarakis, Stylianos E ^a   Pulver, Ann E ^d   more..

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e SECOND UNIVERSITY OF NAPLES   (Italy)

^f UNIVERSITY MENTAL HEALTH RESEARCH INSTITUTE   (Greece)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 13Q; CHROMOSOME 8P; FEMALE; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PEDIGREE ANALYSIS; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADULT; CHROMOSOMES, HUMAN, PAIR 13; CHROMOSOMES, HUMAN, PAIR 8; DISEASE SUSCEPTIBILITY; FEMALE; GENES, DOMINANT; HUMANS; LINKAGE (GENETICS); LOD SCORE; MALE; MICROSATELLITE REPEATS; MODELS, GENETIC; SCHIZOPHRENIA;

EID: 17344364477     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/1734     Document Type: Article

References (30)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association, Washington D.C., 1994).
2. Rao, D.C., Morton, D.E., Gottesman, I.I. & Lew, R. Path analysts of qualitative data on pairs of relatives: Application to schizophrenia. Hum. Hered. 31, 325-333 (1981).
3. Tsuang, M.T. & Faraone, S.V. The case for heterogeneity in the etiology of schizophrenia. Schizophr. Res. 17, 161-175 (1995).
4. Pulver, A.E. & Liang, K.Y. Estimating effects of probands' characteristics on familial risk: II. The association between age at onset and familial risk in the Maryland schizophrenic sample. Genet. Epidemiol. 8, 339-350 (1991).
5. Pulver, A.E. et al. Risk factors in schizophrenia: season of birth, gender and familial risk. Br. J. Psychiatry 160, 65-71 (1992).
6. Melton, B., Liang, K.Y. & Pulver, A.E. An extended latent class approach to the study of familial/sporadic forms of disease: Its application to the study of the heterogeneity of schizophrenia. Genet. Epidemiol. 11, 311-327 (1994).
7. Pulver, A.E. et al. Sequential strategy to identify a susceptibility gene for schizophrenia: Report of potential linkage on chromosome 22q12-q13.1: Part 1. Am. J. Med. Genet. 54, 36-43 (1994).
8. Pulver, A.E. et al. Schizophrenia: A genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am. J. Med. Genet. 60, 252-260 (1995).
9. Pulver, A.E. et al. Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. J. Nerv. Ment. Dis. 182, 476-478 (1994).
10. Lasseter, V.K. et al. Follow-up report of potential linkage for schizophrenia on chromosome 22q: Part 3. Am. J. Med. Genet. 60, 172-173 (1995).
11. Gill, M. et al. A combined analysis of D225278 marker alleles in affected sib-pairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12. Am. J. Med Genet. 67, 40-45 (1996).
12. Schizophrenia Linkage Collaborative Group for Chromosomes 3, 6 and 8; A Multicenter Study. Additional support for schizophrenia linkage on chromosome 6 and 8. Am. J. Med. Genet. 67, 580-594 (1996).
13. Kendler, K.S. et al. Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish study of high-density schizophrenia families. Am. J. Psychiatry 153, 1534-1540 (1996).
14. Lander, E. & Kruglyak, L. (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet. 11, 241-247.
15. Straub, R.E. et al. A potential vulnerability locus for schizophrenia on chromosome 6p24-p22: Evidence for genetic heterogeneity. Nature Genet. 11, 287-293 (1995).
16. Freedman, R. et al. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc. Natl Acad. Sci. USA 94, 587-592 (1997).
17. Straub, R.E., MacLean, C.J., O'Neill, F.A., Walsh. D. & Kendler, K.S. Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish families. Mol. Psychiatry 2, 148-155 (1997).
18. Wildenauer, D.B. et al. Searching for susceptibility genes in schizophrenia by genetic linkage analysis. Cold Spring Harb. Symp. Quant. Biol. 61, 845-650 (1996).
19. Antonarakis, S.E. et al. Schizophrenia susceptibility and chromosome 6p24-p22. Nature Genet. 11, 235-236 (1995).
20. Antonarakis, S.E. et al. Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21. Am. J. Med. Genet. in press.
21. Lin, M.W. et al. Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32. Psychiatr. Genet. 5, 117-126 (1995).
22. Lin, M.W. et al. Suggestive evidence for linkage of schizophrenia to markers on chromosome 13 in Caucasian but not Oriental populations. Hum. Genet. 99, 417-420 (1997).
23. Pulver, A.E. et al. The Johns Hopkins University Schizophrenia Study: An epidemiologic-genetic approach to test the heterogeneity hypothesis and identify schizophrenia susceptibility genes. Cold Spring Harb. Symp. Quant. Biol. 61, 797-814 (1996).
24. Pulver, A.E. & Bale, S.J. Availabilty of schizophranic patients and their families for genetic linkage studies: Findings from the Maryland epidemiology study. Genet. Epidemiol. 6, 671-680 (1989).
25. Lasher, L., Refer, J. & Chakravarti, A. Effects of genotyping error on the estimation of chromosome map length. Am. J. Hum. Genet. 49, 369 (1991).
26. Buetow. K. H. Influence of aberrant observations on high-resolution linkage analysis outcomes. Am. J. Hum. Genet. 49, 985-994 (1991).
27. Dausset. J. et al. Centre d'etude du polymorphisme humain (CEPH): collaborative genetic mapping of the human genome. Genomics 6, 575-577 (1990).
28. Matise, T.C., Perlin, M. & Chakravarti, A. Automated construction of genetic linkage maps using an expert system (Multimap): a human genome linkage map. Nature Genet. 6, 384-390 (1994).
29. Kruglyak, L., Daly, M.J., Reeve-Daly, M.P. & Lander, E.S. Parametric and nonparametric linkage analysis: A unified multipoint approach. Am. J. Hum. Genet. 58, 1347-1363 (1996).
30. Conneally, P.M. et al. Report of the committee on methods of linkage analysis and reporting. Cytogenet. Cell Genet. 40, 356-359 (1985).