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Volumn 85, Issue 7, 2002, Pages 1869-1876

Towards nucleotide prodrugs derived from 2,2-bis(hydroxymethyl)malonate and its congeners: Hydrolytic cleavage of 2-cyano-2-(hydroxymethyl)-3-methoxy-3-oxopropyl and 3-(alkylamino)-2-cyano-2-(hydroxymethyl)-3-oxopropyl protections from the internucleosidic phosphodiester and phosphorothioate linkages

(6) Poijärvi, Päivi a Mäki, Esa a Tomperi, Jussi a Ora, Mikko a Oivanen, Mikko a Lönnberg, Harri a

a UNIVERSITY OF TURKU (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

FORMALDEHYDE; PH EFFECTS; PHOSPHATES; REACTION KINETICS; SYNTHESIS (CHEMICAL);

OLIGONUCLEOTIDES;

DRUG PRODUCTS;

2,2 BIS(HYDROXYMETHYL)MALONATE; [2 CYANO 2 (HYDROXYMETHYL) 3 METHOXY 3 OXOPROPYL] 4 THIOTHYMIDYLYL(3'-5')THYMIDINE; [2 CYANO 2 (HYDROXYMETHYL) 3 METHOXY 3 OXOPROPYL]THYMIDYLYL(3'-5')THYMIDINE; [2 CYANO 2 (HYDROXYMETHYL) 3 OXO 3 [(2 PHENYLETHYL)AMINO]PROPYL] 4 THIOTHYMIDYLYL(3'-5')THYMIDINE; [2 CYANO 2 [[(4,4' DIMETHOXYTRITYL)OXY]METHYL] 3 METHOXY 3 OXOPROPYL] 4 THIOTHYMIDYLYL(3'-5')THYMIDINE; [2 CYANO 2 [[(4,4' DIMETHOXYTRITYL)OXY]METHYL] 3 METHOXY 3 OXOPROPYL]THYMIDYLYL(3'-5')THYMIDINE; [2 CYANO 2 [[(4,4' DIMETHOXYTRITYL)OXY]METHYL] 3 OXO 3 [(2 PHENYLETHYL)AMINO]PROPYL] 4 THIOTHYMIDYLYL(3'-5')THYMIDINE; MALONIC ACID DERIVATIVE; NUCLEOTIDE DERIVATIVE; PHOSPHOROTHIOIC ACID DERIVATIVE; PRODRUG; THYMIDINE DERIVATIVE; THYMIDYLYL(3'-5')THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; DRUG SYNTHESIS; HYDROLYSIS; PH; PRIORITY JOURNAL;

EID: 0036334340 PISSN: 0018019X EISSN: None Source Type: Journal
DOI: 10.1002/1522-2675(200207)85:7<1869::AID-HLCA1869>3.0.CO;2-W Document Type: Article

Times cited : (13)

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