Synthesis of nucleoside boranophosphoramidate prodrugs conjugated with amino acids

Journal of Organic Chemistry

Volumn 70, Issue 6, 2005, Pages 2171-2183

  Li, Ping ^a   Shaw, Barbara Ramsay ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DRUG PRODUCTS; MATHEMATICAL MODELS; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; REACTION KINETICS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

ANTICANCER AGENTS; BORANOPHOSPHATES; DIASTEREOMERS; NUCLEOSIDE PRODRUGS;

PHOSPHATES;

2 [(2',3' DIDEOXY 2',3' DIDEHYDROTHYMIDIN 5' YL)BORANOPHOSPHORYLAMINO] 3 (3 INDOLYL)PROPIONIC ACID METHYL ESTER; 2 [(2',3' DIDEOXY 2',3' DIDEHYDROTHYMIDIN 5' YL)BORANOPHOSPHORYLAMINO] PROPIONIC ACID METHYL ESTER; 2 [(3' DEOXY 3' AZIDOTHYMIDIN 5' YL)BORANOPHOSPHORYLAMINO] 3 (3 INDOLYL)PROPIONIC ACID METHYL ESTER; 2 [(3' DEOXY 3' AZIDOTHYMIDIN 5' YL)BORANOPHOSPHORYLAMINO]PROPIONIC ACID METHYL ESTER; 2 [(3' O ACETYLTHYMIDIN 5' YL)BORANOPHOSPHORYLAMINO] 3 (3 INDOLYL)PROPIONIC ACID METHYL ESTER; 2 [(3' O ACETYLTHYMIDIN 5' YL)BORANOPHOSPHORYLAMINO]PROPIONIC ACID METHYL ESTER; AMINO ACID; ANTIVIRUS AGENT; DIPHENYLCHLOROPHOSPHATE; NUCLEOSIDE DERIVATIVE; PHOSPHATE; PHOSPHONIC ACID DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; PHOSPHORAMIDOUS ACID; PRODRUG; REAGENT; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL PROCEDURES; CHEMICAL REACTION; CHEMISTRY; DIASTEREOISOMER; DRUG CONJUGATION; DRUG SYNTHESIS; MEASUREMENT; METHODOLOGY; MOLECULAR MECHANICS; MOLECULAR MODEL; PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; RACEMIZATION; REACTION ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RING OPENING; SEPARATION TECHNIQUE; SILYLATION;

AMIDES; AMINO ACIDS; BORON COMPOUNDS; DRUG DESIGN; MOLECULAR CONFORMATION; NUCLEOSIDES; PHOSPHORIC ACIDS; PRODRUGS;

EID: 15444378402     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0481248     Document Type: Article

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