Total synthesis of the CP molecules CP-263,114 and CP-225,917- Part 1: Synthesis of key intermediates and intelligence gathering

Angewandte Chemie - International Edition

Volumn 38, Issue 11, 1999, Pages 1669-1675

  Nicolaou, K C ^a,b   Baran, Phil S ^a,b   Zhong, Yong Li ^a,b   Choi, Ha Soon ^a,b   Yoon, Won Hyung ^a,b   He, Yun ^a,b   Fong, Kin Chiu ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Domino reactions; Natural products; Polycycles; Total synthesis

Indexed keywords

CP 225917; CP 263114; FARNESYL TRANS TRANSFERASE; HYPOCHOLESTEROLEMIC AGENT; SQUALENE SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER; CYCLIZATION; DRUG ISOLATION; DRUG SYNTHESIS; ENZYME INHIBITION; FUNGUS; METHYLATION; OXIDATION; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

EID: 0033153049     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(19990601)38:11<1669::AID-ANIE1669>3.0.CO;2-D     Document Type: Article

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48. Crystallographic data (excluding structure factors) for the structure reported in this paper have been deposited with the Cambridge Crystallographic Data Centre as Supplementary publication no. CCDC-118962. Copies of the data can be obtained free of charge on application to CCDC, 12 Union road, Cambridge CB21EZ, UK (fax: (+44)1223-336-033: e-mail: deposit@ccc.cam.ac.uk).