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Volumn 122, Issue 32, 2000, Pages 7825-7826

Total synthesis of (-)-CP-263,114 (phomoidride B) [8]

Author keywords

[No Author keywords available]

Indexed keywords

PHOMOIDRIDE B; PROTEIN FARNESYLTRANSFERASE INHIBITOR; SQUALENE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0034675030     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja001664b     Document Type: Letter
Times cited : (82)

References (34)
  • 19
    • 0000118924 scopus 로고    scopus 로고
    • (o) For reviews: see ref 1c and Diederichsen, U. Nachr. Chem. Technol. Lab. 1999, 47, 1423; Starr, J. T.; Carreira, E. M. Angew. Chem., Int. Ed. 2000, 39, 1415.
    • (1999) Nachr. Chem. Technol. Lab. , vol.47 , pp. 1423
    • Diederichsen, U.1
  • 20
    • 0034678605 scopus 로고    scopus 로고
    • (o) For reviews: see ref 1c and Diederichsen, U. Nachr. Chem. Technol. Lab. 1999, 47, 1423; Starr, J. T.; Carreira, E. M. Angew. Chem., Int. Ed. 2000, 39, 1415.
    • (2000) Angew. Chem., Int. Ed. , vol.39 , pp. 1415
    • Starr, J.T.1    Carreira, E.M.2
  • 26
    • 0343625589 scopus 로고    scopus 로고
    • note
    • A detailed procedure for the preparation of this compound is described in Supporting Information.
  • 30
    • 0343625588 scopus 로고    scopus 로고
    • note
    • In preliminary studies we found that the aldehyde 7b, which was derived from L-malic acid (S-configuration), formed a matched pair with 6.
  • 32
    • 0342755361 scopus 로고    scopus 로고
    • note
    • In the absence of pyridine, an acid-catalyzed double bond isomerization occurred to give a small amount of the unreactive 1,3-diene isomer.
  • 33
    • 0343190008 scopus 로고    scopus 로고
    • note
    • NOEs between H-9 and H-12, H-12 and H-16, H-17 and H-26, respectively, were observed.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.