-
1
-
-
0037189889
-
-
S. F. Brady, C. J. Chao, J. Clardy, J. Am. Chem. Soc. 2002, 124, 9968.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 9968
-
-
Brady, S.F.1
Chao, C.J.2
Clardy, J.3
-
2
-
-
0242575114
-
-
a) V. Knight, J. J. Sanglier, D. DiTullio, S. Braccili, P. Bonner, J. Waters, D. Hughes, L. Zhang, Appl. Microbiol. Biotechnol. 2003, 62, 446;
-
(2003)
Appl. Microbiol. Biotechnol.
, vol.62
, pp. 446
-
-
Knight, V.1
Sanglier, J.J.2
DiTullio, D.3
Braccili, S.4
Bonner, P.5
Waters, J.6
Hughes, D.7
Zhang, L.8
-
3
-
-
0034082239
-
-
b) D. J. Newman, G. M. Cragg, K. M. Snader, Nat. Prod. Rep. 2000, 17, 215.
-
(2000)
Nat. Prod. Rep.
, vol.17
, pp. 215
-
-
Newman, D.J.1
Cragg, G.M.2
Snader, K.M.3
-
7
-
-
0042844744
-
-
d) D. J. Newman, G. M. Cragg, K. M. Snader, J. Nat. Prod. 2003, 66, 1022.
-
(2003)
J. Nat. Prod.
, vol.66
, pp. 1022
-
-
Newman, D.J.1
Cragg, G.M.2
Snader, K.M.3
-
8
-
-
3042518847
-
-
and references therein
-
A. G. Ravelo, A. Estevez-Braun, H. Chavez-Orellana, E. Perez-Sacau, D. Mesa-Siverio, Curr. Top. Med. Chem. 2004, 2, 241, and references therein.
-
(2004)
Curr. Top. Med. Chem.
, vol.2
, pp. 241
-
-
Ravelo, A.G.1
Estevez-Braun, A.2
Chavez-Orellana, H.3
Perez-Sacau, E.4
Mesa-Siverio, D.5
-
9
-
-
0015211527
-
-
M. C. Wani, H. L. Taylor, M. E. Wall, P. Coggan, A. T. McPhail, J. Am. Chem. Soc. 1971, 93, 2325.
-
(1971)
J. Am. Chem. Soc.
, vol.93
, pp. 2325
-
-
Wani, M.C.1
Taylor, H.L.2
Wall, M.E.3
Coggan, P.4
McPhail, A.T.5
-
13
-
-
0002767594
-
-
d) K. C. Nicolaou, W.-M. Dai, R. K. Guy, Angew. Chem. 1994, 106, 38
-
(1994)
Angew. Chem.
, vol.106
, pp. 38
-
-
Nicolaou, K.C.1
Dai, W.-M.2
Guy, R.K.3
-
16
-
-
0000052734
-
-
D. Guenard, F. Gueritte-Vogelein, P. Potier, Acc. Chem. Res. 1993, 26, 160.
-
(1993)
Acc. Chem. Res.
, vol.26
, pp. 160
-
-
Guenard, D.1
Gueritte-Vogelein, F.2
Potier, P.3
-
17
-
-
11044223276
-
-
S. J. Danishefsky, J. J. Masters, W. B. Young, J. T. Link, L. B. Snyder, T. V. Magee, D. K. Jung, R. C. A. Isaacs, W. G. Bornmann, C. A. Alaimo, C. A. Coburn, M. J. DiGrandi, J. Am. Chem. Soc. 1996, 118, 2843.
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 2843
-
-
Danishefsky, S.J.1
Masters, J.J.2
Young, W.B.3
Link, J.T.4
Snyder, L.B.5
Magee, T.V.6
Jung, D.K.7
Isaacs, R.C.A.8
Bornmann, W.G.9
Alaimo, C.A.10
Coburn, C.A.11
DiGrandi, M.J.12
-
18
-
-
0028012837
-
-
a) K. C. Nicolaou, Z. Yang, J. J. Liu, H. Ueno, P. G. Nantermet, R. K. Guy, C. F. Claiborne, J. Renaud, E. A. Couladouros, K. Paulvannan, E. J. Sorenson, Nature 1994, 367, 630;
-
(1994)
Nature
, vol.367
, pp. 630
-
-
Nicolaou, K.C.1
Yang, Z.2
Liu, J.J.3
Ueno, H.4
Nantermet, P.G.5
Guy, R.K.6
Claiborne, C.F.7
Renaud, J.8
Couladouros, E.A.9
Paulvannan, K.10
Sorenson, E.J.11
-
19
-
-
0028810338
-
-
b) K. C. Nicolaou, P. G. Nantermet, H. Ueno, R. K. Guy, E. A. Couladouros, E. J. Sorenson, J. Am. Chem. Soc. 1995, 117, 624;
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 624
-
-
Nicolaou, K.C.1
Nantermet, P.G.2
Ueno, H.3
Guy, R.K.4
Couladouros, E.A.5
Sorenson, E.J.6
-
20
-
-
0028792481
-
-
c) K. C. Nicolaou, J. J. Liu, Z. Yang, H. Ueno, E. J. Sorenson, C. F. Claiborne, R. K. Guy, C. K. Hwang, M. Nakada, P. G. Nantermet, J. Am. Chem, Soc. 1995, 117, 634;
-
(1995)
J. Am. Chem, Soc.
, vol.117
, pp. 634
-
-
Nicolaou, K.C.1
Liu, J.J.2
Yang, Z.3
Ueno, H.4
Sorenson, E.J.5
Claiborne, C.F.6
Guy, R.K.7
Hwang, C.K.8
Nakada, M.9
Nantermet, P.G.10
-
21
-
-
0028849334
-
-
d) K. C. Nicolaou, Z. Yang, J. J. Liu, P. G. Nantermet, C. F. Claiborne, J. Renaud, R. K. Guy, K. Shibayama, J. Am. Chem. Soc. 1995, 117, 645;
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 645
-
-
Nicolaou, K.C.1
Yang, Z.2
Liu, J.J.3
Nantermet, P.G.4
Claiborne, C.F.5
Renaud, J.6
Guy, R.K.7
Shibayama, K.8
-
22
-
-
0028868994
-
-
e) K. C. Nicolaou, H. Ueno, J. J. Liu, P. G. Nantermet, Z. Yang, J. Renaud, K. Paulvannan, R. Chadha, J. Am. Chem. Soc. 1995, 117, 653.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 653
-
-
Nicolaou, K.C.1
Ueno, H.2
Liu, J.J.3
Nantermet, P.G.4
Yang, Z.5
Renaud, J.6
Paulvannan, K.7
Chadha, R.8
-
23
-
-
0028213668
-
-
a) R. A. Holton, C. Somoza, H. B. Kim, F. Liang, R. J. Biediger, P. D. Boatman, M. Shindo, C. C. Smith, S. C. Kim, H. Nadizadeh, Y. Suzuki, C. L. Tao, P. Vu, S. H. Tang, P. S. Zhang, K. K. Murthi, L. N. Gentile, J. H. Liu, J. Am. Chem. Soc. 1994, 116, 1597;
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 1597
-
-
Holton, R.A.1
Somoza, C.2
Kim, H.B.3
Liang, F.4
Biediger, R.J.5
Boatman, P.D.6
Shindo, M.7
Smith, C.C.8
Kim, S.C.9
Nadizadeh, H.10
Suzuki, Y.11
Tao, C.L.12
Vu, P.13
Tang, S.H.14
Zhang, P.S.15
Murthi, K.K.16
Gentile, L.N.17
Liu, J.H.18
-
24
-
-
0028353983
-
-
b) R. A. Holton, H. B. Kim, C. Somoza, F. Liang, R. J. Biediger, P. D. Boatman, M. Shindo, C. C. Smith, S. C. Kim, H. Nadizadeh, Y. Suzuki, C. L. Tao, P. Vu, S. H. Tang, P. S. Zhang, K. K. Murthi, L. N. Gentile, J. H. Liu, J. Am. Chem. Soc. 1994, 116, 1599.
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 1599
-
-
Holton, R.A.1
Kim, H.B.2
Somoza, C.3
Liang, F.4
Biediger, R.J.5
Boatman, P.D.6
Shindo, M.7
Smith, C.C.8
Kim, S.C.9
Nadizadeh, H.10
Suzuki, Y.11
Tao, C.L.12
Vu, P.13
Tang, S.H.14
Zhang, P.S.15
Murthi, K.K.16
Gentile, L.N.17
Liu, J.H.18
-
25
-
-
0027228024
-
-
a) E. K. Rowinsky, E. A. Eisenhauer, V. Chaudhry, S. G. Arbuck, R. C. Donehawer, Semin. Oncol. 1993, 20, 1;
-
(1993)
Semin. Oncol.
, vol.20
, pp. 1
-
-
Rowinsky, E.K.1
Eisenhauer, E.A.2
Chaudhry, V.3
Arbuck, S.G.4
Donehawer, R.C.5
-
26
-
-
0026702494
-
-
b) B. S. Fletcher, D. A. Kujubadu, D. M. Perrin, H. R. Herschman, J. Biol. Chem. 1992, 267, 4338;
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 4338
-
-
Fletcher, B.S.1
Kujubadu, D.A.2
Perrin, D.M.3
Herschman, H.R.4
-
28
-
-
0030039047
-
-
d) D. M. Essayan, A. Kagey-Sobotka, P. J. Colarusso, L. M. Lichtenstein, R. F. Ozols, E. D. King, J. Allergy Clin. Immunol. 1996, 97, 42;
-
(1996)
J. Allergy Clin. Immunol.
, vol.97
, pp. 42
-
-
Essayan, D.M.1
Kagey-Sobotka, A.2
Colarusso, P.J.3
Lichtenstein, L.M.4
Ozols, R.F.5
King, E.D.6
-
29
-
-
0030758777
-
-
and references therein
-
e) P. Giannakakou, D. L. Sackett, Y.-K. Kang, Z. Zhan, J. T. Buters, T. Fojo, M. S. Poruchynsky, J. Biol. Chem. 1997, 272, 17118, and references therein.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 17118
-
-
Giannakakou, P.1
Sackett, D.L.2
Kang, Y.-K.3
Zhan, Z.4
Buters, J.T.5
Fojo, T.6
Poruchynsky, M.S.7
-
30
-
-
0001363111
-
-
(GBF), DE-B 4138042 ,1993
-
G. Höfle, N. Bedorf, K. Gerth, H. Reichenbach (GBF), DE-B 4138042 ,1993; Chem. Abstr. 1993, 120, 52841.
-
(1993)
Chem. Abstr.
, vol.120
, pp. 52841
-
-
Höfle, G.1
Bedorf, N.2
Gerth, K.3
Reichenbach, H.4
-
31
-
-
0029049468
-
-
D. M. Bollag, P. A. McQueney, J. Zhu, O. Hensens, L. Koupal, J. Liesch, M. Goetz, E. Lazarides, C. M. Woods, Cancer Res. 1995, 55, 2325. We thank Professor Gunda Georg of the University of Kansas for calling this publication to our attention, and Dr. D. M. Bollag of Merck Sharp and Dohme for providing us with about 1 mg of epothilone A to commence studies (ultimately unsuccessful) towards the determination of its configuration.
-
(1995)
Cancer Res.
, vol.55
, pp. 2325
-
-
Bollag, D.M.1
McQueney, P.A.2
Zhu, J.3
Hensens, O.4
Koupal, L.5
Liesch, J.6
Goetz, M.7
Lazarides, E.8
Woods, C.M.9
-
32
-
-
84888898285
-
-
See reference [12]
-
a) See reference [12] ;
-
-
-
-
33
-
-
0000429459
-
-
b) R. J. Kowalski, E. Terhaar, R. E. Longley, S. P. Gunasekera, C. M. Lin, B. V. Day, E. Hamel, Mol. Biol. Cell 1995, 6, 2137;
-
(1995)
Mol. Biol. Cell
, vol.6
, pp. 2137
-
-
Kowalski, R.J.1
Terhaar, E.2
Longley, R.E.3
Gunasekera, S.P.4
Lin, C.M.5
Day, B.V.6
Hamel, E.7
-
34
-
-
0027228024
-
-
c) E. K. Rowinsky, E. A. Eisenhauer, V. Chaudhry, S. G. Arbuck, R. C. Donehawer, Semin. Oncol. 1993, 20, 1;
-
(1993)
Semin. Oncol.
, vol.20
, pp. 1
-
-
Rowinsky, E.K.1
Eisenhauer, E.A.2
Chaudhry, V.3
Arbuck, S.G.4
Donehawer, R.C.5
-
35
-
-
0026702494
-
-
d) B. S. Fletcher, D. A. Kujubadu, D. M. Perrin, H. R. Herschman, J. Biol. Chem. 1992, 267, 4338;
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 4338
-
-
Fletcher, B.S.1
Kujubadu, D.A.2
Perrin, D.M.3
Herschman, H.R.4
-
37
-
-
0030039047
-
-
f) D. M. Essayan, A. Kagey-Sobotka, P. J. Colarusso, L. M. Lichtenstein, R. F. Ozols, E. D. King, J. Allergy Clin. Immunol. 1996, 97, 42;
-
(1996)
J. Allergy Clin. Immunol.
, vol.97
, pp. 42
-
-
Essayan, D.M.1
Kagey-Sobotka, A.2
Colarusso, P.J.3
Lichtenstein, L.M.4
Ozols, R.F.5
King, E.D.6
-
38
-
-
0030758777
-
-
and references therein
-
g) P. Giannakakou, D. L. Sackett, Y.-K. Kang, Z. Zhan, J. T. Buters, T. Fojo, M. S. Poruchynsky, J. Biol. Chem. 1997, 272, 17118, and references therein.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 17118
-
-
Giannakakou, P.1
Sackett, D.L.2
Kang, Y.-K.3
Zhan, Z.4
Buters, J.T.5
Fojo, T.6
Poruchynsky, M.S.7
-
39
-
-
0001448991
-
-
G. H. Höfle, N. Bedorf, H. Steinmetz, D. Schomburg, K. Gerth, H. Reichenbach, Angew. Chem. 1996, 108, 1671;
-
(1996)
Angew. Chem.
, vol.108
, pp. 1671
-
-
Höfle, G.H.1
Bedorf, N.2
Steinmetz, H.3
Schomburg, D.4
Gerth, K.5
Reichenbach, H.6
-
41
-
-
0001682838
-
-
a) A. Balog, D. F. Meng, T. Kamenecka, P. Bertinato, D.-S. Su, E. J. Sorensen, S. J. Danishefsky, Angew. Chem. 1996, 108, 2976;
-
(1996)
Angew. Chem.
, vol.108
, pp. 2976
-
-
Balog, A.1
Meng, D.F.2
Kamenecka, T.3
Bertinato, P.4
Su, D.-S.5
Sorensen, E.J.6
Danishefsky, S.J.7
-
43
-
-
0000148379
-
-
b) D.-S. Su, D. F. Meng, P. Bertinato, A. Balog, E. J. Sorensen, S. J. Danishefsky, Y. H. Zheng, T.-C. Chou, L. F. He, S. B. Horwitz, Angew. Chem. 1997, 109, 775;
-
(1997)
Angew. Chem.
, vol.109
, pp. 775
-
-
Su, D.-S.1
Meng, D.F.2
Bertinato, P.3
Balog, A.4
Sorensen, E.J.5
Danishefsky, S.J.6
Zheng, Y.H.7
Chou, T.-C.8
He, L.F.9
Horwitz, S.B.10
-
45
-
-
0030669587
-
-
c) D. F. Meng, P. Bertinato, A. Balog, D.-S. Su, T. Kamenecka, E. J. Sorensen, S. J. Danishefsky, J. Am. Chem. Soc. 1997, 119, 10073.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 10073
-
-
Meng, D.F.1
Bertinato, P.2
Balog, A.3
Su, D.-S.4
Kamenecka, T.5
Sorensen, E.J.6
Danishefsky, S.J.7
-
46
-
-
0037433593
-
-
a) A. Rivkin, F. Yoshimura, A. E. Gabarda, T.-C. Chou, H. Dong, W. P. Tong, S. J. Danishefsky, J. Am. Chem. Soc. 2003, 125, 2899;
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 2899
-
-
Rivkin, A.1
Yoshimura, F.2
Gabarda, A.E.3
Chou, T.-C.4
Dong, H.5
Tong, W.P.6
Danishefsky, S.J.7
-
47
-
-
5344277815
-
-
b) T.-C. Chou, H. Dong, A. Rivkin, F. Yoshimura, A. E. Gabarda, Y. S. Cho, W. P. Tong, S. J. Danishefsky, Angew. Chem. 2003, 115, 4910;
-
(2003)
Angew. Chem.
, vol.115
, pp. 4910
-
-
Chou, T.-C.1
Dong, H.2
Rivkin, A.3
Yoshimura, F.4
Gabarda, A.E.5
Cho, Y.S.6
Tong, W.P.7
Danishefsky, S.J.8
-
49
-
-
0041783937
-
-
c) F. Yoshimura, A. Rivkin, A. E. Gabarda, T.-C. Chou, H. Dong, G. Sukenick, S. J. Danishefsky, Angew. Chem. 2003, 115, 2622;
-
(2003)
Angew. Chem.
, vol.115
, pp. 2622
-
-
Yoshimura, F.1
Rivkin, A.2
Gabarda, A.E.3
Chou, T.-C.4
Dong, H.5
Sukenick, G.6
Danishefsky, S.J.7
-
51
-
-
1542763298
-
-
In an early RCM-based approach studied in our laboratory, the 12,13-epoxide was already in place. We also investigated RCM to reach the 12,13-alkene, but only in the context of surveying various possibilities. For reviews of RCM, see: a) R. H. Grubbs, S. J. Miller, G. C. Fu, Acc. Chem. Res. 1995, 28, 446;
-
(1995)
Acc. Chem. Res.
, vol.28
, pp. 446
-
-
Grubbs, R.H.1
Miller, S.J.2
Fu, G.C.3
-
57
-
-
1442285541
-
-
See reference [16c] and A. Rivkin, Y. S. Cho, A. E. Gabarda, Y. Fumihiko, S. J. Danishefsky, J. Nat. Prod. 2004, 67, 139.
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 139
-
-
Rivkin, A.1
Cho, Y.S.2
Gabarda, A.E.3
Fumihiko, Y.4
Danishefsky, S.J.5
-
61
-
-
84888929039
-
-
note
-
Naturally, when we conceived this remarkable aldolization we were aware of the non-enolizability of the "C3" aldehyde in the C2-C3 seco structure.
-
-
-
-
63
-
-
0001125046
-
-
See reference [16a]. Shortly after our synthesis, two other efforts, each exploiting olefin metathesis, were described: a) Z. Yang, Y. He, D. Vourloumis, H. Vallberg, K. C. Nicolaou, Angew. Chem. 1997, 109, 170;
-
(1997)
Angew. Chem.
, vol.109
, pp. 170
-
-
Yang, Z.1
He, Y.2
Vourloumis, D.3
Vallberg, H.4
Nicolaou, K.C.5
-
65
-
-
0001556960
-
-
b) D. Schinzer, A. Limberg, A. Bauer, O. Böhm, M. Cordes, Angew. Chem. 1997, 109, 543;
-
(1997)
Angew. Chem.
, vol.109
, pp. 543
-
-
Schinzer, D.1
Limberg, A.2
Bauer, A.3
Böhm, O.4
Cordes, M.5
-
67
-
-
0000482525
-
-
For the first SAR (structure-activity relationship) map, see: a) D.-S. Su, A. Balog, D. Meng, P. Bertinato, S. J. Danishefsky, Y.-H. Zheng, T.-C. Chou, L. He, S. B. Horwitz, Angew. Chem. 1997, 109, 2178;
-
(1997)
Angew. Chem.
, vol.109
, pp. 2178
-
-
Su, D.-S.1
Balog, A.2
Meng, D.3
Bertinato, P.4
Danishefsky, S.J.5
Zheng, Y.-H.6
Chou, T.-C.7
He, L.8
Horwitz, S.B.9
-
69
-
-
0000460258
-
-
see also: b) K. C. Nicolaou, D. Vourloumis, T. Li. , J. Pastor, N. Winssinger, Y. He, S. Ninkovic, F. Sarabia, H. Vallberg, F. Roschanger, N. P. King, M. Ray, V. Finlay, P. Giannakakou, P. Verdier-Pinard, E. Hamel, Angew. Chem. 1997, 109, 2181;
-
(1997)
Angew. Chem.
, vol.109
, pp. 2181
-
-
Nicolaou, K.C.1
Vourloumis, D.2
Li, T.3
Pastor, J.4
Winssinger, N.5
He, Y.6
Ninkovic, S.7
Sarabia, F.8
Vallberg, H.9
Roschanger, F.10
King, N.P.11
Ray, M.12
Finlay, V.13
Giannakakou, P.14
Verdier-Pinard, P.15
Hamel, E.16
-
71
-
-
0032416734
-
-
for the earliest in vivo assays of dEpoB, see: c)T.-C. Chou, X. G. Zhang, C. R. Harris, S. D. Kuduk, A. Balog, K. A. Savin, J. R. Bertino, S. J. Danishefsky, Proc. Natl. Acad. Sci. USA 1998, 95, 15 798;
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15798
-
-
Chou, T.-C.1
Zhang, X.G.2
Harris, C.R.3
Kuduk, S.D.4
Balog, A.5
Savin, K.A.6
Bertino, J.R.7
Danishefsky, S.J.8
-
72
-
-
0032483019
-
-
d) T.-C. Chou, X. G. Zhang, A. Balog, D. Su, D. F. Meng, K. Savin, J. R. Bertino, S. J. Danishefsky, Proc. Natl. Acad. Sci. USA 1998, 95, 9642;
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 9642
-
-
Chou, T.-C.1
Zhang, X.G.2
Balog, A.3
Su, D.4
Meng, D.F.5
Savin, K.6
Bertino, J.R.7
Danishefsky, S.J.8
-
73
-
-
0034939512
-
-
e) T.-C. Chou, O. A. O'Connor, W. P. Tong, Y. Guan, Z.-G. Zhang, S. J. Stachel, C. Lee, S. J. Danishefsky, Proc. Natl. Acad. Sci. USA 2001, 98, 8113.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 8113
-
-
Chou, T.-C.1
O'Connor, O.A.2
Tong, W.P.3
Guan, Y.4
Zhang, Z.-G.5
Stachel, S.J.6
Lee, C.7
Danishefsky, S.J.8
-
74
-
-
0034678986
-
-
Novartis is the sponsor of the clinical trials with EpoB. For EpoB preclinical data reported by Novartis, see: a) K.-H. Altmann, M. Wartmann, T. O'Reilly, Biochim. Biophys. Acta 2000, 1470, M79;
-
(2000)
Biochim. Biophys. Acta
, vol.1470
-
-
Altmann, K.-H.1
Wartmann, M.2
O'Reilly, T.3
-
75
-
-
0037838495
-
-
b) J. Rothermel, M. Wartmann, T. Chen, J. Hohneker, Semin. Oncol. 2003, 6(Suppl.30), 51.
-
(2003)
Semin. Oncol.
, vol.6
, Issue.30 SUPPL.
, pp. 51
-
-
Rothermel, J.1
Wartmann, M.2
Chen, T.3
Hohneker, J.4
-
76
-
-
0033523260
-
-
C. R. Harris, S. D. Kuduk, A. Balog, K. Savin, P. W. Glunz, S. J. Danishefsky, J. Am. Chem. Soc. 1999, 121, 7051.
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 7051
-
-
Harris, C.R.1
Kuduk, S.D.2
Balog, A.3
Savin, K.4
Glunz, P.W.5
Danishefsky, S.J.6
-
77
-
-
0029827812
-
-
N.-H. Lin, L. E. Overman, M. H. Rabinowitz, L. A. Robinson, M. J. Sharp, J. Zablocki, J. Am. Chem. Soc. 1996, 118, 9062.
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 9062
-
-
Lin, N.-H.1
Overman, L.E.2
Rabinowitz, M.H.3
Robinson, L.A.4
Sharp, M.J.5
Zablocki, J.6
-
78
-
-
0001924336
-
-
D. A. Evans, J. V. Nelson, T. R. Taber, Top. Stereochem. 1982, 13, 1.
-
(1982)
Top. Stereochem.
, vol.13
, pp. 1
-
-
Evans, D.A.1
Nelson, J.V.2
Taber, T.R.3
-
79
-
-
33845282793
-
-
R. Noyori, T. Ohkuma, M. Kitamura, H. Takaya, N. Sayo, H. Kumobayahshi, S. Akutagawa, J. Am. Chem. Soc. 1987, 109, 5856.
-
(1987)
J. Am. Chem. Soc.
, vol.109
, pp. 5856
-
-
Noyori, R.1
Ohkuma, T.2
Kitamura, M.3
Takaya, H.4
Sayo, N.5
Kumobayahshi, H.6
Akutagawa, S.7
-
80
-
-
0034692354
-
-
Bristol-Myers Squibb (BMS) is sponsoring clinical trials of the 15-desoxy-15-aza congener: a) R. M. Borzilleri, X. Zheng, R. J. Schmidt, J. A. Johnson, S.-H. Kim, J. D. DiMarco, C. R. Fairchild, J. Z. Gougoutas, F. Y. F. Lee, B. H. Long, G. D. Vite, J. Am. Chem. Soc. 2000, 122, 8890;
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 8890
-
-
Borzilleri, R.M.1
Zheng, X.2
Schmidt, R.J.3
Johnson, J.A.4
Kim, S.-H.5
DiMarco, J.D.6
Fairchild, C.R.7
Gougoutas, J.Z.8
Lee, F.Y.F.9
Long, B.H.10
Vite, G.D.11
-
81
-
-
0034895987
-
-
b) F. Y. F. Lee, R. Borzilleri, C. R. Fairchild, S.-H Kim, B. H. Long, C. Reventos-Suarez, G. D. Vite, W. C. Rose, R. A. Kramer, Clin. Cancer Res. 2001, 7, 1429;
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1429
-
-
Lee, F.Y.F.1
Borzilleri, R.2
Fairchild, C.R.3
Kim, S.-H.4
Long, B.H.5
Reventos-Suarez, C.6
Vite, G.D.7
Rose, W.C.8
Kramer, R.A.9
-
82
-
-
0036998727
-
-
BMS is also sponsoring clinical trials of another epothilone derivative (BMS310705): c) R. M. Borzilleri, G. D. Vite, Drugs Future 2002, 27, 1149.
-
(2002)
Drugs Future
, vol.27
, pp. 1149
-
-
Borzilleri, R.M.1
Vite, G.D.2
-
83
-
-
0034723333
-
-
L. Tang, S. Shah, L. Chung, J. Carney, L. Katz, C. Khosla, B. Julien, Science 2000, 287, 640.
-
(2000)
Science
, vol.287
, pp. 640
-
-
Tang, L.1
Shah, S.2
Chung, L.3
Carney, J.4
Katz, L.5
Khosla, C.6
Julien, B.7
-
84
-
-
84888899052
-
-
For more information about the clinical trials of dEpoB, visit: www.kosan.com.
-
-
-
-
85
-
-
0036239554
-
-
R. L. Arslanian, L. Tang, S. Blough, W. Ma, R. G. Qiu, L. Katz, J. R. Carn, J. Nat. Prod. 2002, 65, 570.
-
(2002)
J. Nat. Prod.
, vol.65
, pp. 570
-
-
Arslanian, R.L.1
Tang, L.2
Blough, S.3
Ma, W.4
Qiu, R.G.5
Katz, L.6
Carn, J.R.7
-
86
-
-
0034201169
-
-
M. D. Chappell, S. J. Stachel, C. B. Lee, S. J. Danishefsky, Org. Lett. 2000, 2, 1633.
-
(2000)
Org. Lett.
, vol.2
, pp. 1633
-
-
Chappell, M.D.1
Stachel, S.J.2
Lee, C.B.3
Danishefsky, S.J.4
-
87
-
-
0037151663
-
-
K. Biswas, H. Lin, J. T. Njardarson, M. D. Chappell, T.-C. Chou, Y. Guan, W. P. Tong, L. He, S. B. Horwitz, S. J. Danishefsky, J. Am. Chem. Soc. 2002, 124, 9825.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 9825
-
-
Biswas, K.1
Lin, H.2
Njardarson, J.T.3
Chappell, M.D.4
Chou, T.-C.5
Guan, Y.6
Tong, W.P.7
He, L.8
Horwitz, S.B.9
Danishefsky, S.J.10
-
90
-
-
17944378190
-
-
c) R. A. Newman, J. Yang, M. R. V. Finlay, F. Cabral, D. Vourloumis, L. C. Stephens, P. Troncoso, X. Wu, C. J. Logothetis, K. C. Nicolaou, N. M. Navone, Cancer Chemother. Pharmacol. 2001, 48, 319;
-
(2001)
Cancer Chemother. Pharmacol.
, vol.48
, pp. 319
-
-
Newman, R.A.1
Yang, J.2
Finlay, M.R.V.3
Cabral, F.4
Vourloumis, D.5
Stephens, L.C.6
Troncoso, P.7
Wu, X.8
Logothetis, C.J.9
Nicolaou, K.C.10
Navone, N.M.11
-
91
-
-
4944231418
-
Fluorine in the Life Sciences
-
d) Special issue on "Fluorine in the Life Sciences", ChemBioChem 2004, 5, 557-726.
-
(2004)
ChemBioChem
, vol.5
, pp. 557-726
-
-
-
92
-
-
0037078811
-
-
A. Rivkin, K. Biswas, T.-C. Chou, S. J. Danishefsky, Org. Lett. 2002, 4, 4081.
-
(2002)
Org. Lett.
, vol.4
, pp. 4081
-
-
Rivkin, A.1
Biswas, K.2
Chou, T.-C.3
Danishefsky, S.J.4
-
93
-
-
84888899019
-
-
Unpublished results
-
Unpublished results.
-
-
-
-
94
-
-
0036827835
-
-
A. Rivkin, J. T. Njardarson, K. Biswas, T.-C. Chou, S. J. Danishefsky, J. Org. Chem. 2002, 67, 7737.
-
(2002)
J. Org. Chem.
, vol.67
, pp. 7737
-
-
Rivkin, A.1
Njardarson, J.T.2
Biswas, K.3
Chou, T.-C.4
Danishefsky, S.J.5
-
95
-
-
0001886335
-
-
K. C. Nicolaou, F. Sarabia, S. Ninkovic, M. Ray, V. Finlay, C. N. C. Boddy, Angew. Chem. 1998, 110, 85;
-
(1998)
Angew. Chem.
, vol.110
, pp. 85
-
-
Nicolaou, K.C.1
Sarabia, F.2
Ninkovic, S.3
Ray, M.4
Finlay, V.5
Boddy, C.N.C.6
-
97
-
-
4444339511
-
-
A. Rivkin, F. Yoshimura, A. E. Gabarda, Y. S. Cho, T.-C. Chou, H. Dong, S. J. Danishefsky, J. Am. Chem. Soc. 2004, 126, 10913.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 10913
-
-
Rivkin, A.1
Yoshimura, F.2
Gabarda, A.E.3
Cho, Y.S.4
Chou, T.-C.5
Dong, H.6
Danishefsky, S.J.7
-
98
-
-
0034820136
-
-
J. D. White, R. G. Carter, K. F. Sundermann, M. Wartmann, J. Am. Chem. Soc. 2001, 123, 5407.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 5407
-
-
White, J.D.1
Carter, R.G.2
Sundermann, K.F.3
Wartmann, M.4
-
99
-
-
79955878231
-
-
J. D. White, R. G. Carter, K. F. Sundermann, M. Wartmann, J. Am. Chem. Soc. 2003, 125, 3190.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 3190
-
-
White, J.D.1
Carter, R.G.2
Sundermann, K.F.3
Wartmann, M.4
-
100
-
-
0035110756
-
-
For a recent and impressive case of long-term cure, see: M. J. Towle, K. A. Salvato, J. Budrow, B. F. Wels, G. Kuznetsov, K. K. Aalfs, S. Welsh, W. Zheng, B. M. Seletsky, M. H. Palme, G. J. Habgood, L. A. Singer, L. V. DiPietro, Y. Wang, J. J. Chen, D. A. Quincy, A. Davis, K. Yoshimatsu, Y. Kishi, M. J. Yu, B. A. Littlefield, Cancer Res. 2001, 61, 1013. Our case is particularly noteworthy in that the cures were established consistently. Furthermore, they were established on high tumor burdens, and the drug shows oral-administration efficacy.
-
(2001)
Cancer Res.
, vol.61
, pp. 1013
-
-
Towle, M.J.1
Salvato, K.A.2
Budrow, J.3
Wels, B.F.4
Kuznetsov, G.5
Aalfs, K.K.6
Welsh, S.7
Zheng, W.8
Seletsky, B.M.9
Palme, M.H.10
Habgood, G.J.11
Singer, L.A.12
DiPietro, L.V.13
Wang, Y.14
Chen, J.J.15
Quincy, D.A.16
Davis, A.17
Yoshimatsu, K.18
Kishi, Y.19
Yu, M.J.20
Littlefield, B.A.21
more..
-
101
-
-
0001452901
-
-
R. Breinbauer, I. R. Vetter, H. Waldmann, Angew. Chem. 2002, 114, 3002;
-
(2002)
Angew. Chem.
, vol.114
, pp. 3002
-
-
Breinbauer, R.1
Vetter, I.R.2
Waldmann, H.3
|