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Volumn 15, Issue 3 SPEC. ISS., 2005, Pages 331-341

Post-transcriptional gene silencing by siRNAs and miRNAs

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DOUBLE STRANDED RNA; MESSENGER RNA; MICRORNA; RIBONUCLEASE; RNA HELICASE; RNA POLYMERASE II; SMALL INTERFERING RNA;

EID: 20444457846     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sbi.2005.05.006     Document Type: Review
Times cited : (467)

References (84)
  • 1
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • V. Ambros The functions of animal microRNAs Nature 431 2004 350 355
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 2
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 3
    • 4644242349 scopus 로고    scopus 로고
    • RNA silencing in plants
    • D. Baulcombe RNA silencing in plants Nature 431 2004 356 363
    • (2004) Nature , vol.431 , pp. 356-363
    • Baulcombe, D.1
  • 4
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: Small RNAs with a big role in gene regulation
    • L. He, and G.J. Hannon MicroRNAs: small RNAs with a big role in gene regulation Nat Rev Genet 5 2004 522 531
    • (2004) Nat Rev Genet , vol.5 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 5
    • 4644312235 scopus 로고    scopus 로고
    • The role of RNA interference in heterochromatic silencing
    • Z. Lippman, and R. Martienssen The role of RNA interference in heterochromatic silencing Nature 431 2004 364 370
    • (2004) Nature , vol.431 , pp. 364-370
    • Lippman, Z.1    Martienssen, R.2
  • 6
    • 10644237968 scopus 로고    scopus 로고
    • RNAi-mediated pathways in the nucleus
    • M.A. Matzke, and J.A. Birchler RNAi-mediated pathways in the nucleus Nat Rev Genet 6 2005 24 35
    • (2005) Nat Rev Genet , vol.6 , pp. 24-35
    • Matzke, M.A.1    Birchler, J.A.2
  • 7
    • 4644223259 scopus 로고    scopus 로고
    • Mechanisms of gene silencing by double-stranded RNA
    • G. Meister, and T. Tuschl Mechanisms of gene silencing by double-stranded RNA Nature 431 2004 343 349
    • (2004) Nature , vol.431 , pp. 343-349
    • Meister, G.1    Tuschl, T.2
  • 8
    • 10944254152 scopus 로고    scopus 로고
    • Transcription and processing of human microRNA precursors
    • B.R. Cullen Transcription and processing of human microRNA precursors Mol Cell 16 2004 861 865
    • (2004) Mol Cell , vol.16 , pp. 861-865
    • Cullen, B.R.1
  • 9
    • 0141843656 scopus 로고    scopus 로고
    • The nuclear RNase III Drosha initiates microRNA processing
    • Y. Lee, C. Ahn, J. Han, H. Choi, J. Kim, J. Yim, J. Lee, P. Provost, O. Radmark, and S. Kim The nuclear RNase III Drosha initiates microRNA processing Nature 425 2003 415 419 This paper describes the identification of Drosha as an enzyme that processes primary miRNA transcripts (pri-miRNAs) into ∼70-nt pre-miRNA hairpins; these are further processed into mature miRNAs by Dicer in the cytoplasm.
    • (2003) Nature , vol.425 , pp. 415-419
    • Lee, Y.1    Ahn, C.2    Han, J.3    Choi, H.4    Kim, J.5    Yim, J.6    Lee, J.7    Provost, P.8    Radmark, O.9    Kim, S.10
  • 13
    • 9144225636 scopus 로고    scopus 로고
    • The Microprocessor complex mediates the genesis of microRNAs
    • • ] identify proteins Pasha and DGCR8, which function together with Drosha in processing pri-miRNAs to pre-miRNAs in Drosophila and mammals, respectively. Interestingly, the DGCR8 gene is one of the few genes located in a chromosomal region deleted in DiGeorge syndrome.
    • (2004) Nature , vol.432 , pp. 235-240
    • Gregory, R.I.1    Yan, K.P.2    Amuthan, G.3    Chendrimada, T.4    Doratotaj, B.5    Cooch, N.6    Shiekhattar, R.7
  • 14
    • 4644227434 scopus 로고    scopus 로고
    • Trans-splicing and polyadenylation of let-7 microRNA primary transcripts
    • J. Bracht, S. Hunter, R. Eachus, P. Weeks, and A.E. Pasquinelli Trans-splicing and polyadenylation of let-7 microRNA primary transcripts RNA 10 2004 1586 1594
    • (2004) RNA , vol.10 , pp. 1586-1594
    • Bracht, J.1    Hunter, S.2    Eachus, R.3    Weeks, P.4    Pasquinelli, A.E.5
  • 15
    • 4344637081 scopus 로고    scopus 로고
    • Arabidopsis micro-RNA biogenesis through Dicer-like 1 protein functions
    • Y. Kurihara, and Y. Watanabe Arabidopsis micro-RNA biogenesis through Dicer-like 1 protein functions Proc Natl Acad Sci USA 101 2004 12753 12758
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 12753-12758
    • Kurihara, Y.1    Watanabe, Y.2
  • 16
    • 1442360415 scopus 로고    scopus 로고
    • RNase III enzymes and the initiation of gene silencing
    • M.A. Carmell, and G.J. Hannon RNase III enzymes and the initiation of gene silencing Nat Struct Mol Biol 11 2004 214 218
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 214-218
    • Carmell, M.A.1    Hannon, G.J.2
  • 17
    • 3142613181 scopus 로고    scopus 로고
    • Single processing center models for human Dicer and bacterial RNase III
    • H. Zhang, F.A. Kolb, L. Jaskiewicz, E. Westhof, and W. Filipowicz Single processing center models for human Dicer and bacterial RNase III Cell 118 2004 57 68 This paper describes a model of Dicer function in dsRNA and pre-miRNA processing, based on biochemical experiments and structural modeling. The Dicer mechanism is similar to that proposed for bacterial RNase III.
    • (2004) Cell , vol.118 , pp. 57-68
    • Zhang, H.1    Kolb, F.A.2    Jaskiewicz, L.3    Westhof, E.4    Filipowicz, W.5
  • 18
    • 0035662491 scopus 로고    scopus 로고
    • Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage
    • J. Blaszczyk, J.E. Tropea, M. Bubunenko, K.M. Routzahn, D.S. Waugh, D.L. Court, and X. Ji Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage Structure 9 2001 1225 1236
    • (2001) Structure , vol.9 , pp. 1225-1236
    • Blaszczyk, J.1    Tropea, J.E.2    Bubunenko, M.3    Routzahn, K.M.4    Waugh, D.S.5    Court, D.L.6    Ji, X.7
  • 19
    • 0036845374 scopus 로고    scopus 로고
    • Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
    • H. Zhang, F.A. Kolb, V. Brondani, E. Billy, and W. Filipowicz Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP EMBO J 21 2002 5875 5885
    • (2002) EMBO J , vol.21 , pp. 5875-5885
    • Zhang, H.1    Kolb, F.A.2    Brondani, V.3    Billy, E.4    Filipowicz, W.5
  • 20
    • 1842816517 scopus 로고    scopus 로고
    • Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways
    • ••], combines genetic and biochemical approaches to demonstrate that two Drosophila Dicers, Dcr-1 and Dcr-2, have specialized functions in miRNA and RNAi pathways, respectively. These papers also show that Dicer is important for RISC function and that RISC assembly follows an orderly pathway that can be followed on native gels.
    • (2004) Cell , vol.117 , pp. 69-81
    • Lee, Y.S.1    Nakahara, K.2    Pham, J.W.3    Kim, K.4    He, Z.5    Sontheimer, E.J.6    Carthew, R.W.7
  • 21
    • 0035887005 scopus 로고    scopus 로고
    • Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
    • R.F. Ketting, S.E. Fischer, E. Bernstein, T. Sijen, G.J. Hannon, and R.H. Plasterk Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans Genes Dev 15 2001 2654 2659
    • (2001) Genes Dev , vol.15 , pp. 2654-2659
    • Ketting, R.F.1    Fischer, S.E.2    Bernstein, E.3    Sijen, T.4    Hannon, G.J.5    Plasterk, R.H.6
  • 22
    • 0141868916 scopus 로고    scopus 로고
    • R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway
    • Q. Liu, T.A. Rand, S. Kalidas, F. Du, H.E. Kim, D.P. Smith, and X. Wang R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway Science 301 2003 1921 1925 This paper describes the identification of the R2D2 protein, which works together with Drosophila Dcr-2 during the incorporation of siRNAs into the RISC. It is shown that Dcr-2 alone can cleave dsRNA, but the Dcr-2-R2D2 complex is required for productive interaction with siRNAs.
    • (2003) Science , vol.301 , pp. 1921-1925
    • Liu, Q.1    Rand, T.A.2    Kalidas, S.3    Du, F.4    Kim, H.E.5    Smith, D.P.6    Wang, X.7
  • 24
    • 1642603943 scopus 로고    scopus 로고
    • RISC assembly defects in the Drosophila RNAi mutant armitage
    • Y. Tomari, T. Du, B. Haley, D.S. Schwarz, R. Bennett, H.A. Cook, B.S. Koppetsch, W.E. Theurkauf, and P.D. Zamore RISC assembly defects in the Drosophila RNAi mutant armitage Cell 116 2004 831 841 This paper describes the stepwise assembly of the RISC complex in Drosophila and provides evidence of the requirement for an RNA helicase/ATPase Armitage at the early step of assembly.
    • (2004) Cell , vol.116 , pp. 831-841
    • Tomari, Y.1    Du, T.2    Haley, B.3    Schwarz, D.S.4    Bennett, R.5    Cook, H.A.6    Koppetsch, B.S.7    Theurkauf, W.E.8    Zamore, P.D.9
  • 25
    • 0037188904 scopus 로고    scopus 로고
    • The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans
    • H. Tabara, E. Yigit, H. Siomi, and C.C. Mello The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans Cell 109 2002 861 871
    • (2002) Cell , vol.109 , pp. 861-871
    • Tabara, H.1    Yigit, E.2    Siomi, H.3    Mello, C.C.4
  • 26
    • 0037425583 scopus 로고    scopus 로고
    • Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors
    • N. Doi, S. Zenno, R. Ueda, H. Ohki-Hamazaki, K. Ui-Tei, and K. Saigo Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors Curr Biol 13 2003 41 46
    • (2003) Curr Biol , vol.13 , pp. 41-46
    • Doi, N.1    Zenno, S.2    Ueda, R.3    Ohki-Hamazaki, H.4    Ui-Tei, K.5    Saigo, K.6
  • 27
    • 1642487115 scopus 로고    scopus 로고
    • Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer
    • N. Tahbaz, F.A. Kolb, H. Zhang, K. Jaronczyk, W. Filipowicz, and T.C. Hobman Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer EMBO Rep 5 2004 189 194
    • (2004) EMBO Rep , vol.5 , pp. 189-194
    • Tahbaz, N.1    Kolb, F.A.2    Zhang, H.3    Jaronczyk, K.4    Filipowicz, W.5    Hobman, T.C.6
  • 28
    • 13444287967 scopus 로고    scopus 로고
    • Assembly and function of RNA silencing complexes
    • E.J. Sontheimer Assembly and function of RNA silencing complexes Nat Rev Mol Cell Biol 6 2005 127 138
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 127-138
    • Sontheimer, E.J.1
  • 29
    • 0036792769 scopus 로고    scopus 로고
    • Fragile X-related protein and VIG associate with the RNA interference machinery
    • A.A. Caudy, M. Myers, G.J. Hannon, and S.M. Hammond Fragile X-related protein and VIG associate with the RNA interference machinery Genes Dev 16 2002 2491 2496
    • (2002) Genes Dev , vol.16 , pp. 2491-2496
    • Caudy, A.A.1    Myers, M.2    Hannon, G.J.3    Hammond, S.M.4
  • 32
    • 0036791671 scopus 로고    scopus 로고
    • A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins
    • A. Ishizuka, M.C. Siomi, and H. Siomi A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins Genes Dev 16 2002 2497 2508
    • (2002) Genes Dev , vol.16 , pp. 2497-2508
    • Ishizuka, A.1    Siomi, M.C.2    Siomi, H.3
  • 34
    • 0036828639 scopus 로고    scopus 로고
    • The Argonaute family: Tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis
    • M.A. Carmell, Z. Xuan, M.Q. Zhang, and G.J. Hannon The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis Genes Dev 16 2002 2733 2742
    • (2002) Genes Dev , vol.16 , pp. 2733-2742
    • Carmell, M.A.1    Xuan, Z.2    Zhang, M.Q.3    Hannon, G.J.4
  • 35
    • 0345359925 scopus 로고    scopus 로고
    • Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain
    • A. Lingel, B. Simon, E. Izaurralde, and M. Sattler Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain Nature 426 2003 465 469
    • (2003) Nature , vol.426 , pp. 465-469
    • Lingel, A.1    Simon, B.2    Izaurralde, E.3    Sattler, M.4
  • 37
    • 0642345790 scopus 로고    scopus 로고
    • Structure and conserved RNA binding of the PAZ domain
    • K.S. Yan, S. Yan, A. Farooq, A. Han, L. Zeng, and M.M. Zhou Structure and conserved RNA binding of the PAZ domain Nature 426 2003 468 474
    • (2003) Nature , vol.426 , pp. 468-474
    • Yan, K.S.1    Yan, S.2    Farooq, A.3    Han, A.4    Zeng, L.5    Zhou, M.M.6
  • 38
    • 2442679207 scopus 로고    scopus 로고
    • Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain
    • •]. Both structures indicate that PAZ domains recognize 2-nt 3′ protruding ends of siRNAs and double-stranded forms of miRNAs.
    • (2004) Nature , vol.429 , pp. 318-322
    • Ma, J.B.1    Ye, K.2    Patel, D.J.3
  • 40
    • 4444302947 scopus 로고    scopus 로고
    • Crystal structure of Argonaute and its implications for RISC slicer activity
    • •]. Most interestingly, the Piwi domains of both proteins have a fold similar to that of RNase H. The P. furiosus protein also contains a PAZ domain with conserved aromatic amino acids the counterparts of which in eukaryotic proteins bind the siRNA 3′ overhang nucleotides.
    • (2004) Science , vol.305 , pp. 1434-1437
    • Song, J.J.1    Smith, S.K.2    Hannon, G.J.3    Joshua-Tor, L.4
  • 41
  • 43
    • 2442495329 scopus 로고    scopus 로고
    • RISC is a 5′ phosphomonoester-producing RNA endonuclease
    • • ], describes a detailed analysis of the enzymatic properties of the RISC endonuclease and requirements for productive siRNA-RNA target interaction within the RISC.
    • (2004) Genes Dev , vol.18 , pp. 975-980
    • Martinez, J.1    Tuschl, T.2
  • 45
    • 5144225452 scopus 로고    scopus 로고
    • Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity
    • T.A. Rand, K. Ginalski, N.V. Grishin, and X. Wang Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity Proc Natl Acad Sci USA 101 2004 14385 14389
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 14385-14389
    • Rand, T.A.1    Ginalski, K.2    Grishin, N.V.3    Wang, X.4
  • 47
    • 10744225153 scopus 로고    scopus 로고
    • Asymmetry in the assembly of the RNAi enzyme complex
    • ••], shows that selection of the siRNA strand incorporated into the RISC is specified by the relative strength of base pairing at the two ends of the siRNA duplex. The selected strand is generally the one whose 5′ terminus is at the thermodynamically less stable end of the siRNA.
    • (2003) Cell , vol.115 , pp. 199-208
    • Schwarz, D.S.1    Hutvagner, G.2    Du, T.3    Xu, Z.4    Aronin, N.5    Zamore, P.D.6
  • 48
    • 8844271740 scopus 로고    scopus 로고
    • A protein sensor for siRNA asymmetry
    • Y. Tomari, C. Matranga, B. Haley, N. Martinez, and P.D. Zamore A protein sensor for siRNA asymmetry Science 306 2004 1377 1380 This paper describes how the Dcr-2-R2D2 heterodimer senses the differential stability of the duplex ends and determines which siRNA strand is incorporated into the RISC. Photocross-linking to siRNAs containing 5-iodouracils at different positions demonstrated that Dicer binds to a less stable and R2D2 to a more stable siRNA end. siRNA unwinding requires a functional Ago2, which gradually displaces the Dcr-2-R2D2 heterodimer.
    • (2004) Science , vol.306 , pp. 1377-1380
    • Tomari, Y.1    Matranga, C.2    Haley, B.3    Martinez, N.4    Zamore, P.D.5
  • 49
    • 0037031576 scopus 로고    scopus 로고
    • Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
    • J. Martinez, A. Patkaniowska, H. Urlaub, R. Luhrmann, and T. Tuschl Single-stranded antisense siRNAs guide target RNA cleavage in RNAi Cell 110 2002 563 574
    • (2002) Cell , vol.110 , pp. 563-574
    • Martinez, J.1    Patkaniowska, A.2    Urlaub, H.3    Luhrmann, R.4    Tuschl, T.5
  • 50
    • 0035798415 scopus 로고    scopus 로고
    • ATP requirements and small interfering RNA structure in the RNA interference pathway
    • A. Nykanen, B. Haley, and P.D. Zamore ATP requirements and small interfering RNA structure in the RNA interference pathway Cell 107 2001 309 321
    • (2001) Cell , vol.107 , pp. 309-321
    • Nykanen, A.1    Haley, B.2    Zamore, P.D.3
  • 51
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • S.M. Elbashir, W. Lendeckel, and T. Tuschl RNA interference is mediated by 21- and 22-nucleotide RNAs Genes Dev 15 2001 188 200
    • (2001) Genes Dev , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 54
    • 3142729150 scopus 로고    scopus 로고
    • Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways
    • K. Okamura, A. Ishizuka, H. Siomi, and M.C. Siomi Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways Genes Dev 18 2004 1655 1666 This article shows that Drosophila Ago1 and Ago2 have specialized functions in miRNA and RNAi pathways, respectively. Importantly, embryos lacking Ago2 are still capable of miRNA-directed target RNA cleavage, which indicates that, in Drosophila, both Ago1 and Ago2 have Slicer activity.
    • (2004) Genes Dev , vol.18 , pp. 1655-1666
    • Okamura, K.1    Ishizuka, A.2    Siomi, H.3    Siomi, M.C.4
  • 55
    • 17844364875 scopus 로고    scopus 로고
    • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    • A. Grishok, A.E. Pasquinelli, D. Conte, N. Li, S. Parrish, I. Ha, D.L. Baillie, A. Fire, G. Ruvkun, and C.C. Mello Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing Cell 106 2001 23 34
    • (2001) Cell , vol.106 , pp. 23-34
    • Grishok, A.1    Pasquinelli, A.E.2    Conte, D.3    Li, N.4    Parrish, S.5    Ha, I.6    Baillie, D.L.7    Fire, A.8    Ruvkun, G.9    Mello, C.C.10
  • 56
    • 4644310115 scopus 로고    scopus 로고
    • Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis
    • R.S. Pillai, C.G. Artus, and W. Filipowicz Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis RNA 10 2004 1518 1525 This paper reports that the repressive effect of miRNAs on protein synthesis can be mimicked in HeLa cells by the miRNA-independent tethering of human Argonautes hAgo2-4 to the mRNA reporter. This indicates that a major function of miRNAs is to guide their associated proteins to the mRNA.
    • (2004) RNA , vol.10 , pp. 1518-1525
    • Pillai, R.S.1    Artus, C.G.2    Filipowicz, W.3
  • 57
    • 2142654329 scopus 로고    scopus 로고
    • MicroRNA-directed cleavage of HOXB8 mRNA
    • S. Yekta, I.H. Shih, and D.P. Bartel MicroRNA-directed cleavage of HOXB8 mRNA Science 304 2004 594 596
    • (2004) Science , vol.304 , pp. 594-596
    • Yekta, S.1    Shih, I.H.2    Bartel, D.P.3
  • 58
    • 0033572284 scopus 로고    scopus 로고
    • The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
    • P.H. Olsen, and V. Ambros The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation Dev Biol 216 1999 671 680
    • (1999) Dev Biol , vol.216 , pp. 671-680
    • Olsen, P.H.1    Ambros, V.2
  • 59
    • 0037418839 scopus 로고    scopus 로고
    • Bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
    • J. Brennecke, D.R. Hipfner, A. Stark, R.B. Russell, and S.M. Cohen bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila Cell 113 2003 25 36
    • (2003) Cell , vol.113 , pp. 25-36
    • Brennecke, J.1    Hipfner, D.R.2    Stark, A.3    Russell, R.B.4    Cohen, S.M.5
  • 61
    • 0041691111 scopus 로고    scopus 로고
    • MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
    • Y. Zeng, R. Yi, and B.R. Cullen MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms Proc Natl Acad Sci USA 100 2003 9779 9784
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 9779-9784
    • Zeng, Y.1    Yi, R.2    Cullen, B.R.3
  • 62
    • 1242296375 scopus 로고    scopus 로고
    • MiRNP:mRNA association in polyribosomes in a human neuronal cell line
    • P.T. Nelson, A.G. Hatzigeorgiou, and Z. Mourelatos miRNP:mRNA association in polyribosomes in a human neuronal cell line RNA 10 2004 387 394
    • (2004) RNA , vol.10 , pp. 387-394
    • Nelson, P.T.1    Hatzigeorgiou, A.G.2    Mourelatos, Z.3
  • 63
    • 1642374097 scopus 로고    scopus 로고
    • Specificity of microRNA target selection in translational repression
    • • ] describe the first detailed experimental validation of the particular importance to translational repression of the perfect Watson-Crick base pairing between the 5′-proximal region of miRNA and its RNA target.
    • (2004) Genes Dev , vol.18 , pp. 504-511
    • Doench, J.G.1    Sharp, P.A.2
  • 64
    • 13444312098 scopus 로고    scopus 로고
    • Substrate requirements for let-7 function in the developing zebrafish embryo
    • W.P. Kloosterman, E. Wienholds, R.F. Ketting, and R.H. Plasterk Substrate requirements for let-7 function in the developing zebrafish embryo Nucleic Acids Res 32 2004 6284 6291
    • (2004) Nucleic Acids Res , vol.32 , pp. 6284-6291
    • Kloosterman, W.P.1    Wienholds, E.2    Ketting, R.F.3    Plasterk, R.H.4
  • 66
    • 0037123630 scopus 로고    scopus 로고
    • Induction and suppression of RNA silencing by an animal virus
    • H. Li, W.X. Li, and S.W. Ding Induction and suppression of RNA silencing by an animal virus Science 296 2002 1319 1321
    • (2002) Science , vol.296 , pp. 1319-1321
    • Li, H.1    Li, W.X.2    Ding, S.W.3
  • 67
    • 8644247492 scopus 로고    scopus 로고
    • Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and microRNA biogenesis
    • S. Lu, and B.R. Cullen Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and microRNA biogenesis J Virol 78 2004 12868 12876
    • (2004) J Virol , vol.78 , pp. 12868-12876
    • Lu, S.1    Cullen, B.R.2
  • 69
    • 0347357615 scopus 로고    scopus 로고
    • Recognition of small interfering RNA by a viral suppressor of RNA silencing
    • •• ] describe crystal structures of the p19 viral RNAi suppressor dimer bound to siRNA. In the structure, two pairs of tryptophan residues are positioned on both sides of the siRNA duplex, stacking on the top of terminal base pairs and effectively preventing the siRNA from functioning in RNAi.
    • (2003) Nature , vol.426 , pp. 874-878
    • Ye, K.1    Malinina, L.2    Patel, D.J.3
  • 70
    • 1342346710 scopus 로고    scopus 로고
    • A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans
    • S. Kennedy, D. Wang, and G. Ruvkun A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans Nature 427 2004 645 649 A genetic screen in C. elegans led to the identification of ERI-1, mutations in which strongly enhance RNAi. eri-1 and its human counterpart encode an exonuclease that degrades siRNAs in vitro in a reaction dependent on 3′ overhangs. Thus, this enzyme may modulate levels of siRNAs (and miRNAs) in the cell.
    • (2004) Nature , vol.427 , pp. 645-649
    • Kennedy, S.1    Wang, D.2    Ruvkun, G.3
  • 73
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • B.P. Lewis, C.B. Burge, and D.P. Bartel Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 120 2005 15 20
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 77
    • 4644286235 scopus 로고    scopus 로고
    • SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis
    • A. Peragine, M. Yoshikawa, G. Wu, H.L. Albrecht, and R.S. Poethig SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis Genes Dev 18 2004 2368 2379
    • (2004) Genes Dev , vol.18 , pp. 2368-2379
    • Peragine, A.1    Yoshikawa, M.2    Wu, G.3    Albrecht, H.L.4    Poethig, R.S.5
  • 79
    • 7744223490 scopus 로고    scopus 로고
    • MicroRNA binding sites in Arabidopsis class III HD-ZIP mRNAs are required for methylation of the template chromosome
    • N. Bao, K.W. Lye, and M.K. Barton MicroRNA binding sites in Arabidopsis class III HD-ZIP mRNAs are required for methylation of the template chromosome Dev Cell 7 2004 653 662
    • (2004) Dev Cell , vol.7 , pp. 653-662
    • Bao, N.1    Lye, K.W.2    Barton, M.K.3
  • 80
    • 14844295120 scopus 로고    scopus 로고
    • RNA polymerase IV directs silencing of endogenous DNA
    • A.J. Herr, M.B. Jensen, T. Dalmay, and D.C. Baulcombe RNA polymerase IV directs silencing of endogenous DNA Science 308 2005 118 120
    • (2005) Science , vol.308 , pp. 118-120
    • Herr, A.J.1    Jensen, M.B.2    Dalmay, T.3    Baulcombe, D.C.4
  • 81
    • 15844402005 scopus 로고    scopus 로고
    • Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex
    • ••], reports the structure of the archaeal Piwi protein complexed with siRNA mimics. The structures identify a highly conserved basic pocket, which serves as an anchor site for the phosphorylated 5′-terminal nucleotide of the siRNA guide strand. The identified siRNA-Piwi contacts also involve four additional 5′-proximal nucleotides (positions 2-5) of the guide strand, consistent with the 5′ end of both miRNAs and siRNAs representing a nucleation region for pairing with target mRNAs.
    • (2005) Nature , vol.434 , pp. 663-666
    • Parker, J.S.1    Roe, S.M.2    Barford, D.3
  • 83
    • 18744407284 scopus 로고    scopus 로고
    • Purified Argonaute2 and an siRNA form recombinant human RISC
    • F.V. Rivas, N.H. Tolia, J.J. Song, J.P. Aragon, J. Liu, G.J. Hannon, and L. Joshua-Tor Purified Argonaute2 and an siRNA form recombinant human RISC Nat Struct Mol Biol 12 2005 340 349 This paper describes the reconstitution of an active RISC from bacterially expressed human Ago2 and an siRNA. This represents a final proof that Argonaute is indeed a catalytic engine of the RISC. Mutagenesis of the recombinant hAgo2 indicated that a DDH rather than DDE triad of amino acids is required for catalysis.
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 340-349
    • Rivas, F.V.1    Tolia, N.H.2    Song, J.J.3    Aragon, J.P.4    Liu, J.5    Hannon, G.J.6    Joshua-Tor, L.7
  • 84
    • 14644393684 scopus 로고    scopus 로고
    • Perspective: Machines for RNAi
    • Y. Tomari, and P.D. Zamore Perspective: machines for RNAi Genes Dev 19 2005 517 529
    • (2005) Genes Dev , vol.19 , pp. 517-529
    • Tomari, Y.1    Zamore, P.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.