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Volumn , Issue 5, 1998, Pages 837-846

Nucleotide Delivery from cycloSaligenyl-3′-azido-3′-deoxythymidine Monophosphates (cycloSal-AZTMP)

Author keywords

AZT; cyclosal pro nucleotide; HIV chemotherapy; Nucleotide delivery; Prodrugs

Indexed keywords


EID: 0003188936     PISSN: 1434193X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-0690(199805)1998:5<837::AID-EJOC837>3.0.CO;2-7     Document Type: Article
Times cited : (69)

References (66)
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    • A preliminary account of this work was presented at the 9th International Conference on Antiviral Research, Fukushima, Japan, May 19-24, 1996; Congress abstract: C. Meier, M. Lorey, E. De Clercq, J. Balzarini, Antiviral Res. 1996, 28, A29, and at the 4th Swedish-German Symposium, Reisensburg, Germany, November 23-26, 1996; Congress abstract: C. Meier, E. De Clercq, J. Balzarini, Nucleosides & Nucleotides 1997, 16, 793-796.
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    • Meier, C.1    Lorey, M.2    De Clercq, E.3    Balzarini, J.4
  • 2
    • 0030811807 scopus 로고    scopus 로고
    • 4th Swedish-German Symposium
    • Reisensburg, Germany, November 23-26, 1996; Congress abstract
    • A preliminary account of this work was presented at the 9th International Conference on Antiviral Research, Fukushima, Japan, May 19-24, 1996; Congress abstract: C. Meier, M. Lorey, E. De Clercq, J. Balzarini, Antiviral Res. 1996, 28, A29, and at the 4th Swedish-German Symposium, Reisensburg, Germany, November 23-26, 1996; Congress abstract: C. Meier, E. De Clercq, J. Balzarini, Nucleosides & Nucleotides 1997, 16, 793-796.
    • (1997) Nucleosides & Nucleotides , vol.16 , pp. 793-796
    • Meier, C.1    De Clercq, E.2    Balzarini, J.3
  • 39
    • 0039796582 scopus 로고
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    • C. Meier, Angew. Chem 1993, 105, 1854-1856; Angew. Chem., Int. Ed. Engl. 1993, 32, 1704-1706.
    • (1993) Angew. Chem., Int. Ed. Engl. , vol.32 , pp. 1704-1706
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    • Meier, C.1
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    • 2742597959 scopus 로고    scopus 로고
    • University of Würzburg, unpublished results
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    • (1997)
    • Meier, C.1
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    • 2742592342 scopus 로고    scopus 로고
    • note
    • Beside the anti-HIV active dideoxynucleosides mentioned here, the cycloSal-concept has also been applied to the anti-tumor agent 5-fluoro-2′-deoxyuridine:
  • 57
    • 2642599622 scopus 로고
    • It is well known in the literature that phosphodiesters are extremely stable towards chemical hydrolysis at physiological pH values: C. A. Bunton, M. M. Mhala, K. G. Oldham, C. A. Vernon, J. Chem Soc. 1960, 3293-3301. Even the "reactive" diphenylphosphate showed a half-life of 180 years(!) at pH 7.0 and 100°C: A. J. Kirby, M. Younas, J. Chem. Soc. (B) 1970, 510-513.
    • (1960) J. Chem Soc. , pp. 3293-3301
    • Bunton, C.A.1    Mhala, M.M.2    Oldham, K.G.3    Vernon, C.A.4
  • 58
    • 37049128024 scopus 로고
    • It is well known in the literature that phosphodiesters are extremely stable towards chemical hydrolysis at physiological pH values: C. A. Bunton, M. M. Mhala, K. G. Oldham, C. A. Vernon, J. Chem Soc. 1960, 3293-3301. Even the "reactive" diphenylphosphate showed a half-life of 180 years(!) at pH 7.0 and 100°C: A. J. Kirby, M. Younas, J. Chem. Soc. (B) 1970, 510-513.
    • (1970) J. Chem. Soc. (B) , pp. 510-513
    • Kirby, A.J.1    Younas, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.