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Volumn 44, Issue 19, 2005, Pages 2838-2850

On the remarkable antitumor properties of fludelone: How we got there

Author keywords

Anticancer drugs; Drug development; Epothilones; Natural products; Total synthesis

Indexed keywords

BIOMOLECULES; CLINICAL VALUE; EPOTHILONES; FLUDELONE;

EID: 18844378165     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200461751     Document Type: Short Survey
Times cited : (119)

References (102)
  • 31
    • 0029049468 scopus 로고
    • D. M. Bollag, P. A. McQueney, J. Zhu, O. Hensens, L. Koupal, J. Liesch, M. Goetz, E. Lazarides, C. M. Woods, Cancer Res. 1995, 55, 2325. We thank Professor Gunda Georg of the University of Kansas for calling this publication to our attention, and Dr. D. M. Bollag of Merck Sharp and Dohme for providing us with about 1 mg of epothilone A to commence studies (ultimately unsuccessful) towards the determination of its configuration.
    • (1995) Cancer Res. , vol.55 , pp. 2325
    • Bollag, D.M.1    McQueney, P.A.2    Zhu, J.3    Hensens, O.4    Koupal, L.5    Liesch, J.6    Goetz, M.7    Lazarides, E.8    Woods, C.M.9
  • 32
    • 84888898285 scopus 로고    scopus 로고
    • See reference [12]
    • a) See reference [12] ;
  • 51
    • 1542763298 scopus 로고
    • In an early RCM-based approach studied in our laboratory, the 12,13-epoxide was already in place. We also investigated RCM to reach the 12,13-alkene, but only in the context of surveying various possibilities. For reviews of RCM, see: a) R. H. Grubbs, S. J. Miller, G. C. Fu, Acc. Chem. Res. 1995, 28, 446;
    • (1995) Acc. Chem. Res. , vol.28 , pp. 446
    • Grubbs, R.H.1    Miller, S.J.2    Fu, G.C.3
  • 61
    • 84888929039 scopus 로고    scopus 로고
    • note
    • Naturally, when we conceived this remarkable aldolization we were aware of the non-enolizability of the "C3" aldehyde in the C2-C3 seco structure.
  • 82
    • 0036998727 scopus 로고    scopus 로고
    • BMS is also sponsoring clinical trials of another epothilone derivative (BMS310705): c) R. M. Borzilleri, G. D. Vite, Drugs Future 2002, 27, 1149.
    • (2002) Drugs Future , vol.27 , pp. 1149
    • Borzilleri, R.M.1    Vite, G.D.2
  • 84
    • 84888899052 scopus 로고    scopus 로고
    • For more information about the clinical trials of dEpoB, visit: www.kosan.com.
  • 91
    • 4944231418 scopus 로고    scopus 로고
    • Fluorine in the Life Sciences
    • d) Special issue on "Fluorine in the Life Sciences", ChemBioChem 2004, 5, 557-726.
    • (2004) ChemBioChem , vol.5 , pp. 557-726
  • 93
    • 84888899019 scopus 로고    scopus 로고
    • Unpublished results
    • Unpublished results.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.