Prodrug approaches of nucleotides and oligonucleotides

Current Medicinal Chemistry

Volumn 13, Issue 28, 2006, Pages 3441-3465

  Poijärvi Virta, Päivi ^a   Lönnberg, Harri ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

Bis(POM) Nucleotides; Cyclic phosphoramidate pronucleotides; Nucleotide prodrug; Protecting groups; S Acyloxymethyl; Short interfering RNAs

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 5 (2 BROMOVINYL) 2' DEOXYURIDINE; ADEFOVIR; ALANINE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CYCLIC 1,3 PROPANYL ESTER DERIVATIVE; CYCLOSALIGENYL NUCLEOSIDE MONOPHOSPHATE; DEOXYURIDINE PHOSPHATE; DIALKYL PHOSPHOTRIESTER DERIVATIVE; DIOXAPHOSPHOCYCLOHEXYL DERIVATIVE; DIOXAPHOSPHORINANYL DERIVATIVE; DRUG CARRIER; FLOXURIDINE PHOSPHATE; FLUOROURACIL; HEPDIRECT; KETOL PHOSPHATE TRIESTER DERIVATIVE; NITROFURYLMETHYL DERIVATIVE; NUCLEOSIDE AMINO ACID BORANOPHOSPHORAMIDATE DERIVATIVE; NUCLEOSIDE AMINO ACID PHOSPHORAMIDATE DERIVATIVE; NUCLEOTIDE DERIVATIVE; OLIGONUCLEOTIDE; OXAZAPHOSPHOCYCLOHEXYL DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; PRODRUG; STAVUDINE; TENOFOVIR; TRYPTOPHAN; UNINDEXED DRUG; VIDARABINE DERIVATIVE; ZIDOVUDINE;

CATALYSIS; CONCENTRATION RESPONSE; CYCLIZATION; DECARBOXYLATION; DESULFURIZATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HYDROLYSIS; DRUG MECHANISM; DRUG PENETRATION; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME MECHANISM; HUMAN; LEUKEMIA; LIPOPHILICITY; NONHUMAN; REVIEW; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS STRAIN;

ANIMALS; NUCLEOTIDES; OLIGONUCLEOTIDES; PRODRUGS;

EID: 33845333328     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986706779010270     Document Type: Review

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