Theoretical aspects of rational drug design - An overview

Journal of Scientific and Industrial Research

Volumn 60, Issue 9, 2001, Pages 699-716

  Roy, Kunal ^a,b   Sengupta, C ^a   De, A U ^a  

^a JADAVPUR UNIVERSITY   (India)

^b SEEMANTA INSTITUTE OF PHARMACEUTICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 22844444515     PISSN: 00224456     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (197)

1. Kubinyi H, in QSAR: Hansch analysis and related approaches. Methods and principles in medicinal chemistry, edited by R Mannhold, P Krogsgaard-Larsen and H Timmerman, (VCH, Weinheim) 1993.
2. Hansch C, Leo A & Hoekman D H, Exploring QSAR : structure activity relations in chemistry and biology (American Chemical Society, Washington DC) 1995.
3. Rainer F, Theoretical drug design methods, Vol 7 (Elsevier, Amsterdam) 1984.
4. th ed, edited by W O Foye, T L Lemke and D A Williams (B I Waverly Pvt Ltd, New Delhi) 1995, 12.
5. Hansch C & Fujita T, J Am Chem Soc, 86 (1964) 1616.
6. De A U, Indian J Pharm Edu, 35 (2001) 71.
7. th ed, edited by J G Hardman and L E Limbard (McGraw-Hill, New York) 1996, 3.
8. Zanger M, in Remington's pharmaceutical sciences, edited by A R Gennaro (Mack Publishing Co., Pennsylvania) 1985, 435.
9. rd ed, edited by W O Foye (Varghese Publishing House, Bombay) 1989, 49.
10. rd ed, edited by W O Foye (Varghese Publishing House, Bombay) 1989, 49.
11. William M, Deecher D C & Sullivan J P, in Burger's medicinal chemistry and drug discovery, edited by M E Wolff , Vol 1 (John Wiley & Sons, New York) 1995, 349.
12. th ed (Jaypee Brothers, New Delhi) 1999, 36.
13. th ed, edited by J G Hardman and L E Limbard (McGraw-Hill, New York) 1996, 29.
14. th ed, edited by R F Doerge (J B Lippincott Co, Pennsylvania) 1982, 5.
15. Kubinyi H, in Burger's medicinal chemistry and drug discovery, edited by M E Wolff, Vol 1 (John Wiley & Sons, New York) 1995, 497.
16. th ed, edited by J G Hardman and L E Limbard (McGraw-Hill, New York) 1996, 1707.
17. nd ed (CBS Publishers & Distributors, Delhi) 1993, 268.
18. (a) Dutta H, Sengupta M, Ghosh A, Sengupta C & De A U, Indian J Biochem Biophys, 28 (1991) 210;
19. (b) Dutta H, Sengupta M, Pal D K, De A U & Sengupta C, Indian J Biochem Biophys, 30 (1993) 128;
20. (c) Sengupta M, Dutta H, Pal D K, De A U & Sengupta C, Indian J Exp Biology, 31 (1993) 21;
21. (d) Sengupta M, De A U & Sengupta C, Indian J Biochem Biophys, 32 (1995) 302;
22. (e) Dutta H, De A U & Sengupta C, Indian J Biochem Biophys, 33 (1996) 76;
23. (f) Roy K, Rudra S, De A U & Sengupta C, Indian J Pharm Sci, 60 (1998) 153;
24. (g) Roy K, Saha A, Chakraborty S & Sengupta C, Indian J Pharm Sci, 62 (2000) 46;
25. (h) Saha A, Roy K, De K & Sengupta C, Indian J Pharm Sci, 62 (2000) 115;
26. (i) Saha A, Roy K, De K & Sengupta C, Acta Polonie Pharmaceutica - Drug Research, 57 (2000) 441.
27. nd ed (Jaypee Brothers, New Delhi) 1988, 180.
28. Stacey N H, Cartilena L R & Kiassen C D, Toxicol Appl Pharmacol, 53 (1988) 470.
29. Kale R K & Sitaswad S L, Radiat Phys Chem, 36 (1990) 361.
30. Suresh C & Khajuria R S, Everyman's Sci, 33 (1999) 149.
31. Esterbauer H, Zollner H & Schaur R J, Biochemistry, 1 (1988) 311.
32. nd ed (Oxford University Press, Oxford) 1989.
33. Halliwell B, Drugs, 42 (1990) 569.
34. Gutteridge J M C & Halliwell B, Antioxidants in nutrition, health and disease (Oxford University Press, Oxford) 1994.
35. Lai Y L, Wu H D & Chen C F, J Cardiovasc Pharmacol, 32 (1998) 714.
36. Luo X, Evrovsky Y, Cole D, Trines J, Benson C N & Lehotay D C, Biochim Biophys Acta, 1360 (1997) 45.
37. Gaziano J M, Proc Assoc Am Physicians, 111 (1999) 2.
38. Christen W G, Proc Assoc Am Physicians, 111 (1999) 16.
39. Lee I M, Proc Assoc Am Physicians, 111 (1999) 10.
40. Tarin J, Ten J, Vendrell F J, de Oliveira M N & Cano A, Reprod Nutr Dev, 38 (1998) 499.
41. Lebedev A A & Petrenko N A, Eksp Klin Farmakol, 59 (1996) 28.
42. Kitiyakara C & Wilcox C S, Curr Opin Nephrol Hypertens, 7 (1998) 531.
43. Gupta P & Kar A, J Appl Toxicol, 18 (1998) 317.
44. Singhal P K, Siveski-Iliskovic N, Hill M, Thomas T P & Li T, J Mol Cell Cardiol, 27 (1995) 1055.
45. (a) Ip S P & Ko K M, Biochem Pharmacol, 52 (1996) 1687;
46. (b) Nagy A, Sellei P, Valen G, Sjoquist P O & Vaage J, Free Radic Biol Med, 20 (1996) 567;
47. (c) Kumar K V, Naidu M U, Shifow A A, Prayag A & Ratnakar K S, Transplantation, 67 (1999) 1065;
48. (d) Schonfeld J V, Weisbrod B & Muller M K, Cellular and Molecular Life Sciences, 53 (1997) 917;
49. (e) De A K, Biomedicine, 17 (1997) 99;
50. (f) Currin R T, Toole J G, Thurman R G & Lemasters J J, Transplantation, 50 (1990) 1076;
51. (g) Parkhomenko A E, Bryl Zh V, Irkin O I, Shkliar L V & Antonov A Ia, Ter Arkh, 68 (1996) 47.
52. (a) Roy K, Rudra S, De A U & Sengupta C, Indian J Pharm Sci, 61 (1999) 44;
53. (b) Roy K, De A U & Sengupta C, Indian J Pharm Sci, 61 (1999) 76;
54. (c) Roy K, De A U & Sengupta C, Indian J Exp Biol, 38 (2000) 580;
55. (d) Roy K, Saha A, De K & Sengupta C, Acta Polonie Pharmaceutica - Drug Research, 57 (2000) 385;
56. (e) De K, Roy K, Saha A & Sengupta C, Indian J Pharm Sci, 62(2000) 343.
57. Christoffersen R E & Marr J J, in Burger's medicinal chemistry and drug discovery, edited by M E Wolff, Vol 1 (John Wiley & Sons, New York) 1995, 9.
58. th ed, edited by W O Foye, T L Lemke and D A Williams (B I Waverly Pvt Ltd, New Delhi) 1995, 58.
59. Wohl J A, in Molecular orbital studies in chemical pharmacology, edited by L B Kier (Springer, New York) 1970, 262.
60. Aranda A, CR Acad Sci, 276 (1973) 1301.
61. Topliss J G & Yudis M D, J Med Chem, 15 (1972) 394.
62. Rouot B, Leclerc G, Wermuth C G & Miesch F, J Pharmac, 8 (1977) 95.
63. Martin Y C & Biel J H, in Neuropsychopharmacology of monoamines and their regulatory enzymes, edited by E Usdin (Raven Press, New York) 1974, 37.
64. Kakey N, Aoki M, Kamada A & Yata N, Chem Pharm Bull, 17 (1969) 1010.
65. Kakey N, Yata N, Kamada A & Aoki M, Chem Pharm Bull, 17 (1969) 2558.
66. Purcell W P, Biochim Biophys Acta, 105 (1965) 201.
67. Beasley J C & Purcell W P, Biochim Biophys Acta, 178 (1969) 175.
68. Michel H-J, Franke R & Willitzer H in Quantitative structure-activity analysis, edited by R Franke and P Oehme (Akademie-Verlag, Berlin) 1978, 89.
69. Montero J L & Imbach J L, C R Acad Sci Ser, 279 (1974) 809.
70. Remers W A & Schepman C S, J Med Chem, 17 (1974) 729.
71. Seydel J K & Wempe E, Arzneimittel- Forsch, 21 (1971) 187.
72. Seydel J K & Schaper K-J, Chemische struktur und biologische aktivitat von wirkstoffen (Verlag Chemie, Weinheim) 1979.
73. Martin Y C, Quantitative drug design (Marcel Dekker, New York) 1978.
74. Dirmla J P, Czuba L J, Domminy B W, James R B, Pezzullo R M, Presslitz J E & Windisch R M, J Med Chem, 22 (1979) 1118.
75. Kaufman J J & Koski W S, Int J Quant Chem, 2 (1975) 35.
76. Tollenaere J P, Moereels H & Protiva M, Eur J Med Chem, 11 (1976) 298.
77. Jorgensen E C & Reid J A, J Med Chem, 8 (1965) 533.
78. Broughton B J, Chaplen P, Knowles P, Lunt E, Marshall S M, Pain D L & Woolridge K R H, J Med Chem, 18 (1975) 1117.
79. Hopfinger A J, J Am Chem Soc, 102 (1980) 7196.
80. Martin Y C in Strategy in drug research, edited by W T Nauta and R F Rekker, Vol 4, edited by J A K Buisman (Elsevier, Amsterdam) 1982, 269.
81. Hammett L P, Physical organic chemistry (McGraw-Hill, New York), 1940, 184.
82. Harper N J & Simmonds A B in Advances in drug research, Vol 6, edited by M S Tute (Academic Press, New York) 1971, 53.
83. Purcell W P, Bass G E & Clayton J M, Strategy of drug design (John Wiley, New York) 1973.
84. (a) Roy K, Pal D K, De A U & Sengupta C, Indian J Chem, 38B (1999) 1194;
85. (b) Roy K, Pal D K & Sengupta C, Drug Design and Discovery, 17 (2000) 483;
86. (c) Roy K, Pal D K & Sengupta C, J Indian Chem Soc, 77 (2000) 428;
87. (d) Roy K, Pal D K, De A U & Sengupta C, Drug Design and Discovery, 17 (2001) 199.
88. Free S M & Wilson J W, J Med Chem, 7 (1964) 395.
89. Fujita T & Ban T, J Med Chem, 14 (1971) 148.
90. Roy K, Pal D K, Ghosh C C, De A U & Sengupta C, Indian J Chem, 40B (2001) 209.
91. Wilson R, Introduction to graph theory (Academic Press, New York) 1972.
92. Kier L B & Hall L H, Molecular connectivity in chemistry and drug research (Academic Press, New York) 1976.
93. Randic M, J Am Chem Soc, 97 (1975) 6609.
94. Kier L B, Hall L H, Murray W J & Randic M, J Pharm Sci, 64 (1975) 1971.
95. Hall L H, Kier L B & Murray W J, J Pharm Sci, 64 (1975) 1974.
96. Murray W J, Hall L H & Kier L B, J Pharm Sci, 64 (1975) 1978.
97. Kier L B, Murray W J, Randic M & Hall L H, J Pharm Sci, 65 (1976) 1226.
98. Kier L B & Hall L H, J Pharm Sci, 65 (1976) 1806.
99. Hall L H & Kier L B, Tetrahedron, 33 (1977) 1953.
100. Kier L B & Hall L H, Molecular connectivity in structure activity analysis (Research Studies Press Ltd, Letchworth, England) 1986.
101. Pal D K, Sengupta C & De A U, Indian J Chem, 27B (1988) 734.
102. Pal D K, Sengupta C & De A U, Indian J Chem, 28B (1989) 261.
103. Pal D K, Sengupta M, Sengupta C & De A U, Indian J Chem, 29B (1990) 451.
104. Pal D K, Purkayastha S K, Sengupta C & De A U, Indian J Chem, 31B (1992) 109.
105. Roy K, Pal D K, De A U & Sengupta C, Indian J Chem, 38B (1999) 664.
106. Roy K, Pal D K, De A U & Sengupta C, Indian J Chem, 40B (2001) 129.
107. Kier L B, J Pharm Sci, 69 (1980) 807.
108. Shannon C E & Weaver W, The mathematical theory of communications (University of Illinois Press, Urbana III) 1949.
109. (a) Kier L B, Quant Struct-Act Relat, 4 (1985) 109;
110. (b) Kier L B, Med Chem Res, 7 (1997) 394.
111. Hall L H, Mohney B & Kier L B, Quant Struct-Act Relat, 10 (1991) 43.
112. Kier L B, in Chemometric methods in molecular design, edited by H van de Waterbeemd (VCH, Weinheim) 1995, 39.
113. (a) Roy K, De A U & Sengupta C, Indian J Chem. 38B (1999) 942;
114. (b) Roy K, Pal D K & Sengupta C, Drug Design and Discovery, 17 (2001) 207;
115. (c) Saha A, Roy K, De K & Sengupta C, J Indian Chem Soc, 78 (2000) 92;
116. (d) Roy K, Pal D K, Saha A & Sengupta C, Indian J Chem, 40B, 2001 (In Press).
117. (a) Cramer R D, in Quantitative structure-activity relationships, edited by M Tichy (Akademiai Kiado, Budapest) 1978;
118. (b) Hodes L, in Computer-assisted drug design, edited by E C Olson and R E Christofferson (ACS Symposium Series) 112,1979, 583;
119. (c) Golender V E & Rozenblit A B in Drug design, Vol 9, edited by E J Ariens (Academic Press, New York) 1980, 300;
120. (d) Hubel S, Rosner T & Franke R, Pharmazie, 35 (1980) 424.
121. Kirschner G L & Kowallski B R in Drug design, Vol 8, edited by E J Ariens (Academic Press, New York) 1979, 73.
122. (a) Collous T, Discriminant analysis and applications (Academic Press, New York) 1973;
123. (b) Waterbeemd H van de, in Chemometric methods in molecular design, edited by H van de Waterbeemd (VCH, Weinheim) 1995, 283.
124. (a) Duran B S & Odell P L, Cluster analysis - a survey (Springer-Verlag, New York) 1974;
125. (b) McFarland J W & Gans D J, Chemometric methods in molecular design, edited by H van de Waterbeemd (VCH, Weinheim) 1995, 295.
126. (a) Joliffe I J, Principal component analysis, (Springer-Verlag, New York) 1986;
127. (b) Franke R & Gruska A, Chemometric methods in molecular design, edited by H van de Waterbeemd (VCH, Weinheim) 1995, 113.
128. Malinowski E R & Howery D G, Factor analysis in chemistry (Wiley, New York) 1980.
129. Cover T M & Hart P E, IEEE Trans Inf Theory, IT-13 (1967) 21.
130. Moriguchi I & Komatsu K, Chem Pharm Bull, 25 (1977) 2800.
131. (a) Wold S, Albano C, Dunn III W J, Edlund U, Esbensen K, Geladi P, Hellberg S, Johansson E, Lindberg W & Sjostrom M, in Chemometrics, mathematics and statistics in chemistry, edited by B R Kowalski (Reidel Publishing Co, Dordrecht) 1984, 17;
132. (b) Wold S, Chemometric methods in molecular design, edited by H van de Waterbeemd (VCH, Weinheim) 1995, 196.
133. (a) Aoyama T, Suzuki Y & Ichikawa, J Med Chem, 33 (1990) 905;
134. (b) Aoyama T, Suzuki Y & Ichikawa, J Med Chem, 33 (1990) 2583.
135. Manallack D T & Livingstone D J, in Advanced computer-assisted technologies in drug discovery, edited by H van de Waterbeemd (VCH, Weinheim) 1995, 293.
136. Hilpert K, Ackermann J, Banner D W, Gast A, Gubernator K, Hadvary P, Lablar L, Muller K, Schimd G, Tschopp T B & Waterbeemd H van de, J Med Chem, 37 (1994) 3889.
137. (a) Montgomery J A, Synder H W (Jr), Walsch D A & Walsch G M, Drugs Future, 18 (1993) 887;
138. (b) Montgomery J A & Secrist III J W, Perspect Drug Disc Design, 2 (1994) 205.
139. Touroutoglou N & Pazdur R, Clin Cancer Res, 2 (1996) 227.
140. Baldwin J J, Ponticello G S, Anderson P S, Christy M E, Murcko M A, Randall W C, Schwan H, Sugrue M F, Springer J P, Gautheron P, Grove J, Mallogra P, Vaider M -P, Mckeever B M & Navia M A, J Med Chem, 32 (1989) 2510.
141. Navia M A & Murcko M A, Curr Opin Struct Biol, 2 (1992) 202.
142. Greer J, Erickson J W, Baldwin J L & Varney M D, J Med Chem, 37 (1994) 1035.
143. Sestanj K, Bellini F, Fung S, Abraham N, Treasurywala A, Humber L, Simard-Dequesne N & Dvornik D, J Med Chem, 27 (1984) 255.
144. (a) Kempf D J, Marsh K C, Denissen J F, McDonald E, Vasavanonda S, Flentge C A, Green B E, Fino L, Park C H, Kong X P, Wideburg N E, Saldivar A, Ruiz L, Kati W M, Sham H L, Robins T, Stewart K D, Hsu A, Plattner J J, Leonard J M & Norbeck D W, Proc Natl Acad Sci, USA, 92 (1995) 2484;
145. (b) Appell K, in Structure-based drug design, edited by P Veerapandian (Marcel Dekker, Inc, New York) 1997, 1.
146. (a) Katakura S-I, Nagahara T, Hara T & Iwamoto M, Biochem Biophys Res Comm, 197 (1993) 965;
147. (b) Ripka W C, in Structure-based drug design, edited by P Veerapandian (Marcel Dekker, Inc, New York) 1997, 265.
148. (a) O'Brien P M, Ortwine D F, Pavlovsky A G, Picard J A, Sliskovic D R, Roth B D, Dyer R D, Johnson L L, Man C F & Hallak H, J Med Chem, 43 (2000) 156;
149. (b) Scozzafava A & Supuran C T, J Me. Chem, 43 (2000) 1858.
150. Marshall G R, in Burger's medicinal chemistry and drug discovery, edited by M E Wolff (John Wiley & Sons, New York) 1995, 573.
151. (a) De A U, Ghose A K & Hore A, J Indian Chem Soc, 54 (1977) 1071;
152. (b) De A U & Ghose A K, Indian J Chem, 16B (1978) 1104;
153. (c) De A U & Ghose A K, Indian J Chem,16B (1978) 716;
154. (d) De A U & Ghose A K, Indian J Chem,16B (1979) 57;
155. (e) De A U & Ghose A K, Indian J Chem,17B (1979) 261;
156. (f) De A U & Ghose A K, Indian J Chem,18B (1979) 172;
157. (g) De A U, Ghose A K, Bhattacharyya S & De A, Indian J Chem,19B (1980) 787;
158. (h) De A U & Ghose A K, Indian J Chem,20B (1981) 58;
159. (i) De A U & Ghose A K, Indian J Chem,21B (1982) 430.
160. th ed, edited by W O Foye, T L Lemke and D A Williams (B I Waverly Pvt Ltd, New Delhi) 1995, 50.
161. Hopfinger A J & Tokarshi J S, in Practical application of computer aided drug design, edited by P S Charifson (Marcel Dekker Inc, New York) 1997, 105.
162. (a) Thibuat U, in 3D QSAR in drug design : theory, methods and applications, edited by H. Kubinyi (ESCOM Science Publishers, Leiden) 1993, 661;
163. (b) Wise M, Molecular Graphics and Drug Design, edited by A S V Burgen, G C K Roberts and M S Tute (Elsevier, New York) 1986, 183;
164. (c) Davis A M, in Advanced computer-assisted technologies in drug discovery, edited by H van de Waterbeemd (VCH, Weinheim) 1995, 39.
165. Hopfinger A J, J Am Chem Soc, 120 (1980) 7196.
166. Good A C, So S & Richards W G, J Med Chem, 36 (1993) 433.
167. Crippen G M, Mol Pharm, 22 (1982) 11.
168. Doweyko A M, J Med Chem, 31 (1988) 1396.
169. Walters D E & Hinds R M, J Med Chem, 37 (1994) 2527.
170. Jain A N, Koile K & Chapman D, J Med Chem, 37 (1994) 2315.
171. Hopfinger A J, Nakata Y & Max N in Intermolecular Forces, edited by B Pullman (D Riedel Publishing, Dordrecht) 1981, 431.
172. Holloway M K, Wai J M, Halgren T A, Fitzgerald P M D, Vacca J P, Dorsey B D, Levlin R B, Thompson W J, Chen L J, DeSolms S J, Gaffin N, Ghosh A K, Giuliani E A, Graham S L, Guare J P, Hungate R W, Lyle T A, Sanders W M, Tucker T J, Wiggins M, Wiscount C M, Woltersdorf D W, Young S D, Darke P L & Zugay J A, J Med Chem, 38 (1995) 305.
173. Ortiz A R, Pisabarro M T, Gago F & Wade R C, J Med Chem, 38 (1995) 2681.
174. Peitsch M C, in Practical application of computer aided drug design, edited by P S Charifson (Marcel Dekker Inc, New York) 1997, 227.
175. Murcko M A, in Practical application of computer aided drug design, edited by P S Charifson (Marcel Dekker Inc, New York) 1997, 305.
176. Kier L B, Molecular orbital studies in chemical pharmacology (Springer-Verlag, New York) 1970.
177. Weinstein H, Srebrenik S, Pauncz R, Maayani C, Cohen S & Sokolovsky M, in Chemical and biochemical reactivity, edited by E Bergmann and B Pullman (D Reidl Publishing Co., Dordrecht) 1974, 493.
178. Gund P, in Progress in molecular and subcellular biology, edited by F Hahn, H Kersten, W Kersten and W Szybalski (Springer-Verlag, Berlin) 1977, 117.
179. Babalan A T, Chiriac A, Motoc I & Siman Z, Steric fit in quantitative structure-activity relations (Springer-Verlag, Berlin) 1980.
180. Lindquist R N, in Drug design, Vol 5, edited by E J Ariens (Academic Press, New York) 1975, 24.
181. Kearsley S K & Smith G M, Tetrahedron Comput Methodol, 3 (1990) 615.
182. Hodgkin E E, Miller A & Whittaker M, J Comput Aided Mol Design, 7 (1993) 515.
183. Holland J H, Sci Am, 267 (1992) 66.
184. Magee P S, Quant Struct-Act Relat, 9 (1990) 202.
185. Sweetnam P M, Price C H & Ferkany J W, in Burger's medicinal chemistry and drug discovery, edited by M E Wolff , Vol 1 (John Wiley & Sons, New York) 1995, 697.
186. Spellmeyer D C, Blaney J M & Martin E, in Practical application of computer aided drug design, edited by P S Charifson (Marcel Dekker Inc, New York) 1997, 165.
187. Williams M & Jarvis M F, in Drug discovery technologies, edited by C R Clark and W H Moos (Ellis Horwood, Chichester, UK) 1990, 129.
188. Venuti M C, in Burger's medicinal chemistry and drug discovery, edited by M E Wolff (John Wiley & Sons, New York) 1995, 661.
189. Marderosian A H D, in Remington : the science and practice of pharmacy, 19th ed, edited by A R Gennaro, Vol I (Mack Publishing Co, Pennsylvania) 1995, 809.
190. (a) Goodman M & Ro S, in Burger's medicinal chemistry and drug discovery, edited by M E Wolff, Vol 1 (John Wiley & Sons, New York) 1995, 803;
191. (b) Hirschmann R, Smith A B III & Sprengler P A, in New perspectives in drug design, edited by P M Dean, G Jolles and C G Newton (Academic Press, London) 1995, 1.
192. Crooke S T, in Burger's medicinal chemistry and drug discovery, edited by M E Wolff, Vol 1 (John Wiley & Sons, New York) 1995, 863.
193. (a) Musser J H, Fugedi P & Anderson M B, in Burger's medicinal chemistry and drug discovery, edited by M E Wolff, Vol 1 (John Wiley & Sons, New York) 1995, 901;
194. (b) Wang C-H, in New perspectives in drug design, edited by P M Dean, G Jolles and C G Newton (Academic Press, London) 1995, 35.
195. Balant L P & Doelker E, in Burger's medicinal chemistry and drug discovery, edited by M E Wolff, Vol 1 (John Wiley & Sons, New York) 1995, 949.
196. Pandeya S N & Dimmock J R, An introduction to drug design (New Age International Pvt Ltd, New Delhi) 1998, 39.
197. th ed (B I Waverly Pvt Ltd, New Delhi) 1999, 512.