Hydrolytic stability of nucleoside phosphotriesters derived from bis(hydroxymethyl)-1,3-dicarbonyl compounds and their congeners: Towards a novel pro-drug strategy for antisense oligonucleotides

Journal of the Chemical Society, Perkin Transactions 2

Volumn , Issue 6, 2001, Pages 881-885

  Ora, M ^a   Maki E ^a   Poijarvi P ^a   Neuvonen, K ^a   Oivanen, M ^a   Lonnberg H ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CONDENSATION; DRUG PRODUCTS; HYDROLYSIS; ISOMERS; NEGATIVE IONS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERS; PH EFFECTS; RATE CONSTANTS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

CHEMICAL PROPERTIES; ION-CATALYZED CLEAVAGE REACTIONS;

NUCLEIC ACID SEQUENCES;

EID: 0034742867     PISSN: 14701820     EISSN: None     Source Type: Journal    
DOI: 10.1039/b101754n     Document Type: Article

References (14)