Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-β- arabinofuranosylcytosine: Evidence of phosphoramidase activity

Journal of Medicinal Chemistry

Volumn 39, Issue 23, 1996, Pages 4569-4575

  Abraham, Timothy W ^a   Kalman, Thomas I ^b   McIntee, Edward J ^a   Wagner, Carston R ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 FLUORO 2' DEOXY 5' URIDYL N (1 CARBOMETHOXY 2 INDOLYLETHYL)PHOSPHOROIMIDATE; 5 FLUORO 2' DEOXY 5' URIDYL N (1 CARBOMETHOXY 2 PHENYLETHYL)PHOSPHOROIMIDATE; CYTARABINE DERIVATIVE; FLOXURIDINE DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG METABOLISM; DRUG STABILITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM;

ANIMALS; CELL DIVISION; CELL LINE; CYTARABINE; FLOXURIDINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHORIC MONOESTER HYDROLASES; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED;

EID: 0029851158     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9603680     Document Type: Article

References (22)

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22. Although the purity of 5a,b and 8a,b was verified by NMR, HPLC, and MS analyses, their hydroscopic nature prevented the obtaining of satisfactory (<0.5% of theoretical) elemental analyses. Compounds were therefore judged pure by observation of a single peak using two different RP-HPLC methods.