Fluoride-labile protecting groups for the synthesis of base-sensitive methyl-SATE oligonucleotide prodrugs

European Journal of Organic Chemistry

Volumn , Issue 12, 2003, Pages 2327-2335

  Guerlavais Dagland, Typhaine ^a   Meyer, Albert ^a   Imbach, Jean Louis ^a   Morvan, François ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

Oligonucleotides; Prodrugs; Protecting groups

Indexed keywords

(TRIMETHYLSILYL)ETHYL DERIVATIVE; 5' O (4,4' DIMETHOXYTRITYL)THYMIDINE 3' O [2 (TRIMETHYLSILYL)ETHYL]DIISOPROPYL PHOSPHORAMIDITE; BENZYL DERIVATIVE; FLUORIDE; N 2 [2 [(TERT BUTYL)(DIPHENYL)SILYLOXYMETHYL]BENZOYL] 5' O (4,4' DIMETHOXYTRITYL) 2' DEOXYGUANOSINE 3' O [(2 TRIMETHYLSILYL)ETHYL]DIISOPROPYL PHOSPHORAMIDITE; N 4 [2 [(TERT BUTYL)(DIPHENYL)SILYLOXYMETHYL]BENZOYL] 5' O (4,4' DIMETHOXYTRITYL) 2' DEOXYCYTIDINE 3' O [(2 TRIMETHYLSILYL)ETHYL]DIISOPROPYL PHOSPHORAMIDITE; N 6 [2 [(TERT BUTYL)(DIPHENYL)SILYLOXYMETHYL]BENZOYL] 5' O (4,4' DIMETHOXYTRITYL) 2' DEOXYADENOSINE 3' O [(2 TRIMETHYLSILYL)ETHYL]DIISOPROPYL PHOSPHORAMIDITE; NUCLEIC ACID BASE; OLIGONUCLEOTIDE; PHOSPHORAMIDIC ACID DERIVATIVE; PRODRUG; TRIMETHYLSILYL DERIVATIVE; UNCLASSIFIED DRUG; [(TERT BUTYL)(DIPHENYL)SILYLOXYMETHYL]BENZOYL DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DEPROTECTION REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PHOTOLYSIS; SYNTHESIS;

EID: 0038729663     PISSN: 1434193X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ejoc.200300069     Document Type: Article

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